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The map label for this gene is ispB [H]

Identifier: 110633068

GI number: 110633068

Start: 783303

End: 784319

Strand: Direct

Name: ispB [H]

Synonym: Meso_0711

Alternate gene names: 110633068

Gene position: 783303-784319 (Clockwise)

Preceding gene: 110633059

Following gene: 110633069

Centisome position: 17.75

GC content: 61.36

Gene sequence:

>1017_bases
GTGGGCGTAGTGTTGAACCTCGAAGACGGCAAGCGCAATGGTGCCTCCATCGAGCGCCTGATCGGCCTGACGAAGGACGA
CATGGCGCGCGTCAACGATCTGATCCTGTCCAAGGCGGGATCGGATGTCGAGCTGATCCCTCAGCTTGCGCGCCATCTCA
TTTCCTCGGGCGGCAAAAGGCTGCGCCCGATGATCACCCTCGCGGCTGCCCAGATGTTCGGCTATTCGGGCGAGGGGCAT
GTGAAGCTCGCCACGAGTGTTGAATTCATGCACACGGCCACGCTGCTGCATGACGATGTGGTCGACGAAAGCGATATGCG
GCGCGGCAAGAAGACCGCGCGGACGATTTGGGGCAATCAGGCCAGCGTGCTCGTGGGGGATTACCTTCTGGGCCAGGCGT
TCCGAATGATGGTCGATGTTGGCTCGCTGGAAGCGCTGGATGTGCTTTCGTCGGCGGCTTCCATTATCGCCGAAGGCGAG
GTGATGCAGCTTGGCGTCTCCAAGAACCTGGAGACCACCGAGGACGAATATCTGAGCGTCATCAAGGCCAAGACCGCCGC
TCTGTTTTCCGCCGCCGCGGAGGTGGGGCCGATCATCGCAGAGGCTTCCCGCAATGACCGGGCAGCGCTCCGCTCCTTCG
GCATAAATCTCGGGCTCGCGTTCCAGCTTGTGGATGACGCGTTGGACTATGGCGGCAGCAGCCGCGATCTCGGCAAGAAT
GTCGGCGACGATTTCCGTGAGGGAAAGGTAACGCTGCCGGTTATTCTCAGCTACCGGCGCGGTTCGGAGGAAGAGCGGCT
ATTCTGGAAGCGCGCCATCGAAGAGAACCAGAACGACGACGACGCGCTCGCAAAAGCGATCGGCCTGATGAATCGGCACG
GCTCGATCGGCGACACGATTGCGCGCGCCCGCCATTTCGGCGAGATCGCGCGAGATGCGCTGGCTCCTCTGAAGAGCACA
CCGCAGAAGGCGGCGCTGTTCGATGTCATCGATTTCTGCATTAGCAGGGTGTCTTAG

Upstream 100 bases:

>100_bases
TGTAAATGAGCGCCGCTTGCCTTACCCAAACCGCGCCAACTCGCCGCTTGCGGTCGGGCGGGCTGCGACCATACATTCCA
GGAATGGAAGGAGAGCACCG

Downstream 100 bases:

>100_bases
AGCTGGTTGGTTCTCTATTTACGATTGCGGCACCATCGTAAAAAGGCCATCCTCTGCGGCTAGCAGGTTTCCGCAAGGGA
AGGGCCGAACCGACGGAAGG

Product: polyprenyl synthetase

Products: NA

Alternate protein names: All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MGVVLNLEDGKRNGASIERLIGLTKDDMARVNDLILSKAGSDVELIPQLARHLISSGGKRLRPMITLAAAQMFGYSGEGH
VKLATSVEFMHTATLLHDDVVDESDMRRGKKTARTIWGNQASVLVGDYLLGQAFRMMVDVGSLEALDVLSSAASIIAEGE
VMQLGVSKNLETTEDEYLSVIKAKTAALFSAAAEVGPIIAEASRNDRAALRSFGINLGLAFQLVDDALDYGGSSRDLGKN
VGDDFREGKVTLPVILSYRRGSEEERLFWKRAIEENQNDDDALAKAIGLMNRHGSIGDTIARARHFGEIARDALAPLKST
PQKAALFDVIDFCISRVS

Sequences:

>Translated_338_residues
MGVVLNLEDGKRNGASIERLIGLTKDDMARVNDLILSKAGSDVELIPQLARHLISSGGKRLRPMITLAAAQMFGYSGEGH
VKLATSVEFMHTATLLHDDVVDESDMRRGKKTARTIWGNQASVLVGDYLLGQAFRMMVDVGSLEALDVLSSAASIIAEGE
VMQLGVSKNLETTEDEYLSVIKAKTAALFSAAAEVGPIIAEASRNDRAALRSFGINLGLAFQLVDDALDYGGSSRDLGKN
VGDDFREGKVTLPVILSYRRGSEEERLFWKRAIEENQNDDDALAKAIGLMNRHGSIGDTIARARHFGEIARDALAPLKST
PQKAALFDVIDFCISRVS
>Mature_337_residues
GVVLNLEDGKRNGASIERLIGLTKDDMARVNDLILSKAGSDVELIPQLARHLISSGGKRLRPMITLAAAQMFGYSGEGHV
KLATSVEFMHTATLLHDDVVDESDMRRGKKTARTIWGNQASVLVGDYLLGQAFRMMVDVGSLEALDVLSSAASIIAEGEV
MQLGVSKNLETTEDEYLSVIKAKTAALFSAAAEVGPIIAEASRNDRAALRSFGINLGLAFQLVDDALDYGGSSRDLGKNV
GDDFREGKVTLPVILSYRRGSEEERLFWKRAIEENQNDDDALAKAIGLMNRHGSIGDTIARARHFGEIARDALAPLKSTP
QKAALFDVIDFCISRVS

Specific function: Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=296, Percent_Identity=26.6891891891892, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4758430, Length=206, Percent_Identity=23.3009708737864, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI83700220, Length=206, Percent_Identity=23.3009708737864, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789578, Length=321, Percent_Identity=47.0404984423676, Blast_Score=280, Evalue=9e-77,
Organism=Escherichia coli, GI1786623, Length=223, Percent_Identity=32.7354260089686, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17505681, Length=255, Percent_Identity=28.6274509803922, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319475, Length=222, Percent_Identity=33.7837837837838, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325188, Length=241, Percent_Identity=22.4066390041494, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24651612, Length=323, Percent_Identity=31.2693498452012, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI281365769, Length=300, Percent_Identity=24.6666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24660002, Length=300, Percent_Identity=24.6666666666667, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.90 [H]

Molecular weight: Translated: 36563; Mature: 36432

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVVLNLEDGKRNGASIERLIGLTKDDMARVNDLILSKAGSDVELIPQLARHLISSGGKR
CCEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHH
LRPMITLAAAQMFGYSGEGHVKLATSVEFMHTATLLHDDVVDESDMRRGKKTARTIWGNQ
HHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
ASVLVGDYLLGQAFRMMVDVGSLEALDVLSSAASIIAEGEVMQLGVSKNLETTEDEYLSV
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHH
IKAKTAALFSAAAEVGPIIAEASRNDRAALRSFGINLGLAFQLVDDALDYGGSSRDLGKN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHCCC
VGDDFREGKVTLPVILSYRRGSEEERLFWKRAIEENQNDDDALAKAIGLMNRHGSIGDTI
CCCHHHCCCEEEHEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHH
ARARHFGEIARDALAPLKSTPQKAALFDVIDFCISRVS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVVLNLEDGKRNGASIERLIGLTKDDMARVNDLILSKAGSDVELIPQLARHLISSGGKR
CEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHH
LRPMITLAAAQMFGYSGEGHVKLATSVEFMHTATLLHDDVVDESDMRRGKKTARTIWGNQ
HHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
ASVLVGDYLLGQAFRMMVDVGSLEALDVLSSAASIIAEGEVMQLGVSKNLETTEDEYLSV
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHH
IKAKTAALFSAAAEVGPIIAEASRNDRAALRSFGINLGLAFQLVDDALDYGGSSRDLGKN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHCCC
VGDDFREGKVTLPVILSYRRGSEEERLFWKRAIEENQNDDDALAKAIGLMNRHGSIGDTI
CCCHHHCCCEEEHEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHH
ARARHFGEIARDALAPLKSTPQKAALFDVIDFCISRVS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8312607; 9278503; 2670911; 8037730 [H]