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The map label for this gene is hsrA [H]

Identifier: 110632830

GI number: 110632830

Start: 517398

End: 518837

Strand: Direct

Name: hsrA [H]

Synonym: Meso_0469

Alternate gene names: 110632830

Gene position: 517398-518837 (Clockwise)

Preceding gene: 110632827

Following gene: 110632841

Centisome position: 11.73

GC content: 61.6

Gene sequence:

>1440_bases
TTGAACCGCACACTGCCCCTGGTCCTTGCCGTCGCCCTTTTCATGGAGCAGATGGATTCCACGGTAATCGCCACCTCCTT
ACCGGCGATCGCCGAGGACATTGGCACCAATCCCGTGACGCTGAAGCTTGCCTTGACCACCTATCTGGTGGCGGTCGCAA
TCTTCATCCCGGTCAGCGGCTGGATGGCGGACCGCTTCGGGGCCAAGCGGATATTCCGGCTCGCACTCGCGATCTTCGTG
CTCGGCTCGATCGCCTGCGCGGTGTCCAACTCTCTTCTCGCCTTTGTCCTGGCGCGTTTCCTGCAGGGAATAGGCGGGGC
GATGATGACGCCGGTGGCGAGATTGGTGCTGGTTCGCGCCACACCGAGGAACCAGCTTATTTCAGCCATGGCGTGGCTCT
CTGTGCCGGCCCTTATCGGTCCCATTTCCGGCCCGCCGCTAGGCGGCTTCATCACCACCTATTTTTCCTGGCACTGGATC
TTTCTGATAAATGTGCCCATCGGGCTTGCAGGCATCCTGCTCTCGGGCCGCGTCCTGCCTGATTTAGAGCCGGAACATAA
AAAAAAGCTCGATTCCACGGGGTTTGCGCTCTCCGGTCTGGCGGCCTCGGGGATTGTTTTCGGTCTTTCCGTGATAAGTC
TTCCTGCGCTCCCGCCCATTATCGGTATTGTCACCGCAGCCTTCGGCTTCGTGATGGCGTTCCTTTATATTTTCCACGCG
CGCCGCGCGGCAGATCCGATTTTGAACCTGCGGCTCTTCGCCATCCCTGCCTTTCGCGCCGCTATAATAGGAGGGAGCCT
CTTCCGGGTTGGCGTCGGCGCGGTTCCGTTCCTTCTGCCGCTGATGTTGCAGCTCCAGTTCGGGCTGACGCCCTTTCAAT
CCGGCATGCTTACCTTCGCGTCCGCGCTGGGCGCCATCTCGGTCAAAATGATCGCTTCCACGGCATTGCGGGCCGTTGGT
TTCCGCCTCACGCTCATTTTCGCGGCCATCTTCGGCAGCCTGCTGATTGCCGCCAATGCTCTATTCACCGCTGCCACGCC
CCATCTCACCATTGTGGCGGTTTTGGTGGCCGCCGGTTTCTTCCGCTCTCTTTTCTTCACCTCCAACAACGCGCTCGTTT
TTGCCGAACTCGGAGACCGTGAAGCGGGGCAAGCGACCGCGATCGCGGCCGCGTCGCAGCAGATCAGCATCGCCATAGGC
GTGGCGGTGGGGGGAGGCATTCTGGAGATCACCGGCTATGTCACCGGGGAGCCGCTCGGGCGCGACGCCTTTGTCAACGC
GTTTGTGATTGTGGGATTTGTGTCGGCGCTGGCCGCCTTGCCGTTCCTGCGTCTTCCCGCCGACACCGGAAGTGCCGTAT
CCGGCCACGGCCGCAAGCGCGTGGCAGAAGAGGAACAGGCCTTGGCCGCGGAACGGACTGCTCAGCCCTCCGCAGCCTGA

Upstream 100 bases:

>100_bases
GAAGCGAAGATGCTAAGGGCAAGATATTGTTAGATCAGACGCGGGCTCGGCATCACCGCGCGCCCGTGGTGTTCTCGCCT
ATCACGTCCAAGAGTCCGCC

Downstream 100 bases:

>100_bases
CGGCCTTTGAAGTCCTTTGCAAGAATGTAAAGCTCGACCGATTCATCGCGGGAAGCAGGCGGCTTGACGTGATGGACCGA
ACGGAAATTCCTTTTGAGCA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MNRTLPLVLAVALFMEQMDSTVIATSLPAIAEDIGTNPVTLKLALTTYLVAVAIFIPVSGWMADRFGAKRIFRLALAIFV
LGSIACAVSNSLLAFVLARFLQGIGGAMMTPVARLVLVRATPRNQLISAMAWLSVPALIGPISGPPLGGFITTYFSWHWI
FLINVPIGLAGILLSGRVLPDLEPEHKKKLDSTGFALSGLAASGIVFGLSVISLPALPPIIGIVTAAFGFVMAFLYIFHA
RRAADPILNLRLFAIPAFRAAIIGGSLFRVGVGAVPFLLPLMLQLQFGLTPFQSGMLTFASALGAISVKMIASTALRAVG
FRLTLIFAAIFGSLLIAANALFTAATPHLTIVAVLVAAGFFRSLFFTSNNALVFAELGDREAGQATAIAAASQQISIAIG
VAVGGGILEITGYVTGEPLGRDAFVNAFVIVGFVSALAALPFLRLPADTGSAVSGHGRKRVAEEEQALAAERTAQPSAA

Sequences:

>Translated_479_residues
MNRTLPLVLAVALFMEQMDSTVIATSLPAIAEDIGTNPVTLKLALTTYLVAVAIFIPVSGWMADRFGAKRIFRLALAIFV
LGSIACAVSNSLLAFVLARFLQGIGGAMMTPVARLVLVRATPRNQLISAMAWLSVPALIGPISGPPLGGFITTYFSWHWI
FLINVPIGLAGILLSGRVLPDLEPEHKKKLDSTGFALSGLAASGIVFGLSVISLPALPPIIGIVTAAFGFVMAFLYIFHA
RRAADPILNLRLFAIPAFRAAIIGGSLFRVGVGAVPFLLPLMLQLQFGLTPFQSGMLTFASALGAISVKMIASTALRAVG
FRLTLIFAAIFGSLLIAANALFTAATPHLTIVAVLVAAGFFRSLFFTSNNALVFAELGDREAGQATAIAAASQQISIAIG
VAVGGGILEITGYVTGEPLGRDAFVNAFVIVGFVSALAALPFLRLPADTGSAVSGHGRKRVAEEEQALAAERTAQPSAA
>Mature_479_residues
MNRTLPLVLAVALFMEQMDSTVIATSLPAIAEDIGTNPVTLKLALTTYLVAVAIFIPVSGWMADRFGAKRIFRLALAIFV
LGSIACAVSNSLLAFVLARFLQGIGGAMMTPVARLVLVRATPRNQLISAMAWLSVPALIGPISGPPLGGFITTYFSWHWI
FLINVPIGLAGILLSGRVLPDLEPEHKKKLDSTGFALSGLAASGIVFGLSVISLPALPPIIGIVTAAFGFVMAFLYIFHA
RRAADPILNLRLFAIPAFRAAIIGGSLFRVGVGAVPFLLPLMLQLQFGLTPFQSGMLTFASALGAISVKMIASTALRAVG
FRLTLIFAAIFGSLLIAANALFTAATPHLTIVAVLVAAGFFRSLFFTSNNALVFAELGDREAGQATAIAAASQQISIAIG
VAVGGGILEITGYVTGEPLGRDAFVNAFVIVGFVSALAALPFLRLPADTGSAVSGHGRKRVAEEEQALAAERTAQPSAA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=472, Percent_Identity=40.0423728813559, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1788392, Length=460, Percent_Identity=33.0434782608696, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789042, Length=298, Percent_Identity=31.5436241610738, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788710, Length=413, Percent_Identity=26.634382566586, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081983, Length=410, Percent_Identity=26.5853658536585, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790146, Length=158, Percent_Identity=29.1139240506329, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=151, Percent_Identity=30.4635761589404, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=164, Percent_Identity=30.4878048780488, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49984; Mature: 49984

Theoretical pI: Translated: 10.76; Mature: 10.76

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTLPLVLAVALFMEQMDSTVIATSLPAIAEDIGTNPVTLKLALTTYLVAVAIFIPVSG
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCC
WMADRFGAKRIFRLALAIFVLGSIACAVSNSLLAFVLARFLQGIGGAMMTPVARLVLVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEC
TPRNQLISAMAWLSVPALIGPISGPPLGGFITTYFSWHWIFLINVPIGLAGILLSGRVLP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEEECCHHHHHHHHCCCCCC
DLEPEHKKKLDSTGFALSGLAASGIVFGLSVISLPALPPIIGIVTAAFGFVMAFLYIFHA
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RRAADPILNLRLFAIPAFRAAIIGGSLFRVGVGAVPFLLPLMLQLQFGLTPFQSGMLTFA
HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SALGAISVKMIASTALRAVGFRLTLIFAAIFGSLLIAANALFTAATPHLTIVAVLVAAGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FRSLFFTSNNALVFAELGDREAGQATAIAAASQQISIAIGVAVGGGILEITGYVTGEPLG
HHHHHEECCCEEEEEECCCCCCCCHHHHHHCCCEEEEEEEEEECCCEEEEEEEECCCCCC
RDAFVNAFVIVGFVSALAALPFLRLPADTGSAVSGHGRKRVAEEEQALAAERTAQPSAA
CHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRTLPLVLAVALFMEQMDSTVIATSLPAIAEDIGTNPVTLKLALTTYLVAVAIFIPVSG
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCC
WMADRFGAKRIFRLALAIFVLGSIACAVSNSLLAFVLARFLQGIGGAMMTPVARLVLVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEC
TPRNQLISAMAWLSVPALIGPISGPPLGGFITTYFSWHWIFLINVPIGLAGILLSGRVLP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEEECCHHHHHHHHCCCCCC
DLEPEHKKKLDSTGFALSGLAASGIVFGLSVISLPALPPIIGIVTAAFGFVMAFLYIFHA
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RRAADPILNLRLFAIPAFRAAIIGGSLFRVGVGAVPFLLPLMLQLQFGLTPFQSGMLTFA
HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SALGAISVKMIASTALRAVGFRLTLIFAAIFGSLLIAANALFTAATPHLTIVAVLVAAGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FRSLFFTSNNALVFAELGDREAGQATAIAAASQQISIAIGVAVGGGILEITGYVTGEPLG
HHHHHEECCCEEEEEECCCCCCCCHHHHHHCCCEEEEEEEEEECCCEEEEEEEECCCCCC
RDAFVNAFVIVGFVSALAALPFLRLPADTGSAVSGHGRKRVAEEEQALAAERTAQPSAA
CHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]