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The map label for this gene is hisD [H]

Identifier: 110632552

GI number: 110632552

Start: 232277

End: 233569

Strand: Reverse

Name: hisD [H]

Synonym: Meso_0190

Alternate gene names: 110632552

Gene position: 233569-232277 (Counterclockwise)

Preceding gene: 110632553

Following gene: 110632551

Centisome position: 5.29

GC content: 63.11

Gene sequence:

>1293_bases
ATGCCGATGAGACTTTCCACCGCCGAGAGGGACTTTGAAACGGCTTTCGCCGCCTTCTTGTCGACCAAACGCGAGGTTTC
CGAGGAAGTAGACACCGCCGTGCGGGAGATTATCGCCCGCGTGCGGGCTGAAGGCGATTCAGCCGTGGCTGACTATACCA
GGCGGTTCGATCGTTTTGATCCTGCGCAGATCCAAATGCGCGTTTCGCGCGAGGAGATCGAGGCGGCATACGGGAAGACG
GATCCCGAGACGCTTGAAGCCTTGAAGCTCGCGCAGGACCGTATCGAGGCGCACCACCGCCGCCAGCTTCCTGCCGATGC
GCGCTACACCGATCCGCTCGGGGTGGAACTCGGCTGGCGATGGACGCCGATTACCGCCGTGGGCCTTTATGTGCCTGGCG
GGCTCGCCAGCTATCCAAGCTCGGTGCTCATGAATGCGATACCGGCCCGTGTGGCCGGCGTCGAGCGCGTGGTGATGACG
GTCCCCTCCCCGGACGGCGAGATCAATCCTCTTGTGCTGGTTGCGGCTGATCTGGCGGGCGTGAGCGAGATCTACCGGAT
CGGCGGCGCACAGGCCGTGGCTGCGCTTGCCTATGGAACGGAGAGCATCGCCCCCGTCTACAAGATCGTCGGCCCAGGAA
ATGCCTATGTAGCCGCCGCAAAGCGGCAGGTCTTCGGACAGGTCGGTATCGATATGATCGCCGGCCCCTCCGAAGTGCTG
GTCGTCGCGGACCGTGACAACGATCCTGACTGGATCGCGGCCGATCTTCTGGCCCAGGCTGAACATGATGCAGCGGCGCA
GTCGATCCTCATGACGGACGATCCAAACTTCGCTGAAGCGGTGTCCGATGCCGTCGAGCGGCAGCTTACGCGGCTTTCCC
GGTCGGAAATCGCGGGCGCGAGCTGGCGTGATTTCGGGGCAGTCATTCTCGTCCGCAGCTTCGAGGAAGTCCCTCAACTC
GTTGATCGGATCGCACCGGAGCATCTGGAGCTGGCGACGGAGAATGCAGAAGTGCTGCTTTCGCGTATCCGCAATGCGGG
GGCGGCCTTTATCGGCCGCCACACGCCTGAGGTCATCGGGGACTATGTGGGCGGATCCAACCACGTATTGCCGACGGCCC
GCTCAGCACGCTTTTCCTCAGGCCTTTCCGTGCTCGACTTCATGAAGCGCATGTCGATACTTCGGCTCGGCGCGGATCAG
CTGCGGGTACTGGGCCCGGCCGCCATTGCTCTCGCGAAGGCTGAAGGCCTGGAGGCGCATGGCCGTTCCGTCTCGATACG
GCTCAATACCTAG

Upstream 100 bases:

>100_bases
GTCCAGCTCGAGGTGGAGTGCATTGAGGCGCGGCTGAGCGATTTAGGTGCGGCCTGGGAAACGCCGGTTCGCCCCCGGCA
CAGCAATTGAGGGCGCACGC

Downstream 100 bases:

>100_bases
AGGCTGCCAAGGTAAACCGATGGGCGAGCGGAGTTCAGCCAAGGCACGCCTCATCGATGTCGAGCTGGACGAGACCGTCG
GGCGCGCACCGCCCGATGTG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MPMRLSTAERDFETAFAAFLSTKREVSEEVDTAVREIIARVRAEGDSAVADYTRRFDRFDPAQIQMRVSREEIEAAYGKT
DPETLEALKLAQDRIEAHHRRQLPADARYTDPLGVELGWRWTPITAVGLYVPGGLASYPSSVLMNAIPARVAGVERVVMT
VPSPDGEINPLVLVAADLAGVSEIYRIGGAQAVAALAYGTESIAPVYKIVGPGNAYVAAAKRQVFGQVGIDMIAGPSEVL
VVADRDNDPDWIAADLLAQAEHDAAAQSILMTDDPNFAEAVSDAVERQLTRLSRSEIAGASWRDFGAVILVRSFEEVPQL
VDRIAPEHLELATENAEVLLSRIRNAGAAFIGRHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFMKRMSILRLGADQ
LRVLGPAAIALAKAEGLEAHGRSVSIRLNT

Sequences:

>Translated_430_residues
MPMRLSTAERDFETAFAAFLSTKREVSEEVDTAVREIIARVRAEGDSAVADYTRRFDRFDPAQIQMRVSREEIEAAYGKT
DPETLEALKLAQDRIEAHHRRQLPADARYTDPLGVELGWRWTPITAVGLYVPGGLASYPSSVLMNAIPARVAGVERVVMT
VPSPDGEINPLVLVAADLAGVSEIYRIGGAQAVAALAYGTESIAPVYKIVGPGNAYVAAAKRQVFGQVGIDMIAGPSEVL
VVADRDNDPDWIAADLLAQAEHDAAAQSILMTDDPNFAEAVSDAVERQLTRLSRSEIAGASWRDFGAVILVRSFEEVPQL
VDRIAPEHLELATENAEVLLSRIRNAGAAFIGRHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFMKRMSILRLGADQ
LRVLGPAAIALAKAEGLEAHGRSVSIRLNT
>Mature_429_residues
PMRLSTAERDFETAFAAFLSTKREVSEEVDTAVREIIARVRAEGDSAVADYTRRFDRFDPAQIQMRVSREEIEAAYGKTD
PETLEALKLAQDRIEAHHRRQLPADARYTDPLGVELGWRWTPITAVGLYVPGGLASYPSSVLMNAIPARVAGVERVVMTV
PSPDGEINPLVLVAADLAGVSEIYRIGGAQAVAALAYGTESIAPVYKIVGPGNAYVAAAKRQVFGQVGIDMIAGPSEVLV
VADRDNDPDWIAADLLAQAEHDAAAQSILMTDDPNFAEAVSDAVERQLTRLSRSEIAGASWRDFGAVILVRSFEEVPQLV
DRIAPEHLELATENAEVLLSRIRNAGAAFIGRHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFMKRMSILRLGADQL
RVLGPAAIALAKAEGLEAHGRSVSIRLNT

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=407, Percent_Identity=42.2604422604423, Blast_Score=292, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=414, Percent_Identity=39.6135265700483, Blast_Score=260, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46402; Mature: 46271

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMRLSTAERDFETAFAAFLSTKREVSEEVDTAVREIIARVRAEGDSAVADYTRRFDRFD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
PAQIQMRVSREEIEAAYGKTDPETLEALKLAQDRIEAHHRRQLPADARYTDPLGVELGWR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCE
WTPITAVGLYVPGGLASYPSSVLMNAIPARVAGVERVVMTVPSPDGEINPLVLVAADLAG
ECCCEEEEEECCCCHHHCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEECHHHH
VSEIYRIGGAQAVAALAYGTESIAPVYKIVGPGNAYVAAAKRQVFGQVGIDMIAGPSEVL
HHHHHHHCCHHHHHHHHHCCCHHCCCEEEECCCCHHHHHHHHHHHHHCCCHHCCCCCEEE
VVADRDNDPDWIAADLLAQAEHDAAAQSILMTDDPNFAEAVSDAVERQLTRLSRSEIAGA
EEEECCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
SWRDFGAVILVRSFEEVPQLVDRIAPEHLELATENAEVLLSRIRNAGAAFIGRHTPEVIG
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCHHHCCCCHHHHH
DYVGGSNHVLPTARSARFSSGLSVLDFMKRMSILRLGADQLRVLGPAAIALAKAEGLEAH
HHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
GRSVSIRLNT
CCEEEEEECC
>Mature Secondary Structure 
PMRLSTAERDFETAFAAFLSTKREVSEEVDTAVREIIARVRAEGDSAVADYTRRFDRFD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
PAQIQMRVSREEIEAAYGKTDPETLEALKLAQDRIEAHHRRQLPADARYTDPLGVELGWR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCE
WTPITAVGLYVPGGLASYPSSVLMNAIPARVAGVERVVMTVPSPDGEINPLVLVAADLAG
ECCCEEEEEECCCCHHHCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEECHHHH
VSEIYRIGGAQAVAALAYGTESIAPVYKIVGPGNAYVAAAKRQVFGQVGIDMIAGPSEVL
HHHHHHHCCHHHHHHHHHCCCHHCCCEEEECCCCHHHHHHHHHHHHHCCCHHCCCCCEEE
VVADRDNDPDWIAADLLAQAEHDAAAQSILMTDDPNFAEAVSDAVERQLTRLSRSEIAGA
EEEECCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
SWRDFGAVILVRSFEEVPQLVDRIAPEHLELATENAEVLLSRIRNAGAAFIGRHTPEVIG
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCHHHCCCCHHHHH
DYVGGSNHVLPTARSARFSSGLSVLDFMKRMSILRLGADQLRVLGPAAIALAKAEGLEAH
HHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
GRSVSIRLNT
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA