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The map label for this gene is xseA

Identifier: 110632544

GI number: 110632544

Start: 226866

End: 228425

Strand: Reverse

Name: xseA

Synonym: Meso_0182

Alternate gene names: 110632544

Gene position: 228425-226866 (Counterclockwise)

Preceding gene: 110632545

Following gene: 110632543

Centisome position: 5.18

GC content: 62.88

Gene sequence:

>1560_bases
ATGGAAGAAGCAAAAAAAGACGATTCGCTCAGCAATGTCGCCGAATATTCGGTGAGCGAGATCTCGCATGCACTGAAGCG
CACGATCGAAGATACCTTCGGACATGTGCGCGTGCGTGGCGAGATCTCCGGTTTCCGTGGAGCCCATTCATCGGGCCATT
GCTATTTCTCGCTCAAGGACGAGCGGGCACGTATGGAAGCGGTGATCTGGAAAACCACTTTCGCCAGATTGCGCTTTCCT
CCACAGGAAGGGCTGGAGGTGATCGCGACAGGCCGCCTCACCACCTTTCCGGGCTCGTCAAAATATCAAATCGTCATCGA
GAGTCTTGAACCGGCCGGGGCCGGCGCTCTGATGGCGCTCCTGGAGGAGCGGAAGCGCAAGCTGGCCGCAGAAGGGTTGT
TTGCGGAGAGCCGAAAACGGCCGCTGCCTTTCATGCCGCATGTGATCGGCGTCGTTACCTCGCCAACCGGTGCCGTTATC
AGGGATATCATTCATCGCATCACCGACCGGTTTCCCGTCCATGTCGTCGTTTGGCCTGTGCGGGTCCAGGGAGAGACTAC
CGGCGCGGAAGTTGCCGCCGCGATCTCAGGCTTCAATGCGCTTCAGCCGGGCGGGACAATCCCGCGACCCGATATCCTTA
TCGTCGCGCGCGGCGGCGGCAGCCTGGAGGATCTGTGGGGCTTTAATGACGAGGCGGTTGTGCGCGCCGCCGCCGCATCC
GCGATTCCGTTGATCTCGGCGGTCGGTCACGAGACGGACTGGACACTCATAGACCTTGCCGCCGACCGGCGCGCACCGAC
CCCGACGGGCGCCGCCGAAGTGGCCGTGCCGGTGAAAGCGGAACTGGAGGCCAATATCGCGCGCCTTTCCGCCCGGCTTA
AGGGCGCCATATCCCGTTGTCTCGACCGGCGGCGGCAGGAGACGCGCAGTCTGGCGCGTGCGCTCCCCTCCCCTGACCAG
CTCTTCGCATTGCCGCGCCGACGCTTCGACGAAGCGGCAGGCAGGCTGGGCCGTGCGCTGCAAACCTCCACGCAAGGCAA
GCGCCTGCATCTAAACGCCGTCCGGGTTTCCATCGCCACGCTCGATCGGCGGATTGCACAGGCAAGGCGCGATGCCAACC
AATGCGGTGAGCGGCTGCCCCTCGTCTATCAAGGCCTGGTACGCCATCGCCGCGCCCGTTTCGACCGCGATGCCGCACGC
GTCAGCCCGCGCGTGACGCTGCAGCGAATAACAACTCTTGGCGAGCGCCTGAAGATTGCCATAGCGAGGAAGGACCGCGC
AGTTTCCCTCCGGGTGGAACGCGCGAGGACGGTTTATGAGCAGGCGGTCAGGCTCGCGGAATCGCTTTCCTATAAAAGCG
TTCTGGAACGCGGTTTCGCGCTGGTGCGGGATGGCGAAGACAGGCCGCTTAAGCGCGCGAGCGATGTGAAGCCGGGCGAG
ACGCTACGCCTGCAATTTGCGGACGGCAACATAGGGGCGATCTCAACCGGGAAGTCCTCGAATACGAACCGGAAAAGCGC
TCCTGCACGAGAGCCCGGAAAGCAAGGCTCACTTTTCTGA

Upstream 100 bases:

>100_bases
CAATTGCCGTGACGTCCCGCGATAGCCGGTGGCCGGTGGGAGGTCCGTCGGCGGCTTAGAACGGGTTGACGCTGGAAGCG
GCAGGCTGCTCAATCGAAAA

Downstream 100 bases:

>100_bases
AGAATAATTTACCTAAAAGCCTGGGGTTTCATTTATAAAACGGCAATGCATTTCTCATATCGTAGAATAGTAAAATGGAA
TTTGTATAGTTTATTAGGTT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MEEAKKDDSLSNVAEYSVSEISHALKRTIEDTFGHVRVRGEISGFRGAHSSGHCYFSLKDERARMEAVIWKTTFARLRFP
PQEGLEVIATGRLTTFPGSSKYQIVIESLEPAGAGALMALLEERKRKLAAEGLFAESRKRPLPFMPHVIGVVTSPTGAVI
RDIIHRITDRFPVHVVVWPVRVQGETTGAEVAAAISGFNALQPGGTIPRPDILIVARGGGSLEDLWGFNDEAVVRAAAAS
AIPLISAVGHETDWTLIDLAADRRAPTPTGAAEVAVPVKAELEANIARLSARLKGAISRCLDRRRQETRSLARALPSPDQ
LFALPRRRFDEAAGRLGRALQTSTQGKRLHLNAVRVSIATLDRRIAQARRDANQCGERLPLVYQGLVRHRRARFDRDAAR
VSPRVTLQRITTLGERLKIAIARKDRAVSLRVERARTVYEQAVRLAESLSYKSVLERGFALVRDGEDRPLKRASDVKPGE
TLRLQFADGNIGAISTGKSSNTNRKSAPAREPGKQGSLF

Sequences:

>Translated_519_residues
MEEAKKDDSLSNVAEYSVSEISHALKRTIEDTFGHVRVRGEISGFRGAHSSGHCYFSLKDERARMEAVIWKTTFARLRFP
PQEGLEVIATGRLTTFPGSSKYQIVIESLEPAGAGALMALLEERKRKLAAEGLFAESRKRPLPFMPHVIGVVTSPTGAVI
RDIIHRITDRFPVHVVVWPVRVQGETTGAEVAAAISGFNALQPGGTIPRPDILIVARGGGSLEDLWGFNDEAVVRAAAAS
AIPLISAVGHETDWTLIDLAADRRAPTPTGAAEVAVPVKAELEANIARLSARLKGAISRCLDRRRQETRSLARALPSPDQ
LFALPRRRFDEAAGRLGRALQTSTQGKRLHLNAVRVSIATLDRRIAQARRDANQCGERLPLVYQGLVRHRRARFDRDAAR
VSPRVTLQRITTLGERLKIAIARKDRAVSLRVERARTVYEQAVRLAESLSYKSVLERGFALVRDGEDRPLKRASDVKPGE
TLRLQFADGNIGAISTGKSSNTNRKSAPAREPGKQGSLF
>Mature_519_residues
MEEAKKDDSLSNVAEYSVSEISHALKRTIEDTFGHVRVRGEISGFRGAHSSGHCYFSLKDERARMEAVIWKTTFARLRFP
PQEGLEVIATGRLTTFPGSSKYQIVIESLEPAGAGALMALLEERKRKLAAEGLFAESRKRPLPFMPHVIGVVTSPTGAVI
RDIIHRITDRFPVHVVVWPVRVQGETTGAEVAAAISGFNALQPGGTIPRPDILIVARGGGSLEDLWGFNDEAVVRAAAAS
AIPLISAVGHETDWTLIDLAADRRAPTPTGAAEVAVPVKAELEANIARLSARLKGAISRCLDRRRQETRSLARALPSPDQ
LFALPRRRFDEAAGRLGRALQTSTQGKRLHLNAVRVSIATLDRRIAQARRDANQCGERLPLVYQGLVRHRRARFDRDAAR
VSPRVTLQRITTLGERLKIAIARKDRAVSLRVERARTVYEQAVRLAESLSYKSVLERGFALVRDGEDRPLKRASDVKPGE
TLRLQFADGNIGAISTGKSSNTNRKSAPAREPGKQGSLF

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=479, Percent_Identity=34.0292275574113, Blast_Score=238, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_MESSB (Q11LY8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_672752.1
- STRING:   Q11LY8
- GeneID:   4179743
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0182
- NMPDR:   fig|266779.1.peg.3341
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   LVWPVKV
- PhylomeDB:   Q11LY8
- BioCyc:   MSP266779:MESO_0182-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 56927; Mature: 56927

Theoretical pI: Translated: 11.09; Mature: 11.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEAKKDDSLSNVAEYSVSEISHALKRTIEDTFGHVRVRGEISGFRGAHSSGHCYFSLKD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCEEEEEECC
ERARMEAVIWKTTFARLRFPPQEGLEVIATGRLTTFPGSSKYQIVIESLEPAGAGALMAL
HHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCEEECCCCCEEEEEEECCCCCCHHHHHHH
LEERKRKLAAEGLFAESRKRPLPFMPHVIGVVTSPTGAVIRDIIHRITDRFPVHVVVWPV
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEECCCCHHHHHHHHHHHHCCCCEEEEEEEE
RVQGETTGAEVAAAISGFNALQPGGTIPRPDILIVARGGGSLEDLWGFNDEAVVRAAAAS
EECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHH
AIPLISAVGHETDWTLIDLAADRRAPTPTGAAEVAVPVKAELEANIARLSARLKGAISRC
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
LDRRRQETRSLARALPSPDQLFALPRRRFDEAAGRLGRALQTSTQGKRLHLNAVRVSIAT
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
LDRRIAQARRDANQCGERLPLVYQGLVRHRRARFDRDAARVSPRVTLQRITTLGERLKIA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHEEE
IARKDRAVSLRVERARTVYEQAVRLAESLSYKSVLERGFALVRDGEDRPLKRASDVKPGE
EEECCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEECCCCCCCCHHCCCCCCC
TLRLQFADGNIGAISTGKSSNTNRKSAPAREPGKQGSLF
EEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEEAKKDDSLSNVAEYSVSEISHALKRTIEDTFGHVRVRGEISGFRGAHSSGHCYFSLKD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCEEEEEECC
ERARMEAVIWKTTFARLRFPPQEGLEVIATGRLTTFPGSSKYQIVIESLEPAGAGALMAL
HHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCEEECCCCCEEEEEEECCCCCCHHHHHHH
LEERKRKLAAEGLFAESRKRPLPFMPHVIGVVTSPTGAVIRDIIHRITDRFPVHVVVWPV
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEECCCCHHHHHHHHHHHHCCCCEEEEEEEE
RVQGETTGAEVAAAISGFNALQPGGTIPRPDILIVARGGGSLEDLWGFNDEAVVRAAAAS
EECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHH
AIPLISAVGHETDWTLIDLAADRRAPTPTGAAEVAVPVKAELEANIARLSARLKGAISRC
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
LDRRRQETRSLARALPSPDQLFALPRRRFDEAAGRLGRALQTSTQGKRLHLNAVRVSIAT
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
LDRRIAQARRDANQCGERLPLVYQGLVRHRRARFDRDAARVSPRVTLQRITTLGERLKIA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHEEE
IARKDRAVSLRVERARTVYEQAVRLAESLSYKSVLERGFALVRDGEDRPLKRASDVKPGE
EEECCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEECCCCCCCCHHCCCCCCC
TLRLQFADGNIGAISTGKSSNTNRKSAPAREPGKQGSLF
EEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA