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The map label for this gene is punA [H]

Identifier: 110632512

GI number: 110632512

Start: 183560

End: 184399

Strand: Reverse

Name: punA [H]

Synonym: Meso_0150

Alternate gene names: 110632512

Gene position: 184399-183560 (Counterclockwise)

Preceding gene: 110632513

Following gene: 110632510

Centisome position: 4.18

GC content: 62.5

Gene sequence:

>840_bases
ATGCCAGAAAGCTTGCTCGAACGGCTCAATCGCGCTGATGGCTCGATCGCCGCGCGGGCTGGCCCACCGGTCGAGGTCGG
TATCATCCTGGGCTCCGGTCTTGGGGATCTGGCTCAATCCGTCGACGACGCGGAGGTGATCCCATATACCGAGATCGAAG
CCTTTCCGGTTCCAACCGCCCCCGGGCATAAAGGACAGCTCGTCATTGGCACTCTCCACGGGAGGCGGGTGGCGGTGATG
CAAGGCCGGCTTCACCTCTATGAAGGTCGCAGCCCGCAGGACATCGCGCTTGGTCCTTATCTCCTCAAGCGGCTTGGCAG
CGCCAGCCTCATCGTCACAAATGCCGCCAGCGGCCTTCATCCGGCATACCGGCCAGGGGACGTGATGCTGATTGAGGATC
ACCTCAATTTCACCGGCCTCAATCCGCTTGTCGGCTCCAACAGCCCCGAGATCGGCCTGCGCTTTCCCGATATGTCGCGG
GCCTATGATCCCGCCCTCCTCGATCTTGCAGAGGAAGCTGCAGAGCGAGCGCTCCAGCCAGTCCACAAGGGAATCTATGG
AGGCATTCTCGGCCCTTCCCTGGAGACGCTTGCCGAGCGTCGCTTTTTACGCGCTTCCGGATGTGACGCCGTGGGGATGT
CGACTGTTACGGAGGTCATCGCGGCGGTGCATGGCGGATTGCGCGTCATCGGCATTTCCGCGATCACCAATACCGCCGCC
ATCGGAGACCGGCGCACGGACACGATCGAGGAGGCGCTGACCAGCGCGGCCAACTGCGCAGAGAAGATCGACGCTATTCT
GCGGCAGCTCCTTCCACTCCTGCCGCATCATACTCGCTGA

Upstream 100 bases:

>100_bases
TGGGCGAAGAGCGGCTGCAAAGACTCCTGGGCGAGGCCGTGGAAGCGGCCCGGCAGCGTTCCATAGAGCTTGGAAAGTAA
TCTCCCGGGGAGAAGAGCCA

Downstream 100 bases:

>100_bases
GGCAGGAGCTTCCCGAATTACGGGTTGCGCAGCGCCAACCCGGCAGCGATCCAGCCCACGCCGGCAAAGATCAGATCGAC
GCCCAGGAAGATACCCAGCA

Product: inosine guanosine and xanthosine phosphorylase family protein

Products: NA

Alternate protein names: Inosine phosphorylase; Purine nucleoside phosphorylase I; PNP I; PU-NPase I [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MPESLLERLNRADGSIAARAGPPVEVGIILGSGLGDLAQSVDDAEVIPYTEIEAFPVPTAPGHKGQLVIGTLHGRRVAVM
QGRLHLYEGRSPQDIALGPYLLKRLGSASLIVTNAASGLHPAYRPGDVMLIEDHLNFTGLNPLVGSNSPEIGLRFPDMSR
AYDPALLDLAEEAAERALQPVHKGIYGGILGPSLETLAERRFLRASGCDAVGMSTVTEVIAAVHGGLRVIGISAITNTAA
IGDRRTDTIEEALTSAANCAEKIDAILRQLLPLLPHHTR

Sequences:

>Translated_279_residues
MPESLLERLNRADGSIAARAGPPVEVGIILGSGLGDLAQSVDDAEVIPYTEIEAFPVPTAPGHKGQLVIGTLHGRRVAVM
QGRLHLYEGRSPQDIALGPYLLKRLGSASLIVTNAASGLHPAYRPGDVMLIEDHLNFTGLNPLVGSNSPEIGLRFPDMSR
AYDPALLDLAEEAAERALQPVHKGIYGGILGPSLETLAERRFLRASGCDAVGMSTVTEVIAAVHGGLRVIGISAITNTAA
IGDRRTDTIEEALTSAANCAEKIDAILRQLLPLLPHHTR
>Mature_278_residues
PESLLERLNRADGSIAARAGPPVEVGIILGSGLGDLAQSVDDAEVIPYTEIEAFPVPTAPGHKGQLVIGTLHGRRVAVMQ
GRLHLYEGRSPQDIALGPYLLKRLGSASLIVTNAASGLHPAYRPGDVMLIEDHLNFTGLNPLVGSNSPEIGLRFPDMSRA
YDPALLDLAEEAAERALQPVHKGIYGGILGPSLETLAERRFLRASGCDAVGMSTVTEVIAAVHGGLRVIGISAITNTAAI
GDRRTDTIEEALTSAANCAEKIDAILRQLLPLLPHHTR

Specific function: Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI157168362, Length=261, Percent_Identity=44.0613026819923, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI47132622, Length=264, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788746, Length=249, Percent_Identity=38.9558232931727, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17541190, Length=236, Percent_Identity=40.2542372881356, Blast_Score=167, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6323238, Length=224, Percent_Identity=43.3035714285714, Blast_Score=159, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45552887, Length=286, Percent_Identity=40.2097902097902, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45552885, Length=286, Percent_Identity=39.8601398601399, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24656093, Length=260, Percent_Identity=41.1538461538462, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24656090, Length=260, Percent_Identity=41.1538461538462, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24762376, Length=221, Percent_Identity=35.2941176470588, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011268
- InterPro:   IPR000845
- InterPro:   IPR011270
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.1 [H]

Molecular weight: Translated: 29498; Mature: 29367

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESLLERLNRADGSIAARAGPPVEVGIILGSGLGDLAQSVDDAEVIPYTEIEAFPVPTA
CCHHHHHHHHHCCCCEEECCCCCEEEEEEEECCHHHHHHCCCCCCCCCCCCCCEECCCCC
PGHKGQLVIGTLHGRRVAVMQGRLHLYEGRSPQDIALGPYLLKRLGSASLIVTNAASGLH
CCCCCCEEEEECCCCEEEEEECCEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCC
PAYRPGDVMLIEDHLNFTGLNPLVGSNSPEIGLRFPDMSRAYDPALLDLAEEAAERALQP
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHH
VHKGIYGGILGPSLETLAERRFLRASGCDAVGMSTVTEVIAAVHGGLRVIGISAITNTAA
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEHHHHHHHH
IGDRRTDTIEEALTSAANCAEKIDAILRQLLPLLPHHTR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PESLLERLNRADGSIAARAGPPVEVGIILGSGLGDLAQSVDDAEVIPYTEIEAFPVPTA
CHHHHHHHHHCCCCEEECCCCCEEEEEEEECCHHHHHHCCCCCCCCCCCCCCEECCCCC
PGHKGQLVIGTLHGRRVAVMQGRLHLYEGRSPQDIALGPYLLKRLGSASLIVTNAASGLH
CCCCCCEEEEECCCCEEEEEECCEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCC
PAYRPGDVMLIEDHLNFTGLNPLVGSNSPEIGLRFPDMSRAYDPALLDLAEEAAERALQP
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHH
VHKGIYGGILGPSLETLAERRFLRASGCDAVGMSTVTEVIAAVHGGLRVIGISAITNTAA
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEHHHHHHHH
IGDRRTDTIEEALTSAANCAEKIDAILRQLLPLLPHHTR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10537218; 8969508; 9384377; 1629150 [H]