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The map label for this gene is dxs [H]

Identifier: 109947511

GI number: 109947511

Start: 848357

End: 850207

Strand: Reverse

Name: dxs [H]

Synonym: Hac_0968

Alternate gene names: 109947511

Gene position: 850207-848357 (Counterclockwise)

Preceding gene: 109947512

Following gene: 109947510

Centisome position: 54.71

GC content: 40.95

Gene sequence:

>1851_bases
TTGCAAAATAAAACTTTTGATTTAAACCCTAATGATATTGCAAGCTTGGAAGCAGTGTGCCAAACACTGCGGGAGCGTAT
TTTAGAAGTGGTGAGCACTAATGGGGGGCATTTAAGCTCCTCTTTAGGGGCTGTAGAGCTTATTGTGGGCATGCATGCCT
TATTTGATTGCCAAAAAAACCCTTTTATTTTTGACACTTCGCATCAAGCTTACGCCCACAAGCTTTTAACTGGTCGTTTT
GAAAGCTTTAGCACTTTAAGGCAATTTAAAGGTTTGAGCGGTTTTACTAAACCCAGCGAGAGTGCATACGATTATTTCAT
CGCTGGGCATAGCTCCACTTCGGTTTCTGTGGGCGTGGGGGTGGCGAAAGCCTTTCGTTTGAAACAAGAACTAGGCATGC
CTATCGCTTTATTAGGCGATGGGAGTATTAGCGCTGGGATTTTTTATGAAGCCTTAAACGAGCTAGGCGATAGGAAATAC
CCCATGATTATGATATTAAATGATAATGAAATGAGTATCAGCACGCCTATTGGAGCCTTATCCAAAGCCCTTAGCCAGCT
CATGAAAGGTCCGTTTTATCAGTCTTTCCGCTCTAAAGTGAAAAAAATCTTAAACACCTTACCTGAAAGCGTGAATTATT
TAGTGAGCCGTTTTGAAGAATCTTTTAAACTCATCACCCCAGGCGTGTTTTTTGAAGAATTAGGCATTAACTACATAGGG
CCTATTAATGGGCATGATTTAAGCACGATTATTGAAACCTTAAAATTAGCTAGAGAGCTTAAAGAACCGGTGCTTATTCA
TGCACAAACCTTAAAGGGTAAAGGCTATAAAATCGCTGAAGGGCGGTATGAAAAATGGCATGGGGTAGGGCCTTTTGATT
TGGATACCGGCATGTCTAAAAAAACTAAAAGCGCGATTTTATCGCCCACTGAAATCTATTCTAACACCCTTTTAGAATTA
GCCAAGAAAGATGACAAAATCGTAGGCGTAACCGCTGCGATGCCTAGCGGCACAGGGTTAGACAAGCTCATTGACGCTTA
CCCTTTGCGTTTTTTTGATGTCGCTATCGCTGAACAGCATGCCTTAACCTCTAGCAGCGCTATGGCTAAAGAAGGGTTTA
AACCTTTTGTGAGCATCTATTCTACTTTTTTACAGAGAGCTTATGATTCCATTGTGCATGACGCTTGCATTTCTAGTTTG
CCGATTAAATTAGCTATTGACAGAGCTGGGATTGTGGGTGAAGATGGTGAGACGCACCAAGGCCTTTTAGATGTGTCGTA
TTTGCGCTCTATCCCCAACATGGTCATTTTTGCCCCACGAGATAATGAGACTTTAAAAAACGCCGTGCATTTTGCTAATG
AATACGATTTAAGCCCTTGCGCGTTCCGCTACCCTAGGGGATCGTTTGTATTAAAAGAGGGGGTTTTTGAGCCTAGCGGA
TTTGTTTTAGGGCAAAGCGAATTATTACAAAAAGAGGGCGAAATTTTGCTCATTGGCTATGGTAATGGCGTAGGGAGGGC
TTATTTAGTCCAATTGGCTTTAAAAGAAAAAAACATAGAGTGCGCTCTTTTAGACTTGAGATTCCTTAAACCTTTAGATC
ACAATTTAAGCTCAATTGTCGCGCCTTATAAAAAGCTCTATGTTTTTAGCGATAATTACAAGCTTGGGGGGGTGGCTAGT
GCGATTTTAGAGTTTTTGAGCGAACAAAATATATTAAAGCCTGTTAAAAGCTTTGAAATTGTTGATGAATTTGTCATGCA
TGGGAACACCGCTTTAGTGGAAAAATCCTTAGGCTTAGATACAGAGAGTTTGACTGACGCCATTTTAAAAGATTTAGGAC
AAGAGAAATGA

Upstream 100 bases:

>100_bases
GCGTTATGATCACTAGTTCTAATGGGAGCCTTGATGGGAGTTTAATGGAGCGCTTTAGAACGCTTAAAGAAAGCGTTTTG
GATAATTTTAAGGTGTGATT

Downstream 100 bases:

>100_bases
AACCAACGACGCCAACGCCTATGAAAAATATCCGCAATTTTTCCATTATCGCTCATATTGACCATGGTAAAAGCACTTTA
GCGGATTGCTTGATCGCTGA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MQNKTFDLNPNDIASLEAVCQTLRERILEVVSTNGGHLSSSLGAVELIVGMHALFDCQKNPFIFDTSHQAYAHKLLTGRF
ESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSVGVGVAKAFRLKQELGMPIALLGDGSISAGIFYEALNELGDRKY
PMIMILNDNEMSISTPIGALSKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLVSRFEESFKLITPGVFFEELGINYIG
PINGHDLSTIIETLKLARELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGMSKKTKSAILSPTEIYSNTLLEL
AKKDDKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSL
PIKLAIDRAGIVGEDGETHQGLLDVSYLRSIPNMVIFAPRDNETLKNAVHFANEYDLSPCAFRYPRGSFVLKEGVFEPSG
FVLGQSELLQKEGEILLIGYGNGVGRAYLVQLALKEKNIECALLDLRFLKPLDHNLSSIVAPYKKLYVFSDNYKLGGVAS
AILEFLSEQNILKPVKSFEIVDEFVMHGNTALVEKSLGLDTESLTDAILKDLGQEK

Sequences:

>Translated_616_residues
MQNKTFDLNPNDIASLEAVCQTLRERILEVVSTNGGHLSSSLGAVELIVGMHALFDCQKNPFIFDTSHQAYAHKLLTGRF
ESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSVGVGVAKAFRLKQELGMPIALLGDGSISAGIFYEALNELGDRKY
PMIMILNDNEMSISTPIGALSKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLVSRFEESFKLITPGVFFEELGINYIG
PINGHDLSTIIETLKLARELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGMSKKTKSAILSPTEIYSNTLLEL
AKKDDKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSL
PIKLAIDRAGIVGEDGETHQGLLDVSYLRSIPNMVIFAPRDNETLKNAVHFANEYDLSPCAFRYPRGSFVLKEGVFEPSG
FVLGQSELLQKEGEILLIGYGNGVGRAYLVQLALKEKNIECALLDLRFLKPLDHNLSSIVAPYKKLYVFSDNYKLGGVAS
AILEFLSEQNILKPVKSFEIVDEFVMHGNTALVEKSLGLDTESLTDAILKDLGQEK
>Mature_616_residues
MQNKTFDLNPNDIASLEAVCQTLRERILEVVSTNGGHLSSSLGAVELIVGMHALFDCQKNPFIFDTSHQAYAHKLLTGRF
ESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSVGVGVAKAFRLKQELGMPIALLGDGSISAGIFYEALNELGDRKY
PMIMILNDNEMSISTPIGALSKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLVSRFEESFKLITPGVFFEELGINYIG
PINGHDLSTIIETLKLARELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGMSKKTKSAILSPTEIYSNTLLEL
AKKDDKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSL
PIKLAIDRAGIVGEDGETHQGLLDVSYLRSIPNMVIFAPRDNETLKNAVHFANEYDLSPCAFRYPRGSFVLKEGVFEPSG
FVLGQSELLQKEGEILLIGYGNGVGRAYLVQLALKEKNIECALLDLRFLKPLDHNLSSIVAPYKKLYVFSDNYKLGGVAS
AILEFLSEQNILKPVKSFEIVDEFVMHGNTALVEKSLGLDTESLTDAILKDLGQEK

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=412, Percent_Identity=24.5145631067961, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4507521, Length=412, Percent_Identity=24.5145631067961, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI225637459, Length=384, Percent_Identity=25, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI225637461, Length=384, Percent_Identity=25, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI225637463, Length=384, Percent_Identity=25, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI133778974, Length=372, Percent_Identity=22.5806451612903, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1786622, Length=598, Percent_Identity=41.1371237458194, Blast_Score=453, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17539652, Length=396, Percent_Identity=24.2424242424242, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24666278, Length=270, Percent_Identity=29.2592592592593, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24645119, Length=391, Percent_Identity=25.5754475703325, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551847, Length=391, Percent_Identity=25.5754475703325, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550715, Length=391, Percent_Identity=25.5754475703325, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67799; Mature: 67799

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKTFDLNPNDIASLEAVCQTLRERILEVVSTNGGHLSSSLGAVELIVGMHALFDCQKN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PFIFDTSHQAYAHKLLTGRFESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSVGVG
CEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEHHH
VAKAFRLKQELGMPIALLGDGSISAGIFYEALNELGDRKYPMIMILNDNEMSISTPIGAL
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHHHH
SKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLVSRFEESFKLITPGVFFEELGINYIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEC
PINGHDLSTIIETLKLARELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGMSK
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCHHCCCCCCCCCCCCCCH
KTKSAILSPTEIYSNTLLELAKKDDKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQH
HHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHHH
ALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSLPIKLAIDRAGIVGEDGETHQ
HHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
GLLDVSYLRSIPNMVIFAPRDNETLKNAVHFANEYDLSPCAFRYPRGSFVLKEGVFEPSG
CHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCCCCCC
FVLGQSELLQKEGEILLIGYGNGVGRAYLVQLALKEKNIECALLDLRFLKPLDHNLSSIV
CEECHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEHHHHHCHHCCCHHHHH
APYKKLYVFSDNYKLGGVASAILEFLSEQNILKPVKSFEIVDEFVMHGNTALVEKSLGLD
HHHHHEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCC
TESLTDAILKDLGQEK
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQNKTFDLNPNDIASLEAVCQTLRERILEVVSTNGGHLSSSLGAVELIVGMHALFDCQKN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PFIFDTSHQAYAHKLLTGRFESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSVGVG
CEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEHHH
VAKAFRLKQELGMPIALLGDGSISAGIFYEALNELGDRKYPMIMILNDNEMSISTPIGAL
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHHHH
SKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLVSRFEESFKLITPGVFFEELGINYIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEC
PINGHDLSTIIETLKLARELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGMSK
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCHHCCCCCCCCCCCCCCH
KTKSAILSPTEIYSNTLLELAKKDDKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQH
HHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHHH
ALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSLPIKLAIDRAGIVGEDGETHQ
HHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
GLLDVSYLRSIPNMVIFAPRDNETLKNAVHFANEYDLSPCAFRYPRGSFVLKEGVFEPSG
CHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCCCCCC
FVLGQSELLQKEGEILLIGYGNGVGRAYLVQLALKEKNIECALLDLRFLKPLDHNLSSIV
CEECHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEHHHHHCHHCCCHHHHH
APYKKLYVFSDNYKLGGVASAILEFLSEQNILKPVKSFEIVDEFVMHGNTALVEKSLGLD
HHHHHEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCC
TESLTDAILKDLGQEK
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA