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The map label for this gene is gpt [C]

Identifier: 109947259

GI number: 109947259

Start: 599735

End: 600196

Strand: Direct

Name: gpt [C]

Synonym: Hac_0684

Alternate gene names: 109947259

Gene position: 599735-600196 (Clockwise)

Preceding gene: 109947258

Following gene: 109947260

Centisome position: 38.59

GC content: 36.58

Gene sequence:

>462_bases
ATGCATTATTCTTATGAAACCTTTTTAAAAGACAGCCTAAAATTAGTGGAACAAGTAGAACAAATTTGCGGTATCCCAGA
AGCCCTTGTGTGCGTGATGCGAGGGGGCATGACTTTAGCGCATTTTTTGAGTTTGCATTGGAATTTAAGGGAAGTTTATG
GCATCAATGCGATTTCTTATGACACTACAAACCGACAAAACGCCCTAAAAATTGAAAATATCCCCACAATCAAAGATTAT
TTAAAAACCATTCTTGTGGTAGATGAAATCGTAGATAGCGGTAATTCTTTAGAAGCGGTGCTTAAAGTGTTGCAGGAAAA
ACACCTTGATAAAAAGTTTTATAGCGCGAGTTTGTTCCAAAAGACAAGCGCAAAATACAAAGCCGATGCGTTTTTAAAAG
ACGCTCCTGAATGGATTGATTTCTTTTGGGAAGTGGATTTGAAAAACTTTAAAAGCCATTAA

Upstream 100 bases:

>100_bases
ATACCCTAGAATTAGCCCTAAACGATTTGAATTTAAGGGAATTTGATGGCGTAGCGAACACAACCTTTTTAAAGCAATAT
TATGAAATTTAAGGATCACA

Downstream 100 bases:

>100_bases
CATGCAAAAAGAAAACAAACAACTTTGCTTAATCTCATTAGGTTGCTCTAAAAACTTGGTGGATTCAGAAGTGATGTTGG
GCAAGCTCTATAATTACACG

Product: xanthine-guanine phosphoribosyltransferase

Products: 5-phospho-alpha-D-ribose 1-diphosphate; xanthine

Alternate protein names: Nucleotide Phosphoribosyltransferase; Xanthine Guanine Phosphoribosyl Transferase; Xanthine-Guanine Phosphoribosyl Transferase; Xanthine Phosphoribosyltransferase

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MHYSYETFLKDSLKLVEQVEQICGIPEALVCVMRGGMTLAHFLSLHWNLREVYGINAISYDTTNRQNALKIENIPTIKDY
LKTILVVDEIVDSGNSLEAVLKVLQEKHLDKKFYSASLFQKTSAKYKADAFLKDAPEWIDFFWEVDLKNFKSH

Sequences:

>Translated_153_residues
MHYSYETFLKDSLKLVEQVEQICGIPEALVCVMRGGMTLAHFLSLHWNLREVYGINAISYDTTNRQNALKIENIPTIKDY
LKTILVVDEIVDSGNSLEAVLKVLQEKHLDKKFYSASLFQKTSAKYKADAFLKDAPEWIDFFWEVDLKNFKSH
>Mature_153_residues
MHYSYETFLKDSLKLVEQVEQICGIPEALVCVMRGGMTLAHFLSLHWNLREVYGINAISYDTTNRQNALKIENIPTIKDY
LKTILVVDEIVDSGNSLEAVLKVLQEKHLDKKFYSASLFQKTSAKYKADAFLKDAPEWIDFFWEVDLKNFKSH

Specific function: Acts On Guanine, Xanthine And To A Lesser Extent Hypoxanthine. [C]

COG id: COG2236

COG function: function code R; Predicted phosphoribosyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.4.2.22

Molecular weight: Translated: 17709; Mature: 17709

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYSYETFLKDSLKLVEQVEQICGIPEALVCVMRGGMTLAHFLSLHWNLREVYGINAISY
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCCEEC
DTTNRQNALKIENIPTIKDYLKTILVVDEIVDSGNSLEAVLKVLQEKHLDKKFYSASLFQ
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KTSAKYKADAFLKDAPEWIDFFWEVDLKNFKSH
HHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHYSYETFLKDSLKLVEQVEQICGIPEALVCVMRGGMTLAHFLSLHWNLREVYGINAISY
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCCEEC
DTTNRQNALKIENIPTIKDYLKTILVVDEIVDSGNSLEAVLKVLQEKHLDKKFYSASLFQ
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KTSAKYKADAFLKDAPEWIDFFWEVDLKNFKSH
HHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.053 {5-phospho-alpha-D-ribose} 0.02 {xanthine}} [C]

Substrates: 9-(5-phospho-beta-D-ribosyl)xanthine; diphosphate

Specific reaction: 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine

General reaction: Glycosyl and Pentosyl group transfer [C]

Inhibitor: 2-Thioxanthine; 6-Thioxanthine; 8-Mercaptoxanthine; ATP; CDP; CTP; GDP; GMP; GTP; TDP; TTP; UDP; UTP; Xanthine; XDP; XMP; XTP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA