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The map label for this gene is eaeH [C]

Identifier: 108812492

GI number: 108812492

Start: 2612246

End: 2613250

Strand: Reverse

Name: eaeH [C]

Synonym: YPN_2331

Alternate gene names: 108812492

Gene position: 2613250-2612246 (Counterclockwise)

Preceding gene: 108812493

Following gene: 108812491

Centisome position: 57.63

GC content: 43.98

Gene sequence:

>1005_bases
ATGTATTTTAATAAAATAATTTCATTTAATATTATTTCACGAATAGTTATTTGTATCTTTTTGATATGTGGAATGTTCAT
GGCTGGGGCTTCAGAAAAATATGATGCTAACGCACCGCAACAGGTCCAGCCTTATTCTGTCTCTTCATCTGCATTTGAAA
ATCTCCATCCTAATAATGAAATGGAGAGTTCAATCAATCCCTTTTCCGCATCGGATACAGAAAGAAATGCTGCAATAATA
GATCGCGCCAATAAGGAGCAGGAGACTGAAGCGGTGAATAAGATGATAAGCACCGGGGCCAGGTTAGCTGCATCAGGCAG
GGCATCTGATGTTGCTCACTCAATGGTGGGCGATGCGGTTAATCAAGAAATCAAACAGTGGTTAAATCGATTCGGTACGG
CTCAAGTTAATCTGAATTTTGACAAAAATTTTTCGCTAAAAGAAAGCTCTCTTGATTGGCTGGCTCCTTGGTATGACTCT
GCTTCATTCCTCTTTTTTAGTCAGTTAGGTATTCGCAATAAAGACAGCCGCAACACACTTAACCTTGGCGTCGGGATACG
TACATTGGAGAACGGTTGGCTGTACGGACTTAATACTTTTTATGATAATGATTTGACCGGCCACAACCACCGTATCGGTC
TTGGTGCCGAGGCCTGGACCGATTATTTACAGTTGGCTGCCAATGGGTATTTTCGCCTCAATGGATGGCACTCGTCGCGT
GATTTCTCCGACTATAAAGAGCGCCCAGCCACTGGGGGGGATTTGCGCGCGAATGCTTATTTACCTGCACTCCCACAACT
GGGGGGGAAGTTGATGTATGAGCAATACACCGGTGAGCGTGTTGCTTTATTGTGCCCAGAAAACCCCCAGCTAGGCTGGG
GGTTCAGTAAAGCTTTCAGCTTTGGGTCAGTTATAAAAACCCCTTTTGATTTGTTAAAACAGTTTGCGGTCTGGCAACTG
CAAATGTTCAACAAGAAATCAAAAGGGGGTCCCAATGAGGGATGA

Upstream 100 bases:

>100_bases
TGCAGTTTGACGTATGACAGGTATGCTTTATTTCATTTAAATTATGATGGTTTTCCAGCCAATCAGTGAGTTTCTCTTGA
TAAGGAATGCGGGAATGTCT

Downstream 100 bases:

>100_bases
AAAGAGCTTAGCGCACACCCGATGGAACTGTAAATATCATATAGTTTTTGCGCCGAAGTACCGAAGGCAGGTGTTCTACA
GGGAAAAACGCAGAGCGATT

Product: invasin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MYFNKIISFNIISRIVICIFLICGMFMAGASEKYDANAPQQVQPYSVSSSAFENLHPNNEMESSINPFSASDTERNAAII
DRANKEQETEAVNKMISTGARLAASGRASDVAHSMVGDAVNQEIKQWLNRFGTAQVNLNFDKNFSLKESSLDWLAPWYDS
ASFLFFSQLGIRNKDSRNTLNLGVGIRTLENGWLYGLNTFYDNDLTGHNHRIGLGAEAWTDYLQLAANGYFRLNGWHSSR
DFSDYKERPATGGDLRANAYLPALPQLGGKLMYEQYTGERVALLCPENPQLGWGFSKAFSFGSVIKTPFDLLKQFAVWQL
QMFNKKSKGGPNEG

Sequences:

>Translated_334_residues
MYFNKIISFNIISRIVICIFLICGMFMAGASEKYDANAPQQVQPYSVSSSAFENLHPNNEMESSINPFSASDTERNAAII
DRANKEQETEAVNKMISTGARLAASGRASDVAHSMVGDAVNQEIKQWLNRFGTAQVNLNFDKNFSLKESSLDWLAPWYDS
ASFLFFSQLGIRNKDSRNTLNLGVGIRTLENGWLYGLNTFYDNDLTGHNHRIGLGAEAWTDYLQLAANGYFRLNGWHSSR
DFSDYKERPATGGDLRANAYLPALPQLGGKLMYEQYTGERVALLCPENPQLGWGFSKAFSFGSVIKTPFDLLKQFAVWQL
QMFNKKSKGGPNEG
>Mature_334_residues
MYFNKIISFNIISRIVICIFLICGMFMAGASEKYDANAPQQVQPYSVSSSAFENLHPNNEMESSINPFSASDTERNAAII
DRANKEQETEAVNKMISTGARLAASGRASDVAHSMVGDAVNQEIKQWLNRFGTAQVNLNFDKNFSLKESSLDWLAPWYDS
ASFLFFSQLGIRNKDSRNTLNLGVGIRTLENGWLYGLNTFYDNDLTGHNHRIGLGAEAWTDYLQLAANGYFRLNGWHSSR
DFSDYKERPATGGDLRANAYLPALPQLGGKLMYEQYTGERVALLCPENPQLGWGFSKAFSFGSVIKTPFDLLKQFAVWQL
QMFNKKSKGGPNEG

Specific function: Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell surface [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 Big-1 (bacterial Ig-like domain 1) domains [H]

Homologues:

Organism=Escherichia coli, GI145693153, Length=211, Percent_Identity=43.1279620853081, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI145693120, Length=227, Percent_Identity=35.2422907488987, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003344
- InterPro:   IPR016186
- InterPro:   IPR016187
- InterPro:   IPR003535
- InterPro:   IPR013117
- InterPro:   IPR008964
- InterPro:   IPR015217 [H]

Pfam domain/function: PF02369 Big_1; PF07979 Intimin_C; PF09134 Invasin_D3 [H]

EC number: NA

Molecular weight: Translated: 37346; Mature: 37346

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFNKIISFNIISRIVICIFLICGMFMAGASEKYDANAPQQVQPYSVSSSAFENLHPNNE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCH
MESSINPFSASDTERNAAIIDRANKEQETEAVNKMISTGARLAASGRASDVAHSMVGDAV
HHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHH
NQEIKQWLNRFGTAQVNLNFDKNFSLKESSLDWLAPWYDSASFLFFSQLGIRNKDSRNTL
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCEE
NLGVGIRTLENGWLYGLNTFYDNDLTGHNHRIGLGAEAWTDYLQLAANGYFRLNGWHSSR
EECCEEEEECCCEEEEEHHHCCCCCCCCCCEECCCHHHHHHHHHHHCCCEEEEECCCCCC
DFSDYKERPATGGDLRANAYLPALPQLGGKLMYEQYTGERVALLCPENPQLGWGFSKAFS
CCHHHHHCCCCCCCCCCCCCCCCCHHHCCEEEHHHCCCCEEEEECCCCCCCCCCHHHHHH
FGSVIKTPFDLLKQFAVWQLQMFNKKSKGGPNEG
HHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYFNKIISFNIISRIVICIFLICGMFMAGASEKYDANAPQQVQPYSVSSSAFENLHPNNE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCH
MESSINPFSASDTERNAAIIDRANKEQETEAVNKMISTGARLAASGRASDVAHSMVGDAV
HHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHH
NQEIKQWLNRFGTAQVNLNFDKNFSLKESSLDWLAPWYDSASFLFFSQLGIRNKDSRNTL
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCEE
NLGVGIRTLENGWLYGLNTFYDNDLTGHNHRIGLGAEAWTDYLQLAANGYFRLNGWHSSR
EECCEEEEECCCEEEEEHHHCCCCCCCCCCEECCCHHHHHHHHHHHCCCEEEEECCCCCC
DFSDYKERPATGGDLRANAYLPALPQLGGKLMYEQYTGERVALLCPENPQLGWGFSKAFS
CCHHHHHCCCCCCCCCCCCCCCCCHHHCCEEEHHHCCCCEEEEECCCCCCCCCCHHHHHH
FGSVIKTPFDLLKQFAVWQLQMFNKKSKGGPNEG
HHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3304658; 1693333; 10514372 [H]