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The map label for this gene is ampR [H]

Identifier: 108812216

GI number: 108812216

Start: 2318253

End: 2319179

Strand: Reverse

Name: ampR [H]

Synonym: YPN_2054

Alternate gene names: 108812216

Gene position: 2319179-2318253 (Counterclockwise)

Preceding gene: 108812220

Following gene: 108812215

Centisome position: 51.14

GC content: 50.38

Gene sequence:

>927_bases
ATGAGAAAACTCCCATCACTCCGTATGTTGCGTGTGTTTGAAGAGGCCTGCCACACGCTGAGTTTCAGTAAAGCAGCGGA
GGCGTTATTTATGACGCAAAGCGCCGCCAGTCGTCAGATTAAGCAACTGGAAAATTTTCTGGGGAAATCGCTATTTATAC
GCGGACACAGAGGGTTAGAGTTGACCCAAGATGAGATGACTATGTTACCTATCGTCAGACAGTCGTTGGATTTACTGGAG
GAGGGGGTGAAACATGTCCAGTTAAGTAATCCACTGCAACATCTGCGCTTACAGGTCGCGCCGACATTTGCCACCCGCTG
GTTGGCCCCCCGGTTGGTTACGTTACTGCAACGTAATAGTCAGCTACAAATTGCCCTGATCAGTGAGATTCGTCAGAAGT
ATTGTGATTTTGACAGCGCGATCCGCTTTGGTGATATTCGTCGGGACCTGTCGAATGGGCACCTGCTCTGCTACGAACAG
CTCTGTTTAGTCGCCAGCCCTCTGGTGATGCAACAGGGGCGTTTTCCCCCACTGACCGCTTTACCACAGTTGCATATTCT
TAATGGCGATAGTCGTCTGACAAACTGGCAGCAATGGCTGGATGCGGCACAGATAACCGTAGCCGCAGGGCATAACGCGC
TTGAGTTCAGTACTCAAGACCAGGTGATCAGTGCCTGCACTACTGGTGCCGGTTACGCAGTGTTAGATATTCTGATGATT
AGCCATGAACTGGATAATGGGTTATTGAGACAGGTTTTGCCGCTGACGGTGACCAGCACTCATGGCTACTGGCTAGAGAT
CCCACAGGATAAAGGCCATTCGCCAAGGGTGATTATTTTTCAGGAGTGGTTACAGCGGGAGTTGAAGCGTGATATTGCCA
AGCGCTACTCAAAAGGGGAAGCCAAACCTCTACCGGCTGTGCTTTAG

Upstream 100 bases:

>100_bases
ATGTAAAATGCGCATATTGGCAACATAAAATTAACGATTTTCTGGGTTGTGGTTTTTGCGCCAGGCAATATTTCATCGTT
GGTATGGAGACGGTATTCCT

Downstream 100 bases:

>100_bases
CAGCCCAATGGCGATTGAATTAAGATATTGGCCGGAATGTGGCTCCTGCGGTTCAGTAAGACAAGGCACCAAATGTGAGC
GCTGAGAAGAGAAGCAGGGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQLENFLGKSLFIRGHRGLELTQDEMTMLPIVRQSLDLLE
EGVKHVQLSNPLQHLRLQVAPTFATRWLAPRLVTLLQRNSQLQIALISEIRQKYCDFDSAIRFGDIRRDLSNGHLLCYEQ
LCLVASPLVMQQGRFPPLTALPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQVISACTTGAGYAVLDILMI
SHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQEWLQRELKRDIAKRYSKGEAKPLPAVL

Sequences:

>Translated_308_residues
MRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQLENFLGKSLFIRGHRGLELTQDEMTMLPIVRQSLDLLE
EGVKHVQLSNPLQHLRLQVAPTFATRWLAPRLVTLLQRNSQLQIALISEIRQKYCDFDSAIRFGDIRRDLSNGHLLCYEQ
LCLVASPLVMQQGRFPPLTALPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQVISACTTGAGYAVLDILMI
SHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQEWLQRELKRDIAKRYSKGEAKPLPAVL
>Mature_308_residues
MRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQLENFLGKSLFIRGHRGLELTQDEMTMLPIVRQSLDLLE
EGVKHVQLSNPLQHLRLQVAPTFATRWLAPRLVTLLQRNSQLQIALISEIRQKYCDFDSAIRFGDIRRDLSNGHLLCYEQ
LCLVASPLVMQQGRFPPLTALPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQVISACTTGAGYAVLDILMI
SHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQEWLQRELKRDIAKRYSKGEAKPLPAVL

Specific function: This protein is a positive regulator of gene expression of beta-lactamase (AmpC) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786448, Length=290, Percent_Identity=29.6551724137931, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789173, Length=293, Percent_Identity=30.7167235494881, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788706, Length=293, Percent_Identity=24.5733788395904, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693193, Length=297, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786401, Length=298, Percent_Identity=26.510067114094, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34950; Mature: 34950

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQLENFLGKSLFIRGHRGLE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCE
LTQDEMTMLPIVRQSLDLLEEGVKHVQLSNPLQHLRLQVAPTFATRWLAPRLVTLLQRNS
ECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCC
QLQIALISEIRQKYCDFDSAIRFGDIRRDLSNGHLLCYEQLCLVASPLVMQQGRFPPLTA
CEEHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCHHHHHCCCCCCCCC
LPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQVISACTTGAGYAVLDILMI
CCCEEEECCCCHHHHHHHHHHHHHEEEECCCCCEECCHHHHHHHHHHCCCCHHHHHHHHH
SHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQEWLQRELKRDIAKRYSKGE
HHHHCHHHHHHHHHHEEEECCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
AKPLPAVL
CCCCCCCC
>Mature Secondary Structure
MRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQLENFLGKSLFIRGHRGLE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCE
LTQDEMTMLPIVRQSLDLLEEGVKHVQLSNPLQHLRLQVAPTFATRWLAPRLVTLLQRNS
ECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCC
QLQIALISEIRQKYCDFDSAIRFGDIRRDLSNGHLLCYEQLCLVASPLVMQQGRFPPLTA
CEEHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCHHHHHCCCCCCCCC
LPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQVISACTTGAGYAVLDILMI
CCCEEEECCCCHHHHHHHHHHHHHEEEECCCCCEECCHHHHHHHHHHCCCCHHHHHHHHH
SHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQEWLQRELKRDIAKRYSKGE
HHHHCHHHHHHHHHHEEEECCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
AKPLPAVL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1510392 [H]