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The map label for this gene is tibA [H]

Identifier: 108811413

GI number: 108811413

Start: 1418380

End: 1418700

Strand: Reverse

Name: tibA [H]

Synonym: YPN_1250

Alternate gene names: 108811413

Gene position: 1418700-1418380 (Counterclockwise)

Preceding gene: 108811414

Following gene: 108811401

Centisome position: 31.29

GC content: 51.71

Gene sequence:

>321_bases
ATGTTTCGCCATACGTGGCAATTGAGCGCCTTTAGCTCGGGTAAAAGCGCGGTCAAACTGTCTAACGGCATGGTGGCGCA
AAGCAGCAGCACCCGCTCGATGATAGGCACCCTTGGGGTGAATGCGGGTTACCGCTTCGTGCTGAAAAATGGCGTAGAAA
TGAAACCTTATGTCAGCGCCTCGGTTGATCACGAATTTGCTGCCAATAATAAATTCAGAGTGAACCAGGAGATGTTCGAT
AACAACCTGAACGGCACGCGAGTGAACACCGGTGCAGGCCTGAACGTCAACATCACCCCTAACCTGTCGGTTCTGAAGTG
A

Upstream 100 bases:

>100_bases
CATGTCACCAGCGCCGATAACAGCGCCAGCGGCAACACTAATTTCTCGGGTATGGGGGTGGCAGTGAAAGCCGGTAAGCA
TATCAACCATAATCATCTGT

Downstream 100 bases:

>100_bases
AGTTGTCCAGCGGAAAAAACATCAAAACGCCAGTGACCGTTAATCTGAACGTGGGTTATCGCTTCTAAGTGAATAAAATC
ATTTTTTAGAGATGACGGTG

Product: hypothetical protein

Products: NA

Alternate protein names: Glycoprotein TibA [H]

Number of amino acids: Translated: 106; Mature: 106

Protein sequence:

>106_residues
MFRHTWQLSAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSASVDHEFAANNKFRVNQEMFD
NNLNGTRVNTGAGLNVNITPNLSVLK

Sequences:

>Translated_106_residues
MFRHTWQLSAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSASVDHEFAANNKFRVNQEMFD
NNLNGTRVNTGAGLNVNITPNLSVLK
>Mature_106_residues
MFRHTWQLSAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSASVDHEFAANNKFRVNQEMFD
NNLNGTRVNTGAGLNVNITPNLSVLK

Specific function: Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation [H]

COG id: COG3468

COG function: function code MU; Type V secretory pathway, adhesin AidA

Gene ontology:

Cell location: Adhesin/invasin TibA translocator:Cell outer membrane; Multi-pass membrane protein (Potential). Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR012332
- InterPro:   IPR011050
- InterPro:   IPR004899
- InterPro:   IPR003991 [H]

Pfam domain/function: PF03797 Autotransporter; PF03212 Pertactin [H]

EC number: NA

Molecular weight: Translated: 11529; Mature: 11529

Theoretical pI: Translated: 10.86; Mature: 10.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRHTWQLSAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSA
CCCEEEEEEECCCCCCEEEECCCEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEC
SVDHEFAANNKFRVNQEMFDNNLNGTRVNTGAGLNVNITPNLSVLK
CCCCCCCCCCEEEECHHHHCCCCCCCEEECCCCEEEEECCCCEEEC
>Mature Secondary Structure
MFRHTWQLSAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSA
CCCEEEEEEECCCCCCEEEECCCEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEC
SVDHEFAANNKFRVNQEMFDNNLNGTRVNTGAGLNVNITPNLSVLK
CCCCCCCCCCEEEECHHHHCCCCCCCEEECCCCEEEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10417177 [H]