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The map label for this gene is fur

Identifier: 108811283

GI number: 108811283

Start: 1289798

End: 1290244

Strand: Reverse

Name: fur

Synonym: YPN_1120

Alternate gene names: 108811283

Gene position: 1290244-1289798 (Counterclockwise)

Preceding gene: 108811284

Following gene: 108811276

Centisome position: 28.45

GC content: 42.73

Gene sequence:

>447_bases
ATGACTGACAACAACAAAGCCTTAAAAAACGCTGGCCTTAAAGTCACACTCCCCCGGCTTAAAATTCTGGAAGTGTTGCA
AAATCCTGCGTGTCACCACGTCAGCGCGGAAGATCTTTATAAAATACTGATCGATATTGGTGAAGAGATTGGCTTAGCAA
CGGTTTACCGTGTTCTGAACCAATTTGATGATGCTGGTATTGTTACCCGCCACAATTTCGAAGGGGGTAAATCAGTTTTT
GAGCTGACTCAACAACATCACCACGATCACCTAATTTGCCTGGATTGCGGCAAAGTGATCGAGTTTAGCAACGAATCCAT
TGAATCACTTCAACGTGAAATTGCTAAACAACATGGCATCAAGCTGACTAATCATAGCCTGTATTTATACGGTCACTGTG
AAACCGGCAATTGCCGTGAAGATGAGTCTGCACACAGTAAAAGATAA

Upstream 100 bases:

>100_bases
CTAGCAGCTCTATAATAAGACGCAATTATGATTATTGCGCCACGGATGTCATAGGCTAAACAGCCTTAATTTGAATCGAT
TGTAACAGGACTGAATCCGC

Downstream 100 bases:

>100_bases
TATCGTTTTATCGCATTACTCTTATAAAGATTTTAAGCACTGCTAGGTTTACTGTTTATGTTTGATAAGGCCATGTCACT
AGAGCGTTACACATCAGGCT

Product: ferric uptake regulator

Products: NA

Alternate protein names: Ferric uptake regulator

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MTDNNKALKNAGLKVTLPRLKILEVLQNPACHHVSAEDLYKILIDIGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVF
ELTQQHHHDHLICLDCGKVIEFSNESIESLQREIAKQHGIKLTNHSLYLYGHCETGNCREDESAHSKR

Sequences:

>Translated_148_residues
MTDNNKALKNAGLKVTLPRLKILEVLQNPACHHVSAEDLYKILIDIGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVF
ELTQQHHHDHLICLDCGKVIEFSNESIESLQREIAKQHGIKLTNHSLYLYGHCETGNCREDESAHSKR
>Mature_147_residues
TDNNKALKNAGLKVTLPRLKILEVLQNPACHHVSAEDLYKILIDIGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFE
LTQQHHHDHLICLDCGKVIEFSNESIESLQREIAKQHGIKLTNHSLYLYGHCETGNCREDESAHSKR

Specific function: Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family

Homologues:

Organism=Escherichia coli, GI1786899, Length=148, Percent_Identity=85.8108108108108, Blast_Score=263, Evalue=4e-72,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): FUR_YERPE (P33086)

Other databases:

- EMBL:   Z12101
- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AE0321
- PIR:   S70733
- RefSeq:   NP_668533.1
- RefSeq:   NP_992452.1
- RefSeq:   YP_002347588.1
- ProteinModelPortal:   P33086
- SMR:   P33086
- GeneID:   1146155
- GeneID:   1175467
- GeneID:   2764103
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2634
- KEGG:   ypk:y1208
- KEGG:   ypm:YP_1081
- HOGENOM:   HBG731501
- OMA:   GEVIEFF
- ProtClustDB:   PRK09462
- BioCyc:   YPES187410:Y1208-MONOMER
- BioCyc:   YPES214092:YPO2634-MONOMER
- GO:   GO:0005737
- InterPro:   IPR002481

Pfam domain/function: PF01475 FUR

EC number: NA

Molecular weight: Translated: 16728; Mature: 16597

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNNKALKNAGLKVTLPRLKILEVLQNPACHHVSAEDLYKILIDIGEEIGLATVYRVLN
CCCCCCHHHHCCCEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
QFDDAGIVTRHNFEGGKSVFELTQQHHHDHLICLDCGKVIEFSNESIESLQREIAKQHGI
HCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHCCC
KLTNHSLYLYGHCETGNCREDESAHSKR
EEECCEEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDNNKALKNAGLKVTLPRLKILEVLQNPACHHVSAEDLYKILIDIGEEIGLATVYRVLN
CCCCCHHHHCCCEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
QFDDAGIVTRHNFEGGKSVFELTQQHHHDHLICLDCGKVIEFSNESIESLQREIAKQHGI
HCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHCCC
KLTNHSLYLYGHCETGNCREDESAHSKR
EEECCEEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1406286; 11586360; 12142430