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The map label for this gene is purK [H]

Identifier: 108811178

GI number: 108811178

Start: 1172326

End: 1173390

Strand: Reverse

Name: purK [H]

Synonym: YPN_1013

Alternate gene names: 108811178

Gene position: 1173390-1172326 (Counterclockwise)

Preceding gene: 108811179

Following gene: 108811174

Centisome position: 25.88

GC content: 52.49

Gene sequence:

>1065_bases
ATGAAACCAGTTTGTGTACTGGGTAATGGCCAGTTAGGGCGAATGCTGCGGCAGGCAGGTGAACCGCTGGGAATTGCGGT
TTATCCCGTCGGCTTAGATGCTGAACCTGAAGCGGTGCCTTATCAGCACAGTGTGATCACCGCTGAAATTGAACGTTGGC
CGGAAACCGCCTTAACCCGTGAATTAGCTACCCATACTGCTTTTGTTAATCGCGATATTTTTCCACGTCTGGCAGATCGT
CTGCCCCAAAAGCAGTTACTCGATAGCTTGGGTTTGGCAACTGCGCCGTGGCAATTGTTATCCAGCGCCAGTGAATGGCC
TGAGGTGTTCGCCACGTTGGGTGAGCTAGCCATCGTAAAACGGCGGGTCGGCGGCTATGACGGCCGGGGTCAATGGCGTT
TACGCCCTGGTGAGCAGGGTACCTTACCCCCCGATGCTTACGGCGAGTGTATTGTCGAACAGGGGATTAACTTCTCCGGC
GAAGTCTCATTGATCGGCGCGCGCAGCCACCAAGGTGAATCGGTATTTTATCCACTGACCCATAATCTGCATGAAGATGG
CATTTTGCGCATGAGCGTGGCATTACCACAGCCCAACAGCAAACTACAGCAGCAAGCCGAAAAAATGCTGTCAGCCATTA
TGGATAAGCTGAATTATGTCGGTGTGATGGCGATGGAGTGTTTTATCGTCGGCGACCGTCTGTTGATCAATGAACTGGCC
CCGCGCGTTCATAACAGTGGTCACTGGACACAAAACGGCGCATCAATTAGCCAGTTCGAATTGCATCTGCGGGCCATTTT
GGATCTGCCACTGCCGCAGCCGGTGGTGAATACCCCGTCAGCGATGGTTAATCTGATTGGCACGCCAGTAAATATTCAGT
GGCTGTCTCTGCCATTAGTACATCTGCATTGGTACGACAAAGAAGTCCGTGAAGGCCGCAAAGTTGGTCATCTGAATTTA
AACGATCCAGAGGGTACGGCATTAAGCGCATCCCTGGCCGCACTGGCTCCTTTGCTACCCGCGGAGTATCAGAACGCACT
GCGTTGGGCGCAAGATAAGTTATAA

Upstream 100 bases:

>100_bases
TCTTAGCATTACACGATACTGAATTAGCTGGCCGCTTGGCACATTGGCGTCAAAGTCAAACGGATGACGTGCTGGACAAC
CCTGATCCGAGGGAAGAAGC

Downstream 100 bases:

>100_bases
CAATAAATATCCTCCGGCATAGCCGGAGGTTTTTCATATGCGCCTATAAGGCTCTGTTACCAGCCGCGCCCTAACAGGCG
CATCGCGATCTGACATTTGC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKPVCVLGNGQLGRMLRQAGEPLGIAVYPVGLDAEPEAVPYQHSVITAEIERWPETALTRELATHTAFVNRDIFPRLADR
LPQKQLLDSLGLATAPWQLLSSASEWPEVFATLGELAIVKRRVGGYDGRGQWRLRPGEQGTLPPDAYGECIVEQGINFSG
EVSLIGARSHQGESVFYPLTHNLHEDGILRMSVALPQPNSKLQQQAEKMLSAIMDKLNYVGVMAMECFIVGDRLLINELA
PRVHNSGHWTQNGASISQFELHLRAILDLPLPQPVVNTPSAMVNLIGTPVNIQWLSLPLVHLHWYDKEVREGRKVGHLNL
NDPEGTALSASLAALAPLLPAEYQNALRWAQDKL

Sequences:

>Translated_354_residues
MKPVCVLGNGQLGRMLRQAGEPLGIAVYPVGLDAEPEAVPYQHSVITAEIERWPETALTRELATHTAFVNRDIFPRLADR
LPQKQLLDSLGLATAPWQLLSSASEWPEVFATLGELAIVKRRVGGYDGRGQWRLRPGEQGTLPPDAYGECIVEQGINFSG
EVSLIGARSHQGESVFYPLTHNLHEDGILRMSVALPQPNSKLQQQAEKMLSAIMDKLNYVGVMAMECFIVGDRLLINELA
PRVHNSGHWTQNGASISQFELHLRAILDLPLPQPVVNTPSAMVNLIGTPVNIQWLSLPLVHLHWYDKEVREGRKVGHLNL
NDPEGTALSASLAALAPLLPAEYQNALRWAQDKL
>Mature_354_residues
MKPVCVLGNGQLGRMLRQAGEPLGIAVYPVGLDAEPEAVPYQHSVITAEIERWPETALTRELATHTAFVNRDIFPRLADR
LPQKQLLDSLGLATAPWQLLSSASEWPEVFATLGELAIVKRRVGGYDGRGQWRLRPGEQGTLPPDAYGECIVEQGINFSG
EVSLIGARSHQGESVFYPLTHNLHEDGILRMSVALPQPNSKLQQQAEKMLSAIMDKLNYVGVMAMECFIVGDRLLINELA
PRVHNSGHWTQNGASISQFELHLRAILDLPLPQPVVNTPSAMVNLIGTPVNIQWLSLPLVHLHWYDKEVREGRKVGHLNL
NDPEGTALSASLAALAPLLPAEYQNALRWAQDKL

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=354, Percent_Identity=77.1186440677966, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI1788155, Length=212, Percent_Identity=30.188679245283, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324702, Length=370, Percent_Identity=29.7297297297297, Blast_Score=126, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39057; Mature: 39057

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVCVLGNGQLGRMLRQAGEPLGIAVYPVGLDAEPEAVPYQHSVITAEIERWPETALTR
CCCEEEECCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHEEEHHHHHCCHHHHHH
ELATHTAFVNRDIFPRLADRLPQKQLLDSLGLATAPWQLLSSASEWPEVFATLGELAIVK
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHH
RRVGGYDGRGQWRLRPGEQGTLPPDAYGECIVEQGINFSGEVSLIGARSHQGESVFYPLT
HHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEECCC
HNLHEDGILRMSVALPQPNSKLQQQAEKMLSAIMDKLNYVGVMAMECFIVGDRLLINELA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
PRVHNSGHWTQNGASISQFELHLRAILDLPLPQPVVNTPSAMVNLIGTPVNIQWLSLPLV
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEE
HLHWYDKEVREGRKVGHLNLNDPEGTALSASLAALAPLLPAEYQNALRWAQDKL
EEEECCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPVCVLGNGQLGRMLRQAGEPLGIAVYPVGLDAEPEAVPYQHSVITAEIERWPETALTR
CCCEEEECCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHEEEHHHHHCCHHHHHH
ELATHTAFVNRDIFPRLADRLPQKQLLDSLGLATAPWQLLSSASEWPEVFATLGELAIVK
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHH
RRVGGYDGRGQWRLRPGEQGTLPPDAYGECIVEQGINFSGEVSLIGARSHQGESVFYPLT
HHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEECCC
HNLHEDGILRMSVALPQPNSKLQQQAEKMLSAIMDKLNYVGVMAMECFIVGDRLLINELA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
PRVHNSGHWTQNGASISQFELHLRAILDLPLPQPVVNTPSAMVNLIGTPVNIQWLSLPLV
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEE
HLHWYDKEVREGRKVGHLNLNDPEGTALSASLAALAPLLPAEYQNALRWAQDKL
EEEECCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2464576; 2644189; 9278503; 1534690; 10569930 [H]