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The map label for this gene is cysM [H]

Identifier: 108811108

GI number: 108811108

Start: 1096961

End: 1098001

Strand: Reverse

Name: cysM [H]

Synonym: YPN_0943

Alternate gene names: 108811108

Gene position: 1098001-1096961 (Counterclockwise)

Preceding gene: 108811114

Following gene: 108811106

Centisome position: 24.21

GC content: 47.26

Gene sequence:

>1041_bases
ATGACCAATACATGGGTGAAAAATGCTATCAATGAAATAGAAGCTGACTTTCAACGCTCCGCTGATACGCATTTAATTCG
CTTAAATTTATCAGCTTTTCCAGGTATTTATCTGTATTTAAAAGATGAAAGTACCCACCCAACAGGCAGTTTGAAACACC
GCTTGGCGCGTTCACTGTTTTTATATGGCTTATGCAATGGCTGGATAACCGAAGGGACGACCATTATTGAAGCTTCATCG
GGGAGTACTGCGGTCTCGGAAGCCTACTTTGCTCGCCTGATCGGCCTGCCATTTATCGCTGTCATGCCAAGTGGTACCAC
GCGACGTAAAGTTGAACAAATCACCTTCTACGGTGGCCGTTGCCATTTTGTCGATCATGCAGGACAAATTTATGCCGCAT
CGGAACAACTGGCCCGTGATTTGAACGGTCACTATATGGATCAGTTTACTTATGCGGAACGGGCAACCGATTGGCGCGGC
AATAACAATATTGCAGACAGCATTTTCCGTCAAATGGCACGGGAGCCTTTCCCAACCCCAGATTATATTGTGATGAGCGC
AGGGACCGGTGGCACCTCAGCAACCTTAGGCCGTTATATCCGTTATCAAGGACATGACACTCAGTTGGTGGTGGTCGACC
CGGAAAACTCGGTATTTTATGATTGCTTCTGTACCCGTGACCGCACCGTCACGGGCCGTTGTGGTAGCCGTATTGAAGGG
ATAGGCCGTCCACGTGCTGAGCCTTCTTTTATTCCAGAAGTGATTGATAGCATGCTACGCGTACCTGATGCTGCCAGTAT
CGCCACTCTTCATTGGCTGGAGAGTATTCTTAGCCGTAAAGTGGGAGCCTCAACGGGTACCAATGTCTGGGGTGCATTGC
AATTGGCAAAACAGATGCGTGAACAAGGCAAATCTGGCGCCATCGTGACATTGCTCTGTGACAGTGGTGAACGTTATCTT
GATACCTATTATAACGAGGAATGGGTCAGCAATAACATTGGGGATTTAACACCATTTACCAATGAATTGAATAATCTGTA
G

Upstream 100 bases:

>100_bases
TACCATTTGGCGATAAAGAAGGAAAAATGGCAACGCTTTTTTCTTTGATAACCGTTAACCTAGTCGCCATGACTTAACTA
CCTATATCACAGGCCATCAA

Downstream 100 bases:

>100_bases
GCGAATATATATCTGTGATTCAGATGAATGAGCGCGAATAACGCTGCAGTGGCATTAAGTTTCATTAATGTCCAGTTGCA
GTAACTTTCAGTTTCAGTAA

Product: pyridoxal-phosphate dependent protein

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLFLYGLCNGWITEGTTIIEASS
GSTAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYGGRCHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRG
NNNIADSIFRQMAREPFPTPDYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEG
IGRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMREQGKSGAIVTLLCDSGERYL
DTYYNEEWVSNNIGDLTPFTNELNNL

Sequences:

>Translated_346_residues
MTNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLFLYGLCNGWITEGTTIIEASS
GSTAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYGGRCHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRG
NNNIADSIFRQMAREPFPTPDYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEG
IGRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMREQGKSGAIVTLLCDSGERYL
DTYYNEEWVSNNIGDLTPFTNELNNL
>Mature_345_residues
TNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLFLYGLCNGWITEGTTIIEASSG
STAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYGGRCHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRGN
NNIADSIFRQMAREPFPTPDYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEGI
GRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMREQGKSGAIVTLLCDSGERYLD
TYYNEEWVSNNIGDLTPFTNELNNL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=331, Percent_Identity=24.4712990936556, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI295821200, Length=331, Percent_Identity=24.4712990936556, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4557415, Length=331, Percent_Identity=24.4712990936556, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI2367138, Length=325, Percent_Identity=26.7692307692308, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=358, Percent_Identity=32.9608938547486, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17539800, Length=357, Percent_Identity=31.9327731092437, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17539640, Length=364, Percent_Identity=28.2967032967033, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17535051, Length=337, Percent_Identity=29.3768545994065, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562970, Length=332, Percent_Identity=28.3132530120482, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32566674, Length=315, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI115535073, Length=335, Percent_Identity=28.0597014925373, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=25.3012048192771, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24643623, Length=318, Percent_Identity=27.6729559748428, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20129101, Length=318, Percent_Identity=27.6729559748428, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38556; Mature: 38425

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLF
CCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LYGLCNGWITEGTTIIEASSGSTAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYGGR
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHEEEEECCE
CHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRGNNNIADSIFRQMAREPFPTP
EEEECCCCCEEEHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
DYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEG
CEEEEECCCCCCHHHHHHHHEECCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCHHHC
IGRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMR
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EQGKSGAIVTLLCDSGERYLDTYYNEEWVSNNIGDLTPFTNELNNL
HCCCCCCEEEEEECCCCHHHHHHCCHHHHCCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
TNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLF
CCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LYGLCNGWITEGTTIIEASSGSTAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYGGR
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHEEEEECCE
CHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRGNNNIADSIFRQMAREPFPTP
EEEECCCCCEEEHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
DYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEG
CEEEEECCCCCCHHHHHHHHEECCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCHHHC
IGRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMR
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EQGKSGAIVTLLCDSGERYLDTYYNEEWVSNNIGDLTPFTNELNNL
HCCCCCCEEEEEECCCCHHHHHHCCHHHHCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9034314; 10688204 [H]