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The map label for this gene is ahpC [C]

Identifier: 108811058

GI number: 108811058

Start: 1046324

End: 1046926

Strand: Reverse

Name: ahpC [C]

Synonym: YPN_0893

Alternate gene names: 108811058

Gene position: 1046926-1046324 (Counterclockwise)

Preceding gene: 108811059

Following gene: 108811057

Centisome position: 23.09

GC content: 47.26

Gene sequence:

>603_bases
ATGGTTCTGGTAACTCGTCAAGCCCCTGATTTTACAGCGGCTGCTGTTCTTGGTAACGGCGAAATCGTTGAAAACTTTAA
CCTGAAAAAGCACCTGAACGGCAGACCAGCCGTCCTATTCTTCTGGCCAATGGACTTTACTTTCGTTTGCCCTTCAGAAT
TGATCGCTTTCGACCATCGTTATGAAGAATTCCAAAAACGTGGTGTTGAAGTTGTTGGTGTTTCTTTCGATTCAGAGTTT
GTGCATAACGCATGGCGTAAAACCCCAGTGGATAAAGGCGGTATTGGCGAAGTTAAATACCCAATGGTTGCGGATATCAA
ACGTGAAATCCAGAAAGCTTACGGTATTGAGCACCCAGATGCTGGCGTTGCACTGCGTGGTTCATTCCTGATCGACAAAA
ATGGTATTGTTCGCAGCCAAATCGTTAACGACCTGCCAATCGGCCGTAACATCGACGAAATGATCCGTACCGTTGATGCA
CTGCAATTCCACGAAGAACACGGCGAAGTTTGCCCTGCACAGTGGGAAAAAGGCAAAGCAGGTATGGGCGCATCCCCAGA
CGGCGTAGCTAAATACCTGTCTGAGAACGCATCTAAGCTGTAA

Upstream 100 bases:

>100_bases
ATTGGTATTTATTCCTTTCTTCATCACACTTAAATACCTATGCTGTTACGATAGTTTTTAAGACATCTGGTTAATCCATC
TCTATTAACAGGAGTAATTT

Downstream 100 bases:

>100_bases
TAAGATTTAAACCGTCCCCGACAAGCTCGGGGGCTATCAAGCCAGTCAGTTCACTCTGACTGGCTTTTTTTCCCCTAGAT
ACCGCCCCTCACTTCGATTC

Product: alkyl hydroperoxide reductase subunit c

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MVLVTRQAPDFTAAAVLGNGEIVENFNLKKHLNGRPAVLFFWPMDFTFVCPSELIAFDHRYEEFQKRGVEVVGVSFDSEF
VHNAWRKTPVDKGGIGEVKYPMVADIKREIQKAYGIEHPDAGVALRGSFLIDKNGIVRSQIVNDLPIGRNIDEMIRTVDA
LQFHEEHGEVCPAQWEKGKAGMGASPDGVAKYLSENASKL

Sequences:

>Translated_200_residues
MVLVTRQAPDFTAAAVLGNGEIVENFNLKKHLNGRPAVLFFWPMDFTFVCPSELIAFDHRYEEFQKRGVEVVGVSFDSEF
VHNAWRKTPVDKGGIGEVKYPMVADIKREIQKAYGIEHPDAGVALRGSFLIDKNGIVRSQIVNDLPIGRNIDEMIRTVDA
LQFHEEHGEVCPAQWEKGKAGMGASPDGVAKYLSENASKL
>Mature_200_residues
MVLVTRQAPDFTAAAVLGNGEIVENFNLKKHLNGRPAVLFFWPMDFTFVCPSELIAFDHRYEEFQKRGVEVVGVSFDSEF
VHNAWRKTPVDKGGIGEVKYPMVADIKREIQKAYGIEHPDAGVALRGSFLIDKNGIVRSQIVNDLPIGRNIDEMIRTVDA
LQFHEEHGEVCPAQWEKGKAGMGASPDGVAKYLSENASKL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=45.5958549222798, Blast_Score=188, Evalue=3e-48,
Organism=Homo sapiens, GI4505591, Length=189, Percent_Identity=45.5026455026455, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI32455266, Length=189, Percent_Identity=45.5026455026455, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI32455264, Length=189, Percent_Identity=45.5026455026455, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=44.2708333333333, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI5802974, Length=192, Percent_Identity=43.2291666666667, Blast_Score=173, Evalue=8e-44,
Organism=Homo sapiens, GI32483377, Length=191, Percent_Identity=42.9319371727749, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=50, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI4758638, Length=195, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786822, Length=192, Percent_Identity=38.0208333333333, Blast_Score=130, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17554494, Length=170, Percent_Identity=44.1176470588235, Blast_Score=165, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI193204376, Length=176, Percent_Identity=46.0227272727273, Blast_Score=164, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32565831, Length=176, Percent_Identity=46.0227272727273, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI25153706, Length=183, Percent_Identity=28.9617486338798, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=196, Percent_Identity=38.7755102040816, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320661, Length=179, Percent_Identity=39.6648044692737, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319407, Length=181, Percent_Identity=29.2817679558011, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=46.9072164948454, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=46.9072164948454, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17738015, Length=197, Percent_Identity=43.1472081218274, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21357347, Length=193, Percent_Identity=44.559585492228, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17157991, Length=197, Percent_Identity=40.6091370558376, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24641739, Length=197, Percent_Identity=40.6091370558376, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24581278, Length=182, Percent_Identity=31.8681318681319, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17975518, Length=156, Percent_Identity=32.0512820512821, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24652436, Length=156, Percent_Identity=32.0512820512821, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24652434, Length=156, Percent_Identity=32.0512820512821, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22259; Mature: 22259

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLVTRQAPDFTAAAVLGNGEIVENFNLKKHLNGRPAVLFFWPMDFTFVCPSELIAFDHR
CEEEECCCCCCEEEEEECCCCEEECCCHHHHCCCCCEEEEEECCCEEEECHHHHHHHHHH
YEEFQKRGVEVVGVSFDSEFVHNAWRKTPVDKGGIGEVKYPMVADIKREIQKAYGIEHPD
HHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
AGVALRGSFLIDKNGIVRSQIVNDLPIGRNIDEMIRTVDALQFHEEHGEVCPAQWEKGKA
CCEEEECEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GMGASPDGVAKYLSENASKL
CCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLVTRQAPDFTAAAVLGNGEIVENFNLKKHLNGRPAVLFFWPMDFTFVCPSELIAFDHR
CEEEECCCCCCEEEEEECCCCEEECCCHHHHCCCCCEEEEEECCCEEEECHHHHHHHHHH
YEEFQKRGVEVVGVSFDSEFVHNAWRKTPVDKGGIGEVKYPMVADIKREIQKAYGIEHPD
HHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
AGVALRGSFLIDKNGIVRSQIVNDLPIGRNIDEMIRTVDALQFHEEHGEVCPAQWEKGKA
CCEEEECEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GMGASPDGVAKYLSENASKL
CCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]