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The map label for this gene is ggt [H]

Identifier: 108811056

GI number: 108811056

Start: 1044170

End: 1045684

Strand: Reverse

Name: ggt [H]

Synonym: YPN_0891

Alternate gene names: 108811056

Gene position: 1045684-1044170 (Counterclockwise)

Preceding gene: 108811057

Following gene: 108811048

Centisome position: 23.06

GC content: 50.63

Gene sequence:

>1515_bases
ATGACCATTCATCTTGCCGATGGAACCGATACATTTATTAACTTTCGTGAAACCGCCCCTTCCACGGCTAATGCTGATAT
GTACTTGGATAAAGACGGTAACGTTACCAAGGATGCAAGTTTGTATGGCTATCTGGCGGTAGGTGTACCTGGCACGGTAT
TGGGCATGGATAGTGCGCAAAAAAAATACGGCAAATTAACCCGTCAGCAAGTCATGGCACCGGCTATCCGTTTGGCCCGT
GACGGCTTTATCCTGACTTGCGCCGATACCGATATTCTGGACACCACCGTCAAACGTTTCCGTCAGGATCCTGAGTCTGC
ACGTATCTTCCTGCGTAAAGATGGAGAGGCATTACAACCGGGCGATCGTCTGGTTCAGGCCGATCTCGCGGATACGTTAA
GCGCGATTTCAGAAAAAGGGCCGGATGCGTTCTATCAAGGTAAAATACCGCAAGCTGTGGAAGCAGCGGCTAAAAAGGGA
GGCGGAATACTGACTGCCGCCGATTTCGCCGATTATAAAATCACCGAAACCGCACCGATTACCTGTAGTTATCGCGGTTA
TAAATTCGTTTCAGCCCCACCGCCGAGTTCCGGTGGCGTCACATTATGTGAAACGCTAAATGTTTTGGAGGGCTATAACC
TCAAAAGTATGGGCTTTAACTCCGCTGACTATATCCATACGCTAACGGAGGCAATGCGCCATGCCTATATGGACCGCAAT
ACCTTCCTCGGTGATCCAGAGTTTGTTAAAAATCCGCTTGACCGCCTACTGAGCAAAAGCTATGCCGCCGATATCCGTAA
ACAGATCGTCGCCAACAAAGCAACACCATCAGTAGAAGTACAACCGGGTATGCAACCTCACGAAAAACCGGAGACGACAC
ACTACTCCATCGTCGATCATGAGGGTAATGCCGTTTCTACCACGTATACCGTTAATGGGCGCTTTGGCGCGGTGGTCATT
GCTCCTTGTACTGGCTTCTTCCTCAATAATGAAATGGATGATTTTACAGTTAAAGTGGGTGAACAAAATCTGTATGGATT
GGTACAAGGTGCAACCAACGCTATCGCCCCCGGTAAGCGCCCACTATCGTCAATGAGCCCGACACTAGTGACCAAAGATG
GAAAAACATTTATGGTCTTGGGTTCACCGGGTGGCTCACGGATTATCAGCATCACGCTGCAAACCGCCCTGAACGTCATT
GACCACGGTATGGCCCCGCAAGAAGCGGTTGATGCACCACGTATTCACCATCAGTGGCTACCCGATGAAGTCTATTATGA
GCAACGCGGTGTCTCAGCGGACAGCCTCAATATCCTGAAGAGTATGGGATATAAGATGGTTGAACAGAGCCCTTGGGGCG
CAGCGGAGTTGATTTTAGTCGGCCTGGCCGGTGTTGAGGGCGTCAGCCCGGCTAACTCGGGTAATGATTCTGCTGTCTCC
GGCAAAGTCCGTGAGGGCTACCTGTACGGTGCCAATGATGTCCGTCGCCCCGCAGGGGCTGCTATTGGCTACTAA

Upstream 100 bases:

>100_bases
TAAAAATGGGCGGTAATGCTGTTGATGCCGCGGTAGCAGTAGGATATGCCCAGGCAGTAGTCAATCCTTGCTGTGGCAAT
ATTGGCGGGGGGGGGGTTTT

Downstream 100 bases:

>100_bases
TCAATCTAATGACTACTAATCAATCTAATGGTTGTTAATTAAGATTAAGCCATGGGTCATTAATTAAGCTATTGGTTATT
GATTTAGCTATTGACCGATG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIRLAR
DGFILTCADTDILDTTVKRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAAKKG
GGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYMDRN
TFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGAVVI
APCTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPGKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTALNVI
DHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDSAVS
GKVREGYLYGANDVRRPAGAAIGY

Sequences:

>Translated_504_residues
MTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIRLAR
DGFILTCADTDILDTTVKRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAAKKG
GGILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYMDRN
TFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGAVVI
APCTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPGKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTALNVI
DHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDSAVS
GKVREGYLYGANDVRRPAGAAIGY
>Mature_503_residues
TIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQKKYGKLTRQQVMAPAIRLARD
GFILTCADTDILDTTVKRFRQDPESARIFLRKDGEALQPGDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAAKKGG
GILTAADFADYKITETAPITCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYMDRNT
FLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDHEGNAVSTTYTVNGRFGAVVIA
PCTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPGKRPLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTALNVID
HGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDSAVSG
KVREGYLYGANDVRRPAGAAIGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=424, Percent_Identity=34.4339622641509, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI73915090, Length=424, Percent_Identity=34.4339622641509, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI73915096, Length=424, Percent_Identity=34.4339622641509, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI73915094, Length=424, Percent_Identity=34.4339622641509, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI113429324, Length=432, Percent_Identity=32.8703703703704, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI113429326, Length=432, Percent_Identity=32.6388888888889, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI109148539, Length=453, Percent_Identity=29.8013245033113, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI153266885, Length=431, Percent_Identity=28.7703016241299, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI153266901, Length=432, Percent_Identity=28.7037037037037, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI153266907, Length=401, Percent_Identity=29.1770573566085, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI30581157, Length=177, Percent_Identity=38.9830508474576, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI30581155, Length=177, Percent_Identity=38.9830508474576, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI218505805, Length=174, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI310124095, Length=174, Percent_Identity=30.4597701149425, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789856, Length=505, Percent_Identity=46.5346534653465, Blast_Score=455, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI212646519, Length=428, Percent_Identity=34.8130841121495, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI72000294, Length=428, Percent_Identity=34.8130841121495, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17506189, Length=441, Percent_Identity=32.6530612244898, Blast_Score=205, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17542894, Length=430, Percent_Identity=34.1860465116279, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI193208247, Length=453, Percent_Identity=31.5673289183223, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI193208245, Length=453, Percent_Identity=32.0088300220751, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17564448, Length=377, Percent_Identity=26.2599469496021, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=469, Percent_Identity=29.8507462686567, Blast_Score=153, Evalue=6e-38,
Organism=Drosophila melanogaster, GI161077878, Length=447, Percent_Identity=31.5436241610738, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI161077880, Length=447, Percent_Identity=31.5436241610738, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24642670, Length=447, Percent_Identity=31.5436241610738, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24642666, Length=447, Percent_Identity=31.5436241610738, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI45551474, Length=447, Percent_Identity=31.5436241610738, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI161077496, Length=439, Percent_Identity=31.4350797266515, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI18859893, Length=468, Percent_Identity=30.5555555555556, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI18859741, Length=457, Percent_Identity=29.1028446389497, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 54214; Mature: 54083

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQ
CEEEEECCCCCEEEECCCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCEEECCCHHH
KKYGKLTRQQVMAPAIRLARDGFILTCADTDILDTTVKRFRQDPESARIFLRKDGEALQP
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
GDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAAKKGGGILTAADFADYKITETAPI
CHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCCCEEEECCCCCEEEECCCCE
TCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYMDRN
EEECCCEEEEECCCCCCCCEEHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCC
TFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEEC
EGNAVSTTYTVNGRFGAVVIAPCTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPGKR
CCCEEEEEEEECCCCCEEEEECCCCEEECCCCCCEEEEECCCCCEEEECCCCCCCCCCCC
PLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTALNVIDHGMAPQEAVDAPRIHHQWL
CCCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHHHHHHHCCCCCHHHCCCCCHHHCCC
PDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDSAVS
CHHHHHHHCCCCHHHHHHHHHCCHHHHHCCCCCHHHEEEEEECCCCCCCCCCCCCCCCCC
GKVREGYLYGANDVRRPAGAAIGY
CCEECCEEECCCHHCCCCCCCCCC
>Mature Secondary Structure 
TIHLADGTDTFINFRETAPSTANADMYLDKDGNVTKDASLYGYLAVGVPGTVLGMDSAQ
EEEEECCCCCEEEECCCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCEEECCCHHH
KKYGKLTRQQVMAPAIRLARDGFILTCADTDILDTTVKRFRQDPESARIFLRKDGEALQP
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
GDRLVQADLADTLSAISEKGPDAFYQGKIPQAVEAAAKKGGGILTAADFADYKITETAPI
CHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCCCEEEECCCCCEEEECCCCE
TCSYRGYKFVSAPPPSSGGVTLCETLNVLEGYNLKSMGFNSADYIHTLTEAMRHAYMDRN
EEECCCEEEEECCCCCCCCEEHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCC
TFLGDPEFVKNPLDRLLSKSYAADIRKQIVANKATPSVEVQPGMQPHEKPETTHYSIVDH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEEC
EGNAVSTTYTVNGRFGAVVIAPCTGFFLNNEMDDFTVKVGEQNLYGLVQGATNAIAPGKR
CCCEEEEEEEECCCCCEEEEECCCCEEECCCCCCEEEEECCCCCEEEECCCCCCCCCCCC
PLSSMSPTLVTKDGKTFMVLGSPGGSRIISITLQTALNVIDHGMAPQEAVDAPRIHHQWL
CCCCCCCEEEECCCCEEEEEECCCCCEEEEEEHHHHHHHHHCCCCCHHHCCCCCHHHCCC
PDEVYYEQRGVSADSLNILKSMGYKMVEQSPWGAAELILVGLAGVEGVSPANSGNDSAVS
CHHHHHHHCCCCHHHHHHHHHCCHHHHHCCCCCHHHEEEEEECCCCCCCCCCCCCCCCCC
GKVREGYLYGANDVRRPAGAAIGY
CCEECCEEECCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]