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The map label for this gene is ppe42 [H]

Identifier: 108797923

GI number: 108797923

Start: 1049867

End: 1051456

Strand: Direct

Name: ppe42 [H]

Synonym: Mmcs_0949

Alternate gene names: 108797923

Gene position: 1049867-1051456 (Clockwise)

Preceding gene: 108797917

Following gene: 108797924

Centisome position: 18.4

GC content: 65.72

Gene sequence:

>1590_bases
ATGCGTAAGTCTGCAAACGCAACGATCATCGTCATCGTCTCGCTCATCGCCACCGTCGGCCTCTGGCTCGCGTCGACCTT
CGCGGCAGCGATCGCCTTCGGCGCCATCGCGCTCATCGTGCCGGGCACCGGAACGCACAACGTCACCACCGACACGCAGT
ACCGGGAGAATGCGGCCAACCGCTACATCGACCCGTCCGGCGTGCCGTGTACGTCAGAGGACGGCTGCGACCTCCGAGGC
GTCGACTATCCCGCCAGCTTCTGGCCGATTCCGCTTCCAGGCTGGTGCCCCGGCCTGACGTGCGACACCTGGAACAAGTC
GGTGGGCGAAGGCGTCACCAACCTCAACACCGACCTCGCCGGCATCCTGGCCGACCCGGCCAACGACGACGAGGACATCA
TCGTCTTCGGCTACTCCCAGGGTGGCGCCGTCGTCTCCCGCGCCATGTACGACATCGCCGAACTCGACGAGGAGACCCGG
GACCGCATCACCGTCGTCACCATCGGCAACATCAACAACCCCCAGGGGCTGTGGTCGCGACTGAGCTTCCTGCGCTACAT
CCCGCTCCTCGACGTGTCCTTCGGGCCGCAACTGCCCACCGACATCGGCGTCAAGAGCACCAACTACTCCTTCGAGTACG
ACCCCGTCGGCGACGCCCCGCAGTACTGGGGCAACCCCTTGGCGATGCTCAACGCGCTCATGGCATTCGAGTACGTCCAC
GGTTACTACCTCGACCCCAACAGCAACGGGCCCAACGACTCGATGCCCTACGGCTACGACAACGTCAGCCTCGCCGCCGC
GATCGCGGCCGCGCCCAAGCGCGTCCACGGTGACGCCACCTTCGTGCTCATCCCGCAGCGCGGCACACTCCCGATCTTCA
TGCCGCTCGTCGATCTCGGAAACGCCACCGGCACATCCGCATTCATCGAACCCGTCATCCGGCTGCTGCAGCCGGTGACC
AAGCTGCTGATCGACCTGGGCTACGACCGCACCACCAACCCGGGCATTGCGCGGAACCTGTCGATCCTGCCGTTCAACCC
CTTCGCCTTCAATCCCGTCCAGTTCTCCGTGGACTTCGTCGAAGCCATCGTCCAGGGCATCGAAGACGCCTTCAACGGCG
GCAGCATGATCGCGGTGCCGGTCCCGACACCGTCGGAATCTGAAACCAACGACGTGCTTGCCGCGGGCAAGGCGCTGGGC
CGGCTGGCCGCGGATGAAGCGGAGGAAGGCCTCACCCCGGTCGTCGAGCAGGTCTCGACCGGCAGCGAGGAGTCGGTCGA
AGACCCCTCCGAAAGCGACATCGCGGGCACCCCGCCGATCGCCGACGAAGCCGCGACCAACGACGAGCAGGAACAGATCG
AGGCCCCGAAGGACGAAGAGGCCCAGGAAGTAGCCACCAAGGAAGAGGACCTCGACGAGACCGAGAACCTGCAGGAGGAC
CTCGGGGAAGAGGAACTCCCGCAGGAGGACGTTGAGAGCGAGCAAGAGGACTCCGCCGAGGAGACCGAAGAAGCCGAGGA
CACCGACGACGTCGAGAACGCCGAGGCCGAGGCCGAGACCGCAGCTCCCGAAGAGAAGGCGGCTGCCTGA

Upstream 100 bases:

>100_bases
TCGCGGCAGGTTCTGGACTTCACTCAGCGCCCAAACCGTGACCCGACCGGGCGGCGGAAAACGGCACACGCTCCGCTACG
CATTGTGTGATTGTTGACGC

Downstream 100 bases:

>100_bases
CCTTCCTCGACATCGAACCGCCCGGCACCCAGGAAGTGCCGGGCGGTTCGCTCATTTCGGGGTACTCGACAGAACAGACC
AATCGCCCCGATGACGGGCA

Product: PE-PPE-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MRKSANATIIVIVSLIATVGLWLASTFAAAIAFGAIALIVPGTGTHNVTTDTQYRENAANRYIDPSGVPCTSEDGCDLRG
VDYPASFWPIPLPGWCPGLTCDTWNKSVGEGVTNLNTDLAGILADPANDDEDIIVFGYSQGGAVVSRAMYDIAELDEETR
DRITVVTIGNINNPQGLWSRLSFLRYIPLLDVSFGPQLPTDIGVKSTNYSFEYDPVGDAPQYWGNPLAMLNALMAFEYVH
GYYLDPNSNGPNDSMPYGYDNVSLAAAIAAAPKRVHGDATFVLIPQRGTLPIFMPLVDLGNATGTSAFIEPVIRLLQPVT
KLLIDLGYDRTTNPGIARNLSILPFNPFAFNPVQFSVDFVEAIVQGIEDAFNGGSMIAVPVPTPSESETNDVLAAGKALG
RLAADEAEEGLTPVVEQVSTGSEESVEDPSESDIAGTPPIADEAATNDEQEQIEAPKDEEAQEVATKEEDLDETENLQED
LGEEELPQEDVESEQEDSAEETEEAEDTDDVENAEAEAETAAPEEKAAA

Sequences:

>Translated_529_residues
MRKSANATIIVIVSLIATVGLWLASTFAAAIAFGAIALIVPGTGTHNVTTDTQYRENAANRYIDPSGVPCTSEDGCDLRG
VDYPASFWPIPLPGWCPGLTCDTWNKSVGEGVTNLNTDLAGILADPANDDEDIIVFGYSQGGAVVSRAMYDIAELDEETR
DRITVVTIGNINNPQGLWSRLSFLRYIPLLDVSFGPQLPTDIGVKSTNYSFEYDPVGDAPQYWGNPLAMLNALMAFEYVH
GYYLDPNSNGPNDSMPYGYDNVSLAAAIAAAPKRVHGDATFVLIPQRGTLPIFMPLVDLGNATGTSAFIEPVIRLLQPVT
KLLIDLGYDRTTNPGIARNLSILPFNPFAFNPVQFSVDFVEAIVQGIEDAFNGGSMIAVPVPTPSESETNDVLAAGKALG
RLAADEAEEGLTPVVEQVSTGSEESVEDPSESDIAGTPPIADEAATNDEQEQIEAPKDEEAQEVATKEEDLDETENLQED
LGEEELPQEDVESEQEDSAEETEEAEDTDDVENAEAEAETAAPEEKAAA
>Mature_529_residues
MRKSANATIIVIVSLIATVGLWLASTFAAAIAFGAIALIVPGTGTHNVTTDTQYRENAANRYIDPSGVPCTSEDGCDLRG
VDYPASFWPIPLPGWCPGLTCDTWNKSVGEGVTNLNTDLAGILADPANDDEDIIVFGYSQGGAVVSRAMYDIAELDEETR
DRITVVTIGNINNPQGLWSRLSFLRYIPLLDVSFGPQLPTDIGVKSTNYSFEYDPVGDAPQYWGNPLAMLNALMAFEYVH
GYYLDPNSNGPNDSMPYGYDNVSLAAAIAAAPKRVHGDATFVLIPQRGTLPIFMPLVDLGNATGTSAFIEPVIRLLQPVT
KLLIDLGYDRTTNPGIARNLSILPFNPFAFNPVQFSVDFVEAIVQGIEDAFNGGSMIAVPVPTPSESETNDVLAAGKALG
RLAADEAEEGLTPVVEQVSTGSEESVEDPSESDIAGTPPIADEAATNDEQEQIEAPKDEEAQEVATKEEDLDETENLQED
LGEEELPQEDVESEQEDSAEETEEAEDTDDVENAEAEAETAAPEEKAAA

Specific function: Elicits a high humoral and a low T cell response. Could be involved in directing the host toward development of a more humoral type of immune response [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002989
- InterPro:   IPR013228
- InterPro:   IPR000030 [H]

Pfam domain/function: PF08237 PE-PPE; PF01469 Pentapeptide_2; PF00823 PPE [H]

EC number: NA

Molecular weight: Translated: 56674; Mature: 56674

Theoretical pI: Translated: 3.62; Mature: 3.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSANATIIVIVSLIATVGLWLASTFAAAIAFGAIALIVPGTGTHNVTTDTQYRENAAN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHH
RYIDPSGVPCTSEDGCDLRGVDYPASFWPIPLPGWCPGLTCDTWNKSVGEGVTNLNTDLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHCCCCHH
GILADPANDDEDIIVFGYSQGGAVVSRAMYDIAELDEETRDRITVVTIGNINNPQGLWSR
HEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCHHHHCCEEEEEECCCCCHHHHHHH
LSFLRYIPLLDVSFGPQLPTDIGVKSTNYSFEYDPVGDAPQYWGNPLAMLNALMAFEYVH
HHHHHHHHHEECCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHCCHHHHHHHHHHHHHHH
GYYLDPNSNGPNDSMPYGYDNVSLAAAIAAAPKRVHGDATFVLIPQRGTLPIFMPLVDLG
CEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCHHCCCCEEEEEEECCCCCEEEEHHHHCC
NATGTSAFIEPVIRLLQPVTKLLIDLGYDRTTNPGIARNLSILPFNPFAFNPVQFSVDFV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEHHHHH
EAIVQGIEDAFNGGSMIAVPVPTPSESETNDVLAAGKALGRLAADEAEEGLTPVVEQVST
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GSEESVEDPSESDIAGTPPIADEAATNDEQEQIEAPKDEEAQEVATKEEDLDETENLQED
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHH
LGEEELPQEDVESEQEDSAEETEEAEDTDDVENAEAEAETAAPEEKAAA
CCHHCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MRKSANATIIVIVSLIATVGLWLASTFAAAIAFGAIALIVPGTGTHNVTTDTQYRENAAN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHH
RYIDPSGVPCTSEDGCDLRGVDYPASFWPIPLPGWCPGLTCDTWNKSVGEGVTNLNTDLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHCCCCHH
GILADPANDDEDIIVFGYSQGGAVVSRAMYDIAELDEETRDRITVVTIGNINNPQGLWSR
HEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCHHHHCCEEEEEECCCCCHHHHHHH
LSFLRYIPLLDVSFGPQLPTDIGVKSTNYSFEYDPVGDAPQYWGNPLAMLNALMAFEYVH
HHHHHHHHHEECCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHCCHHHHHHHHHHHHHHH
GYYLDPNSNGPNDSMPYGYDNVSLAAAIAAAPKRVHGDATFVLIPQRGTLPIFMPLVDLG
CEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCHHCCCCEEEEEEECCCCCEEEEHHHHCC
NATGTSAFIEPVIRLLQPVTKLLIDLGYDRTTNPGIARNLSILPFNPFAFNPVQFSVDFV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEHHHHH
EAIVQGIEDAFNGGSMIAVPVPTPSESETNDVLAAGKALGRLAADEAEEGLTPVVEQVST
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GSEESVEDPSESDIAGTPPIADEAATNDEQEQIEAPKDEEAQEVATKEEDLDETENLQED
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHH
LGEEELPQEDVESEQEDSAEETEEAEDTDDVENAEAEAETAAPEEKAAA
CCHHCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]