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The map label for this gene is clpB [H]

Identifier: 108797458

GI number: 108797458

Start: 531584

End: 534130

Strand: Direct

Name: clpB [H]

Synonym: Mmcs_0478

Alternate gene names: 108797458

Gene position: 531584-534130 (Clockwise)

Preceding gene: 108797456

Following gene: 108797459

Centisome position: 9.32

GC content: 68.71

Gene sequence:

>2547_bases
GTGGACTCGTTCAACCCGACGACCAAGACCCAGGCGGCGCTGACTTCGGCGTTGCAGGCGGCCAGTGCCGCAGGCAACCC
CCAGATCGCGCCCGCCCATTTGTTGATGGCATTGCTGACGCAGAACGACGGCATTGCCGCACCCCTTCTGGAGGCCGTCG
GCGTCGAACCCGCGACAGTTCGGGCCGAGACGCAGCGCCTCCTCGACCGGCTGCCCAGCGCCAGCGGCGCCAGCAGCCAG
CCGCAGTTGTCGCGTGAGTCGCTGGCCGCGGTCACCGCCGCCCAGCAGCTCGCCACGGAGATCGACGACGAGTACGTCTC
GACCGAGCACCTGATGGTCGGCCTGGCCACCGGCGACTCCGACGTCGCCAAGCTGCTGACCGGCCACGGCGCCTCGCCGC
AGGCGCTGCGCGAGGCGTTCGTCAAGGTGCGCGGCAGCGCCCGCGTCACCAGCCCGGACCCCGAGGGCAGCTACCAGGCG
CTGGAGAAGTACTCCACCGATCTGACCGCCCGCGCACGCGAAGGCCAGCTCGACCCGGTCATCGGCCGGGACACCGAGAT
CCGCCGCGTCGTACAGGTGCTGAGCCGTCGTACCAAGAACAACCCGGTGCTCATCGGTGAGCCCGGCGTCGGCAAGACCG
CGATCGTCGAAGGCCTGGCCCAGCGCATCGTGGCCGGTGACGTGCCGGAGAGCCTGCGCGGTAAGACCGTCATCTCGCTC
GACCTGGGTTCGATGGTCGCCGGTTCGAAGTACCGCGGTGAGTTCGAGGAACGGCTCAAGGCCGTGCTCGACGACATCAA
GAACTCGGCCGGGCAGATCATCACGTTCATCGACGAGCTGCACACCATCGTCGGCGCCGGCGCGACCGGCGACTCCTCGA
TGGACGCCGGCAACATGATCAAGCCGATGCTCGCCCGCGGTGAGCTGCGGCTGGTCGGCGCCACCACCCTCGACGAGTAC
CGCAAGTACATCGAGAAGGACGCTGCGCTCGAGCGCCGGTTCCAGCAGGTCTACGTCGGCGAACCGTCGGTGGAGGACAC
CGTCGGCATCCTGCGCGGCCTCAAGGAGCGCTACGAGGTGCACCACGGCGTGCGCATCACCGACTCCGCTCTCGTCTCCG
CTGCCACCCTCTCCGACCGCTACATCACCGCCCGGTTCCTGCCGGACAAGGCCATCGACCTGGTCGACGAGGCCGCCTCC
CGGCTGCGCATGGAGATCGACTCCCGGCCCGTCGAGATCGACGAGGTCGAGCGCCTGGTCCGTCGCCTCGAGATCGAGGA
GATGGCGCTGGCCAAGGAGGAGGACGACGCGTCGAAGGAACGGCTGGAGAAGCTGCGCGGTGAGCTGGCCGACTACAAGG
AGAAGCTGGCGGAGCTGACGACGCGGTGGCAGAACGAGAAGAACGCCATCGACATCGTCCGCGAACTCAAGGAGCAGCTC
GAGGCGCTGCGCGGTGAGGCCGACCGGGCCGAGCGCGACGGCAACCTCGAAAAGGCCGCCGAGCTGCGCTACGGCCGCAT
CCCCGAGGTCGAGAAGAAACTCGACGCCGCGGTCCCCCAAGCCGAAGCCCGGGACGACGTGATGCTCAAGGAGGAGGTCG
GACCCGACGACATCGCCGAGGTGGTGTCGGCCTGGACCGGCATCCCCGCAGGCCGCATGCTCGAAGGCGAGACCGCCAAG
CTGCTGCGCATGGAGGACGAACTCGGCAAGCGGGTCGTCGGGCAGCGCAGGGCGGTGCAGGCCGTATCCGACGCGGTGCG
GCGCACCCGGGCCGGCGTCGCCGACCCGAACCGGCCGACCGGCTCGTTCATGTTCCTGGGCCCGACCGGTGTCGGTAAGA
CCGAGCTGGCCAAGGCGCTGGCGGAGTTCCTGTTCGACGACGAACGCGCGATGGTCCGCATCGACATGAGCGAGTACGGC
GAGAAGCACTCCGTCGCCCGCCTGGTCGGTGCGCCTCCGGGATACATCGGATACGACCAGGGCGGCCAGCTGACCGAGGC
GGTGCGGCGTCGCCCGTACACCGTGGTGCTGTTCGACGAGATCGAGAAGGCCCACCCGGACGTGTTCGACGTGTTGCTGC
AGGTGCTCGACGAGGGCCGGCTGACCGACGGTCAGGGCCGCACGGTCGACTTCCGCAACACCATCCTCATCCTGACGTCC
AACCTGGGCGCCGGCGGCACCGAGGACATGGTGATGGCGGCAGTGCGCTCGGCCTTCAAGCCCGAGTTCATCAACCGACT
CGACGACGTGATCGTGTTCGACGGGCTCAACCCCGAGGAGCTGGTGTCCATCGTCGACATCCAGCTGCAGCAGCTGGCCA
AGCGGCTGGCGCAGCGTCGCCTCACGCTCGAGGTGTCGCTGCCGGCGAAGAAGTGGCTGGCCGACCGCGGGTTCGACCCG
CTCTACGGCGCCCGGCCGCTGCGTCGGTTGATCCAGCAGTCCATCGGCGATCAGCTCGCGAAGATGCTGCTGGCCGGTGA
CGTGCACGACGGTGACATCGTGCCGGTCAACGTCAGTCCGGACGGCGAATCGCTGGTGCTGGGATGA

Upstream 100 bases:

>100_bases
GTCCGACATCTGCAAAGGAGTTAAAGTTGAGCGGAACAGACTCAAGATTTAGTGCGTTGAAGTAGCCGACAAGCATTTCA
ACCAGACGATCGGAGGTGTC

Downstream 100 bases:

>100_bases
GCGCTTGCGCGAAGACCCTCGGCCTGGGATGAGCGCTTGCGCGAAGACCCTCGGCCTGGGCTGAGGTCTTGAGCGCCCGA
GATCAGGGTTGGGCACGCCG

Product: ATPase AAA-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 848; Mature: 848

Protein sequence:

>848_residues
MDSFNPTTKTQAALTSALQAASAAGNPQIAPAHLLMALLTQNDGIAAPLLEAVGVEPATVRAETQRLLDRLPSASGASSQ
PQLSRESLAAVTAAQQLATEIDDEYVSTEHLMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEGSYQA
LEKYSTDLTARAREGQLDPVIGRDTEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRGKTVISL
DLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGDSSMDAGNMIKPMLARGELRLVGATTLDEY
RKYIEKDAALERRFQQVYVGEPSVEDTVGILRGLKERYEVHHGVRITDSALVSAATLSDRYITARFLPDKAIDLVDEAAS
RLRMEIDSRPVEIDEVERLVRRLEIEEMALAKEEDDASKERLEKLRGELADYKEKLAELTTRWQNEKNAIDIVRELKEQL
EALRGEADRAERDGNLEKAAELRYGRIPEVEKKLDAAVPQAEARDDVMLKEEVGPDDIAEVVSAWTGIPAGRMLEGETAK
LLRMEDELGKRVVGQRRAVQAVSDAVRRTRAGVADPNRPTGSFMFLGPTGVGKTELAKALAEFLFDDERAMVRIDMSEYG
EKHSVARLVGAPPGYIGYDQGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
NLGAGGTEDMVMAAVRSAFKPEFINRLDDVIVFDGLNPEELVSIVDIQLQQLAKRLAQRRLTLEVSLPAKKWLADRGFDP
LYGARPLRRLIQQSIGDQLAKMLLAGDVHDGDIVPVNVSPDGESLVLG

Sequences:

>Translated_848_residues
MDSFNPTTKTQAALTSALQAASAAGNPQIAPAHLLMALLTQNDGIAAPLLEAVGVEPATVRAETQRLLDRLPSASGASSQ
PQLSRESLAAVTAAQQLATEIDDEYVSTEHLMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEGSYQA
LEKYSTDLTARAREGQLDPVIGRDTEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRGKTVISL
DLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGDSSMDAGNMIKPMLARGELRLVGATTLDEY
RKYIEKDAALERRFQQVYVGEPSVEDTVGILRGLKERYEVHHGVRITDSALVSAATLSDRYITARFLPDKAIDLVDEAAS
RLRMEIDSRPVEIDEVERLVRRLEIEEMALAKEEDDASKERLEKLRGELADYKEKLAELTTRWQNEKNAIDIVRELKEQL
EALRGEADRAERDGNLEKAAELRYGRIPEVEKKLDAAVPQAEARDDVMLKEEVGPDDIAEVVSAWTGIPAGRMLEGETAK
LLRMEDELGKRVVGQRRAVQAVSDAVRRTRAGVADPNRPTGSFMFLGPTGVGKTELAKALAEFLFDDERAMVRIDMSEYG
EKHSVARLVGAPPGYIGYDQGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
NLGAGGTEDMVMAAVRSAFKPEFINRLDDVIVFDGLNPEELVSIVDIQLQQLAKRLAQRRLTLEVSLPAKKWLADRGFDP
LYGARPLRRLIQQSIGDQLAKMLLAGDVHDGDIVPVNVSPDGESLVLG
>Mature_848_residues
MDSFNPTTKTQAALTSALQAASAAGNPQIAPAHLLMALLTQNDGIAAPLLEAVGVEPATVRAETQRLLDRLPSASGASSQ
PQLSRESLAAVTAAQQLATEIDDEYVSTEHLMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEGSYQA
LEKYSTDLTARAREGQLDPVIGRDTEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRGKTVISL
DLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGDSSMDAGNMIKPMLARGELRLVGATTLDEY
RKYIEKDAALERRFQQVYVGEPSVEDTVGILRGLKERYEVHHGVRITDSALVSAATLSDRYITARFLPDKAIDLVDEAAS
RLRMEIDSRPVEIDEVERLVRRLEIEEMALAKEEDDASKERLEKLRGELADYKEKLAELTTRWQNEKNAIDIVRELKEQL
EALRGEADRAERDGNLEKAAELRYGRIPEVEKKLDAAVPQAEARDDVMLKEEVGPDDIAEVVSAWTGIPAGRMLEGETAK
LLRMEDELGKRVVGQRRAVQAVSDAVRRTRAGVADPNRPTGSFMFLGPTGVGKTELAKALAEFLFDDERAMVRIDMSEYG
EKHSVARLVGAPPGYIGYDQGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
NLGAGGTEDMVMAAVRSAFKPEFINRLDDVIVFDGLNPEELVSIVDIQLQQLAKRLAQRRLTLEVSLPAKKWLADRGFDP
LYGARPLRRLIQQSIGDQLAKMLLAGDVHDGDIVPVNVSPDGESLVLG

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=301, Percent_Identity=34.21926910299, Blast_Score=199, Evalue=8e-51,
Organism=Escherichia coli, GI1788943, Length=847, Percent_Identity=55.1357733175915, Blast_Score=936, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=434, Percent_Identity=40.5529953917051, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6320464, Length=728, Percent_Identity=53.5714285714286, Blast_Score=771, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=863, Percent_Identity=42.4101969872538, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 92616; Mature: 92616

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFNPTTKTQAALTSALQAASAAGNPQIAPAHLLMALLTQNDGIAAPLLEAVGVEPATV
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHH
RAETQRLLDRLPSASGASSQPQLSRESLAAVTAAQQLATEIDDEYVSTEHLMVGLATGDS
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCH
DVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEGSYQALEKYSTDLTARAREGQLDPV
HHHHHHHCCCCCHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHCCCHHHHCCCCCCCCC
IGRDTEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRGKTVISL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEE
DLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGDSSMDAGNMI
ECCHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
KPMLARGELRLVGATTLDEYRKYIEKDAALERRFQQVYVGEPSVEDTVGILRGLKERYEV
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
HHGVRITDSALVSAATLSDRYITARFLPDKAIDLVDEAASRLRMEIDSRPVEIDEVERLV
HCCCEECHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RRLEIEEMALAKEEDDASKERLEKLRGELADYKEKLAELTTRWQNEKNAIDIVRELKEQL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EALRGEADRAERDGNLEKAAELRYGRIPEVEKKLDAAVPQAEARDDVMLKEEVGPDDIAE
HHHHCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEHHCCCHHHHHH
VVSAWTGIPAGRMLEGETAKLLRMEDELGKRVVGQRRAVQAVSDAVRRTRAGVADPNRPT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GSFMFLGPTGVGKTELAKALAEFLFDDERAMVRIDMSEYGEKHSVARLVGAPPGYIGYDQ
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHCCCCCCCCCCC
GGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
CCHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEE
NLGAGGTEDMVMAAVRSAFKPEFINRLDDVIVFDGLNPEELVSIVDIQLQQLAKRLAQRR
CCCCCCHHHHHHHHHHHHCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
LTLEVSLPAKKWLADRGFDPLYGARPLRRLIQQSIGDQLAKMLLAGDVHDGDIVPVNVSP
EEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
DGESLVLG
CCCCCCCC
>Mature Secondary Structure
MDSFNPTTKTQAALTSALQAASAAGNPQIAPAHLLMALLTQNDGIAAPLLEAVGVEPATV
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHH
RAETQRLLDRLPSASGASSQPQLSRESLAAVTAAQQLATEIDDEYVSTEHLMVGLATGDS
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCH
DVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEGSYQALEKYSTDLTARAREGQLDPV
HHHHHHHCCCCCHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHCCCHHHHCCCCCCCCC
IGRDTEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRGKTVISL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEE
DLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGDSSMDAGNMI
ECCHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
KPMLARGELRLVGATTLDEYRKYIEKDAALERRFQQVYVGEPSVEDTVGILRGLKERYEV
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
HHGVRITDSALVSAATLSDRYITARFLPDKAIDLVDEAASRLRMEIDSRPVEIDEVERLV
HCCCEECHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RRLEIEEMALAKEEDDASKERLEKLRGELADYKEKLAELTTRWQNEKNAIDIVRELKEQL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EALRGEADRAERDGNLEKAAELRYGRIPEVEKKLDAAVPQAEARDDVMLKEEVGPDDIAE
HHHHCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEHHCCCHHHHHH
VVSAWTGIPAGRMLEGETAKLLRMEDELGKRVVGQRRAVQAVSDAVRRTRAGVADPNRPT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GSFMFLGPTGVGKTELAKALAEFLFDDERAMVRIDMSEYGEKHSVARLVGAPPGYIGYDQ
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHCCCCCCCCCCC
GGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
CCHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEE
NLGAGGTEDMVMAAVRSAFKPEFINRLDDVIVFDGLNPEELVSIVDIQLQQLAKRLAQRR
CCCCCCHHHHHHHHHHHHCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
LTLEVSLPAKKWLADRGFDPLYGARPLRRLIQQSIGDQLAKMLLAGDVHDGDIVPVNVSP
EEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
DGESLVLG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9692182; 12788972 [H]