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The map label for this gene is tcmR [H]

Identifier: 108797389

GI number: 108797389

Start: 455884

End: 456462

Strand: Direct

Name: tcmR [H]

Synonym: Mmcs_0409

Alternate gene names: 108797389

Gene position: 455884-456462 (Clockwise)

Preceding gene: 108797388

Following gene: 108797391

Centisome position: 7.99

GC content: 65.46

Gene sequence:

>579_bases
ATGTCGGTGCCTGAGAAGCAGTCGGGGCTCAGGGAGCGCAAGAAGCTCCAGACCCGCGAGACGATCAGGCGAGAAGCGTT
ACGGCTCATCAAAGAGCGGGGCTACCAGAACACGACGGTCGAACAGATCTCCGCCGCTGCGGACGTCTCGCCGCGAACGT
TCTCCCGGTATTTTCCGACCAAGGAAGCCGTGCTGCTGTCGGACGACCACATCGCCCCGATCATCGAGGCGTTCGTCGAC
GCCCCCGCCGACTTGTCGGTGATCGAGGCCTACCGCCACGCCGTCGCAAGGACGTTCGGCGCGCTGAGCGAGGAGCAGCG
TGCGGAAGCGATCTTCGGTCAGCGGCTGATGTACGCCATCCCCGAGGCGCGTGGACTGATCTACACCGAATACGTCCGGT
TGATCGAGCTGATCACCGAGGCGCTGACGAAGCGCCCCGGCCAGCCGGCCGACACGGTGGAGCGTCGGGTGCTGGCCGGG
GCGATCGTCGGTGTGCTCATCGCGGCGTCACACAACACCCCGCTGCCCGGTGATCCGATCTCCCGGTTCCTGCAGGTGCT
CGACGACAAGCTGAAGTAG

Upstream 100 bases:

>100_bases
CTGTCCTACCGCCGCGACAGCGACGGCAACCACTGGACGCTGGTCCGCAGCCGCACCCCGTAGGGGGCCGGGTTCCGATC
GGGTCTGCGAGAATCGAGCG

Downstream 100 bases:

>100_bases
CACGCACAAGAAAGAGGGGCACCCGACGGGTGCCCCTCCCTTGCTCGTCGTTCAGCGGACGTCGACATAGACGACGCGGT
CGCCGTTGTCGTAGCGCACC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MSVPEKQSGLRERKKLQTRETIRREALRLIKERGYQNTTVEQISAAADVSPRTFSRYFPTKEAVLLSDDHIAPIIEAFVD
APADLSVIEAYRHAVARTFGALSEEQRAEAIFGQRLMYAIPEARGLIYTEYVRLIELITEALTKRPGQPADTVERRVLAG
AIVGVLIAASHNTPLPGDPISRFLQVLDDKLK

Sequences:

>Translated_192_residues
MSVPEKQSGLRERKKLQTRETIRREALRLIKERGYQNTTVEQISAAADVSPRTFSRYFPTKEAVLLSDDHIAPIIEAFVD
APADLSVIEAYRHAVARTFGALSEEQRAEAIFGQRLMYAIPEARGLIYTEYVRLIELITEALTKRPGQPADTVERRVLAG
AIVGVLIAASHNTPLPGDPISRFLQVLDDKLK
>Mature_191_residues
SVPEKQSGLRERKKLQTRETIRREALRLIKERGYQNTTVEQISAAADVSPRTFSRYFPTKEAVLLSDDHIAPIIEAFVDA
PADLSVIEAYRHAVARTFGALSEEQRAEAIFGQRLMYAIPEARGLIYTEYVRLIELITEALTKRPGQPADTVERRVLAGA
IVGVLIAASHNTPLPGDPISRFLQVLDDKLK

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 21468; Mature: 21337

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPEKQSGLRERKKLQTRETIRREALRLIKERGYQNTTVEQISAAADVSPRTFSRYFPT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHCCC
KEAVLLSDDHIAPIIEAFVDAPADLSVIEAYRHAVARTFGALSEEQRAEAIFGQRLMYAI
CCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEARGLIYTEYVRLIELITEALTKRPGQPADTVERRVLAGAIVGVLIAASHNTPLPGDPI
CHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
SRFLQVLDDKLK
HHHHHHHHHHCC
>Mature Secondary Structure 
SVPEKQSGLRERKKLQTRETIRREALRLIKERGYQNTTVEQISAAADVSPRTFSRYFPT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHCCC
KEAVLLSDDHIAPIIEAFVDAPADLSVIEAYRHAVARTFGALSEEQRAEAIFGQRLMYAI
CCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEARGLIYTEYVRLIELITEALTKRPGQPADTVERRVLAGAIVGVLIAASHNTPLPGDPI
CHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
SRFLQVLDDKLK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]