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The map label for this gene is echA8 [H]

Identifier: 108797286

GI number: 108797286

Start: 342977

End: 343762

Strand: Reverse

Name: echA8 [H]

Synonym: Mmcs_0306

Alternate gene names: 108797286

Gene position: 343762-342977 (Counterclockwise)

Preceding gene: 108797287

Following gene: 108797285

Centisome position: 6.03

GC content: 68.7

Gene sequence:

>786_bases
ATGACCGCCGACATGAGCGGTCCGTTGCGCATCACGACGACCGCAGCCATTCAGGTGTGGACGATCGATCTGCCGCACGT
CGGCAATGCGATCACCGACGACGGCTTCATCGCCGCGTTCGAGGCCGCGGTCCACGCCGTCAACGCCGACAACGCGATTC
GTGCCGTCATCCTCACCGGTGAGGGCAAGATCTTCTCCGCCGGCGGCAACGTGAAGGAGATGGCGGACCGGCAGGGCATG
TTCGGCCTGGAGCCGCTCGATCAGCGGCGCGCATACCTCGACGGCATCCAGCGCATTCCCCGTGCGCTCGAGCGGCTCGA
GGTGCCGTTGATCGCCGCGGTCAACGGGGCCGCGGTCGGCGCCGGGTGTGACCTGGCGATGATGTGCGACATCCGGATCG
CCTCCGACCGTGCGTCGTTCGCCGAGAGCTTCGTACAGGTCGGGCTCATCCCCGGGGACGGTGGCACCTGGTTCCTGCCG
CGGGCGGTCGGATATGCGCGCGCCGCGGAGATGACGCTGACCGGGGACCGCATCGACGCGGCCACGGCGGCGGAGTGGGG
CATGGTCAGCCGCGTCGTTCCGCACGAGGATCTTCTCGCCGAAGCGCAGGCGCTCGCCGAGCGCATCACGAAGAACCCCG
CTCACGTCCTGCGGATGGCCAAGCGCCTCCTACAGGAATCGCGGACCGGTTCCCTGGAGTCGACGCTCGGAATGGCCGCG
GCGATGCAACCACTCGCCCATCGCGATGCCGAACACGAGCGGCGCATCAGCCGGTGGCGGAGTTGA

Upstream 100 bases:

>100_bases
TGGCGCCGTTCGGCGGGTACAAGAAGTCCGGCGTCGGCCGGGAACTCGGCCGCGCGGGCTTCGAAGAGTTCCTGCAGACC
AAATCCCTGCAGCTGCCCGC

Downstream 100 bases:

>100_bases
CGTGTTCCGCTGACCGGACAGCCCGGGTGTCATCCGGGCCGCCCGCCGGTTGACTGACCGCCATGAGCAACGAGATCGCG
CTGTCGGAACTGCAGGAGTT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTADMSGPLRITTTAAIQVWTIDLPHVGNAITDDGFIAAFEAAVHAVNADNAIRAVILTGEGKIFSAGGNVKEMADRQGM
FGLEPLDQRRAYLDGIQRIPRALERLEVPLIAAVNGAAVGAGCDLAMMCDIRIASDRASFAESFVQVGLIPGDGGTWFLP
RAVGYARAAEMTLTGDRIDAATAAEWGMVSRVVPHEDLLAEAQALAERITKNPAHVLRMAKRLLQESRTGSLESTLGMAA
AMQPLAHRDAEHERRISRWRS

Sequences:

>Translated_261_residues
MTADMSGPLRITTTAAIQVWTIDLPHVGNAITDDGFIAAFEAAVHAVNADNAIRAVILTGEGKIFSAGGNVKEMADRQGM
FGLEPLDQRRAYLDGIQRIPRALERLEVPLIAAVNGAAVGAGCDLAMMCDIRIASDRASFAESFVQVGLIPGDGGTWFLP
RAVGYARAAEMTLTGDRIDAATAAEWGMVSRVVPHEDLLAEAQALAERITKNPAHVLRMAKRLLQESRTGSLESTLGMAA
AMQPLAHRDAEHERRISRWRS
>Mature_260_residues
TADMSGPLRITTTAAIQVWTIDLPHVGNAITDDGFIAAFEAAVHAVNADNAIRAVILTGEGKIFSAGGNVKEMADRQGMF
GLEPLDQRRAYLDGIQRIPRALERLEVPLIAAVNGAAVGAGCDLAMMCDIRIASDRASFAESFVQVGLIPGDGGTWFLPR
AVGYARAAEMTLTGDRIDAATAAEWGMVSRVVPHEDLLAEAQALAERITKNPAHVLRMAKRLLQESRTGSLESTLGMAAA
MQPLAHRDAEHERRISRWRS

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=215, Percent_Identity=41.3953488372093, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI31542718, Length=171, Percent_Identity=35.672514619883, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI68989263, Length=177, Percent_Identity=32.7683615819209, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI260274832, Length=218, Percent_Identity=27.9816513761468, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI45643119, Length=218, Percent_Identity=27.9816513761468, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI260275230, Length=218, Percent_Identity=27.9816513761468, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI70995211, Length=246, Percent_Identity=31.3008130081301, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI20127408, Length=159, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4502327, Length=178, Percent_Identity=32.5842696629214, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI116235487, Length=209, Percent_Identity=25.3588516746411, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1787659, Length=220, Percent_Identity=32.2727272727273, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1787660, Length=242, Percent_Identity=35.1239669421488, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI221142681, Length=211, Percent_Identity=34.5971563981043, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788682, Length=195, Percent_Identity=31.2820512820513, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788597, Length=226, Percent_Identity=32.3008849557522, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790281, Length=232, Percent_Identity=25.8620689655172, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=249, Percent_Identity=34.9397590361446, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17554946, Length=196, Percent_Identity=34.1836734693878, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560910, Length=200, Percent_Identity=33, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17535521, Length=264, Percent_Identity=26.8939393939394, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=179, Percent_Identity=34.6368715083799, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17558304, Length=187, Percent_Identity=27.807486631016, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144276, Length=187, Percent_Identity=28.8770053475936, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=187, Percent_Identity=28.8770053475936, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=187, Percent_Identity=28.8770053475936, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540306, Length=168, Percent_Identity=32.7380952380952, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=208, Percent_Identity=28.3653846153846, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17549921, Length=212, Percent_Identity=25.9433962264151, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=200, Percent_Identity=28, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20129971, Length=226, Percent_Identity=36.283185840708, Blast_Score=138, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24653477, Length=226, Percent_Identity=36.283185840708, Blast_Score=138, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24653139, Length=210, Percent_Identity=32.8571428571429, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19920382, Length=202, Percent_Identity=35.1485148514851, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922422, Length=204, Percent_Identity=28.4313725490196, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24654903, Length=190, Percent_Identity=25.2631578947368, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24650670, Length=171, Percent_Identity=32.7485380116959, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357171, Length=202, Percent_Identity=27.2277227722772, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28040; Mature: 27909

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADMSGPLRITTTAAIQVWTIDLPHVGNAITDDGFIAAFEAAVHAVNADNAIRAVILTG
CCCCCCCCEEEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEC
EGKIFSAGGNVKEMADRQGMFGLEPLDQRRAYLDGIQRIPRALERLEVPLIAAVNGAAVG
CCEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEC
AGCDLAMMCDIRIASDRASFAESFVQVGLIPGDGGTWFLPRAVGYARAAEMTLTGDRIDA
CCCCEEEEEEEEECCCHHHHHHHHHHEEEEECCCCCEEHHHHHHHHHHHEEEECCCCCCH
ATAAEWGMVSRVVPHEDLLAEAQALAERITKNPAHVLRMAKRLLQESRTGSLESTLGMAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AMQPLAHRDAEHERRISRWRS
HHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
TADMSGPLRITTTAAIQVWTIDLPHVGNAITDDGFIAAFEAAVHAVNADNAIRAVILTG
CCCCCCCEEEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEC
EGKIFSAGGNVKEMADRQGMFGLEPLDQRRAYLDGIQRIPRALERLEVPLIAAVNGAAVG
CCEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEC
AGCDLAMMCDIRIASDRASFAESFVQVGLIPGDGGTWFLPRAVGYARAAEMTLTGDRIDA
CCCCEEEEEEEEECCCHHHHHHHHHHEEEEECCCCCEEHHHHHHHHHHHEEEECCCCCCH
ATAAEWGMVSRVVPHEDLLAEAQALAERITKNPAHVLRMAKRLLQESRTGSLESTLGMAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AMQPLAHRDAEHERRISRWRS
HHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]