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The map label for this gene is ytpA [H]

Identifier: 108797120

GI number: 108797120

Start: 157622

End: 158461

Strand: Direct

Name: ytpA [H]

Synonym: Mmcs_0140

Alternate gene names: 108797120

Gene position: 157622-158461 (Clockwise)

Preceding gene: 108797118

Following gene: 108797121

Centisome position: 2.76

GC content: 70.71

Gene sequence:

>840_bases
ATGGCCAGCACCCGCAGCGAGCGACATTTCGACGGCGTCGGCGGGGTGAGGATCGTCTACGACACCTGGACCCCCGACGC
GCCCGCCCGCGGCGTCGTGGTGCTCTCCCACGGCTACGCCGAGCACGCCCGCCGCTACGACCACGTCGCACAGCGCTTCG
GTGAGGCCGGGCTGATCGTCTACGCGCTCGACCACCGCGGCCACGGGCGCTCCGACGGCAAACGGGTCTACCTGCGCGAC
ATCGCCGAGTACACCGGTGACTTCCACACCCTCGTCGGGATCGCGGCCCGTGAGCACCCCGACCTGCCCCGCATCGTCCT
CGGCCACAGCATGGGCGGCGGTGTGGTGTTCGCCTACGGCGCCGAGCATCCCGGCGACTACGCGGCGATGGTGCTGTCTG
GCCCGGCGGTCTACGCGCAGTCCGCGGTCAAACCGTGGCTGGTCACCGTGGCGAAGCTGCTGGGCCGCATCGCACCCGGG
GTGCCGGTCGAACAACTCGACGCCGACGCGGTGTCCCGCGATCCGGAGGTGGTTGCCGCCTACAAGGCCGATCCGCTCGT
CCATCACGGCAAGCTGCCCGCCGGTGTCGCCCGCGGGCTGTTCACCGTCGGCGAGACCATGCCGCAGCGGGCGGGTGCGC
TGACCGCACCGCTGCTGGTGGTGCACGGTGAGAAGGACCGGCTGATCCCGGTCGAGGGCAGCCACCGGCTCGTCGATCGC
GTGGCGAGCCAGGACGTGCACCTCAAGGTGTACCCCGAGTTGTTCCACGAGGTGTTCAACGAGCCGGAGCGGGCCACCGT
GCTCGACGACGTGATCTCGTGGATCGAGGTGCGGCTGTGA

Upstream 100 bases:

>100_bases
TCGACGGTACGAGCCAGGACGGTCACGCTGGCGAGCTTACGCACGATGGCCGACATCCGGCACCCCGTTGTCCCGGCCGC
GACCGATAGTCTTTCGAGCC

Downstream 100 bases:

>100_bases
AAGCCGTTGTGCGACTGGCTGCCTCGTGTATAGCGGCCGCGCTGCTGGTCGCCGGGTGCGGCTCGGACGATAAGGCCGCG
GACGAGACCGCACCCGCCCA

Product: acylglycerol lipase

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MASTRSERHFDGVGGVRIVYDTWTPDAPARGVVVLSHGYAEHARRYDHVAQRFGEAGLIVYALDHRGHGRSDGKRVYLRD
IAEYTGDFHTLVGIAAREHPDLPRIVLGHSMGGGVVFAYGAEHPGDYAAMVLSGPAVYAQSAVKPWLVTVAKLLGRIAPG
VPVEQLDADAVSRDPEVVAAYKADPLVHHGKLPAGVARGLFTVGETMPQRAGALTAPLLVVHGEKDRLIPVEGSHRLVDR
VASQDVHLKVYPELFHEVFNEPERATVLDDVISWIEVRL

Sequences:

>Translated_279_residues
MASTRSERHFDGVGGVRIVYDTWTPDAPARGVVVLSHGYAEHARRYDHVAQRFGEAGLIVYALDHRGHGRSDGKRVYLRD
IAEYTGDFHTLVGIAAREHPDLPRIVLGHSMGGGVVFAYGAEHPGDYAAMVLSGPAVYAQSAVKPWLVTVAKLLGRIAPG
VPVEQLDADAVSRDPEVVAAYKADPLVHHGKLPAGVARGLFTVGETMPQRAGALTAPLLVVHGEKDRLIPVEGSHRLVDR
VASQDVHLKVYPELFHEVFNEPERATVLDDVISWIEVRL
>Mature_278_residues
ASTRSERHFDGVGGVRIVYDTWTPDAPARGVVVLSHGYAEHARRYDHVAQRFGEAGLIVYALDHRGHGRSDGKRVYLRDI
AEYTGDFHTLVGIAAREHPDLPRIVLGHSMGGGVVFAYGAEHPGDYAAMVLSGPAVYAQSAVKPWLVTVAKLLGRIAPGV
PVEQLDADAVSRDPEVVAAYKADPLVHHGKLPAGVARGLFTVGETMPQRAGALTAPLLVVHGEKDRLIPVEGSHRLVDRV
ASQDVHLKVYPELFHEVFNEPERATVLDDVISWIEVRL

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=273, Percent_Identity=31.1355311355311, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI6005786, Length=273, Percent_Identity=31.1355311355311, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1787678, Length=276, Percent_Identity=24.2753623188406, Blast_Score=68, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322756, Length=298, Percent_Identity=24.1610738255034, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 30356; Mature: 30225

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTRSERHFDGVGGVRIVYDTWTPDAPARGVVVLSHGYAEHARRYDHVAQRFGEAGLIV
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEE
YALDHRGHGRSDGKRVYLRDIAEYTGDFHTLVGIAAREHPDLPRIVLGHSMGGGVVFAYG
EEECCCCCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEC
AEHPGDYAAMVLSGPAVYAQSAVKPWLVTVAKLLGRIAPGVPVEQLDADAVSRDPEVVAA
CCCCCCEEEEEEECCHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCCEEEE
YKADPLVHHGKLPAGVARGLFTVGETMPQRAGALTAPLLVVHGEKDRLIPVEGSHRLVDR
ECCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCHHHHHH
VASQDVHLKVYPELFHEVFNEPERATVLDDVISWIEVRL
HHCCCCEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASTRSERHFDGVGGVRIVYDTWTPDAPARGVVVLSHGYAEHARRYDHVAQRFGEAGLIV
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEE
YALDHRGHGRSDGKRVYLRDIAEYTGDFHTLVGIAAREHPDLPRIVLGHSMGGGVVFAYG
EEECCCCCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEC
AEHPGDYAAMVLSGPAVYAQSAVKPWLVTVAKLLGRIAPGVPVEQLDADAVSRDPEVVAA
CCCCCCEEEEEEECCHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCCEEEE
YKADPLVHHGKLPAGVARGLFTVGETMPQRAGALTAPLLVVHGEKDRLIPVEGSHRLVDR
ECCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCHHHHHH
VASQDVHLKVYPELFHEVFNEPERATVLDDVISWIEVRL
HHCCCCEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]