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The map label for this gene is esxA [H]

Identifier: 108797052

GI number: 108797052

Start: 83763

End: 84050

Strand: Direct

Name: esxA [H]

Synonym: Mmcs_0071

Alternate gene names: 108797052

Gene position: 83763-84050 (Clockwise)

Preceding gene: 108797051

Following gene: 108797053

Centisome position: 1.47

GC content: 69.44

Gene sequence:

>288_bases
ATGTCGGAACAGGTATGGAACTTCGCGGGCATCGAGGGCGGCGCAGGCGAGATCAACGGCGCGGTCAGCACGACCCAGGG
TCTGCTCGACGAGGGCAAGGCCTCGCTCGGCGCGCTGGCGGCGGTGTGGGGCGGTTCGGGTTCGGAGGCCTACCAGGCCG
TCCAGGCCCGCTGGGACAACACCTCGGCGGAGCTCAACGCGGCCCTGCAGAACCTCGCCCAGACCATCAGCGAGGCCGGC
TCCACCATGGCTCAGACCGAAGCCGGCGTCACCGGAATGTTCGCCTGA

Upstream 100 bases:

>100_bases
CTCGGGCACCCAGTACGGCTCGACCGACGAGGATCAGGCCGGCACGCTCGCGTCGTCCATGAATCTCTGACCACTCACAG
ACCAACTCAAGGAGAAATCA

Downstream 100 bases:

>100_bases
CCCACAGCTGCATGAAGGTGGGCGGGGCCGGCCGGCGCTCACGGCACCGGCCGAACTCGCCCACCTCCTGCGCTACGGCG
CAAACCCACCATCGAGAGGC

Product: 6 kDa early secretory antigenic target EsaT6

Products: NA

Alternate protein names: ESAT-6 [H]

Number of amino acids: Translated: 95; Mature: 94

Protein sequence:

>95_residues
MSEQVWNFAGIEGGAGEINGAVSTTQGLLDEGKASLGALAAVWGGSGSEAYQAVQARWDNTSAELNAALQNLAQTISEAG
STMAQTEAGVTGMFA

Sequences:

>Translated_95_residues
MSEQVWNFAGIEGGAGEINGAVSTTQGLLDEGKASLGALAAVWGGSGSEAYQAVQARWDNTSAELNAALQNLAQTISEAG
STMAQTEAGVTGMFA
>Mature_94_residues
SEQVWNFAGIEGGAGEINGAVSTTQGLLDEGKASLGALAAVWGGSGSEAYQAVQARWDNTSAELNAALQNLAQTISEAGS
TMAQTEAGVTGMFA

Specific function: Not known. Elicits high level of IFN-gamma from memory effector cells during the first phase of a protective immune response [H]

COG id: COG4842

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ESAT-6 (esx) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010310 [H]

Pfam domain/function: PF06013 WXG100 [H]

EC number: NA

Molecular weight: Translated: 9552; Mature: 9421

Theoretical pI: Translated: 3.58; Mature: 3.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQVWNFAGIEGGAGEINGAVSTTQGLLDEGKASLGALAAVWGGSGSEAYQAVQARWDN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHCCC
TSAELNAALQNLAQTISEAGSTMAQTEAGVTGMFA
CHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
SEQVWNFAGIEGGAGEINGAVSTTQGLLDEGKASLGALAAVWGGSGSEAYQAVQARWDN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHCCC
TSAELNAALQNLAQTISEAGSTMAQTEAGVTGMFA
CHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631702; 12788972 [H]