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The map label for this gene is phoR1 [H]

Identifier: 108763883

GI number: 108763883

Start: 5976871

End: 5978235

Strand: Direct

Name: phoR1 [H]

Synonym: MXAN_4778

Alternate gene names: 108763883

Gene position: 5976871-5978235 (Clockwise)

Preceding gene: 108763277

Following gene: 108759899

Centisome position: 65.39

GC content: 71.06

Gene sequence:

>1365_bases
ATGCCCCTGCGCGCCACACTCCTTCCGCTCCTGCTGCCCGCCGTCGTCGTCGCGACGCTCGTCGCCCTCCTCGACGGGCC
GAAGGAGGTCTTCGCCGCGGCGCTCGTCGCGCTCGCCGGCTCCCTCATGTCCCTGGGCGTGAGCCGCGGAACGATGCAGC
GGCAGCTCGACCTGCTGGCCCGCCACACCCGGGAGCGCGCCGAGGGCGGCGCCTCCACCGCCGCGCCTGGCGTCCCTGAG
CGGCTGGACGAGGTGGCCGGGCTCGAAGGCGCCATCGACTCGCTGCACGCCCAGCTGTCCGCGCGCAACGCGGCGCTCAC
CCAGGAGGCGCGCACCCTCACCGCCGTGCTCGACGGCATGACAGAAGGCGTCTGGGTGACGGACGCAGAGGGCACGGTGG
TGCGCCACAACGACGCGCTCCGCCCCCTGCTGGCGTCCACGAACAGCCCGCTCACCGGCCAGCGCCCCCTGGCCCTCATC
CGGAACGAGGCGCTGCACGACGCCGTGATGCGCGCCTGCCGGGAGAGCGCATCCAGCCACCTGGAGCTCACGCTGGACGG
CCACTTCCCGCGCACGCTCTCCATCCGGGTGACGCCGCTGGCCAAGGATTTGCCGGGCAGCGCCGCCGTCTTCCACGACG
TCACCGAGCTGCGCCGGCTGGAGAAGGTGCGCAAGGACTTCGTGGCCAACGTGTCGCACGAGCTGCGCACGCCCATCACC
GCCATCCGCGGCTACGCGGAGACGCTCCAGGGCGGCGCCCTCAATGACCCCGTCATGGCGCCGAAGATGGTGGAAATCAT
CCACCGCCAGTCCGAACGCCTGTCCGAACTGGTGGAGGACCTGCTGGAGCTGTCCCGCCTGGAGTCGCGCGAGGTGAGCC
TGAAGCTCGCCCGCGTCACCCTGGCCGACGCCGCCGCCCGCGCCGCCGACACCGTGCGCCCCAAGGCCGGGGGCAAGGGC
CAGGTGGTTTCACTCCACGTCCCTCAAGACCTACTCGCAGTGGGGGACCCCCGTGCCGTGGAGCAGGTGCTGCTCAACCT
GCTGGACAACGCGGTGAAGTACACGCCCGCGGGTGGCCGGGTGGATGTTTACGGTGAGTACGAGCAAGGCCGCTGCGTGG
TGCGGGTGAAGGACACCGGGGTGGGCATCGAGGCCAAGCACCAGTCGCGCATCTTCGAGCGCTTCTACCGGGTGGACAAG
GGCCGCAGCCGGGACATGGGGGGTACCGGACTGGGGCTCGCCATCGTCAAGCACCTGCTGCAGGCCATGGACGGCGAGGT
CAAGGTGGAGAGCGAACCCAACGGGGGGAGCACCTTCACCATTTTTCTGCCCCTGGCGGCTTCATCGAGCGCGGCGACAG
GGTAG

Upstream 100 bases:

>100_bases
ATCAAGCGGCTGCGCGAGAAGCTGGGCCCCGCCGGGGACATCATCGAGACGGTGCGCGGCGTGGGCTACAAGCTCAGCCC
TCCGTGAGGCCGCCCCGCCC

Downstream 100 bases:

>100_bases
GATGGAGTGACCATGCGGGTCGCCATCCTCGCGGACATCCACGGCAATCTTCCCGCCTGCGAGGCCGTCCTCGAGGACAT
CGCCCGCTCTGTATCGCCCG

Product: sensory box histidine kinase PhoR1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MPLRATLLPLLLPAVVVATLVALLDGPKEVFAAALVALAGSLMSLGVSRGTMQRQLDLLARHTRERAEGGASTAAPGVPE
RLDEVAGLEGAIDSLHAQLSARNAALTQEARTLTAVLDGMTEGVWVTDAEGTVVRHNDALRPLLASTNSPLTGQRPLALI
RNEALHDAVMRACRESASSHLELTLDGHFPRTLSIRVTPLAKDLPGSAAVFHDVTELRRLEKVRKDFVANVSHELRTPIT
AIRGYAETLQGGALNDPVMAPKMVEIIHRQSERLSELVEDLLELSRLESREVSLKLARVTLADAAARAADTVRPKAGGKG
QVVSLHVPQDLLAVGDPRAVEQVLLNLLDNAVKYTPAGGRVDVYGEYEQGRCVVRVKDTGVGIEAKHQSRIFERFYRVDK
GRSRDMGGTGLGLAIVKHLLQAMDGEVKVESEPNGGSTFTIFLPLAASSSAATG

Sequences:

>Translated_454_residues
MPLRATLLPLLLPAVVVATLVALLDGPKEVFAAALVALAGSLMSLGVSRGTMQRQLDLLARHTRERAEGGASTAAPGVPE
RLDEVAGLEGAIDSLHAQLSARNAALTQEARTLTAVLDGMTEGVWVTDAEGTVVRHNDALRPLLASTNSPLTGQRPLALI
RNEALHDAVMRACRESASSHLELTLDGHFPRTLSIRVTPLAKDLPGSAAVFHDVTELRRLEKVRKDFVANVSHELRTPIT
AIRGYAETLQGGALNDPVMAPKMVEIIHRQSERLSELVEDLLELSRLESREVSLKLARVTLADAAARAADTVRPKAGGKG
QVVSLHVPQDLLAVGDPRAVEQVLLNLLDNAVKYTPAGGRVDVYGEYEQGRCVVRVKDTGVGIEAKHQSRIFERFYRVDK
GRSRDMGGTGLGLAIVKHLLQAMDGEVKVESEPNGGSTFTIFLPLAASSSAATG
>Mature_453_residues
PLRATLLPLLLPAVVVATLVALLDGPKEVFAAALVALAGSLMSLGVSRGTMQRQLDLLARHTRERAEGGASTAAPGVPER
LDEVAGLEGAIDSLHAQLSARNAALTQEARTLTAVLDGMTEGVWVTDAEGTVVRHNDALRPLLASTNSPLTGQRPLALIR
NEALHDAVMRACRESASSHLELTLDGHFPRTLSIRVTPLAKDLPGSAAVFHDVTELRRLEKVRKDFVANVSHELRTPITA
IRGYAETLQGGALNDPVMAPKMVEIIHRQSERLSELVEDLLELSRLESREVSLKLARVTLADAAARAADTVRPKAGGKGQ
VVSLHVPQDLLAVGDPRAVEQVLLNLLDNAVKYTPAGGRVDVYGEYEQGRCVVRVKDTGVGIEAKHQSRIFERFYRVDKG
RSRDMGGTGLGLAIVKHLLQAMDGEVKVESEPNGGSTFTIFLPLAASSSAATG

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=365, Percent_Identity=32.3287671232877, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=38.0530973451327, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788393, Length=255, Percent_Identity=30.9803921568627, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788549, Length=401, Percent_Identity=27.930174563591, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=31.6017316017316, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1788713, Length=371, Percent_Identity=27.4932614555256, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790861, Length=213, Percent_Identity=35.6807511737089, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1786783, Length=295, Percent_Identity=31.5254237288136, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=30.7692307692308, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI48994928, Length=380, Percent_Identity=27.3684210526316, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=30.2222222222222, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=32.9004329004329, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=242, Percent_Identity=31.404958677686, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=29.535864978903, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790300, Length=358, Percent_Identity=26.2569832402235, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789808, Length=247, Percent_Identity=25.9109311740891, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789403, Length=211, Percent_Identity=31.7535545023697, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788279, Length=235, Percent_Identity=25.9574468085106, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790551, Length=216, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=72, Percent_Identity=45.8333333333333, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48537; Mature: 48406

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRATLLPLLLPAVVVATLVALLDGPKEVFAAALVALAGSLMSLGVSRGTMQRQLDLLA
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RHTRERAEGGASTAAPGVPERLDEVAGLEGAIDSLHAQLSARNAALTQEARTLTAVLDGM
HHHHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TEGVWVTDAEGTVVRHNDALRPLLASTNSPLTGQRPLALIRNEALHDAVMRACRESASSH
CCCEEEECCCCCEEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
LELTLDGHFPRTLSIRVTPLAKDLPGSAAVFHDVTELRRLEKVRKDFVANVSHELRTPIT
EEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIRGYAETLQGGALNDPVMAPKMVEIIHRQSERLSELVEDLLELSRLESREVSLKLARVT
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LADAAARAADTVRPKAGGKGQVVSLHVPQDLLAVGDPRAVEQVLLNLLDNAVKYTPAGGR
HHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCC
VDVYGEYEQGRCVVRVKDTGVGIEAKHQSRIFERFYRVDKGRSRDMGGTGLGLAIVKHLL
EEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QAMDGEVKVESEPNGGSTFTIFLPLAASSSAATG
HHCCCCEEEECCCCCCCEEEEEEEEECCCCCCCC
>Mature Secondary Structure 
PLRATLLPLLLPAVVVATLVALLDGPKEVFAAALVALAGSLMSLGVSRGTMQRQLDLLA
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RHTRERAEGGASTAAPGVPERLDEVAGLEGAIDSLHAQLSARNAALTQEARTLTAVLDGM
HHHHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TEGVWVTDAEGTVVRHNDALRPLLASTNSPLTGQRPLALIRNEALHDAVMRACRESASSH
CCCEEEECCCCCEEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
LELTLDGHFPRTLSIRVTPLAKDLPGSAAVFHDVTELRRLEKVRKDFVANVSHELRTPIT
EEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIRGYAETLQGGALNDPVMAPKMVEIIHRQSERLSELVEDLLELSRLESREVSLKLARVT
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LADAAARAADTVRPKAGGKGQVVSLHVPQDLLAVGDPRAVEQVLLNLLDNAVKYTPAGGR
HHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCC
VDVYGEYEQGRCVVRVKDTGVGIEAKHQSRIFERFYRVDKGRSRDMGGTGLGLAIVKHLL
EEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QAMDGEVKVESEPNGGSTFTIFLPLAASSSAATG
HHCCCCEEEECCCCCCCEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]