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The map label for this gene is ffh [H]

Identifier: 108763420

GI number: 108763420

Start: 6072576

End: 6074222

Strand: Direct

Name: ffh [H]

Synonym: MXAN_4854

Alternate gene names: 108763420

Gene position: 6072576-6074222 (Clockwise)

Preceding gene: 108761635

Following gene: 108761661

Centisome position: 66.44

GC content: 64.97

Gene sequence:

>1647_bases
ATGCTCGAGACCGTAACCAAGGGCTTCCGCGCCGCCAAGAACCGCCTCGCCGGCAAGAGCGAGCTCACCCCGGAGCTGGT
CGACGAGTCGCTGCGCGACATCCGCGTCTCCCTGCTCGAGGCTGACGTCGCCTTCGACGTCGTGAAGAAGTTTGTCGCCC
GCGTCCGCGAGAAGTCCGTGGGCGAGTTGGTGCAGACGACCATCACCGACACGGCTGGCCAGAAGCGCAAGGTCAGCCCG
ATGGACCACTTCATCAAGATCTGCCACGACGAGCTGGAGGCCCTCATGGGGCCCGTCGACACCAGCTTGAAGCTGAAGCC
CAAGGGCCAGCTGTCCGGCATCATGATGGTGGGCCTCCAGGGCTCCGGTAAGACGACCACGACCGGAAAGCTCGCCAGCC
GGCTCCTCCAGGAAGGGCGCAAGCCCCTGCTCGTCGCAGCCGACATCTACCGCCCCGCCGCCGTGGATCAACTCAAGGTC
CTGGGCGAGCGGCTCAAGGTCCCCGTCTACCACGAGCCCGGCATCCAGCCGCCCGAGCTCGCCAAGCGGGGCTACGCCGC
CGCGCGCGAGCAGAAGTGCGACGTGGTGCTCATCGACACCGCCGGCCGGCTCGCCATCGACGAGTCCCTGATGGCCGAAC
TGGAGTCCATCAAGGGCAACGTCCAGCCGGACAACATCCTGCTGGTGTGCGACGCGATGATTGGTCAGGACGCCGTGCGC
ACGGCGGCGGAGTTCGACCGGCGGCTGACGCTGGACGGATTCATCCTCACCAAGCTGGACGGTGACGCCCGCGGCGGCGC
CGCGCTGTCCATCAAGGAAGTCACGGGCAAGCCCATCAAGTTCCTCGGCATGGGCGAGTCCATGGACAAGCTGGAGGAGT
TCCGCCCAGCCGGCCTCGCGGGCCGCATCCTCGGGTTCGGCGACATCGTCGGCCTGATGAAGGACTTCGAGAAGGTCGTC
GACGAGAAGAAGGCCGAGGAGGATGCCAAGAAGCTCCTGTCCGGCCAGTTCACGATGAAGGACTTCGTCGAGCAGATCCG
CATGGTCCGGAAGATGGGACCGCTCAAGGACCTGCTGGAGAAGTTCCCCCTCTTCGGCGACCTCACCGAGCACCTCAATC
CGGACGAGAAGGAACTCACGAAGATCGAGTCGATGTACGACTCGATGACGGCGAAGGAGCGCCTGCGGCCAGATACCGTC
AACAACAGCCGCATCAACCGCATCGCCAAGGGCAGCGGCCGCAAGGTCGAAGAGGTCAAGGAGCTGCTCCAGAAGTTCGG
AATGATGCAGCAGGTAATGGGCACCATCGGCCAGAATCCGGGCCTCTTGGGCCGCATCCCCGGCTTCAAGCAGCTGGGTC
AGCTGTCGCAGATGAAGAACATGGACCTCTCCAGCATGTTCGGCGGCGACCCGAAGATGATGGAGAAGATGATGAGCGGC
GGCATGCCCGGCATGGGCATGCCCATGCAGCTGCCGCAGATTGCACCCGGCTACACGCCGCCCATGGGCCAGGCCGCCAT
GGCCAAGGCCCGGTTGATGGGCTACGCGCCGCCCTCCGCCGCAGGCAAGAGCGAGGACCGCGACGCCATCAAGGAGCGCC
GCAAGCGGGAGAAGGAGAACAAGAAGAAGAACCGGAAGAAGAAGTAG

Upstream 100 bases:

>100_bases
CGCCAGGGAGGCCGGTTTCGGGCCCCCTTCTCTTCACAGTTCGACGGCCGGGTGTGCTCCACCGTCGCATCTCGCCTGAC
CCTGTTATAAAGCGCCCCCC

Downstream 100 bases:

>100_bases
GCCGCTCGCGGCCCCGGTGCCCACGCCCGCCTCCCCGCATCCGTGCTGGGAGGGCGGGCGTTCGTGTTTTTAGAGGGAGC
TGTCCAGAAGGTGAGACGCC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MLETVTKGFRAAKNRLAGKSELTPELVDESLRDIRVSLLEADVAFDVVKKFVARVREKSVGELVQTTITDTAGQKRKVSP
MDHFIKICHDELEALMGPVDTSLKLKPKGQLSGIMMVGLQGSGKTTTTGKLASRLLQEGRKPLLVAADIYRPAAVDQLKV
LGERLKVPVYHEPGIQPPELAKRGYAAAREQKCDVVLIDTAGRLAIDESLMAELESIKGNVQPDNILLVCDAMIGQDAVR
TAAEFDRRLTLDGFILTKLDGDARGGAALSIKEVTGKPIKFLGMGESMDKLEEFRPAGLAGRILGFGDIVGLMKDFEKVV
DEKKAEEDAKKLLSGQFTMKDFVEQIRMVRKMGPLKDLLEKFPLFGDLTEHLNPDEKELTKIESMYDSMTAKERLRPDTV
NNSRINRIAKGSGRKVEEVKELLQKFGMMQQVMGTIGQNPGLLGRIPGFKQLGQLSQMKNMDLSSMFGGDPKMMEKMMSG
GMPGMGMPMQLPQIAPGYTPPMGQAAMAKARLMGYAPPSAAGKSEDRDAIKERRKREKENKKKNRKKK

Sequences:

>Translated_548_residues
MLETVTKGFRAAKNRLAGKSELTPELVDESLRDIRVSLLEADVAFDVVKKFVARVREKSVGELVQTTITDTAGQKRKVSP
MDHFIKICHDELEALMGPVDTSLKLKPKGQLSGIMMVGLQGSGKTTTTGKLASRLLQEGRKPLLVAADIYRPAAVDQLKV
LGERLKVPVYHEPGIQPPELAKRGYAAAREQKCDVVLIDTAGRLAIDESLMAELESIKGNVQPDNILLVCDAMIGQDAVR
TAAEFDRRLTLDGFILTKLDGDARGGAALSIKEVTGKPIKFLGMGESMDKLEEFRPAGLAGRILGFGDIVGLMKDFEKVV
DEKKAEEDAKKLLSGQFTMKDFVEQIRMVRKMGPLKDLLEKFPLFGDLTEHLNPDEKELTKIESMYDSMTAKERLRPDTV
NNSRINRIAKGSGRKVEEVKELLQKFGMMQQVMGTIGQNPGLLGRIPGFKQLGQLSQMKNMDLSSMFGGDPKMMEKMMSG
GMPGMGMPMQLPQIAPGYTPPMGQAAMAKARLMGYAPPSAAGKSEDRDAIKERRKREKENKKKNRKKK
>Mature_548_residues
MLETVTKGFRAAKNRLAGKSELTPELVDESLRDIRVSLLEADVAFDVVKKFVARVREKSVGELVQTTITDTAGQKRKVSP
MDHFIKICHDELEALMGPVDTSLKLKPKGQLSGIMMVGLQGSGKTTTTGKLASRLLQEGRKPLLVAADIYRPAAVDQLKV
LGERLKVPVYHEPGIQPPELAKRGYAAAREQKCDVVLIDTAGRLAIDESLMAELESIKGNVQPDNILLVCDAMIGQDAVR
TAAEFDRRLTLDGFILTKLDGDARGGAALSIKEVTGKPIKFLGMGESMDKLEEFRPAGLAGRILGFGDIVGLMKDFEKVV
DEKKAEEDAKKLLSGQFTMKDFVEQIRMVRKMGPLKDLLEKFPLFGDLTEHLNPDEKELTKIESMYDSMTAKERLRPDTV
NNSRINRIAKGSGRKVEEVKELLQKFGMMQQVMGTIGQNPGLLGRIPGFKQLGQLSQMKNMDLSSMFGGDPKMMEKMMSG
GMPGMGMPMQLPQIAPGYTPPMGQAAMAKARLMGYAPPSAAGKSEDRDAIKERRKREKENKKKNRKKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=503, Percent_Identity=34.3936381709742, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI226371618, Length=427, Percent_Identity=36.0655737704918, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI23308697, Length=323, Percent_Identity=28.4829721362229, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI295424842, Length=323, Percent_Identity=28.4829721362229, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI89061728, Length=145, Percent_Identity=36.551724137931, Blast_Score=104, Evalue=3e-22,
Organism=Escherichia coli, GI1788963, Length=436, Percent_Identity=41.9724770642202, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1789874, Length=237, Percent_Identity=36.7088607594937, Blast_Score=140, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=504, Percent_Identity=31.9444444444444, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI193206261, Length=316, Percent_Identity=29.4303797468354, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=498, Percent_Identity=33.3333333333333, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6320498, Length=207, Percent_Identity=34.2995169082126, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17647949, Length=495, Percent_Identity=30.7070707070707, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24641198, Length=228, Percent_Identity=29.8245614035088, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 60420; Mature: 60420

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETVTKGFRAAKNRLAGKSELTPELVDESLRDIRVSLLEADVAFDVVKKFVARVREKSV
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GELVQTTITDTAGQKRKVSPMDHFIKICHDELEALMGPVDTSLKLKPKGQLSGIMMVGLQ
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEEC
GSGKTTTTGKLASRLLQEGRKPLLVAADIYRPAAVDQLKVLGERLKVPVYHEPGIQPPEL
CCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
AKRGYAAAREQKCDVVLIDTAGRLAIDESLMAELESIKGNVQPDNILLVCDAMIGQDAVR
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHCHHHHH
TAAEFDRRLTLDGFILTKLDGDARGGAALSIKEVTGKPIKFLGMGESMDKLEEFRPAGLA
HHHHHHCCEEECCEEEEEECCCCCCCCEEEECCCCCCCEEEEECCCHHHHHHHHCCCCCH
GRILGFGDIVGLMKDFEKVVDEKKAEEDAKKLLSGQFTMKDFVEQIRMVRKMGPLKDLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
KFPLFGDLTEHLNPDEKELTKIESMYDSMTAKERLRPDTVNNSRINRIAKGSGRKVEEVK
HCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHH
ELLQKFGMMQQVMGTIGQNPGLLGRIPGFKQLGQLSQMKNMDLSSMFGGDPKMMEKMMSG
HHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHC
GMPGMGMPMQLPQIAPGYTPPMGQAAMAKARLMGYAPPSAAGKSEDRDAIKERRKREKEN
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
KKKNRKKK
HHHHCCCC
>Mature Secondary Structure
MLETVTKGFRAAKNRLAGKSELTPELVDESLRDIRVSLLEADVAFDVVKKFVARVREKSV
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GELVQTTITDTAGQKRKVSPMDHFIKICHDELEALMGPVDTSLKLKPKGQLSGIMMVGLQ
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEEC
GSGKTTTTGKLASRLLQEGRKPLLVAADIYRPAAVDQLKVLGERLKVPVYHEPGIQPPEL
CCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
AKRGYAAAREQKCDVVLIDTAGRLAIDESLMAELESIKGNVQPDNILLVCDAMIGQDAVR
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHCHHHHH
TAAEFDRRLTLDGFILTKLDGDARGGAALSIKEVTGKPIKFLGMGESMDKLEEFRPAGLA
HHHHHHCCEEECCEEEEEECCCCCCCCEEEECCCCCCCEEEEECCCHHHHHHHHCCCCCH
GRILGFGDIVGLMKDFEKVVDEKKAEEDAKKLLSGQFTMKDFVEQIRMVRKMGPLKDLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
KFPLFGDLTEHLNPDEKELTKIESMYDSMTAKERLRPDTVNNSRINRIAKGSGRKVEEVK
HCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHH
ELLQKFGMMQQVMGTIGQNPGLLGRIPGFKQLGQLSQMKNMDLSSMFGGDPKMMEKMMSG
HHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHC
GMPGMGMPMQLPQIAPGYTPPMGQAAMAKARLMGYAPPSAAGKSEDRDAIKERRKREKEN
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
KKKNRKKK
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]