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The map label for this gene is lcrD [H]

Identifier: 108762841

GI number: 108762841

Start: 7010628

End: 7012694

Strand: Reverse

Name: lcrD [H]

Synonym: MXAN_5643

Alternate gene names: 108762841

Gene position: 7012694-7010628 (Counterclockwise)

Preceding gene: 108764098

Following gene: 108760554

Centisome position: 76.73

GC content: 70.1

Gene sequence:

>2067_bases
ATGAACCCCCTCATGAAGGTATTGCTGAAGGCCCGAAACTCCTCGGACGTGGTGTTGGCGGTCGCCATGGCCGCGGTTCT
GGGCGCGCTCATCATCCCCTTGCCCGCATGGCTCTTGGACGCGGGGCTCGCCGTCAATCTGGCGGCGTCGGTGGCCCTGC
TGGTGGCCGCGCTGCGTGCCCGGGACGCCTTGAAGGTGACGTCGTTCCCCACGCTGTTGCTGTTCACCACGCTGTTCCGG
TTGGCGCTCAACGTATCCTCCACGCGGCTCGCGCTCGCGGAGGGGCACGCGGGAGACGTCATCCAGGCCTTCGGTGAGTT
CGTCGTCCGGGGCGACTACGTTGTGGGTGCGGTGGTGTTCGCCATCCTCACGCTGGTGCAGTTGCTGGTCGTCACCAAGG
GCGCGGAGCGGGTGGCGGAGGTGTCCGCGAGGTTCACGCTGGACGCGATGCCCGGCAAGCAGATGTCCATCGACGCGGAT
CTGCGCGCGGGCGCCATCGACCAGGCGCAAGCCCGGCGCCGGCGGCGTGACCTGGAGCGCGAGTCACAGATGTTCGGCGC
CATGGACGGCGCGATGAAGTTCGTGAAGGGGGACGTGATTGCGGGCCTGGTCATCGTCGCCGTGAACCTGCTCGGAGGAA
CCGTCATTGGCGTGCTGCAGGGTGGCATGCCCCTGGCCGAGGCGGCGTCGACATTCGCGCTCATTGCCATTGGTGACGGG
CTTGTGTCCCAGGTTCCCTCGCTGTGCATCGCCGTGGCCGCGGGCCTCGTCGTCACGCGCGTCGCCTCGGAGAAGGAAGA
GGACACGCTGGGTGCGGAGATTGGGGCCCAGTTCTTCGGAGAGGCGCGGACGCTCTGGGTGGTGGCGGGCCTGTGCGTCG
CGTTGGCCCTCATGCCGGGAATGCCGCATGTGACGTTCCTTCTGCTGGCGGGAGGCCTGGGGGGGCTTGGCCATGTGCTG
AGCCGCGCGGGTGTTCCGAAGGTCGAGGAGAAAGCAGGCGCGCCCGCGGACGGTGTGGCGCCTGGCGCGGCTGGAGCCCC
ACCGGAGAGTGCCGCGTCGCCCGTGGGTGTCTCCCCGCTCACGTTGGACATGGCGCCTGACCTGACGGTGCTGGCCGAAG
CGGAGGGCGCTGCCTTCGTCCACAAGACGTTGAACGGCGTGCGGGACGAGCTGTTCTTCGAACTGGGGGTTCGGGTGCCC
GGCATCCGGGTGCGCACGCAGGCCGCCTATCTGGGCCCCGGCGAGTACCGCGTCCTGGTGGACGAAGTCCCGGCGGGTGG
AGGGCAGGTGCTGCCGGGGGCGCTCTACGCGCTGGCGCCGCCGGACGAACTGGCGTTCCTCCAGGTGAGCGCGGAGGCCG
CGACGGAGCCCTCGAGCGGGAAGGTCATCAGCCGCATTCCAGAGTCGGCTCGGGTCCTGCTGGAGACGGCGCAAGTGCCG
CTGCGGCGCCCGGGAGAGCTGGTCTCGGACCATGTGCGCGCCATCCTGCGTGTCCGCGCTGCGGACCTGCTGGGGCTGCA
GGACGTCCAGGGACTGCTGGAGGGACTGGAGGCGCAGGCGCCCGTGCTCGTGAAGGAGGCGCTGCAGAAGGTGCCGCTGC
CGCTGCTCACGGATGTGCTTCGCAAGCTGCTCCAAGAGGGCGTCAGCATCCGGGACTTGCGAGCCATCCTGGAGGCGCTT
GTGTCGCCGACGACGGAAGGGGATGCCGTCGCGCTCGCGGAGCGCTGTCGGCAGGCGCTGCGGCGGTACCTCAGCCACAA
GTTCGCGCCCACCGGGCCGCTGTACGCGTACCTCGTGGACCCGGAGGTGGAAGAGGTGCTTCGCGGCATGGGCCCGCGAG
GGCTGGCGCCCGACCCGGAGCGGGTGGCGGAAATCCTCGAAGGCGTGCGGCAGGTGGCCACCGAGGGACGGGCGGTGCTG
CTCACCGCTCCGGATGTCCGGCGGCCCCTGCGCAGACTGTGCGAGGGCGCGTTCCCGGATGTTGCGGTGCTCACCTATGG
CGAGCTGGATGGGGCCCTCCAGATTCGCCCCATCGGCCGGCTGTCGCCGGTGGCGGTGGGGCGCTGA

Upstream 100 bases:

>100_bases
GCGAGCCCATCCCAGAGGAGCTGTACCAGGCGGCGGCGGTCGTCCTGCGCACGGCGATGGATGCGCGGGAGTTGGACGGC
CATCCACGGAGACAGACGTC

Downstream 100 bases:

>100_bases
CGGAGGTGGGCCTAGAGCCCCGTGCCCGTGTTGCCCGGCCCCTTGCTTTCGGGAAGCGGGGGCAGCTCCGTCTGGGCCTG
CTGGGGCGCCGGACGGTTCA

Product: FHIPEP family type III secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 688

Protein sequence:

>688_residues
MNPLMKVLLKARNSSDVVLAVAMAAVLGALIIPLPAWLLDAGLAVNLAASVALLVAALRARDALKVTSFPTLLLFTTLFR
LALNVSSTRLALAEGHAGDVIQAFGEFVVRGDYVVGAVVFAILTLVQLLVVTKGAERVAEVSARFTLDAMPGKQMSIDAD
LRAGAIDQAQARRRRRDLERESQMFGAMDGAMKFVKGDVIAGLVIVAVNLLGGTVIGVLQGGMPLAEAASTFALIAIGDG
LVSQVPSLCIAVAAGLVVTRVASEKEEDTLGAEIGAQFFGEARTLWVVAGLCVALALMPGMPHVTFLLLAGGLGGLGHVL
SRAGVPKVEEKAGAPADGVAPGAAGAPPESAASPVGVSPLTLDMAPDLTVLAEAEGAAFVHKTLNGVRDELFFELGVRVP
GIRVRTQAAYLGPGEYRVLVDEVPAGGGQVLPGALYALAPPDELAFLQVSAEAATEPSSGKVISRIPESARVLLETAQVP
LRRPGELVSDHVRAILRVRAADLLGLQDVQGLLEGLEAQAPVLVKEALQKVPLPLLTDVLRKLLQEGVSIRDLRAILEAL
VSPTTEGDAVALAERCRQALRRYLSHKFAPTGPLYAYLVDPEVEEVLRGMGPRGLAPDPERVAEILEGVRQVATEGRAVL
LTAPDVRRPLRRLCEGAFPDVAVLTYGELDGALQIRPIGRLSPVAVGR

Sequences:

>Translated_688_residues
MNPLMKVLLKARNSSDVVLAVAMAAVLGALIIPLPAWLLDAGLAVNLAASVALLVAALRARDALKVTSFPTLLLFTTLFR
LALNVSSTRLALAEGHAGDVIQAFGEFVVRGDYVVGAVVFAILTLVQLLVVTKGAERVAEVSARFTLDAMPGKQMSIDAD
LRAGAIDQAQARRRRRDLERESQMFGAMDGAMKFVKGDVIAGLVIVAVNLLGGTVIGVLQGGMPLAEAASTFALIAIGDG
LVSQVPSLCIAVAAGLVVTRVASEKEEDTLGAEIGAQFFGEARTLWVVAGLCVALALMPGMPHVTFLLLAGGLGGLGHVL
SRAGVPKVEEKAGAPADGVAPGAAGAPPESAASPVGVSPLTLDMAPDLTVLAEAEGAAFVHKTLNGVRDELFFELGVRVP
GIRVRTQAAYLGPGEYRVLVDEVPAGGGQVLPGALYALAPPDELAFLQVSAEAATEPSSGKVISRIPESARVLLETAQVP
LRRPGELVSDHVRAILRVRAADLLGLQDVQGLLEGLEAQAPVLVKEALQKVPLPLLTDVLRKLLQEGVSIRDLRAILEAL
VSPTTEGDAVALAERCRQALRRYLSHKFAPTGPLYAYLVDPEVEEVLRGMGPRGLAPDPERVAEILEGVRQVATEGRAVL
LTAPDVRRPLRRLCEGAFPDVAVLTYGELDGALQIRPIGRLSPVAVGR
>Mature_688_residues
MNPLMKVLLKARNSSDVVLAVAMAAVLGALIIPLPAWLLDAGLAVNLAASVALLVAALRARDALKVTSFPTLLLFTTLFR
LALNVSSTRLALAEGHAGDVIQAFGEFVVRGDYVVGAVVFAILTLVQLLVVTKGAERVAEVSARFTLDAMPGKQMSIDAD
LRAGAIDQAQARRRRRDLERESQMFGAMDGAMKFVKGDVIAGLVIVAVNLLGGTVIGVLQGGMPLAEAASTFALIAIGDG
LVSQVPSLCIAVAAGLVVTRVASEKEEDTLGAEIGAQFFGEARTLWVVAGLCVALALMPGMPHVTFLLLAGGLGGLGHVL
SRAGVPKVEEKAGAPADGVAPGAAGAPPESAASPVGVSPLTLDMAPDLTVLAEAEGAAFVHKTLNGVRDELFFELGVRVP
GIRVRTQAAYLGPGEYRVLVDEVPAGGGQVLPGALYALAPPDELAFLQVSAEAATEPSSGKVISRIPESARVLLETAQVP
LRRPGELVSDHVRAILRVRAADLLGLQDVQGLLEGLEAQAPVLVKEALQKVPLPLLTDVLRKLLQEGVSIRDLRAILEAL
VSPTTEGDAVALAERCRQALRRYLSHKFAPTGPLYAYLVDPEVEEVLRGMGPRGLAPDPERVAEILEGVRQVATEGRAVL
LTAPDVRRPLRRLCEGAFPDVAVLTYGELDGALQIRPIGRLSPVAVGR

Specific function: Could be involved in the secretion of the yop virulence proteins [H]

COG id: COG4789

COG function: function code U; Type III secretory pathway, component EscV

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=668, Percent_Identity=36.0778443113772, Blast_Score=334, Evalue=1e-92,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001712
- InterPro:   IPR006302 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 71969; Mature: 71969

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00136 SUBTILASE_ASP ; PS00994 FHIPEP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLMKVLLKARNSSDVVLAVAMAAVLGALIIPLPAWLLDAGLAVNLAASVALLVAALRA
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RDALKVTSFPTLLLFTTLFRLALNVSSTRLALAEGHAGDVIQAFGEFVVRGDYVVGAVVF
HCCHHHCCCHHHHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHH
AILTLVQLLVVTKGAERVAEVSARFTLDAMPGKQMSIDADLRAGAIDQAQARRRRRDLER
HHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
ESQMFGAMDGAMKFVKGDVIAGLVIVAVNLLGGTVIGVLQGGMPLAEAASTFALIAIGDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEECCH
LVSQVPSLCIAVAAGLVVTRVASEKEEDTLGAEIGAQFFGEARTLWVVAGLCVALALMPG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
MPHVTFLLLAGGLGGLGHVLSRAGVPKVEEKAGAPADGVAPGAAGAPPESAASPVGVSPL
CCHHHHHHHHCCCCHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
TLDMAPDLTVLAEAEGAAFVHKTLNGVRDELFFELGVRVPGIRVRTQAAYLGPGEYRVLV
EEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECEEEECCCCEEEEE
DEVPAGGGQVLPGALYALAPPDELAFLQVSAEAATEPSSGKVISRIPESARVLLETAQVP
EECCCCCCCCCCCHHEEECCCCCEEEEEEEHHHCCCCCCCCHHHHCCHHHHHHHHHHCCC
LRRPGELVSDHVRAILRVRAADLLGLQDVQGLLEGLEAQAPVLVKEALQKVPLPLLTDVL
CCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
RKLLQEGVSIRDLRAILEALVSPTTEGDAVALAERCRQALRRYLSHKFAPTGPLYAYLVD
HHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
PEVEEVLRGMGPRGLAPDPERVAEILEGVRQVATEGRAVLLTAPDVRRPLRRLCEGAFPD
CCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCC
VAVLTYGELDGALQIRPIGRLSPVAVGR
EEEEEECCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNPLMKVLLKARNSSDVVLAVAMAAVLGALIIPLPAWLLDAGLAVNLAASVALLVAALRA
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RDALKVTSFPTLLLFTTLFRLALNVSSTRLALAEGHAGDVIQAFGEFVVRGDYVVGAVVF
HCCHHHCCCHHHHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHH
AILTLVQLLVVTKGAERVAEVSARFTLDAMPGKQMSIDADLRAGAIDQAQARRRRRDLER
HHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
ESQMFGAMDGAMKFVKGDVIAGLVIVAVNLLGGTVIGVLQGGMPLAEAASTFALIAIGDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEECCH
LVSQVPSLCIAVAAGLVVTRVASEKEEDTLGAEIGAQFFGEARTLWVVAGLCVALALMPG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
MPHVTFLLLAGGLGGLGHVLSRAGVPKVEEKAGAPADGVAPGAAGAPPESAASPVGVSPL
CCHHHHHHHHCCCCHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
TLDMAPDLTVLAEAEGAAFVHKTLNGVRDELFFELGVRVPGIRVRTQAAYLGPGEYRVLV
EEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECEEEECCCCEEEEE
DEVPAGGGQVLPGALYALAPPDELAFLQVSAEAATEPSSGKVISRIPESARVLLETAQVP
EECCCCCCCCCCCHHEEECCCCCEEEEEEEHHHCCCCCCCCHHHHCCHHHHHHHHHHCCC
LRRPGELVSDHVRAILRVRAADLLGLQDVQGLLEGLEAQAPVLVKEALQKVPLPLLTDVL
CCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
RKLLQEGVSIRDLRAILEALVSPTTEGDAVALAERCRQALRRYLSHKFAPTGPLYAYLVD
HHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
PEVEEVLRGMGPRGLAPDPERVAEILEGVRQVATEGRAVLLTAPDVRRPLRRLCEGAFPD
CCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCC
VAVLTYGELDGALQIRPIGRLSPVAVGR
EEEEEECCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11402007 [H]