Click here to switch to the map view.

The map label for this gene is ubiE [H]

Identifier: 108762368

GI number: 108762368

Start: 4105462

End: 4106151

Strand: Reverse

Name: ubiE [H]

Synonym: MXAN_3525

Alternate gene names: 108762368

Gene position: 4106151-4105462 (Counterclockwise)

Preceding gene: 108757653

Following gene: 108757934

Centisome position: 44.93

GC content: 66.67

Gene sequence:

>690_bases
ATGAGTACTGAAGTCCGTGAGATGTTCTCTTCCATCGCCACGAAGTACGACGTGACGAATGAGGTCCTCTCGTTCGGCAT
CCACCGGCTGTGGCGCCGGAAGGCCGTCCGGCTCAGCACCGCGAAGGAAGGAGACCGCGTCCTCGACTGCGCTTCGGGCA
CTGGCGACCTGGCCCTGGCCTTCAAGCGCAAGGTGGGCGTGTCCGGCCGTGTCGTGGGCACGGACTTCTGCCCGGAGATG
CTGGAGAGCGCCCCCGCCAAGGCGGAGAAGGCGGGCCTCCAGGTGGACTTCCAGGTGGCCGACGCGATGGACCTGCCCTT
CGCGGCCGACAGCTTCGACGTGGCCTCCATCTCGTTCGGCATCCGCAACGTGGATGACCCGGTGAAGTGCCTGAAGGAGA
TGGCGCGGGTGGTCCGGCCCGGTGGCCACGTCGTGGTGCTGGAGTTCGGCCAGCCGACGGGGGCCTTCGGGGCCTTGTTC
CGCTTCTACAGCAAGACGGTGATGCCCACGATTGGAGGGCTGCTGACGGGCAACCGCGCCGCGTACCAGTACCTGCCCAA
GACGTCCGCCTCCTTCCCGGCCGGTGACAAGTTCCTGGAGTTGATGGACCAGTCCGGGGCCTACGCGGCAAAGTCCGCGC
ATGCGCTCACGTTCGGCACCGCCTACGTCTATGTCGGCACCGTCCGCTGA

Upstream 100 bases:

>100_bases
AACGCTTCGAGACGTTGATGCGGCGGCTGCCAGCCGTGCTAGACGCGGTGGACCGACACCTTTGGCGGCCGGAAAGCCCG
GCCCAGGTCGTGAGGGCGCG

Downstream 100 bases:

>100_bases
GGAGCGGCGGCACCTCGTTGAACAGATTCTCGCCTCGGTGGATCCCCGGCTCGCGCCGGGACTGAGGGAGGCGGTAGCCC
GCCCGGGCCCCTCCCCGCTC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSTEVREMFSSIATKYDVTNEVLSFGIHRLWRRKAVRLSTAKEGDRVLDCASGTGDLALAFKRKVGVSGRVVGTDFCPEM
LESAPAKAEKAGLQVDFQVADAMDLPFAADSFDVASISFGIRNVDDPVKCLKEMARVVRPGGHVVVLEFGQPTGAFGALF
RFYSKTVMPTIGGLLTGNRAAYQYLPKTSASFPAGDKFLELMDQSGAYAAKSAHALTFGTAYVYVGTVR

Sequences:

>Translated_229_residues
MSTEVREMFSSIATKYDVTNEVLSFGIHRLWRRKAVRLSTAKEGDRVLDCASGTGDLALAFKRKVGVSGRVVGTDFCPEM
LESAPAKAEKAGLQVDFQVADAMDLPFAADSFDVASISFGIRNVDDPVKCLKEMARVVRPGGHVVVLEFGQPTGAFGALF
RFYSKTVMPTIGGLLTGNRAAYQYLPKTSASFPAGDKFLELMDQSGAYAAKSAHALTFGTAYVYVGTVR
>Mature_228_residues
STEVREMFSSIATKYDVTNEVLSFGIHRLWRRKAVRLSTAKEGDRVLDCASGTGDLALAFKRKVGVSGRVVGTDFCPEML
ESAPAKAEKAGLQVDFQVADAMDLPFAADSFDVASISFGIRNVDDPVKCLKEMARVVRPGGHVVVLEFGQPTGAFGALFR
FYSKTVMPTIGGLLTGNRAAYQYLPKTSASFPAGDKFLELMDQSGAYAAKSAHALTFGTAYVYVGTVR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=261, Percent_Identity=32.183908045977, Blast_Score=133, Evalue=1e-31,
Organism=Escherichia coli, GI48994983, Length=225, Percent_Identity=39.5555555555556, Blast_Score=160, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17557039, Length=227, Percent_Identity=33.0396475770925, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323526, Length=242, Percent_Identity=30.9917355371901, Blast_Score=110, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24641702, Length=239, Percent_Identity=35.5648535564854, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 24686; Mature: 24554

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEVREMFSSIATKYDVTNEVLSFGIHRLWRRKAVRLSTAKEGDRVLDCASGTGDLALA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEE
FKRKVGVSGRVVGTDFCPEMLESAPAKAEKAGLQVDFQVADAMDLPFAADSFDVASISFG
EHHHCCCCCEEECCHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCCCCCCCCCCEEEECC
IRNVDDPVKCLKEMARVVRPGGHVVVLEFGQPTGAFGALFRFYSKTVMPTIGGLLTGNRA
CCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AYQYLPKTSASFPAGDKFLELMDQSGAYAAKSAHALTFGTAYVYVGTVR
HHHCCCCCCCCCCCCHHHHHHHHCCCCCHHCCCCEEEEEEEEEEEEECC
>Mature Secondary Structure 
STEVREMFSSIATKYDVTNEVLSFGIHRLWRRKAVRLSTAKEGDRVLDCASGTGDLALA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEE
FKRKVGVSGRVVGTDFCPEMLESAPAKAEKAGLQVDFQVADAMDLPFAADSFDVASISFG
EHHHCCCCCEEECCHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCCCCCCCCCCEEEECC
IRNVDDPVKCLKEMARVVRPGGHVVVLEFGQPTGAFGALFRFYSKTVMPTIGGLLTGNRA
CCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AYQYLPKTSASFPAGDKFLELMDQSGAYAAKSAHALTFGTAYVYVGTVR
HHHCCCCCCCCCCCCHHHHHHHHCCCCCHHCCCCEEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA