Click here to switch to the map view.

The map label for this gene is mmgB [H]

Identifier: 108760694

GI number: 108760694

Start: 4566311

End: 4567159

Strand: Reverse

Name: mmgB [H]

Synonym: MXAN_3800

Alternate gene names: 108760694

Gene position: 4567159-4566311 (Counterclockwise)

Preceding gene: 108759511

Following gene: 108760163

Centisome position: 49.97

GC content: 66.9

Gene sequence:

>849_bases
ATGGCAACGGAACACATTGTCGTCGTCGGGGCAGGGCAGATGGGCGCGGGCATCGCGCAGGTGGCACTCGTCGCAGGCCT
TCGCGTCACGCTGGCGGACGTCTCCGAGGCGGGGCTCGCCAAGGGCGCCGACCGCATCCGCGCCGGCCTGAAGAAGCTGG
TGGAGAAGGGCAAGCTCGACGCCGCGAAGCAGCAGGCCGCCGAGGCCAACCTCCTCACCGTGACGAAGGTCACCGACGCC
AAGGACGTGGACTTCGCCGTCGAGGCCGTGACGGAGAGCGAGGGCCTCAAGCGCGGCATCTTCCTGGACCTGGACGAAAT
CGTGCGCCCGGGCGGCGTGCTCGCCACCAACACGTCGTCCATCCCCATCACCCGGATCGCCGCGTATACCAAGCGCCCCG
AGTCCGTCATCGGCATGCACTTCATGAACCCGGTGCCGGTGATGCAGCTCGTGGAGATCATCCGCGGCGCCGCCACGTCC
GATGAGACGTACGCCACCACGCGGGTCCTCGCGGAGAAGATGGGCAAGACGACGGTGGTCTCCAAGGACTACCCGGGCTT
CATCGTCAACCGCATCCTCATCCCCATGCTCAACGAGGCCTGCTTCGCCGTCATGGAGGGCCTGGGCTCCGTCGAGGACA
TCGACACCGCGATGAAACTGGGCACCAACCAGCCCATGGGCCCGCTGCAGTTGGCGGACTTCATCGGCCTGGACACCGTG
CTCTACATCGCCGAGGTGCTCCACAAGGGCCTGGGCGACCCCAAGTACCGCCCAAGCCCCCTGCTGCGGCAGTACGTGGA
GGCCGGCTGGTACGGCAAGAAGAACGGCCGCGGCTTCTACAAGTACTGA

Upstream 100 bases:

>100_bases
CAGTTGCCCGCCGCAGTTCGTTGACCGACCTGGGGGCGTGGGCTAAGGCCGCCCGCACGCCGTACTTCACGCTTTCCGAC
CCAAGAGGTGCGTACACGTC

Downstream 100 bases:

>100_bases
GCCTCGCGGTTACCCACTTCCACCCCAGGAGCCTCGAACATGGCCTACGAGAACATCCGGCTGGAGCAGGAGGGCGCCAT
CGCGACCCTCTTCATCGACC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MATEHIVVVGAGQMGAGIAQVALVAGLRVTLADVSEAGLAKGADRIRAGLKKLVEKGKLDAAKQQAAEANLLTVTKVTDA
KDVDFAVEAVTESEGLKRGIFLDLDEIVRPGGVLATNTSSIPITRIAAYTKRPESVIGMHFMNPVPVMQLVEIIRGAATS
DETYATTRVLAEKMGKTTVVSKDYPGFIVNRILIPMLNEACFAVMEGLGSVEDIDTAMKLGTNQPMGPLQLADFIGLDTV
LYIAEVLHKGLGDPKYRPSPLLRQYVEAGWYGKKNGRGFYKY

Sequences:

>Translated_282_residues
MATEHIVVVGAGQMGAGIAQVALVAGLRVTLADVSEAGLAKGADRIRAGLKKLVEKGKLDAAKQQAAEANLLTVTKVTDA
KDVDFAVEAVTESEGLKRGIFLDLDEIVRPGGVLATNTSSIPITRIAAYTKRPESVIGMHFMNPVPVMQLVEIIRGAATS
DETYATTRVLAEKMGKTTVVSKDYPGFIVNRILIPMLNEACFAVMEGLGSVEDIDTAMKLGTNQPMGPLQLADFIGLDTV
LYIAEVLHKGLGDPKYRPSPLLRQYVEAGWYGKKNGRGFYKY
>Mature_281_residues
ATEHIVVVGAGQMGAGIAQVALVAGLRVTLADVSEAGLAKGADRIRAGLKKLVEKGKLDAAKQQAAEANLLTVTKVTDAK
DVDFAVEAVTESEGLKRGIFLDLDEIVRPGGVLATNTSSIPITRIAAYTKRPESVIGMHFMNPVPVMQLVEIIRGAATSD
ETYATTRVLAEKMGKTTVVSKDYPGFIVNRILIPMLNEACFAVMEGLGSVEDIDTAMKLGTNQPMGPLQLADFIGLDTVL
YIAEVLHKGLGDPKYRPSPLLRQYVEAGWYGKKNGRGFYKY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=286, Percent_Identity=43.7062937062937, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI296179427, Length=303, Percent_Identity=42.2442244224422, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=36.5248226950355, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI68989263, Length=288, Percent_Identity=32.2916666666667, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI261878539, Length=288, Percent_Identity=32.2916666666667, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI115430219, Length=219, Percent_Identity=27.8538812785388, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1787661, Length=280, Percent_Identity=39.6428571428571, Blast_Score=190, Evalue=8e-50,
Organism=Escherichia coli, GI1790281, Length=264, Percent_Identity=36.3636363636364, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1788682, Length=265, Percent_Identity=38.8679245283019, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=41.2587412587413, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=41.2587412587413, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=38.3275261324042, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=39.4366197183099, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=39.4366197183099, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=39.4366197183099, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=37.4558303886926, Blast_Score=174, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71985923, Length=279, Percent_Identity=31.1827956989247, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=279, Percent_Identity=29.3906810035842, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193203623, Length=203, Percent_Identity=28.0788177339901, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=203, Percent_Identity=28.0788177339901, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921000, Length=278, Percent_Identity=39.2086330935252, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24583077, Length=278, Percent_Identity=39.2086330935252, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24583079, Length=278, Percent_Identity=39.2086330935252, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI45549573, Length=244, Percent_Identity=29.5081967213115, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30238; Mature: 30106

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATEHIVVVGAGQMGAGIAQVALVAGLRVTLADVSEAGLAKGADRIRAGLKKLVEKGKLD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCH
AAKQQAAEANLLTVTKVTDAKDVDFAVEAVTESEGLKRGIFLDLDEIVRPGGVLATNTSS
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCEEEECCCC
IPITRIAAYTKRPESVIGMHFMNPVPVMQLVEIIRGAATSDETYATTRVLAEKMGKTTVV
CCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEE
SKDYPGFIVNRILIPMLNEACFAVMEGLGSVEDIDTAMKLGTNQPMGPLQLADFIGLDTV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIAEVLHKGLGDPKYRPSPLLRQYVEAGWYGKKNGRGFYKY
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATEHIVVVGAGQMGAGIAQVALVAGLRVTLADVSEAGLAKGADRIRAGLKKLVEKGKLD
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCH
AAKQQAAEANLLTVTKVTDAKDVDFAVEAVTESEGLKRGIFLDLDEIVRPGGVLATNTSS
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCEEEECCCC
IPITRIAAYTKRPESVIGMHFMNPVPVMQLVEIIRGAATSDETYATTRVLAEKMGKTTVV
CCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEE
SKDYPGFIVNRILIPMLNEACFAVMEGLGSVEDIDTAMKLGTNQPMGPLQLADFIGLDTV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIAEVLHKGLGDPKYRPSPLLRQYVEAGWYGKKNGRGFYKY
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]