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The map label for this gene is srrB [H]

Identifier: 108760501

GI number: 108760501

Start: 1583730

End: 1585259

Strand: Reverse

Name: srrB [H]

Synonym: MXAN_1350

Alternate gene names: 108760501

Gene position: 1585259-1583730 (Counterclockwise)

Preceding gene: 108762940

Following gene: 108761671

Centisome position: 17.34

GC content: 70.65

Gene sequence:

>1530_bases
GTGTCCCGCACTCCGCCCCGATTCCTCAACTTCCGGCGCACGTTCGCGCTGCTCATCGTCCTGGTGGTGGTGCCATCCGC
CGGCCTGTCCGGCTTCGGGGTGGTGGCCATCATCAACGAGCGCGCGGCCGTGGAGAAACGGCTGGAGGCCGCCTGGCGCG
GCACGCTGGAGTCACTGTCGGAGGAACTGCCGGGCATCCTCGCCTCGGCGAGCCTGGAGCCGGTGAATGGCCAACTCCAG
TTCATCCTCCCCGACGGGCAGCCCGTGTCGGAGCCGGACGGCGCATTCCAGTTGGAGGACGGACAGGTCCGCACCCGGGA
CCCCCAGCTGGCGGAGGCGCTCGCCACCGTGGTGCCCGAGGCGGGCGGACTGCCCACCGAGCCCACCGTCTTCTCGCTCA
CCACGGGCGGGCGCGCGGTGCTGGTGGCCGCCGAGCGACGCGGCAGCGTGGTGCACGGCGTGCGGCTATCGGTGCAGCAG
TTGGAGGCCCTGCTGGCCGAGCGCGTGGACCCCCGAGCCGTGTCCAGCGAACCGGTGCGCTTCGCCCTGCTGCCCGTGCC
CCGGGAGCCCTCCGAGGGCGGACTGATGGGGCGGCTGGTGTCCGAGGTGGCGCAGGCGCGCGCCAGCGCCCTGGGGCCCA
CGGGGCTCGCTGAGCGCGTGCTGTCCTCGCCCCTCCAGGACTTCCGGCTGGTGGTGCTGCCCACCGGCGAGGACCCGGTG
GCGCGCGCGTCCACGCGCAACCGCGTGCTGTACGGCGTGCTGCTGGGCGTGTTCTACCTGACGCTCACCTTCGGCGTCGT
CTACACCGGCCGCGCGCTCTACCGTGAGGCGCAGCTCTCGCGGATGAAGACGGACTTCGTGTCGCTGGTGAGCCACGAGC
TGCGCACACCCCTCACGTCCATCCGCATGTTCATCGAGACCCTGGCCCTGGGGCGGCTGAAGGACCCGGCGCAGACGCAG
GAGGTGCTCACCCTGCTGATGCGCGAAACGGAACGCCTGTCCATCTTCGTCGAGCGCGTGCTGGACTGGGCGCGCATCGA
AGGCGGGCGCAAGGTGTACCAGCGCGAAATCGTGCCGGTGTCGGAACTCGTGAACGCGGCGGTGGAAGCCTTCCGAACCC
AGCGCATGGAGGACGGCGTGGACCTGACGGTGGAGGTGTCAGACGGCTTGCCCGCGCTGGACGTGGACCGGGCCGCGGTG
GCCGGCGCGCTGCTCAACCTGCTGCAGAATGCCTACAAGTACAGTGGGCCGGACAACCGCCGCATCACCCTCCAGGTCCG
GGGCAGCGGCAAGGGCGTGGACCTGACGGTGGAGGACAACGGCGTGGGCATCGCTCCGCAGGAGCGCACTCGCATCTTCG
AGCGCTTCTATCGCGTGGACAACCTGCTGACGCGCAGGACGGAAGGCAGCGGGCTGGGGCTGGCCATTACCCGGCGCATC
ATCGAAACCCACGGAGGCCGCATCTCCGTGCAGAGCGAGCCAGGCAAGGGAAGCCGGTTCACCATCCACCTGCCGGCGGG
GAAGGCATGA

Upstream 100 bases:

>100_bases
GTCCGCACACACTCCAGGTGGGTGGTGCACACTCCCTGTCGCGGGCGTGGATGAAACGCCACGAGCGTGTAGCGCCGGGT
AGGGGTAAAGGAGAGGGGTC

Downstream 100 bases:

>100_bases
GCGACAAGACGCGGAGCATCCTGGTCGTGGAGGACGACCTGTCCATCCTCACGGGCCTGTCCATGAACCTGCGCTTCGAG
GGCTACGAGGTGCTCCAGGC

Product: sensor histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSRTPPRFLNFRRTFALLIVLVVVPSAGLSGFGVVAIINERAAVEKRLEAAWRGTLESLSEELPGILASASLEPVNGQLQ
FILPDGQPVSEPDGAFQLEDGQVRTRDPQLAEALATVVPEAGGLPTEPTVFSLTTGGRAVLVAAERRGSVVHGVRLSVQQ
LEALLAERVDPRAVSSEPVRFALLPVPREPSEGGLMGRLVSEVAQARASALGPTGLAERVLSSPLQDFRLVVLPTGEDPV
ARASTRNRVLYGVLLGVFYLTLTFGVVYTGRALYREAQLSRMKTDFVSLVSHELRTPLTSIRMFIETLALGRLKDPAQTQ
EVLTLLMRETERLSIFVERVLDWARIEGGRKVYQREIVPVSELVNAAVEAFRTQRMEDGVDLTVEVSDGLPALDVDRAAV
AGALLNLLQNAYKYSGPDNRRITLQVRGSGKGVDLTVEDNGVGIAPQERTRIFERFYRVDNLLTRRTEGSGLGLAITRRI
IETHGGRISVQSEPGKGSRFTIHLPAGKA

Sequences:

>Translated_509_residues
MSRTPPRFLNFRRTFALLIVLVVVPSAGLSGFGVVAIINERAAVEKRLEAAWRGTLESLSEELPGILASASLEPVNGQLQ
FILPDGQPVSEPDGAFQLEDGQVRTRDPQLAEALATVVPEAGGLPTEPTVFSLTTGGRAVLVAAERRGSVVHGVRLSVQQ
LEALLAERVDPRAVSSEPVRFALLPVPREPSEGGLMGRLVSEVAQARASALGPTGLAERVLSSPLQDFRLVVLPTGEDPV
ARASTRNRVLYGVLLGVFYLTLTFGVVYTGRALYREAQLSRMKTDFVSLVSHELRTPLTSIRMFIETLALGRLKDPAQTQ
EVLTLLMRETERLSIFVERVLDWARIEGGRKVYQREIVPVSELVNAAVEAFRTQRMEDGVDLTVEVSDGLPALDVDRAAV
AGALLNLLQNAYKYSGPDNRRITLQVRGSGKGVDLTVEDNGVGIAPQERTRIFERFYRVDNLLTRRTEGSGLGLAITRRI
IETHGGRISVQSEPGKGSRFTIHLPAGKA
>Mature_508_residues
SRTPPRFLNFRRTFALLIVLVVVPSAGLSGFGVVAIINERAAVEKRLEAAWRGTLESLSEELPGILASASLEPVNGQLQF
ILPDGQPVSEPDGAFQLEDGQVRTRDPQLAEALATVVPEAGGLPTEPTVFSLTTGGRAVLVAAERRGSVVHGVRLSVQQL
EALLAERVDPRAVSSEPVRFALLPVPREPSEGGLMGRLVSEVAQARASALGPTGLAERVLSSPLQDFRLVVLPTGEDPVA
RASTRNRVLYGVLLGVFYLTLTFGVVYTGRALYREAQLSRMKTDFVSLVSHELRTPLTSIRMFIETLALGRLKDPAQTQE
VLTLLMRETERLSIFVERVLDWARIEGGRKVYQREIVPVSELVNAAVEAFRTQRMEDGVDLTVEVSDGLPALDVDRAAVA
GALLNLLQNAYKYSGPDNRRITLQVRGSGKGVDLTVEDNGVGIAPQERTRIFERFYRVDNLLTRRTEGSGLGLAITRRII
ETHGGRISVQSEPGKGSRFTIHLPAGKA

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=32.0833333333333, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=35.0649350649351, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=28.6919831223629, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=32.7659574468085, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786783, Length=231, Percent_Identity=31.1688311688312, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788393, Length=227, Percent_Identity=32.5991189427313, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=31.0185185185185, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=29.6943231441048, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=31.9148936170213, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=31.4893617021277, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=260, Percent_Identity=32.3076923076923, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI87082128, Length=241, Percent_Identity=32.3651452282158, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87081816, Length=238, Percent_Identity=29.8319327731092, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=29.1479820627803, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790300, Length=237, Percent_Identity=28.2700421940928, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789808, Length=230, Percent_Identity=26.9565217391304, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788279, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=29.951690821256, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1787374, Length=201, Percent_Identity=27.363184079602, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789403, Length=207, Percent_Identity=28.0193236714976, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55388; Mature: 55257

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTPPRFLNFRRTFALLIVLVVVPSAGLSGFGVVAIINERAAVEKRLEAAWRGTLESLS
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
EELPGILASASLEPVNGQLQFILPDGQPVSEPDGAFQLEDGQVRTRDPQLAEALATVVPE
HHCCCHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCC
AGGLPTEPTVFSLTTGGRAVLVAAERRGSVVHGVRLSVQQLEALLAERVDPRAVSSEPVR
CCCCCCCCEEEEEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
FALLPVPREPSEGGLMGRLVSEVAQARASALGPTGLAERVLSSPLQDFRLVVLPTGEDPV
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCC
ARASTRNRVLYGVLLGVFYLTLTFGVVYTGRALYREAQLSRMKTDFVSLVSHELRTPLTS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
IRMFIETLALGRLKDPAQTQEVLTLLMRETERLSIFVERVLDWARIEGGRKVYQREIVPV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCH
SELVNAAVEAFRTQRMEDGVDLTVEVSDGLPALDVDRAAVAGALLNLLQNAYKYSGPDNR
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
RITLQVRGSGKGVDLTVEDNGVGIAPQERTRIFERFYRVDNLLTRRTEGSGLGLAITRRI
EEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IETHGGRISVQSEPGKGSRFTIHLPAGKA
HHHCCCEEEEECCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
SRTPPRFLNFRRTFALLIVLVVVPSAGLSGFGVVAIINERAAVEKRLEAAWRGTLESLS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
EELPGILASASLEPVNGQLQFILPDGQPVSEPDGAFQLEDGQVRTRDPQLAEALATVVPE
HHCCCHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCC
AGGLPTEPTVFSLTTGGRAVLVAAERRGSVVHGVRLSVQQLEALLAERVDPRAVSSEPVR
CCCCCCCCEEEEEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
FALLPVPREPSEGGLMGRLVSEVAQARASALGPTGLAERVLSSPLQDFRLVVLPTGEDPV
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCC
ARASTRNRVLYGVLLGVFYLTLTFGVVYTGRALYREAQLSRMKTDFVSLVSHELRTPLTS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
IRMFIETLALGRLKDPAQTQEVLTLLMRETERLSIFVERVLDWARIEGGRKVYQREIVPV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCH
SELVNAAVEAFRTQRMEDGVDLTVEVSDGLPALDVDRAAVAGALLNLLQNAYKYSGPDNR
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
RITLQVRGSGKGVDLTVEDNGVGIAPQERTRIFERFYRVDNLLTRRTEGSGLGLAITRRI
EEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IETHGGRISVQSEPGKGSRFTIHLPAGKA
HHHCCCEEEEECCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA