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The map label for this gene is cca [H]

Identifier: 108759921

GI number: 108759921

Start: 4078577

End: 4079845

Strand: Direct

Name: cca [H]

Synonym: MXAN_3498

Alternate gene names: 108759921

Gene position: 4078577-4079845 (Clockwise)

Preceding gene: 108757149

Following gene: 108756833

Centisome position: 44.62

GC content: 71.39

Gene sequence:

>1269_bases
ATGATCGCGAACCTCCACAACGCCGACATCCCCCAGCCCGTGCTGGACGTCATCGCGCGGCTGCGCGACCTGGGCCACGC
CGTCTACCTGGTGGGGGGCTGCGTCCGGGACATGGTGCGCCTGGTCCACCCCAAGGACTTCGACGTAGCGACCAGCGCGC
TGCCGCAAGAAGTCCAGGGCGCCTTCCGCAAGGTCATCCCCACGGGCATCCAGCACGGCACCGTCACCGTCCTCCAGAAT
GGCACGCACGTGGAGGTGACGACGTTCCGCTCGGAGGGGGATTACCTCGACGGCCGCCGGCCCAGCTCGGTGGCCTTCGA
GCGCGACATCGTCAAGGACCTGTCCCGGCGCGACTTCACCATCAACGCGATGGCCTACAACCCGCTGGACCGCGAGCTGG
TGGACCCGTTCGGCGGACAATCGGACCTCCGGTCGCAGCTCATCCGCTGCGTGGGCTCCGCGCAGGAGCGCTTCTCCGAG
GACGGCCTGCGCCCCTTGCGCGCCGTGCGCTTCGCCGCGGTGCTCGGCTTCGCGCTCGATTCCGCCACCCGCGCCGCCAT
TCCCGCCACGCTCGGCGTCTTCCGCAAGGTCGCGCTGGAGCGGGTGCGTGAGGAACTGGTGAAGCTGCTCCTGTCACCCC
GGGCGGAGAGCGGTCTGCTGTTGCTCGCGGACACCGGGCTTCTGGACGTGTTCCTTCCGGAGCTGGCGCGCGCGGAAGCC
TCGGCCGCCGCGTCCGTCCGGGCCGCGGTGCAGGCCTCGCCGCTGGAGGTGGAGGTCCGTGTCGCGGTGCTGCTGGCCGA
TTTGGTGGACCGAGCCCAGGCGCGCGACATCGGCCTGCGGCTGAAGTTCCCCAACAAGGTGGCGGACCTGGTGGCGCTGC
TCGTCGAACACGCGAAGGCGGAGACTCGTGTGGGGGAGCCGGACGCCGCGCTTCGCCGGCTCCTGGCTCGCCTGGGGCCG
CCGCAGCTTCCGCTGTGGGCAGCGGTCGTTCGCGCCCGGGTCGGAGTCCGCCAGCCGGACGCGCTCCCAGCGGTGGAGGC
GCTCATTGCCCGCGTGGAGGCGCTCGCCGCCGCGAAGCCGCCGTTGACGGCGAAGGACCTGTCGCTGACAGGAGGCGACA
TCATGGCCGCCCTGGGCGTGGGGCCTTCTCCCATCGTGGGCGAGGCCACCCGCTTCCTCGTCGAGTCCGTCCTGGATGAT
CCGAGCCTGAACACGGCCGACGCCCTGCGGCAGCGGTTGCAGGCGTGGCAGGCGCAGGTTGCTCGCTGA

Upstream 100 bases:

>100_bases
ACAGCGAGGGCCCAAGCCGTCTCGGGGCTTGGAACGCGGGAGTCTGGCCGGTACAACGCGCCCCTGGGCCCGCGGGCATG
TCGTCCTGGCCCCGGCTGTC

Downstream 100 bases:

>100_bases
GCCGGCGGGCTGCACGGAGTGACGGGGAGCGGGAAAGGGCGCCCTTCGCGTCCTCCCCGCGTGCGCCCGGACGCGCGGGC
GTGTAGGAAGGAGCACCATG

Product: tRNA nucleotidyltransferase/poly(A) polymerase family protein

Products: NA

Alternate protein names: tRNA CCA-pyrophosphorylase; tRNA adenylyl-/cytidylyl- transferase; tRNA nucleotidyltransferase; tRNA-NT [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MIANLHNADIPQPVLDVIARLRDLGHAVYLVGGCVRDMVRLVHPKDFDVATSALPQEVQGAFRKVIPTGIQHGTVTVLQN
GTHVEVTTFRSEGDYLDGRRPSSVAFERDIVKDLSRRDFTINAMAYNPLDRELVDPFGGQSDLRSQLIRCVGSAQERFSE
DGLRPLRAVRFAAVLGFALDSATRAAIPATLGVFRKVALERVREELVKLLLSPRAESGLLLLADTGLLDVFLPELARAEA
SAAASVRAAVQASPLEVEVRVAVLLADLVDRAQARDIGLRLKFPNKVADLVALLVEHAKAETRVGEPDAALRRLLARLGP
PQLPLWAAVVRARVGVRQPDALPAVEALIARVEALAAAKPPLTAKDLSLTGGDIMAALGVGPSPIVGEATRFLVESVLDD
PSLNTADALRQRLQAWQAQVAR

Sequences:

>Translated_422_residues
MIANLHNADIPQPVLDVIARLRDLGHAVYLVGGCVRDMVRLVHPKDFDVATSALPQEVQGAFRKVIPTGIQHGTVTVLQN
GTHVEVTTFRSEGDYLDGRRPSSVAFERDIVKDLSRRDFTINAMAYNPLDRELVDPFGGQSDLRSQLIRCVGSAQERFSE
DGLRPLRAVRFAAVLGFALDSATRAAIPATLGVFRKVALERVREELVKLLLSPRAESGLLLLADTGLLDVFLPELARAEA
SAAASVRAAVQASPLEVEVRVAVLLADLVDRAQARDIGLRLKFPNKVADLVALLVEHAKAETRVGEPDAALRRLLARLGP
PQLPLWAAVVRARVGVRQPDALPAVEALIARVEALAAAKPPLTAKDLSLTGGDIMAALGVGPSPIVGEATRFLVESVLDD
PSLNTADALRQRLQAWQAQVAR
>Mature_422_residues
MIANLHNADIPQPVLDVIARLRDLGHAVYLVGGCVRDMVRLVHPKDFDVATSALPQEVQGAFRKVIPTGIQHGTVTVLQN
GTHVEVTTFRSEGDYLDGRRPSSVAFERDIVKDLSRRDFTINAMAYNPLDRELVDPFGGQSDLRSQLIRCVGSAQERFSE
DGLRPLRAVRFAAVLGFALDSATRAAIPATLGVFRKVALERVREELVKLLLSPRAESGLLLLADTGLLDVFLPELARAEA
SAAASVRAAVQASPLEVEVRVAVLLADLVDRAQARDIGLRLKFPNKVADLVALLVEHAKAETRVGEPDAALRRLLARLGP
PQLPLWAAVVRARVGVRQPDALPAVEALIARVEALAAAKPPLTAKDLSLTGGDIMAALGVGPSPIVGEATRFLVESVLDD
PSLNTADALRQRLQAWQAQVAR

Specific function: Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing

COG id: COG0617

COG function: function code J; tRNA nucleotidyltransferase/poly(A) polymerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily [H]

Homologues:

Organism=Homo sapiens, GI155030240, Length=208, Percent_Identity=34.6153846153846, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI87081691, Length=239, Percent_Identity=35.9832635983264, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789436, Length=310, Percent_Identity=30, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71995920, Length=382, Percent_Identity=27.4869109947644, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281360112, Length=204, Percent_Identity=33.8235294117647, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357337, Length=204, Percent_Identity=33.8235294117647, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023068
- InterPro:   IPR002646 [H]

Pfam domain/function: PF01743 PolyA_pol [H]

EC number: =2.7.7.21; =2.7.7.25 [H]

Molecular weight: Translated: 45457; Mature: 45457

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIANLHNADIPQPVLDVIARLRDLGHAVYLVGGCVRDMVRLVHPKDFDVATSALPQEVQG
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHH
AFRKVIPTGIQHGTVTVLQNGTHVEVTTFRSEGDYLDGRRPSSVAFERDIVKDLSRRDFT
HHHHHHCCCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCEE
INAMAYNPLDRELVDPFGGQSDLRSQLIRCVGSAQERFSEDGLRPLRAVRFAAVLGFALD
EEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SATRAAIPATLGVFRKVALERVREELVKLLLSPRAESGLLLLADTGLLDVFLPELARAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHH
SAAASVRAAVQASPLEVEVRVAVLLADLVDRAQARDIGLRLKFPNKVADLVALLVEHAKA
HHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHH
ETRVGEPDAALRRLLARLGPPQLPLWAAVVRARVGVRQPDALPAVEALIARVEALAAAKP
HCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
PLTAKDLSLTGGDIMAALGVGPSPIVGEATRFLVESVLDDPSLNTADALRQRLQAWQAQV
CCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AR
CC
>Mature Secondary Structure
MIANLHNADIPQPVLDVIARLRDLGHAVYLVGGCVRDMVRLVHPKDFDVATSALPQEVQG
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHH
AFRKVIPTGIQHGTVTVLQNGTHVEVTTFRSEGDYLDGRRPSSVAFERDIVKDLSRRDFT
HHHHHHCCCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCEE
INAMAYNPLDRELVDPFGGQSDLRSQLIRCVGSAQERFSEDGLRPLRAVRFAAVLGFALD
EEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SATRAAIPATLGVFRKVALERVREELVKLLLSPRAESGLLLLADTGLLDVFLPELARAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHH
SAAASVRAAVQASPLEVEVRVAVLLADLVDRAQARDIGLRLKFPNKVADLVALLVEHAKA
HHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHH
ETRVGEPDAALRRLLARLGPPQLPLWAAVVRARVGVRQPDALPAVEALIARVEALAAAKP
HCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
PLTAKDLSLTGGDIMAALGVGPSPIVGEATRFLVESVLDDPSLNTADALRQRLQAWQAQV
CCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA