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The map label for this gene is yusP [H]

Identifier: 108759194

GI number: 108759194

Start: 6050649

End: 6052112

Strand: Direct

Name: yusP [H]

Synonym: MXAN_4836

Alternate gene names: 108759194

Gene position: 6050649-6052112 (Clockwise)

Preceding gene: 108762583

Following gene: 108759046

Centisome position: 66.2

GC content: 68.24

Gene sequence:

>1464_bases
ATGCGAACCACTCATCGTCCCCTCACCACCTTGGCCCTGGCCTTGAGCCTCTTCATGGCCGCCTTGGAAGCCACTGTCGT
TTCCACGGCCATGCCCACGGTGGTGGGCGAGTTGGGCGGCATCCAGCACTACGCGTGGGTCTTCACCGCGTACATGTTGT
CCTCCACCATCACCGTGCCCATCTACGGGAAGCTGGCGGACCTCTACGGCCGCAAGCCCGTGCTCGTGTTCGGCATCGTG
CTGTTCCTCGTGGGCTCCATCGCCAGTGGCCTGTCCACGTCCATGGCCATGTTGATCGGCTTCCGGACGCTCCAGGGCCT
GGGCGCGGGCGCCATGCAGCCGGTGGCGCTCACCGTCATCGGGGACATCTACACGCTGGAGGAGCGCGCGAAGGTCCAGG
GCGCGTTCAGCGCGGTGTGGGGCATCGCGGGACTGATCGGGCCCATCACCGGTGGCTTCCTCGTGAAGTACCTCACGTGG
CACTGGGTCTTCTTCATCAACGTCCCGGTGGGCGTGGGCTGCCTCGTCCTGCTCCTGAGCTACTTCCATGAGCGCGTGGA
GCGGAAGCCCCAGAAGCTGGACTACGCGGGCGCCGCGCTGCTCACCGGCTGGGTGGTGGCGCTGCTCGTCGGCGTGCAAG
GTGTGGGCGTGAATCTGTGGGGCTTGCCCGTGGCGGCCGTGCTGCTCGCGGCCTTCGTCGCGGTGGAGCGCAAGGTGGCC
GAGCCCATCATCCCCATGTCCATCTTCAAGGTGCCGGCCATCGTCATCTCCTCCATCGCGGGAGCGCTCTTCTCCGCGGC
GATGTTCGGGGCCACCACCTACGTTCCGCTCTTCGTCCAGGGCGTCCTGGGCGGAACGCCCACCGAGGCCGGCGGGATGA
TTACGCCGATGATTGTCGGCTGGCCGCTGGCGGCCCTCGTGGCCGGGAAGCTGCTGCTCAAGACGGGCTTCCGCCCCCTC
ATCGTGGGCGGGCTGGGATTGACGGTGGTGGGCACGTCGCTGATGGCGCTGCTCCTGGGGCCCCAGGCGCCCAGGCTGCT
GCCGGAGGTGGCCATGGGCCTGTTCGGCATCGGCATGGGCTTCGCGTCCACCGCGCTGCTCATCGCCGTGCAGACCAGCG
TGGGCTGGGAGCTGCGCGGAGTGGCCACCGCCAGCAACATGTTCTTCCGCACCATCGGCGGCGCCATTGGCGTGGGGCTG
ATGGGCGGCGTCATGGTGTCGCAGCTCCTCAAGGACCCGACGGTGCCGATTTCGGCGGCCAACGCCTTGATGAGCCCCGA
CCACGGCCAGGACTTGCCCGCGGATCTGCTGGCGACGCTGAGCGGCGCGCTGGGCACCGGGCTGAGCATCAACTTCTGGC
TGATCTGCGCCTTCACCGTGGCCGCCTTCGCCGCAGGGCTGTTCTTCCCCAAGGTGTCGCGCACCACGACGGTGTCCTCC
ACCGAGGTGGTGGCGCCGCACTGA

Upstream 100 bases:

>100_bases
CGCCCGCACGCTGAGTGACCACCCGGGGCGCGAGGCCGCTTGTTGCTGGCGACCCCCGCCCGCAGCCGTTAAGGAGGGCC
TCTCCCGCGTCGGCGTCTTC

Downstream 100 bases:

>100_bases
CGTCCGTGCGGCGCCCCGTGCGTCGCTCAGAGGCCGTCAATCATCCGCAGGGCCACGTCCGGCACGAACGTGCCTGCGGG
TGTGTTGGGCGCGACGCCGC

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MRTTHRPLTTLALALSLFMAALEATVVSTAMPTVVGELGGIQHYAWVFTAYMLSSTITVPIYGKLADLYGRKPVLVFGIV
LFLVGSIASGLSTSMAMLIGFRTLQGLGAGAMQPVALTVIGDIYTLEERAKVQGAFSAVWGIAGLIGPITGGFLVKYLTW
HWVFFINVPVGVGCLVLLLSYFHERVERKPQKLDYAGAALLTGWVVALLVGVQGVGVNLWGLPVAAVLLAAFVAVERKVA
EPIIPMSIFKVPAIVISSIAGALFSAAMFGATTYVPLFVQGVLGGTPTEAGGMITPMIVGWPLAALVAGKLLLKTGFRPL
IVGGLGLTVVGTSLMALLLGPQAPRLLPEVAMGLFGIGMGFASTALLIAVQTSVGWELRGVATASNMFFRTIGGAIGVGL
MGGVMVSQLLKDPTVPISAANALMSPDHGQDLPADLLATLSGALGTGLSINFWLICAFTVAAFAAGLFFPKVSRTTTVSS
TEVVAPH

Sequences:

>Translated_487_residues
MRTTHRPLTTLALALSLFMAALEATVVSTAMPTVVGELGGIQHYAWVFTAYMLSSTITVPIYGKLADLYGRKPVLVFGIV
LFLVGSIASGLSTSMAMLIGFRTLQGLGAGAMQPVALTVIGDIYTLEERAKVQGAFSAVWGIAGLIGPITGGFLVKYLTW
HWVFFINVPVGVGCLVLLLSYFHERVERKPQKLDYAGAALLTGWVVALLVGVQGVGVNLWGLPVAAVLLAAFVAVERKVA
EPIIPMSIFKVPAIVISSIAGALFSAAMFGATTYVPLFVQGVLGGTPTEAGGMITPMIVGWPLAALVAGKLLLKTGFRPL
IVGGLGLTVVGTSLMALLLGPQAPRLLPEVAMGLFGIGMGFASTALLIAVQTSVGWELRGVATASNMFFRTIGGAIGVGL
MGGVMVSQLLKDPTVPISAANALMSPDHGQDLPADLLATLSGALGTGLSINFWLICAFTVAAFAAGLFFPKVSRTTTVSS
TEVVAPH
>Mature_487_residues
MRTTHRPLTTLALALSLFMAALEATVVSTAMPTVVGELGGIQHYAWVFTAYMLSSTITVPIYGKLADLYGRKPVLVFGIV
LFLVGSIASGLSTSMAMLIGFRTLQGLGAGAMQPVALTVIGDIYTLEERAKVQGAFSAVWGIAGLIGPITGGFLVKYLTW
HWVFFINVPVGVGCLVLLLSYFHERVERKPQKLDYAGAALLTGWVVALLVGVQGVGVNLWGLPVAAVLLAAFVAVERKVA
EPIIPMSIFKVPAIVISSIAGALFSAAMFGATTYVPLFVQGVLGGTPTEAGGMITPMIVGWPLAALVAGKLLLKTGFRPL
IVGGLGLTVVGTSLMALLLGPQAPRLLPEVAMGLFGIGMGFASTALLIAVQTSVGWELRGVATASNMFFRTIGGAIGVGL
MGGVMVSQLLKDPTVPISAANALMSPDHGQDLPADLLATLSGALGTGLSINFWLICAFTVAAFAAGLFFPKVSRTTTVSS
TEVVAPH

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=294, Percent_Identity=30.952380952381, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790195, Length=328, Percent_Identity=29.5731707317073, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87081983, Length=412, Percent_Identity=26.9417475728155, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788710, Length=424, Percent_Identity=28.5377358490566, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788392, Length=340, Percent_Identity=29.4117647058824, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790146, Length=167, Percent_Identity=28.1437125748503, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788509, Length=116, Percent_Identity=35.3448275862069, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=551, Percent_Identity=24.1379310344828, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6325455, Length=530, Percent_Identity=25.2830188679245, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323735, Length=319, Percent_Identity=26.9592476489028, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321663, Length=149, Percent_Identity=32.2147651006711, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319770, Length=395, Percent_Identity=28.3544303797468, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324954, Length=383, Percent_Identity=24.0208877284595, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50542; Mature: 50542

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCC
>Mature Secondary Structure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CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]