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The map label for this gene is bioF [H]

Identifier: 108758682

GI number: 108758682

Start: 4462766

End: 4464304

Strand: Reverse

Name: bioF [H]

Synonym: MXAN_3748

Alternate gene names: 108758682

Gene position: 4464304-4462766 (Counterclockwise)

Preceding gene: 108761631

Following gene: 108763564

Centisome position: 48.84

GC content: 66.8

Gene sequence:

>1539_bases
ATGAGCGACGTCTTCGACAAGTGCCGTAACTGGAAGGACTACCGTATCGCGAAGGCTACGGGTCTCTATCCGTACTTCCG
TGCCATCGAAGCGTCGCACGGTGCCACCGAGGTGGAGATCGAAGGCAAGCGCGTCATCATGGTCGGGTCCAACAACTACC
TGGGCCTGTCCGCCGATCCGCGCGTGAAGGAAGCGGCCATCAAGGCGACGGAGAAGTTCGGCACCACCAGCTCCGGCTCG
CGACTGCTCAACGGCACACTGGCGCTGCACGAGGAGCTGGAAGCGCGGTTGGCGAAGTTCCTCAACCGCGAGTCCGCCAT
CGTCATCTCCACGGGCTTCCAGACGAACCTGGCGCTGGCGTCCATCCTGGGCCGGCACGACATCGTCTTCAGCGACCGGC
AGAACCACGCGTCGCTGGTGGACGGAATCCGCCTGTCCTTCGCCACCGAGCGCAAGTTCCGCCACAACGACATGGACCAC
CTGGAGCAGCTGCTGTCCCAGGCGGATCCGGACGCGGGCAAGATCATCGTCACCGACGGCGTCTTCTCCATGGAGGGCGA
CATCTGCAACCTGCCCCGCATCGTGGAGCTGGCGAAGCACTACAACGCGCGGGTGATGACGGATGACGCGCACGCCATGG
GCGTGCTGGGCACGCGGGGCCGGGGCACCTCCGAGTACTTCGACCTGGAGAAGGAGACGGACCTCGTCATGGGGACCTTC
TCCAAGAGCTTCGCGTCGCTGGGCGGCGTGCTGGCCGGTCCCTTCGAGGTCATCAACTACATCCGCCACAAGGCGCGCTC
GGTCATCTTCTCCGCGTCCATGACGCCGGGCTCCATCGCCGCGGCGCTCAAGGCGCTGGAGATCATCGAAGCGGAGCCGG
AGCGCCGCGCCCGCCTGCTGGACATCGCGGAGAAGATGCACAACGGCTTCCGCGCCATGGGCTTCGACACGGGTGTGTCG
GTGACGCCGGTGGTGCCGGTGCACATCGGCGACCAGGTGAAGTGCTTCCGATTCTGGCGCGCGCTGCATGAGGCCGGCGT
CTTCGCCAACCCGGTGATTCCGCCGGCGGTGGAGCCGGGCCACGCGCTCATCCGCACCTCGTACATGGCCACGCACACGG
ACGCGCAACTGGACCGCGTGCTCGACACCTTCGAGACCATTGGCCGGAAGCTGGGCGTGATTCCGGAGACGCGCCCCTCC
GTCTACGAGCCGGTGCAGATTGCCCGCCCGGGCACCCGCATCCTGTCCAACCGCGCGAGCGAGAAGTGGGCCGCGGGCTC
GAACGGCCTGCTGGCGGACAAGGGCGGCATCACCCTGGACCAACTGTCGCGCATGTCGTCGCGCGAGGTGGCCGGACGCC
TGTTCGACGCGGTGGAGCAGCTCACGTGGCGCGCGGCCAATCTCCAGCCGGAGGACCTGCGGAAGCTGGGCAACGCGCCG
ATGAAGCTGTGGGAGAAGCGCGGCGAGCTGCCGGGCTTGTTGTTGGAGAAGGGCGCTCACTTCTTCATGCGCAACGGCGC
CCACTCCGACCGGAACTGA

Upstream 100 bases:

>100_bases
CGGAACGTTCCTTCAATCGGGGGAGTCGCGACTGGAGAGCCCCAGGCTCCCGGGCCGGTCCATGCCTCCCGACGCAGCCT
GAGAGAAAGACCGATCACCC

Downstream 100 bases:

>100_bases
ACCGCCCATGGCCCTCCACGCCGAGCCAACCCACGCGTCTTCGTCCATGCCCTCGGACGTGCAGGTGACCCCTGTCCGCG
GCGAGGCGGAGCGGATGCAG

Product: class II aminotransferase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSDVFDKCRNWKDYRIAKATGLYPYFRAIEASHGATEVEIEGKRVIMVGSNNYLGLSADPRVKEAAIKATEKFGTTSSGS
RLLNGTLALHEELEARLAKFLNRESAIVISTGFQTNLALASILGRHDIVFSDRQNHASLVDGIRLSFATERKFRHNDMDH
LEQLLSQADPDAGKIIVTDGVFSMEGDICNLPRIVELAKHYNARVMTDDAHAMGVLGTRGRGTSEYFDLEKETDLVMGTF
SKSFASLGGVLAGPFEVINYIRHKARSVIFSASMTPGSIAAALKALEIIEAEPERRARLLDIAEKMHNGFRAMGFDTGVS
VTPVVPVHIGDQVKCFRFWRALHEAGVFANPVIPPAVEPGHALIRTSYMATHTDAQLDRVLDTFETIGRKLGVIPETRPS
VYEPVQIARPGTRILSNRASEKWAAGSNGLLADKGGITLDQLSRMSSREVAGRLFDAVEQLTWRAANLQPEDLRKLGNAP
MKLWEKRGELPGLLLEKGAHFFMRNGAHSDRN

Sequences:

>Translated_512_residues
MSDVFDKCRNWKDYRIAKATGLYPYFRAIEASHGATEVEIEGKRVIMVGSNNYLGLSADPRVKEAAIKATEKFGTTSSGS
RLLNGTLALHEELEARLAKFLNRESAIVISTGFQTNLALASILGRHDIVFSDRQNHASLVDGIRLSFATERKFRHNDMDH
LEQLLSQADPDAGKIIVTDGVFSMEGDICNLPRIVELAKHYNARVMTDDAHAMGVLGTRGRGTSEYFDLEKETDLVMGTF
SKSFASLGGVLAGPFEVINYIRHKARSVIFSASMTPGSIAAALKALEIIEAEPERRARLLDIAEKMHNGFRAMGFDTGVS
VTPVVPVHIGDQVKCFRFWRALHEAGVFANPVIPPAVEPGHALIRTSYMATHTDAQLDRVLDTFETIGRKLGVIPETRPS
VYEPVQIARPGTRILSNRASEKWAAGSNGLLADKGGITLDQLSRMSSREVAGRLFDAVEQLTWRAANLQPEDLRKLGNAP
MKLWEKRGELPGLLLEKGAHFFMRNGAHSDRN
>Mature_511_residues
SDVFDKCRNWKDYRIAKATGLYPYFRAIEASHGATEVEIEGKRVIMVGSNNYLGLSADPRVKEAAIKATEKFGTTSSGSR
LLNGTLALHEELEARLAKFLNRESAIVISTGFQTNLALASILGRHDIVFSDRQNHASLVDGIRLSFATERKFRHNDMDHL
EQLLSQADPDAGKIIVTDGVFSMEGDICNLPRIVELAKHYNARVMTDDAHAMGVLGTRGRGTSEYFDLEKETDLVMGTFS
KSFASLGGVLAGPFEVINYIRHKARSVIFSASMTPGSIAAALKALEIIEAEPERRARLLDIAEKMHNGFRAMGFDTGVSV
TPVVPVHIGDQVKCFRFWRALHEAGVFANPVIPPAVEPGHALIRTSYMATHTDAQLDRVLDTFETIGRKLGVIPETRPSV
YEPVQIARPGTRILSNRASEKWAAGSNGLLADKGGITLDQLSRMSSREVAGRLFDAVEQLTWRAANLQPEDLRKLGNAPM
KLWEKRGELPGLLLEKGAHFFMRNGAHSDRN

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=382, Percent_Identity=33.5078534031414, Blast_Score=223, Evalue=5e-58,
Organism=Homo sapiens, GI284448556, Length=353, Percent_Identity=34.8441926345609, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=35.0684931506849, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI119220554, Length=385, Percent_Identity=35.3246753246753, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI83977444, Length=391, Percent_Identity=30.1790281329923, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI83977442, Length=391, Percent_Identity=30.1790281329923, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI83977440, Length=391, Percent_Identity=30.1790281329923, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI4502025, Length=404, Percent_Identity=28.7128712871287, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI40316939, Length=404, Percent_Identity=28.7128712871287, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI5454084, Length=286, Percent_Identity=36.013986013986, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1790046, Length=387, Percent_Identity=38.2428940568475, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=32.0916905444126, Blast_Score=185, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71994529, Length=386, Percent_Identity=34.1968911917098, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=375, Percent_Identity=35.4666666666667, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17560914, Length=377, Percent_Identity=33.42175066313, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17560912, Length=377, Percent_Identity=33.42175066313, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71982617, Length=279, Percent_Identity=32.9749103942652, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71982625, Length=279, Percent_Identity=32.9749103942652, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6320267, Length=375, Percent_Identity=32.2666666666667, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320438, Length=389, Percent_Identity=28.5347043701799, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=279, Percent_Identity=27.9569892473118, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24662918, Length=381, Percent_Identity=36.2204724409449, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI17136286, Length=385, Percent_Identity=34.8051948051948, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17137420, Length=387, Percent_Identity=32.0413436692506, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24653280, Length=313, Percent_Identity=32.2683706070287, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24653276, Length=313, Percent_Identity=32.2683706070287, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24653278, Length=313, Percent_Identity=32.2683706070287, Blast_Score=161, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 56437; Mature: 56306

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVFDKCRNWKDYRIAKATGLYPYFRAIEASHGATEVEIEGKRVIMVGSNNYLGLSADP
CCCHHHHHCCCCCEEEEHHHCCCHHHHHHHCCCCCEEEEECCCEEEEECCCCEEECCCCC
RVKEAAIKATEKFGTTSSGSRLLNGTLALHEELEARLAKFLNRESAIVISTGFQTNLALA
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
SILGRHDIVFSDRQNHASLVDGIRLSFATERKFRHNDMDHLEQLLSQADPDAGKIIVTDG
HHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECC
VFSMEGDICNLPRIVELAKHYNARVMTDDAHAMGVLGTRGRGTSEYFDLEKETDLVMGTF
EEEECCCCCCCHHHHHHHHHCCCEEEECCCHHHCCEECCCCCCHHHCCCCCCCCHHHHHH
SKSFASLGGVLAGPFEVINYIRHKARSVIFSASMTPGSIAAALKALEIIEAEPERRARLL
HHHHHHHCCHHCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHH
DIAEKMHNGFRAMGFDTGVSVTPVVPVHIGDQVKCFRFWRALHEAGVFANPVIPPAVEPG
HHHHHHHCCCEEECCCCCCEECEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
HALIRTSYMATHTDAQLDRVLDTFETIGRKLGVIPETRPSVYEPVQIARPGTRILSNRAS
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHCCCC
EKWAAGSNGLLADKGGITLDQLSRMSSREVAGRLFDAVEQLTWRAANLQPEDLRKLGNAP
HHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCH
MKLWEKRGELPGLLLEKGAHFFMRNGAHSDRN
HHHHHHCCCCCCHHHHCCCCEEEECCCCCCCC
>Mature Secondary Structure 
SDVFDKCRNWKDYRIAKATGLYPYFRAIEASHGATEVEIEGKRVIMVGSNNYLGLSADP
CCHHHHHCCCCCEEEEHHHCCCHHHHHHHCCCCCEEEEECCCEEEEECCCCEEECCCCC
RVKEAAIKATEKFGTTSSGSRLLNGTLALHEELEARLAKFLNRESAIVISTGFQTNLALA
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
SILGRHDIVFSDRQNHASLVDGIRLSFATERKFRHNDMDHLEQLLSQADPDAGKIIVTDG
HHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECC
VFSMEGDICNLPRIVELAKHYNARVMTDDAHAMGVLGTRGRGTSEYFDLEKETDLVMGTF
EEEECCCCCCCHHHHHHHHHCCCEEEECCCHHHCCEECCCCCCHHHCCCCCCCCHHHHHH
SKSFASLGGVLAGPFEVINYIRHKARSVIFSASMTPGSIAAALKALEIIEAEPERRARLL
HHHHHHHCCHHCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHH
DIAEKMHNGFRAMGFDTGVSVTPVVPVHIGDQVKCFRFWRALHEAGVFANPVIPPAVEPG
HHHHHHHCCCEEECCCCCCEECEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
HALIRTSYMATHTDAQLDRVLDTFETIGRKLGVIPETRPSVYEPVQIARPGTRILSNRAS
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHCCCC
EKWAAGSNGLLADKGGITLDQLSRMSSREVAGRLFDAVEQLTWRAANLQPEDLRKLGNAP
HHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCH
MKLWEKRGELPGLLLEKGAHFFMRNGAHSDRN
HHHHHHCCCCCCHHHHCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA