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The map label for this gene is tcrA [H]

Identifier: 108758444

GI number: 108758444

Start: 4017712

End: 4018392

Strand: Direct

Name: tcrA [H]

Synonym: MXAN_3450

Alternate gene names: 108758444

Gene position: 4017712-4018392 (Clockwise)

Preceding gene: 108758900

Following gene: 108761146

Centisome position: 43.96

GC content: 70.48

Gene sequence:

>681_bases
GTGAGGCTGCTGCTGGTGGAAGACGAGGAGCGGATGGCGAACCTGCTCCGGCGGGGGCTCGGGGAAGAGGGCCACCTCGT
GGACACCTGCCGCACGGCGGAAGACGCGCTCGACCAGGCAGGCGAGGTTGCCTACGACGCCATCATCCTCGACTGGGCCC
TGCCTGGCATGGATGGCGTCGCGCTGCTGCGGCGCTGGCGCGAACGCGGCTTGATGACGCCGGTGCTGATGCTCACCGCC
CGCGGCACGGTGGGGGAGCGGGTGACGGGCCTGCGCGCTGGCGCGGATGACTACCTGGTGAAGCCCTTTGCCTTCGAGGA
ACTGCTCGCGCGCCTGGAGGCGCTGCACCGCCGCTCCGAGGGCCAGACGCAGTCCTGGGGCGGAGGGGCCATCCACATCG
ATGCCCGGCGGCGGATGTTGACGTGTGGCGACCGTGAGGTGGCCTTGACGGGCCGCGAGTTCGCCCTGCTGGGTGAGCTG
GCTTCGCGCGCGGGCGAAGTCCACACCCGCTCCAGCCTGCTGGCGAAGGTGTGGGGCCCCAGCTTCGATGGGCCTCCCAA
CATCGTGGACGTCTACGTGGGCTACGTGCGCACGAAGCTGACCGAGGTGGGCGCGGAAGGGGTGACCATCCAGGCGGTGC
GTGGCGTGGGCTTCCGGTTGGTGATTGAGGGCGCTCGGTGA

Upstream 100 bases:

>100_bases
ACGCTGCTGACCCTGGTCATCCTCCCCACACTCTACCCATGGTTCGCGGGTAGGACGCGCACGCAGGCGCGTGCATGATG
GGGTGAAGGAGGCCGGTGCC

Downstream 100 bases:

>100_bases
GGTTGGTCCGGCGGATGTGGCTGTGGGGCGCGGTGGTGCCCGTGGTGGCGGTGGTCGCCGCGCTGGGCGTGGCTGTCCAG
GTGTTCCGCGTGGTGCTCGA

Product: DNA-binding heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MRLLLVEDEERMANLLRRGLGEEGHLVDTCRTAEDALDQAGEVAYDAIILDWALPGMDGVALLRRWRERGLMTPVLMLTA
RGTVGERVTGLRAGADDYLVKPFAFEELLARLEALHRRSEGQTQSWGGGAIHIDARRRMLTCGDREVALTGREFALLGEL
ASRAGEVHTRSSLLAKVWGPSFDGPPNIVDVYVGYVRTKLTEVGAEGVTIQAVRGVGFRLVIEGAR

Sequences:

>Translated_226_residues
MRLLLVEDEERMANLLRRGLGEEGHLVDTCRTAEDALDQAGEVAYDAIILDWALPGMDGVALLRRWRERGLMTPVLMLTA
RGTVGERVTGLRAGADDYLVKPFAFEELLARLEALHRRSEGQTQSWGGGAIHIDARRRMLTCGDREVALTGREFALLGEL
ASRAGEVHTRSSLLAKVWGPSFDGPPNIVDVYVGYVRTKLTEVGAEGVTIQAVRGVGFRLVIEGAR
>Mature_226_residues
MRLLLVEDEERMANLLRRGLGEEGHLVDTCRTAEDALDQAGEVAYDAIILDWALPGMDGVALLRRWRERGLMTPVLMLTA
RGTVGERVTGLRAGADDYLVKPFAFEELLARLEALHRRSEGQTQSWGGGAIHIDARRRMLTCGDREVALTGREFALLGEL
ASRAGEVHTRSSLLAKVWGPSFDGPPNIVDVYVGYVRTKLTEVGAEGVTIQAVRGVGFRLVIEGAR

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=39.3665158371041, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=41.6289592760181, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=41.3333333333333, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=35.1598173515982, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=37.7777777777778, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=35.4260089686099, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=32.7354260089686, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=31.7596566523605, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=33.7899543378995, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=32.0175438596491, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=33.6244541484716, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.0429184549356, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=26.6375545851528, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=169, Percent_Identity=29.585798816568, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787229, Length=208, Percent_Identity=27.4038461538462, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788191, Length=125, Percent_Identity=35.2, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790299, Length=120, Percent_Identity=31.6666666666667, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790437, Length=111, Percent_Identity=34.2342342342342, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24794; Mature: 24794

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLVEDEERMANLLRRGLGEEGHLVDTCRTAEDALDQAGEVAYDAIILDWALPGMDGV
CEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHEEEECCCCCCCHH
ALLRRWRERGLMTPVLMLTARGTVGERVTGLRAGADDYLVKPFAFEELLARLEALHRRSE
HHHHHHHHCCCCCHHHHEECCCCCHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHCCC
GQTQSWGGGAIHIDARRRMLTCGDREVALTGREFALLGELASRAGEVHTRSSLLAKVWGP
CCCCCCCCCEEEEECCCEEEECCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC
SFDGPPNIVDVYVGYVRTKLTEVGAEGVTIQAVRGVGFRLVIEGAR
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCC
>Mature Secondary Structure
MRLLLVEDEERMANLLRRGLGEEGHLVDTCRTAEDALDQAGEVAYDAIILDWALPGMDGV
CEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHEEEECCCCCCCHH
ALLRRWRERGLMTPVLMLTARGTVGERVTGLRAGADDYLVKPFAFEELLARLEALHRRSE
HHHHHHHHCCCCCHHHHEECCCCCHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHCCC
GQTQSWGGGAIHIDARRRMLTCGDREVALTGREFALLGELASRAGEVHTRSSLLAKVWGP
CCCCCCCCCEEEEECCCEEEECCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC
SFDGPPNIVDVYVGYVRTKLTEVGAEGVTIQAVRGVGFRLVIEGAR
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]