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The map label for this gene is hemN [H]

Identifier: 108758201

GI number: 108758201

Start: 6880959

End: 6882332

Strand: Reverse

Name: hemN [H]

Synonym: MXAN_5532

Alternate gene names: 108758201

Gene position: 6882332-6880959 (Counterclockwise)

Preceding gene: 108758074

Following gene: 108757023

Centisome position: 75.3

GC content: 69.8

Gene sequence:

>1374_bases
ATGGAGCCCCCCCGCCAGGAAGTCCCCACGCCACCCGAAGCCCTGCTGAGCCGGTACGACGTCTCCGGCCCTCGCTACAC
CAGCTACCCCACGGCGCCCGAGTGGCGGAAGGACTTCGGTCCGGAGCATCTGGTGGAGCGGCTCGAGCATGCAGGCTCCC
GGGAGCACGCCGAGCCGCTGTCGCTCTACGTGCACTTGCCCTTCTGCCGCAGTCTCTGCTGGTACTGCGGCTGCAACGTC
GTCATCAGCCGGGACCGGGCCGCGGCGGACCAGTACATCGACCATCTGGAGATGGAGCTGGACCTGGTGGTGCAGCGGCT
CGGCTGCCGGCGCTCCTTGTCCCAGATTCACTGGGGTGGGGGGACGCCCACCTTCCTGGATGAGCGGCAGCTGGAACGGC
TGTGGACGGCGCTCACCCGTCGCTTCCGCATCGCGTCGGACGCGGAGGTGGCCATCGAAATCCACCCGGCCGTGACGACG
CCCGGCCAGCTCACGCTGCTTCGGAGCCTGGGCTTCAACCGCGTGTCCATGGGCCTGCAGGACTTCGACGCGCGCGTGCA
GGAGGTCACCAACCGCATCCAGTCCCCGGAGGAGACGCGGGCGCTGCTGGAGCACGCGCGGCTGCTGGGCTTCAAGGGCG
TGAACTTCGACCTCATCTACGGTCTGCCACACCAGGACGCCGAGGGGTGGGCCCGCACGCTGGACACGGTGTTGTCGATG
CGGCCGGACCGGCTGGCCGTCTACTCCTTCGCGTTCATGCCCGAAGTGCTGAAGCACCAACGGCGCATGCCCGCGGAGGC
CATTCCCAGCGGGCGCGCCAAGCTGGAGTTGTTCCGCTCCGCCTACGCGGCCTTTGTGTCCGCGGGCTACCGGCCCATCG
GCATGGACCACTTCGCGGTGCCCGAGGACGAACTGGCGCGCGCGCAGGCCGAGCGCCGGCTGGGCCGCAACTTCCAGGGC
TACACCGTCAAGGCCGCGTCGGACGTGGTGGCCATTGGCAGCACCGGCATCAGCGACGTGGACGGCGCGTATGCGCAGAA
CGTCCGCGCGCTGCCACGCTACTACGAGCGCGTCTCCCAGGGCTGTCTGGCCACGGAGCGGGGCTTGTCACTGACGGCGG
ACGACCAGCGCCGCCGCGCGGTCATCACCCGGCTCATGTGCAACTTCTGGGTGGACCTGGGGGCGGACGGCGCCGACTAC
TTCGCGCCGGAGTTGGAGCGGCTGCGCGCGTTCGAGGCCGACGGCCTGGTGATGCGCACCGGCTCGCAGTTGGAGCTGAC
GCCCATGGGGCGGCTCTTCGTCCGCAACGTGGCCATGGTGTTCGACGCGTATCTCGCGGGGACGGAGCGCCCCCGCTTTT
CCCGCACGGTGTGA

Upstream 100 bases:

>100_bases
TTGCGCCGTGGGGGGAGGGGGCCGCAAGACCTGCACGACTTGCGCCACATCCCCGTCGTGGATGCTCCTGGCACGAGGCT
TGGAATGGTGAATCGGTGAG

Downstream 100 bases:

>100_bases
AGGGGTCGGTCATGGATGCATTGGACGTGTTGAACCAGGAGCACCGCCACATCCAGCGCGTGCTGGTGGTCCTGGATCGG
GCGGTGGCGAAGGGCCGCGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MEPPRQEVPTPPEALLSRYDVSGPRYTSYPTAPEWRKDFGPEHLVERLEHAGSREHAEPLSLYVHLPFCRSLCWYCGCNV
VISRDRAAADQYIDHLEMELDLVVQRLGCRRSLSQIHWGGGTPTFLDERQLERLWTALTRRFRIASDAEVAIEIHPAVTT
PGQLTLLRSLGFNRVSMGLQDFDARVQEVTNRIQSPEETRALLEHARLLGFKGVNFDLIYGLPHQDAEGWARTLDTVLSM
RPDRLAVYSFAFMPEVLKHQRRMPAEAIPSGRAKLELFRSAYAAFVSAGYRPIGMDHFAVPEDELARAQAERRLGRNFQG
YTVKAASDVVAIGSTGISDVDGAYAQNVRALPRYYERVSQGCLATERGLSLTADDQRRRAVITRLMCNFWVDLGADGADY
FAPELERLRAFEADGLVMRTGSQLELTPMGRLFVRNVAMVFDAYLAGTERPRFSRTV

Sequences:

>Translated_457_residues
MEPPRQEVPTPPEALLSRYDVSGPRYTSYPTAPEWRKDFGPEHLVERLEHAGSREHAEPLSLYVHLPFCRSLCWYCGCNV
VISRDRAAADQYIDHLEMELDLVVQRLGCRRSLSQIHWGGGTPTFLDERQLERLWTALTRRFRIASDAEVAIEIHPAVTT
PGQLTLLRSLGFNRVSMGLQDFDARVQEVTNRIQSPEETRALLEHARLLGFKGVNFDLIYGLPHQDAEGWARTLDTVLSM
RPDRLAVYSFAFMPEVLKHQRRMPAEAIPSGRAKLELFRSAYAAFVSAGYRPIGMDHFAVPEDELARAQAERRLGRNFQG
YTVKAASDVVAIGSTGISDVDGAYAQNVRALPRYYERVSQGCLATERGLSLTADDQRRRAVITRLMCNFWVDLGADGADY
FAPELERLRAFEADGLVMRTGSQLELTPMGRLFVRNVAMVFDAYLAGTERPRFSRTV
>Mature_457_residues
MEPPRQEVPTPPEALLSRYDVSGPRYTSYPTAPEWRKDFGPEHLVERLEHAGSREHAEPLSLYVHLPFCRSLCWYCGCNV
VISRDRAAADQYIDHLEMELDLVVQRLGCRRSLSQIHWGGGTPTFLDERQLERLWTALTRRFRIASDAEVAIEIHPAVTT
PGQLTLLRSLGFNRVSMGLQDFDARVQEVTNRIQSPEETRALLEHARLLGFKGVNFDLIYGLPHQDAEGWARTLDTVLSM
RPDRLAVYSFAFMPEVLKHQRRMPAEAIPSGRAKLELFRSAYAAFVSAGYRPIGMDHFAVPEDELARAQAERRLGRNFQG
YTVKAASDVVAIGSTGISDVDGAYAQNVRALPRYYERVSQGCLATERGLSLTADDQRRRAVITRLMCNFWVDLGADGADY
FAPELERLRAFEADGLVMRTGSQLELTPMGRLFVRNVAMVFDAYLAGTERPRFSRTV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=262, Percent_Identity=27.0992366412214, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI87082341, Length=454, Percent_Identity=45.1541850220264, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1789325, Length=243, Percent_Identity=29.6296296296296, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51639; Mature: 51639

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPPRQEVPTPPEALLSRYDVSGPRYTSYPTAPEWRKDFGPEHLVERLEHAGSREHAEPL
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCE
SLYVHLPFCRSLCWYCGCNVVISRDRAAADQYIDHLEMELDLVVQRLGCRRSLSQIHWGG
EEEEECHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
GTPTFLDERQLERLWTALTRRFRIASDAEVAIEIHPAVTTPGQLTLLRSLGFNRVSMGLQ
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHCCHH
DFDARVQEVTNRIQSPEETRALLEHARLLGFKGVNFDLIYGLPHQDAEGWARTLDTVLSM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
RPDRLAVYSFAFMPEVLKHQRRMPAEAIPSGRAKLELFRSAYAAFVSAGYRPIGMDHFAV
CCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PEDELARAQAERRLGRNFQGYTVKAASDVVAIGSTGISDVDGAYAQNVRALPRYYERVSQ
CHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
GCLATERGLSLTADDQRRRAVITRLMCNFWVDLGADGADYFAPELERLRAFEADGLVMRT
CCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEC
GSQLELTPMGRLFVRNVAMVFDAYLAGTERPRFSRTV
CCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEPPRQEVPTPPEALLSRYDVSGPRYTSYPTAPEWRKDFGPEHLVERLEHAGSREHAEPL
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCE
SLYVHLPFCRSLCWYCGCNVVISRDRAAADQYIDHLEMELDLVVQRLGCRRSLSQIHWGG
EEEEECHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
GTPTFLDERQLERLWTALTRRFRIASDAEVAIEIHPAVTTPGQLTLLRSLGFNRVSMGLQ
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHCCHH
DFDARVQEVTNRIQSPEETRALLEHARLLGFKGVNFDLIYGLPHQDAEGWARTLDTVLSM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
RPDRLAVYSFAFMPEVLKHQRRMPAEAIPSGRAKLELFRSAYAAFVSAGYRPIGMDHFAV
CCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PEDELARAQAERRLGRNFQGYTVKAASDVVAIGSTGISDVDGAYAQNVRALPRYYERVSQ
CHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
GCLATERGLSLTADDQRRRAVITRLMCNFWVDLGADGADYFAPELERLRAFEADGLVMRT
CCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEC
GSQLELTPMGRLFVRNVAMVFDAYLAGTERPRFSRTV
CCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]