Click here to switch to the map view.

The map label for this gene is sppA [H]

Identifier: 108757755

GI number: 108757755

Start: 4573595

End: 4575412

Strand: Reverse

Name: sppA [H]

Synonym: MXAN_3808

Alternate gene names: 108757755

Gene position: 4575412-4573595 (Counterclockwise)

Preceding gene: 108756990

Following gene: 108759882

Centisome position: 50.06

GC content: 69.42

Gene sequence:

>1818_bases
GTGAGCGTCCATTACGGGCCGGGGACCCACATTTCCATTCCGGACGCCATGCTGCGCCTGCCCTTCATCGCCCTCGCCAA
CCTGTACCTCCTCCTGGTCTCCCTGCTGGGCGCGCCCTTCCGGATGATGGCCGCCAGCCACCGGCCCGCCTACGTCCGCT
TCCGGCTGACGGGGGATCCGCCGTACCGCGAGCGACGCCGGCGCCGGTTGCAGTTGGGGGGCAGCCGCCCCGAGCCGTCG
GATGTCACGTCCGTGGAGCGCCTCCGCGAGTCGTTGGAGCTCCTGGCCAAGGACGGCCGGGTGAAGGGCATCCTCCTGGA
GGTGGAGGACCTGGCCGTGCCCGCGGCGAAGCGGGATGCGCTGGTGGCGGTGTTGAGGGCCTTCCGAGCCCAGGGGAAGC
GGGTGGTGGGCTGGGCGGTCCACGTGGACAACGAGGGATATGCCCTCCTGTGCTCGGCGGACGAGGTGCTCCTGCCCCCC
ATGGGCCGCGTGGAGCTGGTGGGCTACGCCGCCGAGTCCACCGCCCTGGGCGTGGGCCTGTCGCGCGTGGGCATCCGGCC
GCAATTCATCCGGCGCGGGGATTACAAGACGGCGCCGGAGCTCTTCACCAGGCCCGTCGTGTCGGACATCCAGACGCGGA
CGGTGGAGTCGTTCCTGGATGAGCGCTACGCGGACCTGTTGGACGTAGTGGCTCGGGGGCGGCGCAAGACGCCGGAGGAG
GTCCGGGCGCTGATCGACCAGGGGCCCTTCAGTGCTCGCCGGGCGGTGGACGCGGGGCTGGCGGACGCACTGGTGAGCGA
GGCGAACCTGCCCGCGTACCTCGGGCTGGCGAAGCCGGGGGACGGGGAGGAGGAGACGGAGCTGGAGCCGATGGAGACCT
ATCTCTCCACGATTCCGTTCCCGCCGGTCCGTTGGAAGCGGCTGCGGCGGAACCCGCGCGTCGCGGTGGTGCCCGTGTCT
GGAATCATCATCCCGGGCAAGGGGGCCAGCGGGAAGATGGCGACCTCGGAGACGGTGGTGAAGGCGCTGCGCGCCGCGGG
GCGGGACAAACGGTCGAAGGCGGTGGTCGTCTACATCAGCAGTCCGGGCGGGACGCCGCTGGCGTCGGAACAGATGCTGG
AGGCAGTGCAACGCGTGGCGCGGAAGAAACCCGTCATCGCGTACATGGACCGGGTGTGTGCCAGCGCGGGGTACATGGTG
GCGGTGGGCGCGAAGGAGATCTGGTCCGCGCCGCACGCCATGGTGGGCTCGATTGGTGTCTTCGCGGGCAAGTTCGACAT
GTCCGGGCTGATGGAGAAGCTCGGGGTGCACAAGACGGTGCTGGTCCGGGGGCAGAACGCGGCCATGCTCTCGTTCTCGC
GTGGCTTCACGCCGCAAGAGGAGGCCACGCTGGAGGCCGAGGTGGAGGAGATGTACCAGGCCTTCCTCGACATCGTCGCG
AAGGGGCGGGGACGGACGAAGGAGGAGATCCACCAGTTGGCGGAAGGCCGCGTGTACTCGGGCGTGCGAGGCAAGGCCGT
GGGGCTGGTGGACCAGGTCGCGGGCTTCGAGGAGGCCTGCCGCCACGCGCTGTCGCTGGCGAAGGTGCCGGCGGCGGAGC
GGTTCGAAATCATGACCTATGGTGCGCCCAAGCAGCGGGTGAACCTGCTGAAGCTGTTGATGGGGGCATCCCATGCGCAG
ACGTATGCGCTGTGCCCCACGGCCTTGAGCCTGAATGGGTTGGGCGGCACGGAGGCGTTTGAAGATGCCGCGCGCTTCGG
GGTGGCCGACGTGGTGGGTAGAGTGTTTCCTGATGACCAGTGGCCATTCGGGGGCTGA

Upstream 100 bases:

>100_bases
TGAGCGCGAGGACGAGGAACATCCGGGGAACAAGGTATCGCATATGGCGGGGGAGGCTATCACGACCCAACGGATGGACT
GAACAGGGCTTGCACGCTGA

Downstream 100 bases:

>100_bases
CGGGCGCGAGCGGTAGACTGGAGGGATGCTGAAGGCACTCGCGCTGCTGACCGCATCCTGTCTGGCCCAGGCGGAGGCTT
CTTCCGCCGCGAAGGTGGAG

Product: signal peptide peptidase SppA

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MSVHYGPGTHISIPDAMLRLPFIALANLYLLLVSLLGAPFRMMAASHRPAYVRFRLTGDPPYRERRRRRLQLGGSRPEPS
DVTSVERLRESLELLAKDGRVKGILLEVEDLAVPAAKRDALVAVLRAFRAQGKRVVGWAVHVDNEGYALLCSADEVLLPP
MGRVELVGYAAESTALGVGLSRVGIRPQFIRRGDYKTAPELFTRPVVSDIQTRTVESFLDERYADLLDVVARGRRKTPEE
VRALIDQGPFSARRAVDAGLADALVSEANLPAYLGLAKPGDGEEETELEPMETYLSTIPFPPVRWKRLRRNPRVAVVPVS
GIIIPGKGASGKMATSETVVKALRAAGRDKRSKAVVVYISSPGGTPLASEQMLEAVQRVARKKPVIAYMDRVCASAGYMV
AVGAKEIWSAPHAMVGSIGVFAGKFDMSGLMEKLGVHKTVLVRGQNAAMLSFSRGFTPQEEATLEAEVEEMYQAFLDIVA
KGRGRTKEEIHQLAEGRVYSGVRGKAVGLVDQVAGFEEACRHALSLAKVPAAERFEIMTYGAPKQRVNLLKLLMGASHAQ
TYALCPTALSLNGLGGTEAFEDAARFGVADVVGRVFPDDQWPFGG

Sequences:

>Translated_605_residues
MSVHYGPGTHISIPDAMLRLPFIALANLYLLLVSLLGAPFRMMAASHRPAYVRFRLTGDPPYRERRRRRLQLGGSRPEPS
DVTSVERLRESLELLAKDGRVKGILLEVEDLAVPAAKRDALVAVLRAFRAQGKRVVGWAVHVDNEGYALLCSADEVLLPP
MGRVELVGYAAESTALGVGLSRVGIRPQFIRRGDYKTAPELFTRPVVSDIQTRTVESFLDERYADLLDVVARGRRKTPEE
VRALIDQGPFSARRAVDAGLADALVSEANLPAYLGLAKPGDGEEETELEPMETYLSTIPFPPVRWKRLRRNPRVAVVPVS
GIIIPGKGASGKMATSETVVKALRAAGRDKRSKAVVVYISSPGGTPLASEQMLEAVQRVARKKPVIAYMDRVCASAGYMV
AVGAKEIWSAPHAMVGSIGVFAGKFDMSGLMEKLGVHKTVLVRGQNAAMLSFSRGFTPQEEATLEAEVEEMYQAFLDIVA
KGRGRTKEEIHQLAEGRVYSGVRGKAVGLVDQVAGFEEACRHALSLAKVPAAERFEIMTYGAPKQRVNLLKLLMGASHAQ
TYALCPTALSLNGLGGTEAFEDAARFGVADVVGRVFPDDQWPFGG
>Mature_604_residues
SVHYGPGTHISIPDAMLRLPFIALANLYLLLVSLLGAPFRMMAASHRPAYVRFRLTGDPPYRERRRRRLQLGGSRPEPSD
VTSVERLRESLELLAKDGRVKGILLEVEDLAVPAAKRDALVAVLRAFRAQGKRVVGWAVHVDNEGYALLCSADEVLLPPM
GRVELVGYAAESTALGVGLSRVGIRPQFIRRGDYKTAPELFTRPVVSDIQTRTVESFLDERYADLLDVVARGRRKTPEEV
RALIDQGPFSARRAVDAGLADALVSEANLPAYLGLAKPGDGEEETELEPMETYLSTIPFPPVRWKRLRRNPRVAVVPVSG
IIIPGKGASGKMATSETVVKALRAAGRDKRSKAVVVYISSPGGTPLASEQMLEAVQRVARKKPVIAYMDRVCASAGYMVA
VGAKEIWSAPHAMVGSIGVFAGKFDMSGLMEKLGVHKTVLVRGQNAAMLSFSRGFTPQEEATLEAEVEEMYQAFLDIVAK
GRGRTKEEIHQLAEGRVYSGVRGKAVGLVDQVAGFEEACRHALSLAKVPAAERFEIMTYGAPKQRVNLLKLLMGASHAQT
YALCPTALSLNGLGGTEAFEDAARFGVADVVGRVFPDDQWPFGG

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=526, Percent_Identity=26.2357414448669, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1787527, Length=171, Percent_Identity=32.7485380116959, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 65724; Mature: 65593

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHYGPGTHISIPDAMLRLPFIALANLYLLLVSLLGAPFRMMAASHRPAYVRFRLTGDP
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEEECCCC
PYRERRRRRLQLGGSRPEPSDVTSVERLRESLELLAKDGRVKGILLEVEDLAVPAAKRDA
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHCCCHHHHH
LVAVLRAFRAQGKRVVGWAVHVDNEGYALLCSADEVLLPPMGRVELVGYAAESTALGVGL
HHHHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCEECCCCCCEEEEEEECCCHHHHCCH
SRVGIRPQFIRRGDYKTAPELFTRPVVSDIQTRTVESFLDERYADLLDVVARGRRKTPEE
HHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VRALIDQGPFSARRAVDAGLADALVSEANLPAYLGLAKPGDGEEETELEPMETYLSTIPF
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCC
PPVRWKRLRRNPRVAVVPVSGIIIPGKGASGKMATSETVVKALRAAGRDKRSKAVVVYIS
CCHHHHHHCCCCCEEEEEECEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEE
SPGGTPLASEQMLEAVQRVARKKPVIAYMDRVCASAGYMVAVGAKEIWSAPHAMVGSIGV
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCHHHHCCCHHHHHHHHH
FAGKFDMSGLMEKLGVHKTVLVRGQNAAMLSFSRGFTPQEEATLEAEVEEMYQAFLDIVA
HCCCCCHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
KGRGRTKEEIHQLAEGRVYSGVRGKAVGLVDQVAGFEEACRHALSLAKVPAAERFEIMTY
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEC
GAPKQRVNLLKLLMGASHAQTYALCPTALSLNGLGGTEAFEDAARFGVADVVGRVFPDDQ
CCCHHHHHHHHHHHCCCCCCEEEECCHHHEECCCCCCHHHHHHHHHCHHHHHHHHCCCCC
WPFGG
CCCCC
>Mature Secondary Structure 
SVHYGPGTHISIPDAMLRLPFIALANLYLLLVSLLGAPFRMMAASHRPAYVRFRLTGDP
CCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEEECCCC
PYRERRRRRLQLGGSRPEPSDVTSVERLRESLELLAKDGRVKGILLEVEDLAVPAAKRDA
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHCCCHHHHH
LVAVLRAFRAQGKRVVGWAVHVDNEGYALLCSADEVLLPPMGRVELVGYAAESTALGVGL
HHHHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCEECCCCCCEEEEEEECCCHHHHCCH
SRVGIRPQFIRRGDYKTAPELFTRPVVSDIQTRTVESFLDERYADLLDVVARGRRKTPEE
HHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VRALIDQGPFSARRAVDAGLADALVSEANLPAYLGLAKPGDGEEETELEPMETYLSTIPF
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCC
PPVRWKRLRRNPRVAVVPVSGIIIPGKGASGKMATSETVVKALRAAGRDKRSKAVVVYIS
CCHHHHHHCCCCCEEEEEECEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEE
SPGGTPLASEQMLEAVQRVARKKPVIAYMDRVCASAGYMVAVGAKEIWSAPHAMVGSIGV
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCHHHHCCCHHHHHHHHH
FAGKFDMSGLMEKLGVHKTVLVRGQNAAMLSFSRGFTPQEEATLEAEVEEMYQAFLDIVA
HCCCCCHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
KGRGRTKEEIHQLAEGRVYSGVRGKAVGLVDQVAGFEEACRHALSLAKVPAAERFEIMTY
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEC
GAPKQRVNLLKLLMGASHAQTYALCPTALSLNGLGGTEAFEDAARFGVADVVGRVFPDDQ
CCCHHHHHHHHHHHCCCCCCEEEECCHHHEECCCCCCHHHHHHHHHCHHHHHHHHCCCCC
WPFGG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]