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The map label for this gene is prpR [H]

Identifier: 108757744

GI number: 108757744

Start: 6129615

End: 6130994

Strand: Direct

Name: prpR [H]

Synonym: MXAN_4899

Alternate gene names: 108757744

Gene position: 6129615-6130994 (Clockwise)

Preceding gene: 108756910

Following gene: 108760280

Centisome position: 67.07

GC content: 70.22

Gene sequence:

>1380_bases
ATGGATAGGCCCGAGGTCACCCAGACCACTCAGACGGAGCAGGAAGGCCGCACCACCCGAATCCCCATCCCCGAATGGAC
GGTGGAGGTGGTTGCCGGACCTGACAAGGGCAAGAAGGTGAAGACGCAGGACGGACTGGTCCGCGTGGGCTCCGACAGCG
CCTGCGACCTGGTCCTCACCGACGCCACGGTGAGCCGCCGCCACCTGGAGGTGGAGCGCACCGCGCGCGGGCTGATGCTG
CGCGACACCGGCAGCCGCAACGGCACCTTCCTGGACGGCCGACAGGTGGTGCAGGCCTACCTGACCAGCGGCGACAAGGT
CGAGCTGGGCAAGACGAAGCTCTCCGTGAAGGTCGCCCCGCGTCCCACCGAGGTGGATGTTGCGGGGGCGGAGTCCTTCG
GCGCGCTGGTGGGCGCCTCGGAGAAGATGCGCTGGGTCTTCACGGAGCTGCGCCGCATCGCCCGCGAGGACATGAGCCTG
CTCGTGGAGGGTGAGACAGGCACCGGCAAGGAGCTGGCGGCGCGCGCGGTGCACCAGCACTCGGCGCGGCGCCACGGCCC
CTTCAAGGTCGTGGACTGCAACCTCATCTCCGAGGAGAAGGCCGAGCGCGAGCTCTTCGGCGGCCTGCGCGCGGGTGACG
GCGAGGACCGCGAGGCGCGGGGCGTCTTCGAGGCGGCCCGGGGCGGCACCCTCTTCATGGACGAGGTGGGCGAGCTGCCG
CTGCCCGTGCAGGGCAAGCTGCTGCGCGTGCTGGAGACGCGCGAGGTGCCGTCGCTGGACGGCCAGCCGGTGGCGGTGGA
CGTGCGCGTCATCGCCTCCACCCACCGGAACCTGGAAGAGGACGTGCGCCAGGGCCGCTTCCGCGCGGACCTGTACTTCC
GGCTCGCGGTGGCGCGCGTGCGCCTGCCGCCCCTGCGCACCCGGCGGGACGATTTGCCCGCGCTGGCCCAGGCCCTGGCC
CAGACGCTGCGCGCCAGCATCACCCTCACGCCCCAGACGCTGGCCCTCTTCGAGGGCTATGAGTGGCCGGGCAACGTGCG
CGAGCTGCGCAACGTGCTGGAGCGCGGCGCCCTCATGGAGGAGACGGGCAACAGCAGCTGGCTGGACTTCCTCGCCCAGC
CCTCGCGACGCGCGGAGGGACAGCCCCCCACCACCCAGGTGGCCACGCTGGTGGGCACCCTGCCCTACCACGAGGCCAAG
GACAGGGTGCTGGCCGACTTCGAGCGCCTGTATTTCGCCGAGGTCATGAAAACCGTGGGCTTCGACATGAAGGCCGCGGA
GCAGCGCACCGGCCTGTCCATGCAGAGCCTTTATCGCCTTTTGAAAAAAAACGGGCTTCGGCTCAAGGACCTCAAGAACG
CCGAGGGCCTGGAGAAGTAA

Upstream 100 bases:

>100_bases
GCAGGATTGTTCCACTCGTACTGCCTTGAGTTTTCCCGATGTGAAGAGGCTCGCGTCGGGCTTGCCCGCCCATGCGACTC
GCACCTAAAGAGGACCCGAT

Downstream 100 bases:

>100_bases
AGAAGTCCGCAAGCAGGTCCACCTCTAGGGAGAACAACCGCATGTTGCGTCGTGTTGCCGTAGCCTCCGTCGTCTTCACT
GCCGCTTGCGCCGGCCAGCA

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MDRPEVTQTTQTEQEGRTTRIPIPEWTVEVVAGPDKGKKVKTQDGLVRVGSDSACDLVLTDATVSRRHLEVERTARGLML
RDTGSRNGTFLDGRQVVQAYLTSGDKVELGKTKLSVKVAPRPTEVDVAGAESFGALVGASEKMRWVFTELRRIAREDMSL
LVEGETGTGKELAARAVHQHSARRHGPFKVVDCNLISEEKAERELFGGLRAGDGEDREARGVFEAARGGTLFMDEVGELP
LPVQGKLLRVLETREVPSLDGQPVAVDVRVIASTHRNLEEDVRQGRFRADLYFRLAVARVRLPPLRTRRDDLPALAQALA
QTLRASITLTPQTLALFEGYEWPGNVRELRNVLERGALMEETGNSSWLDFLAQPSRRAEGQPPTTQVATLVGTLPYHEAK
DRVLADFERLYFAEVMKTVGFDMKAAEQRTGLSMQSLYRLLKKNGLRLKDLKNAEGLEK

Sequences:

>Translated_459_residues
MDRPEVTQTTQTEQEGRTTRIPIPEWTVEVVAGPDKGKKVKTQDGLVRVGSDSACDLVLTDATVSRRHLEVERTARGLML
RDTGSRNGTFLDGRQVVQAYLTSGDKVELGKTKLSVKVAPRPTEVDVAGAESFGALVGASEKMRWVFTELRRIAREDMSL
LVEGETGTGKELAARAVHQHSARRHGPFKVVDCNLISEEKAERELFGGLRAGDGEDREARGVFEAARGGTLFMDEVGELP
LPVQGKLLRVLETREVPSLDGQPVAVDVRVIASTHRNLEEDVRQGRFRADLYFRLAVARVRLPPLRTRRDDLPALAQALA
QTLRASITLTPQTLALFEGYEWPGNVRELRNVLERGALMEETGNSSWLDFLAQPSRRAEGQPPTTQVATLVGTLPYHEAK
DRVLADFERLYFAEVMKTVGFDMKAAEQRTGLSMQSLYRLLKKNGLRLKDLKNAEGLEK
>Mature_459_residues
MDRPEVTQTTQTEQEGRTTRIPIPEWTVEVVAGPDKGKKVKTQDGLVRVGSDSACDLVLTDATVSRRHLEVERTARGLML
RDTGSRNGTFLDGRQVVQAYLTSGDKVELGKTKLSVKVAPRPTEVDVAGAESFGALVGASEKMRWVFTELRRIAREDMSL
LVEGETGTGKELAARAVHQHSARRHGPFKVVDCNLISEEKAERELFGGLRAGDGEDREARGVFEAARGGTLFMDEVGELP
LPVQGKLLRVLETREVPSLDGQPVAVDVRVIASTHRNLEEDVRQGRFRADLYFRLAVARVRLPPLRTRRDDLPALAQALA
QTLRASITLTPQTLALFEGYEWPGNVRELRNVLERGALMEETGNSSWLDFLAQPSRRAEGQPPTTQVATLVGTLPYHEAK
DRVLADFERLYFAEVMKTVGFDMKAAEQRTGLSMQSLYRLLKKNGLRLKDLKNAEGLEK

Specific function: Involved in the transcriptional regulation of the propionate catabolism operon [H]

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1786524, Length=248, Percent_Identity=47.9838709677419, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1788550, Length=252, Percent_Identity=41.2698412698413, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1790437, Length=237, Percent_Identity=43.0379746835443, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87082117, Length=251, Percent_Identity=43.4262948207171, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1790299, Length=223, Percent_Identity=45.7399103139013, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1789233, Length=346, Percent_Identity=34.1040462427746, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1788905, Length=325, Percent_Identity=34.1538461538462, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789087, Length=325, Percent_Identity=38.7692307692308, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI87082152, Length=323, Percent_Identity=36.2229102167183, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081872, Length=334, Percent_Identity=35.3293413173653, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1787583, Length=331, Percent_Identity=34.441087613293, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87081858, Length=218, Percent_Identity=34.8623853211009, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789828, Length=219, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR012704
- InterPro:   IPR010524 [H]

Pfam domain/function: PF02954 HTH_8; PF06506 PrpR_N; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50963; Mature: 50963

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS50006 FHA_DOMAIN ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRPEVTQTTQTEQEGRTTRIPIPEWTVEVVAGPDKGKKVKTQDGLVRVGSDSACDLVLT
CCCCCCCCCCCHHHCCCEEECCCCCCEEEEEECCCCCCEEECCCCEEEECCCCCCEEEEE
DATVSRRHLEVERTARGLMLRDTGSRNGTFLDGRQVVQAYLTSGDKVELGKTKLSVKVAP
CCHHHHHHHHHHHHHCCEEEEECCCCCCCEECHHHHHHHHHCCCCEEEECCEEEEEEECC
RPTEVDVAGAESFGALVGASEKMRWVFTELRRIAREDMSLLVEGETGTGKELAARAVHQH
CCCCEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHH
SARRHGPFKVVDCNLISEEKAERELFGGLRAGDGEDREARGVFEAARGGTLFMDEVGELP
HHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEHHHCCCCC
LPVQGKLLRVLETREVPSLDGQPVAVDVRVIASTHRNLEEDVRQGRFRADLYFRLAVARV
CCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHCCHHHHHHCCCHHHHHHHHHHHHHH
RLPPLRTRRDDLPALAQALAQTLRASITLTPQTLALFEGYEWPGNVRELRNVLERGALME
CCCCCCCCCCCHHHHHHHHHHHHHHEEEECHHHHHHHCCCCCCCCHHHHHHHHHCCCHHH
ETGNSSWLDFLAQPSRRAEGQPPTTQVATLVGTLPYHEAKDRVLADFERLYFAEVMKTVG
CCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
FDMKAAEQRTGLSMQSLYRLLKKNGLRLKDLKNAEGLEK
CCHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCCCCC
>Mature Secondary Structure
MDRPEVTQTTQTEQEGRTTRIPIPEWTVEVVAGPDKGKKVKTQDGLVRVGSDSACDLVLT
CCCCCCCCCCCHHHCCCEEECCCCCCEEEEEECCCCCCEEECCCCEEEECCCCCCEEEEE
DATVSRRHLEVERTARGLMLRDTGSRNGTFLDGRQVVQAYLTSGDKVELGKTKLSVKVAP
CCHHHHHHHHHHHHHCCEEEEECCCCCCCEECHHHHHHHHHCCCCEEEECCEEEEEEECC
RPTEVDVAGAESFGALVGASEKMRWVFTELRRIAREDMSLLVEGETGTGKELAARAVHQH
CCCCEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHH
SARRHGPFKVVDCNLISEEKAERELFGGLRAGDGEDREARGVFEAARGGTLFMDEVGELP
HHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEHHHCCCCC
LPVQGKLLRVLETREVPSLDGQPVAVDVRVIASTHRNLEEDVRQGRFRADLYFRLAVARV
CCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHCCHHHHHHCCCHHHHHHHHHHHHHH
RLPPLRTRRDDLPALAQALAQTLRASITLTPQTLALFEGYEWPGNVRELRNVLERGALME
CCCCCCCCCCCHHHHHHHHHHHHHHEEEECHHHHHHHCCCCCCCCHHHHHHHHHCCCHHH
ETGNSSWLDFLAQPSRRAEGQPPTTQVATLVGTLPYHEAKDRVLADFERLYFAEVMKTVG
CCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
FDMKAAEQRTGLSMQSLYRLLKKNGLRLKDLKNAEGLEK
CCHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]