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The map label for this gene is atoC [H]

Identifier: 108757141

GI number: 108757141

Start: 4138917

End: 4140341

Strand: Reverse

Name: atoC [H]

Synonym: MXAN_3555

Alternate gene names: 108757141

Gene position: 4140341-4138917 (Counterclockwise)

Preceding gene: 108758732

Following gene: 108762950

Centisome position: 45.3

GC content: 67.3

Gene sequence:

>1425_bases
ATGGCCAAGGTCCTGGTCATCGACGACGAGGCGAACCTCCGCAAGGTGCTCGCCGCGATGCTGCGCCGGGACGGCTTCGA
CGTCACCGTGGCGGAGAACGGCGAGCAAGGGCTCGCCGAGTTCCACAAGAACGGCGCGGACATCGTGGTAACGGACCTGG
TGATGCCCAAGGTGGGCGGCATGGAGGTGCTCGGAACCATCCGCGCCGCCAACCCGGACGTCCCCGTCATCATCATCACC
GCGCATGGCACGGTGGACTCCGCCGTGGACGCCATCAAGGCGGGCGCGTTCGACTACATCACCAAGCCCTTCGATCAAGC
GGAGCTGTCCTCCGTCGTCGCCAAGGCCGCGAAGACGAACGAGAGCGCCCGCCGCTCCGTGCGCCCGGACGTGAAGGCGC
GCGCGGCCATCATCGGCGACTCGTCGACGATCCAGGAGGTCTACAAGATCATCGACAAGGTGGCGGACACGCCGTCCACG
GTGCTCATCACCGGGGAGAGCGGCACCGGCAAGGAGCTCATCGCCACCGCGCTGCACGGCGCCTCCAGCCGCCGCGACAA
GCCGTTCATCAAGATCAACTGCGCCGCCATTCCCCACACGCTGCTGGAGAGCGAGCTCTTCGGCTACGAGCGCGGGGCCT
TCACCGGCGCCGTCACGTCCAAGCCCGGTCGCTTCGAGCTGGCCGACGAGGGCACCCTCTTCCTGGACGAGATCGGCGAG
ATTCCGGTGGAGATGCAGGTGAAGCTGCTGCGCGCGATCCAGGAGGGCGAGTTCGAACGCGTGGGCGGCATCAAGACGAC
GCGCGTGGACGTGCGGCTCGTGGCCGCCACCAACCGCGACCTCCAGGCGGAGATTGAAGCCGGCCGCTTCCGCAAGGACC
TCTACTACCGCCTGGCGGTGGTCCCCATCTCCCTGCCCGCCCTGCGCGAGCGCCGCAGCGATGTCCCCATGCTCGCCCGG
CACTTCGTGGAGAAGTACAACCGGCGCCTCAACAAGAAGATTGAAGGCATCGCCGACGACGCCATGGCCTTGCTCCAGGG
CTACGCGTGGCCGGGCAACATCCGCGAGCTGGAGAACCTCATCGAGCGCGTGCTCCTGTTCGCGGACGGGCCTCTCATCA
CCGCCCGCGACCTGCCGGAGCCGGTCCGCCAGGGAACGGGCGTCCAGGCGGGTGCCAACCTGGCCAGCGCGGTGGCCTCC
ATCGACGTTCCGACGGGGGAAGTCGGCCTGAAGGACATCGTCCGGATGAAGGCCGCCGAGCTCGAGCGGGACCTCATCGT
GAAGAAGCTCGAGGAGACGGGTGGCAACGTCACCCGGGCCGCTCGGTTGCTTCAAATCAGCCGCAAGTCACTCCAGACGA
AGATGAAGGAGTTTGGCTTGCGCGACACCACACCAGACGGGCAGGAAGACGGTCCGGACGAATAG

Upstream 100 bases:

>100_bases
GCTGCTGCGCATCAAGCACCCGGACGCCATCTGCACGCTGGAGGGCGCCGGCGCCACGGAACGTCGCTAGTTCCGGTCGC
CCGCGGTCACGACTTCCACC

Downstream 100 bases:

>100_bases
ACCGCGAGGAAGCGGAATTCCGCTTCGCGCGCGTCGGTTCCGGGCCCGCCCACCCATTCCAACTCAGGGAGCTTGTATGC
GGCCGAACCTTCCCACACTC

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MAKVLVIDDEANLRKVLAAMLRRDGFDVTVAENGEQGLAEFHKNGADIVVTDLVMPKVGGMEVLGTIRAANPDVPVIIIT
AHGTVDSAVDAIKAGAFDYITKPFDQAELSSVVAKAAKTNESARRSVRPDVKARAAIIGDSSTIQEVYKIIDKVADTPST
VLITGESGTGKELIATALHGASSRRDKPFIKINCAAIPHTLLESELFGYERGAFTGAVTSKPGRFELADEGTLFLDEIGE
IPVEMQVKLLRAIQEGEFERVGGIKTTRVDVRLVAATNRDLQAEIEAGRFRKDLYYRLAVVPISLPALRERRSDVPMLAR
HFVEKYNRRLNKKIEGIADDAMALLQGYAWPGNIRELENLIERVLLFADGPLITARDLPEPVRQGTGVQAGANLASAVAS
IDVPTGEVGLKDIVRMKAAELERDLIVKKLEETGGNVTRAARLLQISRKSLQTKMKEFGLRDTTPDGQEDGPDE

Sequences:

>Translated_474_residues
MAKVLVIDDEANLRKVLAAMLRRDGFDVTVAENGEQGLAEFHKNGADIVVTDLVMPKVGGMEVLGTIRAANPDVPVIIIT
AHGTVDSAVDAIKAGAFDYITKPFDQAELSSVVAKAAKTNESARRSVRPDVKARAAIIGDSSTIQEVYKIIDKVADTPST
VLITGESGTGKELIATALHGASSRRDKPFIKINCAAIPHTLLESELFGYERGAFTGAVTSKPGRFELADEGTLFLDEIGE
IPVEMQVKLLRAIQEGEFERVGGIKTTRVDVRLVAATNRDLQAEIEAGRFRKDLYYRLAVVPISLPALRERRSDVPMLAR
HFVEKYNRRLNKKIEGIADDAMALLQGYAWPGNIRELENLIERVLLFADGPLITARDLPEPVRQGTGVQAGANLASAVAS
IDVPTGEVGLKDIVRMKAAELERDLIVKKLEETGGNVTRAARLLQISRKSLQTKMKEFGLRDTTPDGQEDGPDE
>Mature_473_residues
AKVLVIDDEANLRKVLAAMLRRDGFDVTVAENGEQGLAEFHKNGADIVVTDLVMPKVGGMEVLGTIRAANPDVPVIIITA
HGTVDSAVDAIKAGAFDYITKPFDQAELSSVVAKAAKTNESARRSVRPDVKARAAIIGDSSTIQEVYKIIDKVADTPSTV
LITGESGTGKELIATALHGASSRRDKPFIKINCAAIPHTLLESELFGYERGAFTGAVTSKPGRFELADEGTLFLDEIGEI
PVEMQVKLLRAIQEGEFERVGGIKTTRVDVRLVAATNRDLQAEIEAGRFRKDLYYRLAVVPISLPALRERRSDVPMLARH
FVEKYNRRLNKKIEGIADDAMALLQGYAWPGNIRELENLIERVLLFADGPLITARDLPEPVRQGTGVQAGANLASAVASI
DVPTGEVGLKDIVRMKAAELERDLIVKKLEETGGNVTRAARLLQISRKSLQTKMKEFGLRDTTPDGQEDGPDE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=464, Percent_Identity=44.3965517241379, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1790437, Length=452, Percent_Identity=45.7964601769911, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1790299, Length=463, Percent_Identity=41.036717062635, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1788905, Length=442, Percent_Identity=39.5927601809955, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI87082117, Length=330, Percent_Identity=47.8787878787879, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1789087, Length=327, Percent_Identity=46.7889908256881, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1789233, Length=363, Percent_Identity=39.6694214876033, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87082152, Length=330, Percent_Identity=43.030303030303, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI87081872, Length=325, Percent_Identity=41.5384615384615, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1786524, Length=399, Percent_Identity=34.3358395989975, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1787583, Length=331, Percent_Identity=35.9516616314199, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI87081858, Length=308, Percent_Identity=33.7662337662338, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1789828, Length=234, Percent_Identity=35.8974358974359, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786784, Length=107, Percent_Identity=34.5794392523364, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788191, Length=116, Percent_Identity=36.2068965517241, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786599, Length=109, Percent_Identity=30.2752293577982, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786911, Length=132, Percent_Identity=34.0909090909091, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789809, Length=107, Percent_Identity=33.6448598130841, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082052, Length=174, Percent_Identity=27.0114942528736, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI2367329, Length=109, Percent_Identity=37.6146788990826, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082012, Length=107, Percent_Identity=31.7757009345794, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790860, Length=110, Percent_Identity=30.9090909090909, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1787375, Length=118, Percent_Identity=28.8135593220339, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51526; Mature: 51395

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVLVIDDEANLRKVLAAMLRRDGFDVTVAENGEQGLAEFHKNGADIVVTDLVMPKVGG
CCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCC
MEVLGTIRAANPDVPVIIITAHGTVDSAVDAIKAGAFDYITKPFDQAELSSVVAKAAKTN
HHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCC
ESARRSVRPDVKARAAIIGDSSTIQEVYKIIDKVADTPSTVLITGESGTGKELIATALHG
HHHHHHCCCCCHHHEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHC
ASSRRDKPFIKINCAAIPHTLLESELFGYERGAFTGAVTSKPGRFELADEGTLFLDEIGE
CCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCEECCCCCCCCCEEECCCCCEEHHHHCC
IPVEMQVKLLRAIQEGEFERVGGIKTTRVDVRLVAATNRDLQAEIEAGRFRKDLYYRLAV
CCHHHHHHHHHHHHCCCHHHHCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHEEEE
VPISLPALRERRSDVPMLARHFVEKYNRRLNKKIEGIADDAMALLQGYAWPGNIRELENL
EECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IERVLLFADGPLITARDLPEPVRQGTGVQAGANLASAVASIDVPTGEVGLKDIVRMKAAE
HHHHHHHCCCCEEECCCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LERDLIVKKLEETGGNVTRAARLLQISRKSLQTKMKEFGLRDTTPDGQEDGPDE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKVLVIDDEANLRKVLAAMLRRDGFDVTVAENGEQGLAEFHKNGADIVVTDLVMPKVGG
CEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCC
MEVLGTIRAANPDVPVIIITAHGTVDSAVDAIKAGAFDYITKPFDQAELSSVVAKAAKTN
HHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCC
ESARRSVRPDVKARAAIIGDSSTIQEVYKIIDKVADTPSTVLITGESGTGKELIATALHG
HHHHHHCCCCCHHHEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHC
ASSRRDKPFIKINCAAIPHTLLESELFGYERGAFTGAVTSKPGRFELADEGTLFLDEIGE
CCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCEECCCCCCCCCEEECCCCCEEHHHHCC
IPVEMQVKLLRAIQEGEFERVGGIKTTRVDVRLVAATNRDLQAEIEAGRFRKDLYYRLAV
CCHHHHHHHHHHHHCCCHHHHCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHEEEE
VPISLPALRERRSDVPMLARHFVEKYNRRLNKKIEGIADDAMALLQGYAWPGNIRELENL
EECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IERVLLFADGPLITARDLPEPVRQGTGVQAGANLASAVASIDVPTGEVGLKDIVRMKAAE
HHHHHHHCCCCEEECCCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LERDLIVKKLEETGGNVTRAARLLQISRKSLQTKMKEFGLRDTTPDGQEDGPDE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]