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The map label for this gene is dhaT [H]

Identifier: 108757039

GI number: 108757039

Start: 6993823

End: 6995007

Strand: Reverse

Name: dhaT [H]

Synonym: MXAN_5629

Alternate gene names: 108757039

Gene position: 6995007-6993823 (Counterclockwise)

Preceding gene: 108757167

Following gene: 108763785

Centisome position: 76.53

GC content: 72.07

Gene sequence:

>1185_bases
ATGAAGCCGTTCGACATTCCCTCCGAGCCGCGCGTCACCGAGATGGCGTGGCCCACGCGCATCGTCTTCGGCGCCGGCGC
GCTGCTGCGCCTGCCCGCGCAGGCCCAGCGTCTGGGCATCCAGCGCCCGCTGCTGGTGACGGACGCGGGCGTGGTGAAGG
CGGGGCTGGCCGCGCGCGTGGCGGACGTGCTCAATACGGCGGGACTGGCCTGTGAAGTCTTCGACCGCGTGGAGCCCAAC
CCCACCGAGCGCGACGTCTTCGCGGGCCTGGAGGCGTACCGGAGCCACTCCTGCGACGGCATCGTCGCGCTGGGGGGCGG
CAGCGCCCTGGACGCGGGCAAGCTGATTCAGCTCCTCACCACACACGAGCCGCCGCTCAGCCGCTATGACGACGCGAAGG
GCGGCGACCAGTACGTGCGCGACGACCTGCCGCCGCTCATCGCGATTCCCACCACCGCGGGCACCGGCTCCGAGGTGGGG
CGCTCGGGCGTGGTGACGCTGGAGGACACGGGCCGCAAGACGGTCATCTTCAGTCCGTACCTGCTGCCGCGCGCCGCCAT
CTGCGACCCGGAGCTGACGCTGGGGCTGCCGCCGGGCATCACCGCGGCCACGGGCATGGATGCCTTCACCCACTGCCTGG
AGGCCTACCTGGCCAATGGCTTCCACCCGCTGGCGGACGCGGTGGCCATTGACGGCATCTACCGCGTGGGCCGTTCGCTG
GAGACGGCGGTGCGCGACGGCAAGGACCTGGCCGCGCGCACGGACATGATGGTGGCGGCGATGGAGGGCGCCATGGCCTT
CCAGAAGGGCCTGGGGGCCTGCCACGCGCTGGCCCACGCGCTCACGCCTGTGTCCAACGTGCACCACGGCCTGGCGAATG
CCATCGTCCTGCCCGTGGTGATGGAGTTCAACCGCGCGGTCTGCACGGCGCGGCTGGCCCGGGTCGCGGTGGCGCTGGGG
GACACGACGCAGGCGCGCGAAGAGGTGCTCGCGGGCAACGCCATCGACCGGGTGCGCAAGCTCAACGCGGCGGTGGGCAT
TCCCTCGCGGCTGCGCGACGCGGGCGTCCAGGAGAAGGACCTGGAGCGGATTGCCGAGAAGGCCTTCCAGGATGCCTCGC
ACCTGAGCAACCCGCGGAAGGTGTCGCAGGCGGACCTGCTGGCCCTGGCGCGCGAGGCCTACTGA

Upstream 100 bases:

>100_bases
CGCGCGAGTGGGAGGTGCGTCAGTACGAGCGCGCCGTCACCAACTGGGAGTTGGAGCGTTACCTGGAGCTCATCTGATGA
GCGCAAATGAGGCAGCCGTC

Downstream 100 bases:

>100_bases
GCCGCCGCCCGCCGGGGGAGGGGATTCCCCCGGCGCGCCGCTTCATGGCTCAGGGCGCTTCGTCCATGGCGCCCATGCCG
CTGCCCTCGGTGCCACCATC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKPFDIPSEPRVTEMAWPTRIVFGAGALLRLPAQAQRLGIQRPLLVTDAGVVKAGLAARVADVLNTAGLACEVFDRVEPN
PTERDVFAGLEAYRSHSCDGIVALGGGSALDAGKLIQLLTTHEPPLSRYDDAKGGDQYVRDDLPPLIAIPTTAGTGSEVG
RSGVVTLEDTGRKTVIFSPYLLPRAAICDPELTLGLPPGITAATGMDAFTHCLEAYLANGFHPLADAVAIDGIYRVGRSL
ETAVRDGKDLAARTDMMVAAMEGAMAFQKGLGACHALAHALTPVSNVHHGLANAIVLPVVMEFNRAVCTARLARVAVALG
DTTQAREEVLAGNAIDRVRKLNAAVGIPSRLRDAGVQEKDLERIAEKAFQDASHLSNPRKVSQADLLALAREAY

Sequences:

>Translated_394_residues
MKPFDIPSEPRVTEMAWPTRIVFGAGALLRLPAQAQRLGIQRPLLVTDAGVVKAGLAARVADVLNTAGLACEVFDRVEPN
PTERDVFAGLEAYRSHSCDGIVALGGGSALDAGKLIQLLTTHEPPLSRYDDAKGGDQYVRDDLPPLIAIPTTAGTGSEVG
RSGVVTLEDTGRKTVIFSPYLLPRAAICDPELTLGLPPGITAATGMDAFTHCLEAYLANGFHPLADAVAIDGIYRVGRSL
ETAVRDGKDLAARTDMMVAAMEGAMAFQKGLGACHALAHALTPVSNVHHGLANAIVLPVVMEFNRAVCTARLARVAVALG
DTTQAREEVLAGNAIDRVRKLNAAVGIPSRLRDAGVQEKDLERIAEKAFQDASHLSNPRKVSQADLLALAREAY
>Mature_394_residues
MKPFDIPSEPRVTEMAWPTRIVFGAGALLRLPAQAQRLGIQRPLLVTDAGVVKAGLAARVADVLNTAGLACEVFDRVEPN
PTERDVFAGLEAYRSHSCDGIVALGGGSALDAGKLIQLLTTHEPPLSRYDDAKGGDQYVRDDLPPLIAIPTTAGTGSEVG
RSGVVTLEDTGRKTVIFSPYLLPRAAICDPELTLGLPPGITAATGMDAFTHCLEAYLANGFHPLADAVAIDGIYRVGRSL
ETAVRDGKDLAARTDMMVAAMEGAMAFQKGLGACHALAHALTPVSNVHHGLANAIVLPVVMEFNRAVCTARLARVAVALG
DTTQAREEVLAGNAIDRVRKLNAAVGIPSRLRDAGVQEKDLERIAEKAFQDASHLSNPRKVSQADLLALAREAY

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=413, Percent_Identity=26.8765133171913, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI87082107, Length=390, Percent_Identity=38.974358974359, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI48994951, Length=378, Percent_Identity=35.978835978836, Blast_Score=224, Evalue=5e-60,
Organism=Escherichia coli, GI1789163, Length=387, Percent_Identity=35.6589147286822, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1787493, Length=422, Percent_Identity=31.9905213270142, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789386, Length=358, Percent_Identity=27.3743016759777, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17537053, Length=418, Percent_Identity=25.1196172248804, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321181, Length=386, Percent_Identity=38.0829015544041, Blast_Score=249, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24657991, Length=422, Percent_Identity=28.6729857819905, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41658; Mature: 41658

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFDIPSEPRVTEMAWPTRIVFGAGALLRLPAQAQRLGIQRPLLVTDAGVVKAGLAARV
CCCCCCCCCCCEEHHCCCHHHEECCCHHHHCCHHHHHCCCCCCEEEECCHHHHHHHHHHH
ADVLNTAGLACEVFDRVEPNPTERDVFAGLEAYRSHSCDGIVALGGGSALDAGKLIQLLT
HHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
THEPPLSRYDDAKGGDQYVRDDLPPLIAIPTTAGTGSEVGRSGVVTLEDTGRKTVIFSPY
CCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCHHHCCCCEEEEECCCCEEEEECCH
LLPRAAICDPELTLGLPPGITAATGMDAFTHCLEAYLANGFHPLADAVAIDGIYRVGRSL
HCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ETAVRDGKDLAARTDMMVAAMEGAMAFQKGLGACHALAHALTPVSNVHHGLANAIVLPVV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEFNRAVCTARLARVAVALGDTTQAREEVLAGNAIDRVRKLNAAVGIPSRLRDAGVQEKD
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHCCCCHHH
LERIAEKAFQDASHLSNPRKVSQADLLALAREAY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPFDIPSEPRVTEMAWPTRIVFGAGALLRLPAQAQRLGIQRPLLVTDAGVVKAGLAARV
CCCCCCCCCCCEEHHCCCHHHEECCCHHHHCCHHHHHCCCCCCEEEECCHHHHHHHHHHH
ADVLNTAGLACEVFDRVEPNPTERDVFAGLEAYRSHSCDGIVALGGGSALDAGKLIQLLT
HHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
THEPPLSRYDDAKGGDQYVRDDLPPLIAIPTTAGTGSEVGRSGVVTLEDTGRKTVIFSPY
CCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCHHHCCCCEEEEECCCCEEEEECCH
LLPRAAICDPELTLGLPPGITAATGMDAFTHCLEAYLANGFHPLADAVAIDGIYRVGRSL
HCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ETAVRDGKDLAARTDMMVAAMEGAMAFQKGLGACHALAHALTPVSNVHHGLANAIVLPVV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEFNRAVCTARLARVAVALGDTTQAREEVLAGNAIDRVRKLNAAVGIPSRLRDAGVQEKD
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHCCCCHHH
LERIAEKAFQDASHLSNPRKVSQADLLALAREAY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]