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The map label for this gene is acdA [H]

Identifier: 108756791

GI number: 108756791

Start: 4562030

End: 4563175

Strand: Reverse

Name: acdA [H]

Synonym: MXAN_3795

Alternate gene names: 108756791

Gene position: 4563175-4562030 (Counterclockwise)

Preceding gene: 108759786

Following gene: 108763761

Centisome position: 49.93

GC content: 69.28

Gene sequence:

>1146_bases
GTGAACCTCGAGCTCACCGAGACGCAGACCCTCATCCGCGACACCGCGCGCAAGTTCGCTCGCGAGCGCGTGGCCCCCCT
GGCCCGGACACTGGACCGCGAAGAGCGCTTTCCCACGGACCTCTTCCGGCAGTTGGGCGAGATGGGACTGCTGGGGGTGA
ACCTCCCGGCGCGCTACGGCGGTTCGGAGGCCGGCGTGGTGGCCTATGCGCTGGCGATGATGGAGATGGCCGCGGCCGAC
GCGTCCACGTCGGTGGCCATGGCCGTCACCAACATGTGCGGCGAGCTCATCAACGCGTTCGGCACCGACGCGCAGCGCGA
GAAGTACGTGACGCGGCTGGCGTCCGGCGAGGCCATCGCGGGCTCGTTCGCGCTGTCCGAGCCCCATGCGGGCTCCGACC
CCGGCGCGCTGCGCACCACCGCGGTGCGGCGCGGGGACGTGTGGGTCCTCAACGGCAGCAAGCAGTGGATCACCTCCGGC
GCGTACGCGGGGGTGATGGTGGTGTGGGCACGCACGTCCCCCGCCGGCAACAAGGGCTTGTCGTGCTTCATCGTCGAAGG
CGGGACGAAGGGGCTCATCATCGGCAAGCACGAGGACAAGATGGGCCTGCGCTCCTCGAACACGGTGTCGCTCACGTTCG
AGGACTGCGAGGTTCCGGCGGAGAACCTGCTGGGCGCCGAAGGGCAGGGCTTCAAGCTGGCCATGGTGGCGCTGGACGGT
GGGCGCATTGGCATCGCGGCGCAGGCCTGCGGCGTGGGGCGCGCGGCGCTCGAGGCGACCGTGGCCTACGTGAAGGACCG
TCAGGCGTTCGGCCAGCCCATTGGCGAGTTCCAGGGCCCGCGCTTCATGCTCGCGGACATGCAGACGCAGTTGGAGGCGG
CGGAGCTGCTGACGCTGCGTGCGGCGTCGATGAAGGAGAAGGGACAGCCGTTCTCCCGCGAGGCCTCCATGGCGAAGCTC
TTCGCCAGCGAGATGAGCAACAAGGTGGCCGACAAGGCCGTGCAGCTCCACGGCGGCTACGGCTACATCGACGAGTTCCC
GGTGGAGCGGTTCTTCCGCGACGCCCGCGTGCAGACCATCTACGAAGGCACCAGCGAGGTGCAGCGGATGGTGATCGCCC
GCGAGAGCTTCAAGCTCCTGGGCTGA

Upstream 100 bases:

>100_bases
GCCGTCCTGTCGTCCATGACCTTCCCGAAGCCTCCGGATGGCACGGACCGCCCCATCGAGTACCCGTTCAACCTCAAGGC
CATCGAGTAGGACAACCGCC

Downstream 100 bases:

>100_bases
CGGCCGGGAAGAAATCCGGGGCCGCCGGCGGTTGAGTGCGGCCCGGAGTTGGCCCTGGAATTTCAGGGCCTTGACTGCCT
GTTCGGGCACCAGGCTGGGG

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MNLELTETQTLIRDTARKFARERVAPLARTLDREERFPTDLFRQLGEMGLLGVNLPARYGGSEAGVVAYALAMMEMAAAD
ASTSVAMAVTNMCGELINAFGTDAQREKYVTRLASGEAIAGSFALSEPHAGSDPGALRTTAVRRGDVWVLNGSKQWITSG
AYAGVMVVWARTSPAGNKGLSCFIVEGGTKGLIIGKHEDKMGLRSSNTVSLTFEDCEVPAENLLGAEGQGFKLAMVALDG
GRIGIAAQACGVGRAALEATVAYVKDRQAFGQPIGEFQGPRFMLADMQTQLEAAELLTLRAASMKEKGQPFSREASMAKL
FASEMSNKVADKAVQLHGGYGYIDEFPVERFFRDARVQTIYEGTSEVQRMVIARESFKLLG

Sequences:

>Translated_381_residues
MNLELTETQTLIRDTARKFARERVAPLARTLDREERFPTDLFRQLGEMGLLGVNLPARYGGSEAGVVAYALAMMEMAAAD
ASTSVAMAVTNMCGELINAFGTDAQREKYVTRLASGEAIAGSFALSEPHAGSDPGALRTTAVRRGDVWVLNGSKQWITSG
AYAGVMVVWARTSPAGNKGLSCFIVEGGTKGLIIGKHEDKMGLRSSNTVSLTFEDCEVPAENLLGAEGQGFKLAMVALDG
GRIGIAAQACGVGRAALEATVAYVKDRQAFGQPIGEFQGPRFMLADMQTQLEAAELLTLRAASMKEKGQPFSREASMAKL
FASEMSNKVADKAVQLHGGYGYIDEFPVERFFRDARVQTIYEGTSEVQRMVIARESFKLLG
>Mature_381_residues
MNLELTETQTLIRDTARKFARERVAPLARTLDREERFPTDLFRQLGEMGLLGVNLPARYGGSEAGVVAYALAMMEMAAAD
ASTSVAMAVTNMCGELINAFGTDAQREKYVTRLASGEAIAGSFALSEPHAGSDPGALRTTAVRRGDVWVLNGSKQWITSG
AYAGVMVVWARTSPAGNKGLSCFIVEGGTKGLIIGKHEDKMGLRSSNTVSLTFEDCEVPAENLLGAEGQGFKLAMVALDG
GRIGIAAQACGVGRAALEATVAYVKDRQAFGQPIGEFQGPRFMLADMQTQLEAAELLTLRAASMKEKGQPFSREASMAKL
FASEMSNKVADKAVQLHGGYGYIDEFPVERFFRDARVQTIYEGTSEVQRMVIARESFKLLG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=48, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=42.8954423592493, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=39.8936170212766, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI7656849, Length=371, Percent_Identity=39.0835579514825, Blast_Score=274, Evalue=8e-74,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=38.3202099737533, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=38.3202099737533, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI226958414, Length=348, Percent_Identity=39.9425287356322, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=35.0267379679144, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI21361497, Length=366, Percent_Identity=37.1584699453552, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI76496475, Length=383, Percent_Identity=34.4647519582245, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4557235, Length=383, Percent_Identity=34.4647519582245, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4503943, Length=375, Percent_Identity=32.5333333333333, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=32.7823691460055, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI48976061, Length=392, Percent_Identity=29.5918367346939, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI211971008, Length=392, Percent_Identity=29.5918367346939, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI38505218, Length=351, Percent_Identity=28.7749287749288, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=31.3157894736842, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=30.8093994778068, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI87081702, Length=360, Percent_Identity=25.2777777777778, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082384, Length=338, Percent_Identity=25.4437869822485, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=41.2868632707775, Blast_Score=298, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=40.9574468085106, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=40.9921671018277, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=39.7368421052632, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=38.2585751978892, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=36.6310160427808, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17533517, Length=367, Percent_Identity=34.6049046321526, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71990804, Length=295, Percent_Identity=44.0677966101695, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=37.037037037037, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=34.4919786096257, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17505929, Length=380, Percent_Identity=33.9473684210526, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551932, Length=384, Percent_Identity=32.8125, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=276, Percent_Identity=31.5217391304348, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=39.1304347826087, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=298, Percent_Identity=35.5704697986577, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=33.4728033472803, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17562446, Length=294, Percent_Identity=28.9115646258503, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17531913, Length=177, Percent_Identity=32.7683615819209, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=337, Percent_Identity=25.8160237388724, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI86563381, Length=337, Percent_Identity=25.8160237388724, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=48.1182795698925, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=44.7089947089947, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=39.247311827957, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=38.3597883597884, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI21355753, Length=377, Percent_Identity=35.8090185676393, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI281363737, Length=376, Percent_Identity=33.7765957446808, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=30.9711286089239, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40991; Mature: 40991

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLELTETQTLIRDTARKFARERVAPLARTLDREERFPTDLFRQLGEMGLLGVNLPARYG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCCCCCC
GSEAGVVAYALAMMEMAAADASTSVAMAVTNMCGELINAFGTDAQREKYVTRLASGEAIA
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEE
GSFALSEPHAGSDPGALRTTAVRRGDVWVLNGSKQWITSGAYAGVMVVWARTSPAGNKGL
CCEEECCCCCCCCCCCHHHHEEECCCEEEECCCHHHHHCCCCEEEEEEEEECCCCCCCCC
SCFIVEGGTKGLIIGKHEDKMGLRSSNTVSLTFEDCEVPAENLLGAEGQGFKLAMVALDG
EEEEEECCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCEEEEEEEECC
GRIGIAAQACGVGRAALEATVAYVKDRQAFGQPIGEFQGPRFMLADMQTQLEAAELLTLR
CCEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEHHHHHHHHHHHHHHHH
AASMKEKGQPFSREASMAKLFASEMSNKVADKAVQLHGGYGYIDEFPVERFFRDARVQTI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHCCHHHHHHHHHHHHH
YEGTSEVQRMVIARESFKLLG
HCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLELTETQTLIRDTARKFARERVAPLARTLDREERFPTDLFRQLGEMGLLGVNLPARYG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCCCCCC
GSEAGVVAYALAMMEMAAADASTSVAMAVTNMCGELINAFGTDAQREKYVTRLASGEAIA
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEE
GSFALSEPHAGSDPGALRTTAVRRGDVWVLNGSKQWITSGAYAGVMVVWARTSPAGNKGL
CCEEECCCCCCCCCCCHHHHEEECCCEEEECCCHHHHHCCCCEEEEEEEEECCCCCCCCC
SCFIVEGGTKGLIIGKHEDKMGLRSSNTVSLTFEDCEVPAENLLGAEGQGFKLAMVALDG
EEEEEECCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCEEEEEEEECC
GRIGIAAQACGVGRAALEATVAYVKDRQAFGQPIGEFQGPRFMLADMQTQLEAAELLTLR
CCEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEHHHHHHHHHHHHHHHH
AASMKEKGQPFSREASMAKLFASEMSNKVADKAVQLHGGYGYIDEFPVERFFRDARVQTI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHCCHHHHHHHHHHHHH
YEGTSEVQRMVIARESFKLLG
HCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]