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The map label for this gene is pyrE [H]

Identifier: 108563626

GI number: 108563626

Start: 1264543

End: 1265148

Strand: Direct

Name: pyrE [H]

Synonym: HPAG1_1201

Alternate gene names: 108563626

Gene position: 1264543-1265148 (Clockwise)

Preceding gene: 108563625

Following gene: 108563627

Centisome position: 79.21

GC content: 43.89

Gene sequence:

>606_bases
ATGGATATTAAGGCATGTTATCAAAACGCTCAAGCGCTATTAGAGGGGCATTTCTTGCTCAGCAGCGGGTTTCATTCCAA
TTATTATTTGCAATCCGCTAAAGTCTTAGAAGATCCCAAACTAGCCGAACAATTAGCGCTAGAATTAGCCAAACAAATCC
AAGAAGCTCATTTGAATATTGAATGCGTTTGCTCGCCGGCTATTGGGGGGATCTTAGCTGGGTATGAGCTTGCAAGGGCT
TTGGGCGTGCGTTTTATCTTCACCGAAAGGGTGGATAATATTATGACATTAAGGCGTGGTTTTGAAGTCAAAAAAAACGA
AAAAATTTTAGTGTGCGAAGACATCATCACTACGGGAAAATCCGCCATGGAATGCGCTAAAGTTTTAGAAGAAAAGGGCG
CTCACATCGTGGCTTTTGGCGCTCTAGCCAATCGGGGCATTTGCAAGCGCGCTCATTCTCATTTAAAAGCCCAAGAGGGC
GCATGTTTGCCTAGCCATTTGCCCCTTTTTGCTTTAGAAGATTTTGTTTTTGACATGCACAAGCCTAGTTCTTGCCCTTT
ATGCGCTACTAGCGTTGCTATAAAGCCAGGAAGTCGTGGCAACTAA

Upstream 100 bases:

>100_bases
AAAAGCCCAAGAACAGATCCAAAAAATCACCGATGAAGCCATTAAAAAAATTGATGAAAGCGTGAAAAACAAAGAAGACG
CGATTTTAAAGGTCTAAAGC

Downstream 100 bases:

>100_bases
AAAAACCAAAAAAAATAAAACTCCAGAAAAAAAACGCGCTTTAGAAAACCCTTTAAAAGGGCTGAATCTCTCTTTACGCT
TAAAGGCCTTCATCACCGAT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MDIKACYQNAQALLEGHFLLSSGFHSNYYLQSAKVLEDPKLAEQLALELAKQIQEAHLNIECVCSPAIGGILAGYELARA
LGVRFIFTERVDNIMTLRRGFEVKKNEKILVCEDIITTGKSAMECAKVLEEKGAHIVAFGALANRGICKRAHSHLKAQEG
ACLPSHLPLFALEDFVFDMHKPSSCPLCATSVAIKPGSRGN

Sequences:

>Translated_201_residues
MDIKACYQNAQALLEGHFLLSSGFHSNYYLQSAKVLEDPKLAEQLALELAKQIQEAHLNIECVCSPAIGGILAGYELARA
LGVRFIFTERVDNIMTLRRGFEVKKNEKILVCEDIITTGKSAMECAKVLEEKGAHIVAFGALANRGICKRAHSHLKAQEG
ACLPSHLPLFALEDFVFDMHKPSSCPLCATSVAIKPGSRGN
>Mature_201_residues
MDIKACYQNAQALLEGHFLLSSGFHSNYYLQSAKVLEDPKLAEQLALELAKQIQEAHLNIECVCSPAIGGILAGYELARA
LGVRFIFTERVDNIMTLRRGFEVKKNEKILVCEDIITTGKSAMECAKVLEEKGAHIVAFGALANRGICKRAHSHLKAQEG
ACLPSHLPLFALEDFVFDMHKPSSCPLCATSVAIKPGSRGN

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 21955; Mature: 21955

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKACYQNAQALLEGHFLLSSGFHSNYYLQSAKVLEDPKLAEQLALELAKQIQEAHLNI
CCHHHHHHHHHHHHHHHHHEECCCCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHCCCE
ECVCSPAIGGILAGYELARALGVRFIFTERVDNIMTLRRGFEVKKNEKILVCEDIITTGK
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCH
SAMECAKVLEEKGAHIVAFGALANRGICKRAHSHLKAQEGACLPSHLPLFALEDFVFDMH
HHHHHHHHHHHCCCEEEEECCHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
KPSSCPLCATSVAIKPGSRGN
CCCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure
MDIKACYQNAQALLEGHFLLSSGFHSNYYLQSAKVLEDPKLAEQLALELAKQIQEAHLNI
CCHHHHHHHHHHHHHHHHHEECCCCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHCCCE
ECVCSPAIGGILAGYELARALGVRFIFTERVDNIMTLRRGFEVKKNEKILVCEDIITTGK
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCH
SAMECAKVLEEKGAHIVAFGALANRGICKRAHSHLKAQEGACLPSHLPLFALEDFVFDMH
HHHHHHHHHHHCCCEEEEECCHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
KPSSCPLCATSVAIKPGSRGN
CCCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA