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The map label for this gene is carA [H]

Identifier: 108563604

GI number: 108563604

Start: 1243015

End: 1244142

Strand: Direct

Name: carA [H]

Synonym: HPAG1_1179

Alternate gene names: 108563604

Gene position: 1243015-1244142 (Clockwise)

Preceding gene: 108563603

Following gene: 108563605

Centisome position: 77.87

GC content: 42.82

Gene sequence:

>1128_bases
ATGATCTCTCTCTATTTAGAAAACGGGCTTTTTTTAAAAGCGCAAAGTTTTGGGGCTAGCGGCACGCAAGTGGGCGAGCT
TGTTTTTAACACTTCTATGAGCGGCTATCAAGAAGTCATCAGCGACCCTAGCTATAAGGGGCAATTTGTGGTTTTTAGCA
TGCCTGAAATTGGGGTTGTGGGCACTAATTCTAAAGATGATGAATCCTTTTTTTCATGCACAGGGGTTTTAGCGCGCCAT
TACAACGAATTTTTTTCTAACTCAAGGGCGGATTTTAGCTTGAGCGCTTATTTGAAAGGGCGTGGCGTTTTAGGGGTTTG
TGGCGTTGATACTAGGAGTTTGATTAAAACCTTACGCCATCATGGGTGCTTGATGATGGTCGCTTCCACGATAGAGCATG
ACAAAAACAAGCTTGAAGAAATTTTAAAAAACGCTCCTAAAATTTCCCACTCCCCTCTAGTGTCTAGCGTTTCTGTGCAA
AAAATCACCACGCACCAGCGCGCGACTTTTGATTTCAAAACCCTAGATTACAAGCCTTTTGATGAAAAAATCTCTCATAA
AATTATCGCCGTGCTAGACTTTGGGGCTAAAGGCAATATCTTAAACGAGCTTCAAAATGTGGGGTTAAAAGCCCTTATTT
ACCCGCACCACACTAAAGCTAACGAGCTGATTAAAGCCTATGAAAAAAAAGAAATTAGCGGGATTTTCCTCTCTAATGGG
CCTGGCGATCCTTTGAGCTTGCAACAAGAAATTAAAGAAATCAAGCAACTCATTAACGCTAAAATCCCTATGTTTGGTAT
TTGCTTAGGGCATCAATTGCTCTCTATCGCGCAAGGCTATCCTACTTACAAGCTCAAATTTGGCCATCATGGGAGCAACC
ACCCCGTTAAAAACCTAAAAACAAACGCCGTTGAAATCACCGCACAAAACCACAACTATTGCGTCCCTGAAGCAATTGAA
GAAATCGCTATTATCACGCACCGCAATCTTTTTGACAACACCATTGAGGGCGTGCGCTATAAAAACGCTCCCATTATTTC
TGTCCAGCACCACCCAGAAAGCAGCCCCGGCCCCAAAGAGAGCCACTATATTTTTAAGGAATTTGTGGGATTGTTGGAGG
GTTCTTAG

Upstream 100 bases:

>100_bases
TCAAGCATTACAAACGCAAACTGCCCGTAGGGAGCGATGAATACGAGTTGGTGTTTGAAAGGCTCTATGAAGAAGAATTA
AGGCGTAAGGGCTTTTTATA

Downstream 100 bases:

>100_bases
GGGTTTTTAAAACAACACCCATAAAGGTTGAAAAGCGTTTTAAAAATAGATTTAAATCTTTTTATCAAAAAATCTCGCAT
TTACTCTAAATTAGCTCTCT

Product: carbamoyl phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MISLYLENGLFLKAQSFGASGTQVGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVVGTNSKDDESFFSCTGVLARH
YNEFFSNSRADFSLSAYLKGRGVLGVCGVDTRSLIKTLRHHGCLMMVASTIEHDKNKLEEILKNAPKISHSPLVSSVSVQ
KITTHQRATFDFKTLDYKPFDEKISHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
PGDPLSLQQEIKEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLKTNAVEITAQNHNYCVPEAIE
EIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKESHYIFKEFVGLLEGS

Sequences:

>Translated_375_residues
MISLYLENGLFLKAQSFGASGTQVGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVVGTNSKDDESFFSCTGVLARH
YNEFFSNSRADFSLSAYLKGRGVLGVCGVDTRSLIKTLRHHGCLMMVASTIEHDKNKLEEILKNAPKISHSPLVSSVSVQ
KITTHQRATFDFKTLDYKPFDEKISHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
PGDPLSLQQEIKEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLKTNAVEITAQNHNYCVPEAIE
EIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKESHYIFKEFVGLLEGS
>Mature_375_residues
MISLYLENGLFLKAQSFGASGTQVGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVVGTNSKDDESFFSCTGVLARH
YNEFFSNSRADFSLSAYLKGRGVLGVCGVDTRSLIKTLRHHGCLMMVASTIEHDKNKLEEILKNAPKISHSPLVSSVSVQ
KITTHQRATFDFKTLDYKPFDEKISHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
PGDPLSLQQEIKEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLKTNAVEITAQNHNYCVPEAIE
EIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKESHYIFKEFVGLLEGS

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=387, Percent_Identity=32.0413436692506, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI169790915, Length=383, Percent_Identity=30.0261096605744, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI21361331, Length=383, Percent_Identity=30.0261096605744, Blast_Score=172, Evalue=5e-43,
Organism=Escherichia coli, GI1786215, Length=378, Percent_Identity=39.6825396825397, Blast_Score=267, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI193204318, Length=383, Percent_Identity=31.0704960835509, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324878, Length=385, Percent_Identity=33.5064935064935, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322331, Length=398, Percent_Identity=31.4070351758794, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24642586, Length=392, Percent_Identity=31.1224489795918, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI45555749, Length=392, Percent_Identity=31.1224489795918, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase [H]

EC number: =6.3.5.5 [H]

Molecular weight: Translated: 41606; Mature: 41606

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLYLENGLFLKAQSFGASGTQVGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVV
CEEEEEECCEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCCEEE
GTNSKDDESFFSCTGVLARHYNEFFSNSRADFSLSAYLKGRGVLGVCGVDTRSLIKTLRH
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHH
HGCLMMVASTIEHDKNKLEEILKNAPKISHSPLVSSVSVQKITTHQRATFDFKTLDYKPF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCC
DEKISHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
HHHHCCEEEEEEECCCCCCHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECC
PGDPLSLQQEIKEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLK
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
TNAVEITAQNHNYCVPEAIEEIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKE
CCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHCCCEECCCCEEEEECCCCCCCCCCH
SHYIFKEFVGLLEGS
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MISLYLENGLFLKAQSFGASGTQVGELVFNTSMSGYQEVISDPSYKGQFVVFSMPEIGVV
CEEEEEECCEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCCEEE
GTNSKDDESFFSCTGVLARHYNEFFSNSRADFSLSAYLKGRGVLGVCGVDTRSLIKTLRH
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHH
HGCLMMVASTIEHDKNKLEEILKNAPKISHSPLVSSVSVQKITTHQRATFDFKTLDYKPF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCC
DEKISHKIIAVLDFGAKGNILNELQNVGLKALIYPHHTKANELIKAYEKKEISGIFLSNG
HHHHCCEEEEEEECCCCCCHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECC
PGDPLSLQQEIKEIKQLINAKIPMFGICLGHQLLSIAQGYPTYKLKFGHHGSNHPVKNLK
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
TNAVEITAQNHNYCVPEAIEEIAIITHRNLFDNTIEGVRYKNAPIISVQHHPESSPGPKE
CCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHCCCEECCCCEEEEECCCCCCCCCCH
SHYIFKEFVGLLEGS
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA