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The map label for this gene is folP-A [H]

Identifier: 108563599

GI number: 108563599

Start: 1238158

End: 1239300

Strand: Direct

Name: folP-A [H]

Synonym: HPAG1_1174

Alternate gene names: 108563599

Gene position: 1238158-1239300 (Clockwise)

Preceding gene: 108563598

Following gene: 108563601

Centisome position: 77.56

GC content: 40.07

Gene sequence:

>1143_bases
ATGATTGTAAAACGCCTTAACCCTGATGCGCTCAAAAACGCTCTACAAAAAATAGGCCCAGAAGAGATTGCGCAAAACCA
TATGCACCAAAAAGGCGTTAGCTTTGTTTTTGAAATCCAACATCTGCCCTTAAGCGCAACGCTCATTTTAAAGCAAGAGG
CCATAAGCGTTGGGGGCGATTTTGCCACGCCAAGAGATTGTATTTTAGCTAAAGAGCCTTTTTATGATGGGGTGTTGATT
GTGAGCGCTAGCCAGTTAGAACGCCTGATTGTGAAGTGCCACTCCCAACCCTTTGGGCTTAAACATTTAGCGCAAGAATT
AAAAAGCCATCTCAAAGCTAAAAAACCTAACGCCCCACAGATCATGGCAATTTTGAATCTCACGCCGGATAGCTTTTATG
AAAAGAGCCGTTTTAGTAGCAAAAAAGCGCTTGAAGAAATCTATCAATTACTAGAAAAGGGTATCACGCTCATTGATATA
GGCGCGGCCAGTTCAAGGCCAGAGAGTGAAATCATTGATCCAAAAACAGAGCAAGATCGCTTAAAAGAAATTTTATTAGA
GATCAAATCCCAAAAACTCTACCAATACGCTAAATTCAGCATAGACACCTACCATGCCAAAACGGCCCAAATGGCTTTGG
AACATCATTTTTCCATCCTTAATGATGTGAGCGGTTTTAATAGCGCTGAAATGCTAGAAGTCGCCAGAGATTACAAGCCC
ACTTGCATTTTAATGCATGCTCAAAAAACCCCCAAAGACATGCAAGAAAATGTTTTTTACCACAATTTATTTGATGAAAT
GGATCGCTTCTTTAAGGAAAAACTAGAGGTTTTAGAAAAATACGCGCTTCAAGATATTATTTTAGATATTGGGTTTGGAT
TCGCTAAATTAAAAGAGCATAATTTAGCCTTAATCAAGCATTTAAGCCACTTTCTCAAATTCAAAAAACCCTTATTGGTG
GGCGCGAGTCGTAAAAACACGATCGGGCTTATCACTGGGCGTGAAGTTCAAGACCGGCTCGCCGGCACTTTGAGTTTGCA
TTTAATGGCGTTGCAAAATGGAGCGAGCGTTTTAAGAGTGCATGATATTGATGAGCATATAGATTTAATCAAAGTGTTTA
AGAGTTTGGAAGAAACGGATTGA

Upstream 100 bases:

>100_bases
AAGCCTTTGATTTAGCGATCAAGGCTAACAGCTCTTATTACAAGCTCAGCTACAATCTTTTACCCCTACTTTTAAGCCTT
TTATCTAAAAAGAAAACGCC

Downstream 100 bases:

>100_bases
ACCAAAATTTTTAGCTTTGATCCCACTAGGCGTTGGTCATCATCAAAACGCTATTTTTGATGATCAATCCTTGATTAACC
CTAATCTTTAAAGAATCACA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MIVKRLNPDALKNALQKIGPEEIAQNHMHQKGVSFVFEIQHLPLSATLILKQEAISVGGDFATPRDCILAKEPFYDGVLI
VSASQLERLIVKCHSQPFGLKHLAQELKSHLKAKKPNAPQIMAILNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDI
GAASSRPESEIIDPKTEQDRLKEILLEIKSQKLYQYAKFSIDTYHAKTAQMALEHHFSILNDVSGFNSAEMLEVARDYKP
TCILMHAQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLV
GASRKNTIGLITGREVQDRLAGTLSLHLMALQNGASVLRVHDIDEHIDLIKVFKSLEETD

Sequences:

>Translated_380_residues
MIVKRLNPDALKNALQKIGPEEIAQNHMHQKGVSFVFEIQHLPLSATLILKQEAISVGGDFATPRDCILAKEPFYDGVLI
VSASQLERLIVKCHSQPFGLKHLAQELKSHLKAKKPNAPQIMAILNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDI
GAASSRPESEIIDPKTEQDRLKEILLEIKSQKLYQYAKFSIDTYHAKTAQMALEHHFSILNDVSGFNSAEMLEVARDYKP
TCILMHAQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLV
GASRKNTIGLITGREVQDRLAGTLSLHLMALQNGASVLRVHDIDEHIDLIKVFKSLEETD
>Mature_380_residues
MIVKRLNPDALKNALQKIGPEEIAQNHMHQKGVSFVFEIQHLPLSATLILKQEAISVGGDFATPRDCILAKEPFYDGVLI
VSASQLERLIVKCHSQPFGLKHLAQELKSHLKAKKPNAPQIMAILNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDI
GAASSRPESEIIDPKTEQDRLKEILLEIKSQKLYQYAKFSIDTYHAKTAQMALEHHFSILNDVSGFNSAEMLEVARDYKP
TCILMHAQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLV
GASRKNTIGLITGREVQDRLAGTLSLHLMALQNGASVLRVHDIDEHIDLIKVFKSLEETD

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=261, Percent_Identity=33.3333333333333, Blast_Score=151, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324073, Length=319, Percent_Identity=28.5266457680251, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 43177; Mature: 43177

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVKRLNPDALKNALQKIGPEEIAQNHMHQKGVSFVFEIQHLPLSATLILKQEAISVGGD
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEHHHHHHCCCC
FATPRDCILAKEPFYDGVLIVSASQLERLIVKCHSQPFGLKHLAQELKSHLKAKKPNAPQ
CCCCHHHEEECCCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
IMAILNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDIGAASSRPESEIIDPKTEQDR
EEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHH
LKEILLEIKSQKLYQYAKFSIDTYHAKTAQMALEHHFSILNDVSGFNSAEMLEVARDYKP
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
TCILMHAQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NLALIKHLSHFLKFKKPLLVGASRKNTIGLITGREVQDRLAGTLSLHLMALQNGASVLRV
HHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHHEECCCCCEEEE
HDIDEHIDLIKVFKSLEETD
ECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIVKRLNPDALKNALQKIGPEEIAQNHMHQKGVSFVFEIQHLPLSATLILKQEAISVGGD
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEHHHHHHCCCC
FATPRDCILAKEPFYDGVLIVSASQLERLIVKCHSQPFGLKHLAQELKSHLKAKKPNAPQ
CCCCHHHEEECCCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
IMAILNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDIGAASSRPESEIIDPKTEQDR
EEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHH
LKEILLEIKSQKLYQYAKFSIDTYHAKTAQMALEHHFSILNDVSGFNSAEMLEVARDYKP
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
TCILMHAQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NLALIKHLSHFLKFKKPLLVGASRKNTIGLITGREVQDRLAGTLSLHLMALQNGASVLRV
HHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHHEECCCCCEEEE
HDIDEHIDLIKVFKSLEETD
ECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]