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The map label for this gene is hemN [H]

Identifier: 108563593

GI number: 108563593

Start: 1233698

End: 1234756

Strand: Reverse

Name: hemN [H]

Synonym: HPAG1_1168

Alternate gene names: 108563593

Gene position: 1234756-1233698 (Counterclockwise)

Preceding gene: 108563600

Following gene: 108563589

Centisome position: 77.35

GC content: 37.49

Gene sequence:

>1059_bases
ATGAAAATGGGAGAAATAAATATGATTTTATACATTCATATCCCCTTTTGTGAAAATAAATGCGGTTATTGCGCTTTCAA
TTCCTATGAAAATAAGCATGGGCTAAAAGAAGAATACACTCAAGCGTTATGCCTGGATTTAAAGCATGCGTTAAATCAAA
CTGATGAACCAATTGAAAGCGTTTTTATTGGTGGCGGCACGCCTAACACTTTAAGCGTAGAGTCTTTTGAAAGGATTTTT
GAAAGCATTCATCACCATGCAAATTTGAGCATGGATTGTGAGATCACCACTGAAGCTAACCCCGAATTGATTACTAAAGC
TTGGTGTCAAGGCTTAAAAGATTTAGGGATCAACCGCTTGAGTTTAGGGGTGCAAAGTTTTAGGGAGGATAAATTATTGT
TTTTAGAGCGCCAACATTCCAAAAATATCGTTCCTGTGATAGAAACTATTTTAAAAAGCGGGATTGAAAATATCAGCATT
GATTTGATTTATAACACCCCATTAGACAATGAAAACTCTTTAAAAGAAGAACTAAAGCTCGCTAAAGAACTCCCTATCAA
CCACTTGAGCGCTTACGCTTTGAGTATTGAAAAAAACACGAATTTAGAAAAAAACGCCAAAAAACCCTCATACACCAATT
TTGACAATGTGGTGAGAGAGACTTTAGAGGGCTTTTCTTTCAAGCAATACGAAGTGTCTAATTACGCTAGAAATTATCAA
GTCAAGCATAATTTAGCTTATTGGGGGGCTAAAGATTATTTAGGGTGCGGGGCTGGGGCTGTAGGCTGCGTGGCGAATGA
GCGCTTTTATGCGAAAAAACTCATAGAAAACTACATCAAAGACCCCCTAAAACGCCAAGTTGAGACGCTTAATAAACAAG
ACAAGCGCTTAGAAAAGTTGTTTTTAGGCTTGAGGTGCGTGCTGGGGGTTGAGCTTGGTTTCTTAGATAAAAATAAAGTA
AAGTTTTTGATTGAAGAAAATAAGGCTTTCATTAAAAATAACCGATTGGTAGCGAGCGATTTTTTCATGGCCGATGAAAT
GGCTTTGTGGCTGTTGTGA

Upstream 100 bases:

>100_bases
CTAAAGCCATAATAACCTTTTTCATCGTTTATCTCCTCTACTTATCAAAATGATCTTAAAATGATACAATTACAAGTTTA
AGTTTTGCTTAAAAACGGAA

Downstream 100 bases:

>100_bases
TTGTAGGCTCTGCTTTAATCAAGCGTTAATAAAACGCCAAAAAGCGTTTTTTAATTAACGCCTACAAAATTTTTAGCCAA
AAACCAACCAATAGCTACCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKMGEINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALNQTDEPIESVFIGGGTPNTLSVESFERIF
ESIHHHANLSMDCEITTEANPELITKAWCQGLKDLGINRLSLGVQSFREDKLLFLERQHSKNIVPVIETILKSGIENISI
DLIYNTPLDNENSLKEELKLAKELPINHLSAYALSIEKNTNLEKNAKKPSYTNFDNVVRETLEGFSFKQYEVSNYARNYQ
VKHNLAYWGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQVETLNKQDKRLEKLFLGLRCVLGVELGFLDKNKV
KFLIEENKAFIKNNRLVASDFFMADEMALWLL

Sequences:

>Translated_352_residues
MKMGEINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALNQTDEPIESVFIGGGTPNTLSVESFERIF
ESIHHHANLSMDCEITTEANPELITKAWCQGLKDLGINRLSLGVQSFREDKLLFLERQHSKNIVPVIETILKSGIENISI
DLIYNTPLDNENSLKEELKLAKELPINHLSAYALSIEKNTNLEKNAKKPSYTNFDNVVRETLEGFSFKQYEVSNYARNYQ
VKHNLAYWGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQVETLNKQDKRLEKLFLGLRCVLGVELGFLDKNKV
KFLIEENKAFIKNNRLVASDFFMADEMALWLL
>Mature_352_residues
MKMGEINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALNQTDEPIESVFIGGGTPNTLSVESFERIF
ESIHHHANLSMDCEITTEANPELITKAWCQGLKDLGINRLSLGVQSFREDKLLFLERQHSKNIVPVIETILKSGIENISI
DLIYNTPLDNENSLKEELKLAKELPINHLSAYALSIEKNTNLEKNAKKPSYTNFDNVVRETLEGFSFKQYEVSNYARNYQ
VKHNLAYWGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQVETLNKQDKRLEKLFLGLRCVLGVELGFLDKNKV
KFLIEENKAFIKNNRLVASDFFMADEMALWLL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=264, Percent_Identity=32.1969696969697, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1789325, Length=272, Percent_Identity=36.7647058823529, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI87082341, Length=291, Percent_Identity=26.4604810996564, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 40324; Mature: 40324

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMGEINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALNQTDEPIES
CCCCCEEEEEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
VFIGGGTPNTLSVESFERIFESIHHHANLSMDCEITTEANPELITKAWCQGLKDLGINRL
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHH
SLGVQSFREDKLLFLERQHSKNIVPVIETILKSGIENISIDLIYNTPLDNENSLKEELKL
HHHHHHHCCCCEEEEEHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHH
AKELPINHLSAYALSIEKNTNLEKNAKKPSYTNFDNVVRETLEGFSFKQYEVSNYARNYQ
HHHCCHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHHHHHHCEE
VKHNLAYWGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQVETLNKQDKRLEKL
EEECEEECCCCHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
FLGLRCVLGVELGFLDKNKVKFLIEENKAFIKNNRLVASDFFMADEMALWLL
HHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHCCEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MKMGEINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALNQTDEPIES
CCCCCEEEEEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
VFIGGGTPNTLSVESFERIFESIHHHANLSMDCEITTEANPELITKAWCQGLKDLGINRL
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHH
SLGVQSFREDKLLFLERQHSKNIVPVIETILKSGIENISIDLIYNTPLDNENSLKEELKL
HHHHHHHCCCCEEEEEHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHH
AKELPINHLSAYALSIEKNTNLEKNAKKPSYTNFDNVVRETLEGFSFKQYEVSNYARNYQ
HHHCCHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHHHHHHCEE
VKHNLAYWGAKDYLGCGAGAVGCVANERFYAKKLIENYIKDPLKRQVETLNKQDKRLEKL
EEECEEECCCCHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
FLGLRCVLGVELGFLDKNKVKFLIEENKAFIKNNRLVASDFFMADEMALWLL
HHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHCCEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]