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The map label for this gene is hisS [H]

Identifier: 108563556

GI number: 108563556

Start: 1192870

End: 1194198

Strand: Reverse

Name: hisS [H]

Synonym: HPAG1_1131

Alternate gene names: 108563556

Gene position: 1194198-1192870 (Counterclockwise)

Preceding gene: 108563558

Following gene: 108563555

Centisome position: 74.81

GC content: 38.45

Gene sequence:

>1329_bases
ATGATTACCCCTAAAGTGTTGAGCGGGTTTAAAGACCGCTTGCCTAAAGATGCGATACAAAAAGCCCAATTGCTTGCGAA
AGTTTCAGTCGTGTTTCAAAGTTTTGGTTTTGTGCCGATTGAAACCCCCCATTTGGAATACGCTGAAGTATTATTGCCTG
ATGCGAGCAGTGATATTCAAAAAGAGATTTATCGTTTTAAAGACCATGGGGATAGAGATGTGGCTTTAAGGTTTGATTTG
ACCGTGCCATTAGCCCGCTTTGTTTCTTTGCACCACCAAATATTAGGCATGCCCTTTAAACGCTACGCTATAGGCAATGT
CTTTAGGGGCGAAAGGGCGCAAAAAGGGCGTTATAGGGAATTTACGCAATGCGATTTTGATTTTATAGGGAGCGAGAGCT
TGGTGTGCGATGCTGAGATCATTCAAGTGATTGTCGCTTCTTTAAAAGCCTTGGATTTAGAAGATTTTTGCGTCTCTATC
AACCACAGAAAAATTTTGAATGGGATATGCGAATATTTTGGCGTTTCTCAAGTGAATGAAGCGTTGCGCATTGTGGATAA
ATTGGAAAAAATTGGCCTAAATGGGGTTGAAGAAGAATTAAAAAAAGAGTGCGATTTGAATTCAAACACCATTAAAGAGC
TTTTAGAAATGGTTCAAATCAAACAAGACGATTTAAGCCATGCGGAATTTTTTGAAAAAATTGCTTATTTGAAAGACTAC
AATGAAAATCTAAAAAAAGGCATACAGGATTTAGAAAGGCTATACCAGTTGCTAGGGGATTTGCAAATTTCTCAAAACCT
GTATAAAATTGATTTTTCTATCGCTAGGGGGTTAGGGTATTATACAGGGATTGTGTATGAAACCACGCTTAATGAAATGA
AGTCTTTAGGGAGCGTGTGTTCAGGGGGGCGTTATGATCATTTGACTAAAAATTTTTCTAAAGAGAATTTACAAGGGGTA
GGGGCTTCTATTGGGATTGATCGATTGATTGTAGCTTTGAATGAAATGCAATTATTAGACGAACGCTCCACCCAAGCTAA
AGTCTTAATCGCTTGCATGCATGAAGAGTATTTTTCTTATGCAAACCGCTTAGCGGAGTCTTTAAGGCAAAGCGGGATTT
TTAGCGAAGTCTATCCAGAAGCTCAAAAAATCAAAAAACCCTTTTCTTATGCCAACCATAAAGGGCATGAGTTTGTGGCT
GTCATTGGCGAAGAAGAGTTTAAAAGCGAAACCTTAAGCTTGAAAAACATGCATTCAGGCATGCAGTTGAATTGCTTGAG
TTTTTTAAAAGCCCTTGAAATCATTGGAGAAAACGATGAAGACTTATAA

Upstream 100 bases:

>100_bases
CAATAAAATACGCATGCGTTTGGGCGCATTTACGCTCATCAATAGCCCTTTTTTAAAGATTTTAAGCTAAAATTTTAGCA
TACAAATACAAGGAAATGGA

Downstream 100 bases:

>100_bases
TGTCGCTATTGTCGGGGCTAGTGGGGCGGTAGGGCAAGAACTGATTAAAGGTTTAGAAAATTCTTCTTTCCCGATTAAAA
AATTTGTCCCGCTCGCTAGC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MITPKVLSGFKDRLPKDAIQKAQLLAKVSVVFQSFGFVPIETPHLEYAEVLLPDASSDIQKEIYRFKDHGDRDVALRFDL
TVPLARFVSLHHQILGMPFKRYAIGNVFRGERAQKGRYREFTQCDFDFIGSESLVCDAEIIQVIVASLKALDLEDFCVSI
NHRKILNGICEYFGVSQVNEALRIVDKLEKIGLNGVEEELKKECDLNSNTIKELLEMVQIKQDDLSHAEFFEKIAYLKDY
NENLKKGIQDLERLYQLLGDLQISQNLYKIDFSIARGLGYYTGIVYETTLNEMKSLGSVCSGGRYDHLTKNFSKENLQGV
GASIGIDRLIVALNEMQLLDERSTQAKVLIACMHEEYFSYANRLAESLRQSGIFSEVYPEAQKIKKPFSYANHKGHEFVA
VIGEEEFKSETLSLKNMHSGMQLNCLSFLKALEIIGENDEDL

Sequences:

>Translated_442_residues
MITPKVLSGFKDRLPKDAIQKAQLLAKVSVVFQSFGFVPIETPHLEYAEVLLPDASSDIQKEIYRFKDHGDRDVALRFDL
TVPLARFVSLHHQILGMPFKRYAIGNVFRGERAQKGRYREFTQCDFDFIGSESLVCDAEIIQVIVASLKALDLEDFCVSI
NHRKILNGICEYFGVSQVNEALRIVDKLEKIGLNGVEEELKKECDLNSNTIKELLEMVQIKQDDLSHAEFFEKIAYLKDY
NENLKKGIQDLERLYQLLGDLQISQNLYKIDFSIARGLGYYTGIVYETTLNEMKSLGSVCSGGRYDHLTKNFSKENLQGV
GASIGIDRLIVALNEMQLLDERSTQAKVLIACMHEEYFSYANRLAESLRQSGIFSEVYPEAQKIKKPFSYANHKGHEFVA
VIGEEEFKSETLSLKNMHSGMQLNCLSFLKALEIIGENDEDL
>Mature_442_residues
MITPKVLSGFKDRLPKDAIQKAQLLAKVSVVFQSFGFVPIETPHLEYAEVLLPDASSDIQKEIYRFKDHGDRDVALRFDL
TVPLARFVSLHHQILGMPFKRYAIGNVFRGERAQKGRYREFTQCDFDFIGSESLVCDAEIIQVIVASLKALDLEDFCVSI
NHRKILNGICEYFGVSQVNEALRIVDKLEKIGLNGVEEELKKECDLNSNTIKELLEMVQIKQDDLSHAEFFEKIAYLKDY
NENLKKGIQDLERLYQLLGDLQISQNLYKIDFSIARGLGYYTGIVYETTLNEMKSLGSVCSGGRYDHLTKNFSKENLQGV
GASIGIDRLIVALNEMQLLDERSTQAKVLIACMHEEYFSYANRLAESLRQSGIFSEVYPEAQKIKKPFSYANHKGHEFVA
VIGEEEFKSETLSLKNMHSGMQLNCLSFLKALEIIGENDEDL

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=436, Percent_Identity=32.1100917431193, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI15029520, Length=436, Percent_Identity=31.1926605504587, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI65287717, Length=414, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788861, Length=423, Percent_Identity=25.7683215130024, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71993686, Length=440, Percent_Identity=32.2727272727273, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71993693, Length=440, Percent_Identity=32.2727272727273, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6325290, Length=456, Percent_Identity=30.4824561403509, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6320489, Length=312, Percent_Identity=22.4358974358974, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24643061, Length=459, Percent_Identity=30.2832244008715, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24643059, Length=478, Percent_Identity=29.0794979079498, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 50260; Mature: 50260

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITPKVLSGFKDRLPKDAIQKAQLLAKVSVVFQSFGFVPIETPHLEYAEVLLPDASSDIQ
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCHHHH
KEIYRFKDHGDRDVALRFDLTVPLARFVSLHHQILGMPFKRYAIGNVFRGERAQKGRYRE
HHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHCCHHCCCCCCCCCCCH
FTQCDFDFIGSESLVCDAEIIQVIVASLKALDLEDFCVSINHRKILNGICEYFGVSQVNE
HHHCCCHHCCCCCCEECHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCHHHHHH
ALRIVDKLEKIGLNGVEEELKKECDLNSNTIKELLEMVQIKQDDLSHAEFFEKIAYLKDY
HHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NENLKKGIQDLERLYQLLGDLQISQNLYKIDFSIARGLGYYTGIVYETTLNEMKSLGSVC
HHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SGGRYDHLTKNFSKENLQGVGASIGIDRLIVALNEMQLLDERSTQAKVLIACMHEEYFSY
CCCCCHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ANRLAESLRQSGIFSEVYPEAQKIKKPFSYANHKGHEFVAVIGEEEFKSETLSLKNMHSG
HHHHHHHHHHCCCHHHHCCCHHHHHCCHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCC
MQLNCLSFLKALEIIGENDEDL
CCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MITPKVLSGFKDRLPKDAIQKAQLLAKVSVVFQSFGFVPIETPHLEYAEVLLPDASSDIQ
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCHHHH
KEIYRFKDHGDRDVALRFDLTVPLARFVSLHHQILGMPFKRYAIGNVFRGERAQKGRYRE
HHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHCCHHCCCCCCCCCCCH
FTQCDFDFIGSESLVCDAEIIQVIVASLKALDLEDFCVSINHRKILNGICEYFGVSQVNE
HHHCCCHHCCCCCCEECHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCHHHHHH
ALRIVDKLEKIGLNGVEEELKKECDLNSNTIKELLEMVQIKQDDLSHAEFFEKIAYLKDY
HHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NENLKKGIQDLERLYQLLGDLQISQNLYKIDFSIARGLGYYTGIVYETTLNEMKSLGSVC
HHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SGGRYDHLTKNFSKENLQGVGASIGIDRLIVALNEMQLLDERSTQAKVLIACMHEEYFSY
CCCCCHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ANRLAESLRQSGIFSEVYPEAQKIKKPFSYANHKGHEFVAVIGEEEFKSETLSLKNMHSG
HHHHHHHHHHCCCHHHHCCCHHHHHCCHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCC
MQLNCLSFLKALEIIGENDEDL
CCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA