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The map label for this gene is cah [H]

Identifier: 108563551

GI number: 108563551

Start: 1186622

End: 1187365

Strand: Direct

Name: cah [H]

Synonym: HPAG1_1126

Alternate gene names: 108563551

Gene position: 1186622-1187365 (Clockwise)

Preceding gene: 108563548

Following gene: 108563557

Centisome position: 74.33

GC content: 42.07

Gene sequence:

>744_bases
ATGAAAAAAACTTTTTTGATCGCTTTAGCGCTTACGGCTTCTCTTATAGGTGCTGAAAATACCCATTGGGATTATAAAAA
TAAAGAAAATGGCCCGCACCGCTGGGACAAATTGCACAAAGATTTTGAAGTGTGCAAAAGCGGTAAAAGCCAATCGCCCA
TCAACATTGAGCATTACTACCACACGCAAGATAAAGCCGATTTGCAATTCAAATACGCCGCTTCTAAACCTAAAGCAGTC
TTTTTCACCCACCACACTTTAAAGGCTTCATTTGAGCCGACTAACCACATCAATTATAGAGGGCATGACTATGTGCTGGA
TAATGTGCATTTCCACGCCCCTATGGAGTTTTTAATCAATAATAAAACCAGGCCTTTGAGCGCGCATTTCGTGCATAAAG
ACGCTAAAGGGCGTTTGTTAGTGTTAGCGATTGGTTTTGAAGAAGGAAAAGAAAACCCCAATCTTGATCCCATTTTAGAA
GGCATTCAAAAGAAACAAAATTTTAAAGAGGTGGCATTAGACGCTTTCTTGCCTAAAAGCATCAATTACTACCATTTTAA
CGGCTCTCTCACCGCTCCCCCTTGCACAGAGGGGGTGGCATGGTTTGTGATAGAAGAGCCTTTGGAAGTCTCTGCCAAAC
AATTGGCTGAAATCAAAAAACGCATGAAAAATTCGCCTAACCAACGCCCCGTTCAGCCTGACTACAACACCGTGATCATT
AAAAGCTCAGCTAAGACCCGCTAA

Upstream 100 bases:

>100_bases
ACCAATCTATTTTTTGTAACTGCGGTCATTGTTGATTAAGCGCTAGAATTAACCCATTGCTTTTTAATATTTTAGAATTT
TAGAACAAAGGATAATTAAA

Downstream 100 bases:

>100_bases
ATTTAAAACCCCCCTCTTTTAAAAGAGGGAGGTAAAAATCATTCTTCATAAAACGCCGCTAAAAATTGCAACCGCTTGTA
TTTTGTGAAACGCTCAAACG

Product: alpha-carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKKTFLIALALTASLIGAENTHWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAV
FFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILE
GIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSAKTR

Sequences:

>Translated_247_residues
MKKTFLIALALTASLIGAENTHWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAV
FFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILE
GIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSAKTR
>Mature_247_residues
MKKTFLIALALTASLIGAENTHWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAV
FFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILE
GIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSAKTR

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4557395, Length=260, Percent_Identity=28.4615384615385, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI258679498, Length=252, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI192447434, Length=252, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI192447432, Length=252, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI192447430, Length=252, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4502517, Length=252, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4885101, Length=260, Percent_Identity=25.3846153846154, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI38348436, Length=251, Percent_Identity=27.4900398406374, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI91208428, Length=90, Percent_Identity=43.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI22027500, Length=241, Percent_Identity=26.1410788381743, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4885099, Length=263, Percent_Identity=25.4752851711027, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI6005723, Length=260, Percent_Identity=25, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24645604, Length=276, Percent_Identity=25.3623188405797, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21358169, Length=275, Percent_Identity=27.6363636363636, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 28308; Mature: 28308

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTFLIALALTASLIGAENTHWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYY
CCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
HTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
ECCCCCCEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEECCEEECCCCEEEEC
NKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKS
CCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
INYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
CEEEEECCEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
KSSAKTR
ECCCCCC
>Mature Secondary Structure
MKKTFLIALALTASLIGAENTHWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYY
CCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
HTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
ECCCCCCEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEECCEEECCCCEEEEC
NKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKS
CCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
INYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
CEEEEECCEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
KSSAKTR
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]