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The map label for this gene is tcyB [H]

Identifier: 108563534

GI number: 108563534

Start: 1168119

End: 1168790

Strand: Direct

Name: tcyB [H]

Synonym: HPAG1_1109

Alternate gene names: 108563534

Gene position: 1168119-1168790 (Clockwise)

Preceding gene: 108563533

Following gene: 108563535

Centisome position: 73.17

GC content: 39.29

Gene sequence:

>672_bases
ATGGGAGTTTTACTAGAATTAGACAATCTCAAGCGTTTGTTAGAAGGGTTTGAAATTACTCTTTTGATCGCTCTTAGCTC
TGCGGTTATTTCAATCATTGTTGGAATGCTTTTGGGGAGCTTGATGGCGTTTGGTTCTCAAATAGTGGTTTTGGCGTGTC
GTGTATATTTAGAAAGCATTCGCATCATCCCGCTTTTAGCATGGCTTTTTATCGTGTATTTTGGGTTAGCGAGTTGGTTT
GATTTGCATATTAGCGCTGTTTGGGCGAGCGTTATTGTTTTTAGCTTGTGGGGTGGCGCTGAAATGATGGATTTGACTAG
AGGGGTTTTAACTTCCGTGAGCAAACACCAAATAGAAAGCGCTCTGGCTTTAGGCATGGATTCAAAAAGGGTGATTTTTA
ACATTATTTTCCCCCAAAGTTTTTTGTCTTTATTGCCCTCAAGCCTTAATTTATTCACGCGCATGATCAAAACCACGGCT
TTAGTCTCTCTCATTGGAGCGATTGATTTGTTAAAAGTGGGCCAGCAAATCATAGAGCTTAACCTCTTACGCATGCCCAA
TGCGAGCTTTGTGGTTTATGGCGTTATCTTAATGTTTTATTTTAGTTTATGCTATAGTTTGAGCCTGTATAGTTCCTATT
TAGAAAAAAAATTCCAACACATTAGAGGGTAA

Upstream 100 bases:

>100_bases
GCCTTTTGATGTTAAGTGTTGCTTATTTGATCGCTTTGCTCCCTTTAAGCGTTTTGTTTGTGATCTTAGAGCGTTTCTTT
AAAAAGAAAGTGGCTTAAAA

Downstream 100 bases:

>100_bases
AATGAGCGTGATTTTAGAAACCAAAGGGTTAAAAAAAACCTATCAAAACCATTTGGTTTTAGACGGCATCAATTTCACTT
TAAACAAGGGTGAAGTGGCA

Product: glutamine ABC transporter, permease protein

Products: ADP; phosphate; L-glutamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MGVLLELDNLKRLLEGFEITLLIALSSAVISIIVGMLLGSLMAFGSQIVVLACRVYLESIRIIPLLAWLFIVYFGLASWF
DLHISAVWASVIVFSLWGGAEMMDLTRGVLTSVSKHQIESALALGMDSKRVIFNIIFPQSFLSLLPSSLNLFTRMIKTTA
LVSLIGAIDLLKVGQQIIELNLLRMPNASFVVYGVILMFYFSLCYSLSLYSSYLEKKFQHIRG

Sequences:

>Translated_223_residues
MGVLLELDNLKRLLEGFEITLLIALSSAVISIIVGMLLGSLMAFGSQIVVLACRVYLESIRIIPLLAWLFIVYFGLASWF
DLHISAVWASVIVFSLWGGAEMMDLTRGVLTSVSKHQIESALALGMDSKRVIFNIIFPQSFLSLLPSSLNLFTRMIKTTA
LVSLIGAIDLLKVGQQIIELNLLRMPNASFVVYGVILMFYFSLCYSLSLYSSYLEKKFQHIRG
>Mature_222_residues
GVLLELDNLKRLLEGFEITLLIALSSAVISIIVGMLLGSLMAFGSQIVVLACRVYLESIRIIPLLAWLFIVYFGLASWFD
LHISAVWASVIVFSLWGGAEMMDLTRGVLTSVSKHQIESALALGMDSKRVIFNIIFPQSFLSLLPSSLNLFTRMIKTTAL
VSLIGAIDLLKVGQQIIELNLLRMPNASFVVYGVILMFYFSLCYSLSLYSSYLEKKFQHIRG

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787030, Length=208, Percent_Identity=29.8076923076923, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788226, Length=218, Percent_Identity=25.6880733944954, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87082239, Length=222, Percent_Identity=29.2792792792793, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788646, Length=173, Percent_Identity=28.9017341040462, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786873, Length=221, Percent_Identity=26.6968325791855, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24851; Mature: 24720

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLLELDNLKRLLEGFEITLLIALSSAVISIIVGMLLGSLMAFGSQIVVLACRVYLESI
CCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIIPLLAWLFIVYFGLASWFDLHISAVWASVIVFSLWGGAEMMDLTRGVLTSVSKHQIES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ALALGMDSKRVIFNIIFPQSFLSLLPSSLNLFTRMIKTTALVSLIGAIDLLKVGQQIIEL
HHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLRMPNASFVVYGVILMFYFSLCYSLSLYSSYLEKKFQHIRG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVLLELDNLKRLLEGFEITLLIALSSAVISIIVGMLLGSLMAFGSQIVVLACRVYLESI
CEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIIPLLAWLFIVYFGLASWFDLHISAVWASVIVFSLWGGAEMMDLTRGVLTSVSKHQIES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ALALGMDSKRVIFNIIFPQSFLSLLPSSLNLFTRMIKTTALVSLIGAIDLLKVGQQIIEL
HHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLRMPNASFVVYGVILMFYFSLCYSLSLYSSYLEKKFQHIRG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-glutamine [Periplasm]; H2O [C]

Specific reaction: ATP + L-glutamine [Periplasm] + H2O = ADP + phosphate + L-glutamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]