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The map label for this gene is atpA [H]

Identifier: 108563497

GI number: 108563497

Start: 1127034

End: 1128545

Strand: Reverse

Name: atpA [H]

Synonym: HPAG1_1072

Alternate gene names: 108563497

Gene position: 1128545-1127034 (Counterclockwise)

Preceding gene: 108563498

Following gene: 108563496

Centisome position: 70.69

GC content: 44.18

Gene sequence:

>1512_bases
ATGTCCCAACTAAAATTGGAAGAAATCAGCTCGGTTATTGAAGAAAAAATCAAGAATTTTGAACTTGATTGCGATATGGC
TGAAGTAGGAAAAGTCGTTTCATACGCTGATGGTGTGGCTAAGGTTTATGGCTTAAATGGTGTGATGTCGTATGAAGTGC
TGGAGTTTGAAACAGGGGATAAAGGCGTTGCGGCTAACTTAGAAGAAGATAGCGTTGGCGTGATTGTGTTTGGTTTTGGC
AACAATATTAAAGAGGGGACTAGCGTTAAACGCACGAAAAATTTGATGAAAGTTCCTGTTGGCGATGCGGTTGTGGGGCG
TGTGTTGAACGCTTTGGGTGAGCCTATTGATGGCAAGGGTGAGATAGAAACGAATGAATTTAGTCTCATCGAGCAAAAAG
CCCCGGGCATTATGGACAGAAAATCGGTGCATGAGCCTTTACAAACTGGCATTAAAGCCATTGATGCGTTGGTGCCTATT
GGGCGCGGGCAAAGGGAATTGATCATTGGGGATAAACAAACCGGTAAAACCACCGTAGCGATCGATGCGATCATTAACCA
AAAAGGGCAAAATGTGATCTGTATCTATGTGGCTATTGGGCAAAAAGAATCCACTGTCGCGCAAGTGGTCCGCAAATTAG
AAGAATATGGGGCGATGGAATACAGCGTCGTGATCAACGCTTCGGCTTCAGATTCAGCTGCAATGCAATATTTAGCCCCT
TATTCAGGTGTGGCTATGGGGGAATACTTTAGAGATCATGCCCGCCATGCCCTAATCGTTTATGATGATTTGAGTAAGCA
TGCTGTCGCTTACAGAGAAATTTCTTTGATTTTGAGAAGACCCCCAGGTAGGGAGGCTTTTCCTGGAGACGTGTTTTATA
TCCACTCACGGCTTTTAGAAAGAGCGGCTAAACTTTGCGATGAAAAGGGTGCCGGCTCTTTGACCGCACTCCCTATTGTG
GAAACTCAAGCGGGCGATGTTTCAGCTTATATCCCTACGAATATCATTTCTATTACAGACGGGCAAATTTTCTTAGAAAC
GGATTTGTTTTATTCAGGGATTCGCCCGGCTATTAATGTGGGCTTGTCGGTTTCAAGGGTTGGAGGGGCCGCTCAAATCA
AAGCGACCAAGCAGGTTTCAGGGACTTTGCGCTTGGATTTAGCGCAATACAGAGAGTTGCAAGCTTTCACGCAATTCGCT
TCTGATTTAGATGAAGCGAGTAAAAAGCAATTAGAAAGGGGGCAACGCATGGTGGAAGTGCTGAAACAAGCCCCTTATTC
ACCCTTGCCTATTGAAAAGCAAGTGGTCATTATTTATGCTGGGGCTAAAGGCTTTTTAGACAGCGTGAGCGTGAAAAAAG
TCGTGGATTTTGAAGAGCAACTGCACCCTTTCTTGGAAGCAAAATACCCCCAAGTTTTAGAAGAAATCCACACTAAAAAA
GCGCTAGATAAGGATTTAGAAGCCATGCTAAGAAAAGTCTTAGAGGAATTTAAGCTCACTTATAGCGAGTAG

Upstream 100 bases:

>100_bases
AGCCTGGATTTAGAAATAGGCTTTTCTAAAGAAGATATTTTAAAGAAAATAGAAAAACAGGTTATTCAATCTATTTAATC
AATCTAAGGAGATAAAGATA

Downstream 100 bases:

>100_bases
GAGACGGCTAGAATATGGCGAATTTAAGAGACATTAGAAAGAAAATTGGAAGCGTTAAAAACACGCAAAAAATCACGCAT
GCGATGAAACTCGTTTCCAC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MSQLKLEEISSVIEEKIKNFELDCDMAEVGKVVSYADGVAKVYGLNGVMSYEVLEFETGDKGVAANLEEDSVGVIVFGFG
NNIKEGTSVKRTKNLMKVPVGDAVVGRVLNALGEPIDGKGEIETNEFSLIEQKAPGIMDRKSVHEPLQTGIKAIDALVPI
GRGQRELIIGDKQTGKTTVAIDAIINQKGQNVICIYVAIGQKESTVAQVVRKLEEYGAMEYSVVINASASDSAAMQYLAP
YSGVAMGEYFRDHARHALIVYDDLSKHAVAYREISLILRRPPGREAFPGDVFYIHSRLLERAAKLCDEKGAGSLTALPIV
ETQAGDVSAYIPTNIISITDGQIFLETDLFYSGIRPAINVGLSVSRVGGAAQIKATKQVSGTLRLDLAQYRELQAFTQFA
SDLDEASKKQLERGQRMVEVLKQAPYSPLPIEKQVVIIYAGAKGFLDSVSVKKVVDFEEQLHPFLEAKYPQVLEEIHTKK
ALDKDLEAMLRKVLEEFKLTYSE

Sequences:

>Translated_503_residues
MSQLKLEEISSVIEEKIKNFELDCDMAEVGKVVSYADGVAKVYGLNGVMSYEVLEFETGDKGVAANLEEDSVGVIVFGFG
NNIKEGTSVKRTKNLMKVPVGDAVVGRVLNALGEPIDGKGEIETNEFSLIEQKAPGIMDRKSVHEPLQTGIKAIDALVPI
GRGQRELIIGDKQTGKTTVAIDAIINQKGQNVICIYVAIGQKESTVAQVVRKLEEYGAMEYSVVINASASDSAAMQYLAP
YSGVAMGEYFRDHARHALIVYDDLSKHAVAYREISLILRRPPGREAFPGDVFYIHSRLLERAAKLCDEKGAGSLTALPIV
ETQAGDVSAYIPTNIISITDGQIFLETDLFYSGIRPAINVGLSVSRVGGAAQIKATKQVSGTLRLDLAQYRELQAFTQFA
SDLDEASKKQLERGQRMVEVLKQAPYSPLPIEKQVVIIYAGAKGFLDSVSVKKVVDFEEQLHPFLEAKYPQVLEEIHTKK
ALDKDLEAMLRKVLEEFKLTYSE
>Mature_502_residues
SQLKLEEISSVIEEKIKNFELDCDMAEVGKVVSYADGVAKVYGLNGVMSYEVLEFETGDKGVAANLEEDSVGVIVFGFGN
NIKEGTSVKRTKNLMKVPVGDAVVGRVLNALGEPIDGKGEIETNEFSLIEQKAPGIMDRKSVHEPLQTGIKAIDALVPIG
RGQRELIIGDKQTGKTTVAIDAIINQKGQNVICIYVAIGQKESTVAQVVRKLEEYGAMEYSVVINASASDSAAMQYLAPY
SGVAMGEYFRDHARHALIVYDDLSKHAVAYREISLILRRPPGREAFPGDVFYIHSRLLERAAKLCDEKGAGSLTALPIVE
TQAGDVSAYIPTNIISITDGQIFLETDLFYSGIRPAINVGLSVSRVGGAAQIKATKQVSGTLRLDLAQYRELQAFTQFAS
DLDEASKKQLERGQRMVEVLKQAPYSPLPIEKQVVIIYAGAKGFLDSVSVKKVVDFEEQLHPFLEAKYPQVLEEIHTKKA
LDKDLEAMLRKVLEEFKLTYSE

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=498, Percent_Identity=59.2369477911647, Blast_Score=611, Evalue=1e-175,
Organism=Homo sapiens, GI4757810, Length=498, Percent_Identity=59.2369477911647, Blast_Score=611, Evalue=1e-175,
Organism=Homo sapiens, GI19913428, Length=299, Percent_Identity=28.7625418060201, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI19913426, Length=298, Percent_Identity=27.5167785234899, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI32189394, Length=417, Percent_Identity=24.220623501199, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI19913424, Length=247, Percent_Identity=25.9109311740891, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790172, Length=511, Percent_Identity=54.7945205479452, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1790170, Length=385, Percent_Identity=24.9350649350649, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788251, Length=376, Percent_Identity=27.6595744680851, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71988063, Length=502, Percent_Identity=58.5657370517928, Blast_Score=614, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI71988080, Length=502, Percent_Identity=58.5657370517928, Blast_Score=613, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI71988074, Length=502, Percent_Identity=54.9800796812749, Blast_Score=563, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17510931, Length=297, Percent_Identity=28.956228956229, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=299, Percent_Identity=29.0969899665552, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25144756, Length=420, Percent_Identity=23.3333333333333, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71988068, Length=71, Percent_Identity=47.887323943662, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=58, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565854, Length=246, Percent_Identity=25.609756097561, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=58.1673306772908, Blast_Score=622, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6319603, Length=299, Percent_Identity=28.7625418060201, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=428, Percent_Identity=25.7009345794392, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24658560, Length=502, Percent_Identity=59.7609561752988, Blast_Score=615, Evalue=1e-176,
Organism=Drosophila melanogaster, GI281361666, Length=301, Percent_Identity=28.2392026578073, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646341, Length=301, Percent_Identity=28.2392026578073, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136796, Length=301, Percent_Identity=28.2392026578073, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574560, Length=407, Percent_Identity=26.7813267813268, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24638766, Length=413, Percent_Identity=23.728813559322, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24583988, Length=254, Percent_Identity=26.7716535433071, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24583986, Length=254, Percent_Identity=26.7716535433071, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24583984, Length=254, Percent_Identity=26.7716535433071, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24583992, Length=254, Percent_Identity=26.7716535433071, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20129479, Length=227, Percent_Identity=29.5154185022026, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55157; Mature: 55026

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLKLEEISSVIEEKIKNFELDCDMAEVGKVVSYADGVAKVYGLNGVMSYEVLEFETGD
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCEEEEEEEEEECCC
KGVAANLEEDSVGVIVFGFGNNIKEGTSVKRTKNLMKVPVGDAVVGRVLNALGEPIDGKG
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
EIETNEFSLIEQKAPGIMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDKQTGKTTVA
CEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEE
IDAIINQKGQNVICIYVAIGQKESTVAQVVRKLEEYGAMEYSVVINASASDSAAMQYLAP
EEEHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHCC
YSGVAMGEYFRDHARHALIVYDDLSKHAVAYREISLILRRPPGREAFPGDVFYIHSRLLE
CCCCHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHH
RAAKLCDEKGAGSLTALPIVETQAGDVSAYIPTNIISITDGQIFLETDLFYSGIRPAINV
HHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECHHHHCCCHHHHC
GLSVSRVGGAAQIKATKQVSGTLRLDLAQYRELQAFTQFASDLDEASKKQLERGQRMVEV
CEEEECCCCCEEEEEHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQAPYSPLPIEKQVVIIYAGAKGFLDSVSVKKVVDFEEQLHPFLEAKYPQVLEEIHTKK
HHHCCCCCCCCCCEEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ALDKDLEAMLRKVLEEFKLTYSE
HHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SQLKLEEISSVIEEKIKNFELDCDMAEVGKVVSYADGVAKVYGLNGVMSYEVLEFETGD
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCEEEEEEEEEECCC
KGVAANLEEDSVGVIVFGFGNNIKEGTSVKRTKNLMKVPVGDAVVGRVLNALGEPIDGKG
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
EIETNEFSLIEQKAPGIMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDKQTGKTTVA
CEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEE
IDAIINQKGQNVICIYVAIGQKESTVAQVVRKLEEYGAMEYSVVINASASDSAAMQYLAP
EEEHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHCC
YSGVAMGEYFRDHARHALIVYDDLSKHAVAYREISLILRRPPGREAFPGDVFYIHSRLLE
CCCCHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHH
RAAKLCDEKGAGSLTALPIVETQAGDVSAYIPTNIISITDGQIFLETDLFYSGIRPAINV
HHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECHHHHCCCHHHHC
GLSVSRVGGAAQIKATKQVSGTLRLDLAQYRELQAFTQFASDLDEASKKQLERGQRMVEV
CEEEECCCCCEEEEEHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQAPYSPLPIEKQVVIIYAGAKGFLDSVSVKKVVDFEEQLHPFLEAKYPQVLEEIHTKK
HHHCCCCCCCCCCEEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ALDKDLEAMLRKVLEEFKLTYSE
HHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA