Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 108563420

GI number: 108563420

Start: 1048774

End: 1050348

Strand: Direct

Name: serA [H]

Synonym: HPAG1_0995

Alternate gene names: 108563420

Gene position: 1048774-1050348 (Clockwise)

Preceding gene: 108563419

Following gene: 108563421

Centisome position: 65.7

GC content: 40.63

Gene sequence:

>1575_bases
ATGTATCAAGTAGCCATTTGCGACCCCATCCATGCTAAAGGCATTCAAATTTTAGAATCTCAAAAAGACATTGTCTTGCA
TGATTATTCCAAATGCCCTAAAAAGGAGCTTTTAGAAAAACTCACTCCCATGGATGCACTCATCACGCGCAGCATGACCC
CTATCACAAGCGATTTTTTAAAGCCCTTAACCCACTTAAAATCCATTGTGAGAGCGGGCGTGGGAGTGGATAATATTGAT
TTAGAAAGTTGCTCTCAAAAAGGCATTGTCGTGATGAATATCCCTACCGCTAACACGATTGCCGCTGTGGAATTAACCAT
GGCGCATTTGATCAATGCGGTGCGCTCGTTCCCTTGCGCGAACGATCAAATCAAACACCAAAGGTTATGGAAAAGAGAAG
ATTGGTATGGCACGGAATTGAAAAATAAAAAGCTGGGCATCATTGGTTTTGGGAATATTGGCTCTAGGGTGGGCATTAGA
GCAAAAGCCTTTGAAATGGAAGTCCTAGCCTATGATCCTTATATCCCTTCTTCAAAAGCCACTGATTTGGGGGTCATTTA
CACAAAAAATTTTGAAGACATTTTGCAATGCGATATGATCACTATCCACACCCCTAAAAATAAAGAAACCATTAACATGA
TAGGCACTAAAGAGATCGAACGCATGAAAAAAGGGGTTATTTTAATTAATTGTGCTAGAGGGGGGCTTTATAATGAAGAC
GCTCTTTATGAAGCCTTAGAAACCAAAAAAGTGCGTTGGCTTGGCATTGATGTCTTTTCTAAAGAGCCTGGCATTCATAA
CAAGCTTTTAGACTTGACTAATGTTTATGCGACCCCCCATATTGGCGCAAACACTTTAGAATCCCAAGAAGAAATTTCCA
AACAAGCCGCTCAAGGGGTTATGGAATCTTTAAGGGGTTCAAGCCACCCGCATGCTTTGAATTTACCCATGCAAGCTTTT
GATGCAAGCGCGAAAGCCTACTTGAATTTAGCGCAAAAATTGGGTTATTTTTCCAGTCAAATCCATAAAGGCGTGTGCCA
AAAAATTGAGATTAGTCTTTGTGGGGAGATCAACCAATTTAAAGACGCTCTTGTAGCCTTTACGTTAGTGGGGGTGTTAA
AACCTGTTGTAGGGGATAAAATCAATTACATTAACGCCCCTTTTGTGGCCAAAGAAAGAGGCATTGAGATTAAGGTTAGC
CTTAAAGAAAGCGCTTCGCCCTATAAAAACATGCTCTCTTTAACTCTAAATGCGGCTAATGGTTCAATCAGCGTGAGCGG
CACGGTGTTTGAAGAAGATATTTTAAAACTCACTGAGATTGATGGGTTCCATATTGATATAGAGCCAAAAGGTAAAATGC
TTCTATTTAGGAATACGGATATTCCAGGCGTTATTGGGAGTGTGGGGAATGCGTTCGCTAGGCATGGCATTAACATCGCT
GATTTTCGTTTGGGGCGTAACACGCAAAAAGAAGCCCTAGCGCTCATTATTGTAGATGAAGAAGTTTCTTTGGAAGTTTT
AGAAGAGCTTAAAAATATTCCTGCATGCTTAAGCGTTCATTATGTGGTTATTTAA

Upstream 100 bases:

>100_bases
CATCATCTATTTAGACAAAAACAAAAAAGAACGCTTTTTAGCTGATTTAGACTATTATAAAATACGCTATCATGCTGTTT
TTTAAATTCAAAGGATAAAA

Downstream 100 bases:

>100_bases
GGTAGTTGGATGCGAGATTTTTTAAAGCTTTTAAAAAAACATAATGAATTAGAAGTCATTGACACCCCCCTTGAAGTGGA
TTTAGAAATCGCTCATCTGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MYQVAICDPIHAKGIQILESQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYNED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLTNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASAKAYLNLAQKLGYFSSQIHKGVCQKIEISLCGEINQFKDALVAFTLVGVLKPVVGDKINYINAPFVAKERGIEIKVS
LKESASPYKNMLSLTLNAANGSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI

Sequences:

>Translated_524_residues
MYQVAICDPIHAKGIQILESQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYNED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLTNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASAKAYLNLAQKLGYFSSQIHKGVCQKIEISLCGEINQFKDALVAFTLVGVLKPVVGDKINYINAPFVAKERGIEIKVS
LKESASPYKNMLSLTLNAANGSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
>Mature_524_residues
MYQVAICDPIHAKGIQILESQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYNED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLTNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASAKAYLNLAQKLGYFSSQIHKGVCQKIEISLCGEINQFKDALVAFTLVGVLKPVVGDKINYINAPFVAKERGIEIKVS
LKESASPYKNMLSLTLNAANGSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=396, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=5e-58,
Organism=Homo sapiens, GI61743967, Length=283, Percent_Identity=31.4487632508834, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4557497, Length=270, Percent_Identity=31.8518518518519, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI145580578, Length=283, Percent_Identity=31.4487632508834, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI4557499, Length=283, Percent_Identity=31.4487632508834, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=31.8518518518519, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=30.5882352941176, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1789279, Length=321, Percent_Identity=32.398753894081, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082289, Length=266, Percent_Identity=28.9473684210526, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=28.2442748091603, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=29.6577946768061, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081824, Length=246, Percent_Identity=26.0162601626016, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=307, Percent_Identity=37.785016286645, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=28.3464566929134, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=337, Percent_Identity=28.1899109792285, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=27.82874617737, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=30.4526748971193, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=298, Percent_Identity=28.1879194630872, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=33.1428571428571, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=287, Percent_Identity=24.0418118466899, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=30.2702702702703, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19921140, Length=313, Percent_Identity=35.7827476038339, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24646446, Length=262, Percent_Identity=30.9160305343511, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646448, Length=262, Percent_Identity=30.9160305343511, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646452, Length=262, Percent_Identity=30.9160305343511, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646450, Length=262, Percent_Identity=30.9160305343511, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=30.9160305343511, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI28574286, Length=306, Percent_Identity=30.0653594771242, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=28.7539936102236, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=28.7539936102236, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=28.7539936102236, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=28.7539936102236, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=28.7539936102236, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=30.2547770700637, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=25.8785942492013, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57912; Mature: 57912

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQVAICDPIHAKGIQILESQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFL
CEEEEECCCCCCCCHHHHCCCCCEEEECCCCCCHHHHHHHHCCHHHHHHCCCCCHHHHHH
KPLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCA
HHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
NDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCC
TDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYNED
CCEEEEEECCHHHHHHCCEEEEECCCCCCEEEECCHHHHHHHHCCEEEEEECCCCCCCHH
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLTNVYATPHIGANTLESQEEISKQAAQGV
HHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHH
MESLRGSSHPHALNLPMQAFDASAKAYLNLAQKLGYFSSQIHKGVCQKIEISLCGEINQF
HHHHCCCCCCCEEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHH
KDALVAFTLVGVLKPVVGDKINYINAPFVAKERGIEIKVSLKESASPYKNMLSLTLNAAN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHEEEEEEEECC
GSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
CEEEEEEEEHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEEEC
>Mature Secondary Structure
MYQVAICDPIHAKGIQILESQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFL
CEEEEECCCCCCCCHHHHCCCCCEEEECCCCCCHHHHHHHHCCHHHHHHCCCCCHHHHHH
KPLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCA
HHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
NDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCC
TDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYNED
CCEEEEEECCHHHHHHCCEEEEECCCCCCEEEECCHHHHHHHHCCEEEEEECCCCCCCHH
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLTNVYATPHIGANTLESQEEISKQAAQGV
HHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHH
MESLRGSSHPHALNLPMQAFDASAKAYLNLAQKLGYFSSQIHKGVCQKIEISLCGEINQF
HHHHCCCCCCCEEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHH
KDALVAFTLVGVLKPVVGDKINYINAPFVAKERGIEIKVSLKESASPYKNMLSLTLNAAN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHEEEEEEEECC
GSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
CEEEEEEEEHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]