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The map label for this gene is typA [H]

Identifier: 108562882

GI number: 108562882

Start: 469973

End: 471772

Strand: Direct

Name: typA [H]

Synonym: HPAG1_0457

Alternate gene names: 108562882

Gene position: 469973-471772 (Clockwise)

Preceding gene: 108562881

Following gene: 108562883

Centisome position: 29.44

GC content: 42.83

Gene sequence:

>1800_bases
ATGAAAAATATTAGAAATATCGCTGTAATCGCGCATGTTGATCATGGGAAAACCACTCTAGTAGATGGCTTACTTTCTCA
ATCTGGCACATTTAGTGAGAGAGAAAAAGTGGATGAAAGGGTGATGGATAGCAATGATTTAGAAAGAGAAAGAGGGATTA
CTATCCTGTCTAAAAACACCGCTATTTATTACAAAGACACTAAAATCAATATCATTGACACTCCCGGGCATGCTGATTTT
GGGGGCGAAGTGGAGCGCGTTTTAAAAATGGTAGATGGGGTGTTGCTTTTAGTGGACGCTCAAGAAGGGGTCATGCCTCA
AACTAAATTCGTGGTTAAAAAGGCTTTGAGTTTTGGGATTTGCCCTATTGTGGTGGTGAATAAAATTGATAAGCCTGCCG
CTGAACCGGACAGAGTGGTGGATGAAGTTTTTGACTTGTTCGTAGCGATGGGGGCTAGTGATAAACAATTGGATTTCCCT
GTCGTGTATGCCGCCGCACGAGATGGCTATGCGATGAAAAGTTTAGACGATGAAAAGAAAAATTTAGAGCCTTTGTTTGA
AACGATTTTAGAGCATGTGCCAAGCCCTAGCGGGAGCGTTGATGAGCCTTTGCAAATGCAAATTTTCACGCTTGATTATG
ACAATTATGTGGGCAAAATCGGTATCGCTAGGGTGTTTAATGGCTCGGTTAAAAAGAATGAAAGCGTGCTGTTGATGAAA
AGCGATGGGAGTAAAGAAAATGGCCGTATCACTAAGCTTATAGGTTTTTTAGGGCTGGCTAGGACTGAGATTGAAAACGC
TTATGCGGGCGATATTGTAGCGCTTGCTGGGTTTAACGCAATGGATGTGGGCGATAGCGTCGTTGATCCTGCTAACCCCA
TGCCTTTAGATCCCATGCATTTAGAAGAGCCTACGATGAGCGTGTATTTTGCTGTCAATGATTCACCCTTAGCCGGGTTA
GAAGGAAAGCATGTTACTGCTAATAAATTGAAAGACAGGCTCTTAAAAGAAATGCAAACCAATATCGCTATGAAATGCGA
AGAAATGGGTGAGGGCAAGTTTAAAGTGAGCGGGCGTGGGGAATTGCAAATCACTATTTTAGCTGAAAACTTGCGCCGTG
AAGGGTTTGAATTTAGCATTTCACGCCCTGAAGTCATCATTAAAGAAGAAAATGGCGTTAAATGCGAGCCTTTTGAGCAT
TTAGTGATTGACACGCCCCAAGATTTTAGCGGGGCTATCATTGAAAGATTAGGCAAAAGAAAAGCCGAGATGAAAGCGAT
GAATCCCATGAGTGATGGCTATACAAGATTAGAATTTGAAATTCCTGCAAGAGGGCTTATCGGCTATAGGAGCGAGTTTT
TAACCGACACTAAGGGCGAAGGCGTGATGAATCATAGCTTTTTAGAATTCCGCCCTTTTAGCGGGAGCGTGGAATCGCGC
AAAAATGGGGCGCTCATTAGCATGGAAAATGGCGAAGCGACCGCTTTTTCCCTTTTCAATATCCAAGAGAGAGGCGTGCT
TTTTATCAACCCCCAAACTAAGGTTTATGTGGGCATGGTCATTGGCGAGCACAGCAGGGATAATGATTTAGATGTCAATC
CCATTAAATCCAAGCATTTAACCAACATGAGAGCGAGCGGGAGCGATGATGCGATCAAACTCACCCCGCCTAGGACTATG
GTGTTAGAAAGAGCGTTAGAATGGATTGAAGAAGATGAGATTTTAGAAGTTACCCCCTTGAATTTAAGGATCAGAAAAAA
GATTTTAGACCCTAACATGAGGAAAAGGGCGAAAAAATAA

Upstream 100 bases:

>100_bases
CCATTCTATAGAACAGGATTTGGCCAAAAAATTCCGCCATTTGGGGCTATTATAATATTGTGTTATACTTCTAATTTCAA
TTTTGCTTGTTAGGACATTC

Downstream 100 bases:

>100_bases
ATAGAATTTTTTGGAATGCATGCCAACTTATTCAACCAAAACGCTAGTAAAAGAGATGTTTTTTTGCACCATTTACGCTC
TAATAATGGGCGTTACAAAC

Product: GTP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MKNIRNIAVIAHVDHGKTTLVDGLLSQSGTFSEREKVDERVMDSNDLERERGITILSKNTAIYYKDTKINIIDTPGHADF
GGEVERVLKMVDGVLLLVDAQEGVMPQTKFVVKKALSFGICPIVVVNKIDKPAAEPDRVVDEVFDLFVAMGASDKQLDFP
VVYAAARDGYAMKSLDDEKKNLEPLFETILEHVPSPSGSVDEPLQMQIFTLDYDNYVGKIGIARVFNGSVKKNESVLLMK
SDGSKENGRITKLIGFLGLARTEIENAYAGDIVALAGFNAMDVGDSVVDPANPMPLDPMHLEEPTMSVYFAVNDSPLAGL
EGKHVTANKLKDRLLKEMQTNIAMKCEEMGEGKFKVSGRGELQITILAENLRREGFEFSISRPEVIIKEENGVKCEPFEH
LVIDTPQDFSGAIIERLGKRKAEMKAMNPMSDGYTRLEFEIPARGLIGYRSEFLTDTKGEGVMNHSFLEFRPFSGSVESR
KNGALISMENGEATAFSLFNIQERGVLFINPQTKVYVGMVIGEHSRDNDLDVNPIKSKHLTNMRASGSDDAIKLTPPRTM
VLERALEWIEEDEILEVTPLNLRIRKKILDPNMRKRAKK

Sequences:

>Translated_599_residues
MKNIRNIAVIAHVDHGKTTLVDGLLSQSGTFSEREKVDERVMDSNDLERERGITILSKNTAIYYKDTKINIIDTPGHADF
GGEVERVLKMVDGVLLLVDAQEGVMPQTKFVVKKALSFGICPIVVVNKIDKPAAEPDRVVDEVFDLFVAMGASDKQLDFP
VVYAAARDGYAMKSLDDEKKNLEPLFETILEHVPSPSGSVDEPLQMQIFTLDYDNYVGKIGIARVFNGSVKKNESVLLMK
SDGSKENGRITKLIGFLGLARTEIENAYAGDIVALAGFNAMDVGDSVVDPANPMPLDPMHLEEPTMSVYFAVNDSPLAGL
EGKHVTANKLKDRLLKEMQTNIAMKCEEMGEGKFKVSGRGELQITILAENLRREGFEFSISRPEVIIKEENGVKCEPFEH
LVIDTPQDFSGAIIERLGKRKAEMKAMNPMSDGYTRLEFEIPARGLIGYRSEFLTDTKGEGVMNHSFLEFRPFSGSVESR
KNGALISMENGEATAFSLFNIQERGVLFINPQTKVYVGMVIGEHSRDNDLDVNPIKSKHLTNMRASGSDDAIKLTPPRTM
VLERALEWIEEDEILEVTPLNLRIRKKILDPNMRKRAKK
>Mature_599_residues
MKNIRNIAVIAHVDHGKTTLVDGLLSQSGTFSEREKVDERVMDSNDLERERGITILSKNTAIYYKDTKINIIDTPGHADF
GGEVERVLKMVDGVLLLVDAQEGVMPQTKFVVKKALSFGICPIVVVNKIDKPAAEPDRVVDEVFDLFVAMGASDKQLDFP
VVYAAARDGYAMKSLDDEKKNLEPLFETILEHVPSPSGSVDEPLQMQIFTLDYDNYVGKIGIARVFNGSVKKNESVLLMK
SDGSKENGRITKLIGFLGLARTEIENAYAGDIVALAGFNAMDVGDSVVDPANPMPLDPMHLEEPTMSVYFAVNDSPLAGL
EGKHVTANKLKDRLLKEMQTNIAMKCEEMGEGKFKVSGRGELQITILAENLRREGFEFSISRPEVIIKEENGVKCEPFEH
LVIDTPQDFSGAIIERLGKRKAEMKAMNPMSDGYTRLEFEIPARGLIGYRSEFLTDTKGEGVMNHSFLEFRPFSGSVESR
KNGALISMENGEATAFSLFNIQERGVLFINPQTKVYVGMVIGEHSRDNDLDVNPIKSKHLTNMRASGSDDAIKLTPPRTM
VLERALEWIEEDEILEVTPLNLRIRKKILDPNMRKRAKK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=309, Percent_Identity=32.6860841423948, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=48.1203007518797, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI18390331, Length=145, Percent_Identity=42.0689655172414, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI4503483, Length=145, Percent_Identity=40, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=45.945945945946, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=45.945945945946, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=45.945945945946, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI25306283, Length=145, Percent_Identity=40, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI25306287, Length=475, Percent_Identity=25.0526315789474, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI19923640, Length=145, Percent_Identity=40, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI217272894, Length=172, Percent_Identity=36.046511627907, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI217272892, Length=172, Percent_Identity=36.046511627907, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI34147630, Length=274, Percent_Identity=26.6423357664234, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI53729339, Length=249, Percent_Identity=28.9156626506024, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI53729337, Length=249, Percent_Identity=28.9156626506024, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=53.3996683250415, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=299, Percent_Identity=36.7892976588629, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=38.5135135135135, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=31.7241379310345, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1789559, Length=140, Percent_Identity=36.4285714285714, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790412, Length=294, Percent_Identity=27.2108843537415, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1789737, Length=294, Percent_Identity=27.2108843537415, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17557151, Length=236, Percent_Identity=36.0169491525424, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=44.3661971830986, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71988819, Length=134, Percent_Identity=41.7910447761194, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988811, Length=134, Percent_Identity=41.7910447761194, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=146, Percent_Identity=41.0958904109589, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17506493, Length=174, Percent_Identity=35.0574712643678, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=36.5671641791045, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994658, Length=256, Percent_Identity=28.515625, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17556456, Length=295, Percent_Identity=26.4406779661017, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=493, Percent_Identity=26.7748478701826, Blast_Score=154, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6324707, Length=163, Percent_Identity=39.8773006134969, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320593, Length=163, Percent_Identity=39.8773006134969, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323098, Length=149, Percent_Identity=38.255033557047, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=35, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=151, Percent_Identity=37.7483443708609, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324761, Length=270, Percent_Identity=27.037037037037, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324550, Length=286, Percent_Identity=24.1258741258741, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325337, Length=318, Percent_Identity=25.1572327044025, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319594, Length=318, Percent_Identity=25.1572327044025, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI78706572, Length=493, Percent_Identity=27.5862068965517, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24582462, Length=148, Percent_Identity=42.5675675675676, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585709, Length=166, Percent_Identity=37.9518072289157, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585711, Length=166, Percent_Identity=37.9518072289157, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24585713, Length=166, Percent_Identity=37.9518072289157, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=40.2877697841727, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357743, Length=171, Percent_Identity=36.8421052631579, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI221458488, Length=233, Percent_Identity=34.3347639484979, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281363316, Length=231, Percent_Identity=30.7359307359307, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17864358, Length=231, Percent_Identity=30.7359307359307, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921738, Length=280, Percent_Identity=28.9285714285714, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45550900, Length=324, Percent_Identity=26.2345679012346, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28572034, Length=238, Percent_Identity=28.9915966386555, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66675; Mature: 66675

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIRNIAVIAHVDHGKTTLVDGLLSQSGTFSEREKVDERVMDSNDLERERGITILSKNT
CCCCCEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHCCEEEEECCE
AIYYKDTKINIIDTPGHADFGGEVERVLKMVDGVLLLVDAQEGVMPQTKFVVKKALSFGI
EEEEECCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCC
CPIVVVNKIDKPAAEPDRVVDEVFDLFVAMGASDKQLDFPVVYAAARDGYAMKSLDDEKK
CCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECCCCCHHH
NLEPLFETILEHVPSPSGSVDEPLQMQIFTLDYDNYVGKIGIARVFNGSVKKNESVLLMK
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEHHCCCCCCCCCEEEEE
SDGSKENGRITKLIGFLGLARTEIENAYAGDIVALAGFNAMDVGDSVVDPANPMPLDPMH
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHCCCCCCCCCCCCCCCCCCC
LEEPTMSVYFAVNDSPLAGLEGKHVTANKLKDRLLKEMQTNIAMKCEEMGEGKFKVSGRG
CCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHHCCCCEEEECCCC
ELQITILAENLRREGFEFSISRPEVIIKEENGVKCEPFEHLVIDTPQDFSGAIIERLGKR
EEEEEEEEEHHHCCCCEEECCCCEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
KAEMKAMNPMSDGYTRLEFEIPARGLIGYRSEFLTDTKGEGVMNHSFLEFRPFSGSVESR
HHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCC
KNGALISMENGEATAFSLFNIQERGVLFINPQTKVYVGMVIGEHSRDNDLDVNPIKSKHL
CCCCEEEECCCCEEEEEEEEECCCCEEEECCCCEEEEEEEEECCCCCCCCCCCCCCHHHH
TNMRASGSDDAIKLTPPRTMVLERALEWIEEDEILEVTPLNLRIRKKILDPNMRKRAKK
CCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHCCCCHHHHCCC
>Mature Secondary Structure
MKNIRNIAVIAHVDHGKTTLVDGLLSQSGTFSEREKVDERVMDSNDLERERGITILSKNT
CCCCCEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHCCEEEEECCE
AIYYKDTKINIIDTPGHADFGGEVERVLKMVDGVLLLVDAQEGVMPQTKFVVKKALSFGI
EEEEECCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCC
CPIVVVNKIDKPAAEPDRVVDEVFDLFVAMGASDKQLDFPVVYAAARDGYAMKSLDDEKK
CCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECCCCCHHH
NLEPLFETILEHVPSPSGSVDEPLQMQIFTLDYDNYVGKIGIARVFNGSVKKNESVLLMK
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEHHCCCCCCCCCEEEEE
SDGSKENGRITKLIGFLGLARTEIENAYAGDIVALAGFNAMDVGDSVVDPANPMPLDPMH
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHCCCCCCCCCCCCCCCCCCC
LEEPTMSVYFAVNDSPLAGLEGKHVTANKLKDRLLKEMQTNIAMKCEEMGEGKFKVSGRG
CCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHHCCCCEEEECCCC
ELQITILAENLRREGFEFSISRPEVIIKEENGVKCEPFEHLVIDTPQDFSGAIIERLGKR
EEEEEEEEEHHHCCCCEEECCCCEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
KAEMKAMNPMSDGYTRLEFEIPARGLIGYRSEFLTDTKGEGVMNHSFLEFRPFSGSVESR
HHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCC
KNGALISMENGEATAFSLFNIQERGVLFINPQTKVYVGMVIGEHSRDNDLDVNPIKSKHL
CCCCEEEECCCCEEEEEEEEECCCCEEEECCCCEEEEEEEEECCCCCCCCCCCCCCHHHH
TNMRASGSDDAIKLTPPRTMVLERALEWIEEDEILEVTPLNLRIRKKILDPNMRKRAKK
CCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]