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The map label for this gene is dxs [H]

Identifier: 108562774

GI number: 108562774

Start: 358613

End: 360469

Strand: Direct

Name: dxs [H]

Synonym: HPAG1_0349

Alternate gene names: 108562774

Gene position: 358613-360469 (Clockwise)

Preceding gene: 108562773

Following gene: 108562775

Centisome position: 22.46

GC content: 43.46

Gene sequence:

>1857_bases
GTGATTTTGCAAAATAAAACTTTTGATTTAAACCCTAATGATATTGCAGGCTTGGAGTTGGTGTGCCAAACGCTACGGGA
GCGTATTTTAGAAGTGGTGAGCGCTAATGGGGGGCATTTAAGCTCTTCTTTAGGGGCTGTGGAGCTGATTGTGGGCATGC
ATGCCTTATTTGATTGCCAAAAAAACCCTTTTATTTTTGACACTTCGCACCAGGCTTACGCTCACAAGCTCTTAACCGGG
CGCTTTGAAAGCTTTAGCACTTTAAGGCAATTCAAGGGTTTGAGCGGCTTTACTAAACCCAGCGAGAGCGCATACGATTA
TTTCATTGCCGGTCATAGCTCCACTTCGGTGTCCATAGGCGTGGGGGTGGCTAAAGCTTTTTGTTTGAAACAAGCGCTAG
GCATGCCTATAGCTTTATTAGGCGATGGGAGCATTAGTGCAGGGATTTTTTATGAAGCCTTAAACGAACTGGGCGATAGG
AAATACCCCATGATCATGATTTTGAACGATAATGAAATGAGTATCAGCACGCCTATTGGCGCTTTATCCAAAGCCCTTAG
CCAGCTGATGAAAGGCCCGTTTTATCAGTCTTTCCGCTCTAAAGTTAAAAAAATCTTAAGCACCTTACCTGAAAGCGTGA
ATTACTTAGCGAGCCGTTTTGAAGAATCTTTCAAGCTCATCACCCCGGGCGTGTTTTTTGAAGAATTGGGTATTAACTAT
ATAGGGCCTATTAACGGGCATGATTTGAGCGCGATTATTGAAACCTTGAAATTAGCCAAAGAGCTTAAAGAACCGGTGCT
AATCCATGCGCAAACCTTAAAAGGCAAAGGCTATAAGATCGCTGAAGGGCGCTATGAAAAATGGCATGGGGTGGGGCCTT
TTGATTTGGATACCGGCTTGTCTAAAAAATCCAAAAGCACGATTTTATCGCCCACTGAAGCGTATTCTAACACCCTTTTA
GAATTAGCTAAAAAAGATGAAAAAATCGTAGGCGTAACCGCTGCGATGCCTAGCGGCACAGGATTAGACAAGCTCATTGA
CGCTTACCCTTTGCGCTTTTTTGATGTCGCTATCGCTGAGCAACACGCCTTAACTTCTAGCAGCGCTATGGCTAAAGAGG
GGTTTAAACCTTTTGTGAGCATCTATTCTACTTTTTTGCAAAGGGCTTATGATTCCATTGTGCATGACGCTTGCATTTCT
AGCTTGCCGATTAAATTAGCCATTGATAGGGCTGGGATTGTGGGAGAAGATGGCGAGACGCACCAAGGGCTTTTAGACGT
GTCGTATTTGCGCTCTATCCCTAACATGGTCATTTTTGCCCCACGAGACAATGAGACTTTAAAAAACGCCGTGCGTTTTG
CTAATGAGCATGATTCAAGCCCTTGCGCGTTCCGCTACCCTAGGGGGTCGTTTGCGTTAAAAGAGGGGGTTTTTGAGCCT
AGCGGTTTTGTTTTGGGGCGAAGCGAATTGTTGAAAAAAGAGGGCGAAATTTTACTCATTGGCTATGGTAATGGCGTGGG
GCGGGCGCATTTAGTCCAACTGGCCTTAAAAGAAAAAAACATAGAGTGCGCTCTTTTGGATCTTAGGTTTTTAAAGCCCT
TAGATCCAAATTTAAGTGCGATCATTGCCCCTTATCAAAAGCTCTATGTTTTTAGCGATAATTACAAGCTTGGGGGGGTG
GCTAGCGCGATTTTAGAGTTTTTGAGCGAACAAAATATTTTAAAGCCTGTTAAAAGCTTTGAAATCATGGATGAATTTAT
CATGCATGGGAACACCGCTTTAGTGGAAAAATCCTTAGGCTTAGACACAGAGAGTTTGACTGATGCTATTTTAAAAGATT
TAGGACAAGAGAGATGA

Upstream 100 bases:

>100_bases
AAGGAGGCGTTATGATCACTAGCTCTAACGGGAGCCTTGATGGGAATTTAATGGAGCGCTTTAAAACGCTCAAAGAAAGC
GTGTTGGAAAATTTTAAGGT

Downstream 100 bases:

>100_bases
AAACAAAAGCGCCAATGAAAAATATCCGCAATTTTTCCATTATCGCTCACATTGACCATGGTAAAAGCACTTTAGCGGAT
TGTTTGATTTCTGAATGCAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MILQNKTFDLNPNDIAGLELVCQTLRERILEVVSANGGHLSSSLGAVELIVGMHALFDCQKNPFIFDTSHQAYAHKLLTG
RFESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIGVGVAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDR
KYPMIMILNDNEMSISTPIGALSKALSQLMKGPFYQSFRSKVKKILSTLPESVNYLASRFEESFKLITPGVFFEELGINY
IGPINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGLSKKSKSTILSPTEAYSNTLL
ELAKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACIS
SLPIKLAIDRAGIVGEDGETHQGLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHDSSPCAFRYPRGSFALKEGVFEP
SGFVLGRSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDPNLSAIIAPYQKLYVFSDNYKLGGV
ASAILEFLSEQNILKPVKSFEIMDEFIMHGNTALVEKSLGLDTESLTDAILKDLGQER

Sequences:

>Translated_618_residues
MILQNKTFDLNPNDIAGLELVCQTLRERILEVVSANGGHLSSSLGAVELIVGMHALFDCQKNPFIFDTSHQAYAHKLLTG
RFESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIGVGVAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDR
KYPMIMILNDNEMSISTPIGALSKALSQLMKGPFYQSFRSKVKKILSTLPESVNYLASRFEESFKLITPGVFFEELGINY
IGPINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGLSKKSKSTILSPTEAYSNTLL
ELAKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACIS
SLPIKLAIDRAGIVGEDGETHQGLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHDSSPCAFRYPRGSFALKEGVFEP
SGFVLGRSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDPNLSAIIAPYQKLYVFSDNYKLGGV
ASAILEFLSEQNILKPVKSFEIMDEFIMHGNTALVEKSLGLDTESLTDAILKDLGQER
>Mature_618_residues
MILQNKTFDLNPNDIAGLELVCQTLRERILEVVSANGGHLSSSLGAVELIVGMHALFDCQKNPFIFDTSHQAYAHKLLTG
RFESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIGVGVAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDR
KYPMIMILNDNEMSISTPIGALSKALSQLMKGPFYQSFRSKVKKILSTLPESVNYLASRFEESFKLITPGVFFEELGINY
IGPINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGLSKKSKSTILSPTEAYSNTLL
ELAKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACIS
SLPIKLAIDRAGIVGEDGETHQGLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHDSSPCAFRYPRGSFALKEGVFEP
SGFVLGRSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDPNLSAIIAPYQKLYVFSDNYKLGGV
ASAILEFLSEQNILKPVKSFEIMDEFIMHGNTALVEKSLGLDTESLTDAILKDLGQER

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=364, Percent_Identity=25.8241758241758, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4507521, Length=364, Percent_Identity=25.8241758241758, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI133778974, Length=372, Percent_Identity=22.8494623655914, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI225637463, Length=382, Percent_Identity=23.8219895287958, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI225637459, Length=382, Percent_Identity=23.8219895287958, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI225637461, Length=382, Percent_Identity=23.8219895287958, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1786622, Length=596, Percent_Identity=41.1073825503356, Blast_Score=443, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17539652, Length=398, Percent_Identity=24.3718592964824, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24666278, Length=269, Percent_Identity=29.7397769516729, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45551847, Length=391, Percent_Identity=26.0869565217391, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550715, Length=391, Percent_Identity=26.0869565217391, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24645119, Length=391, Percent_Identity=26.0869565217391, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67740; Mature: 67740

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILQNKTFDLNPNDIAGLELVCQTLRERILEVVSANGGHLSSSLGAVELIVGMHALFDCQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
KNPFIFDTSHQAYAHKLLTGRFESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIG
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEH
VGVAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDRKYPMIMILNDNEMSISTPIG
HHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHH
ALSKALSQLMKGPFYQSFRSKVKKILSTLPESVNYLASRFEESFKLITPGVFFEELGINY
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCE
IGPINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGL
ECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCHHHCCCCCCCCCCCC
SKKSKSTILSPTEAYSNTLLELAKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHH
QHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSLPIKLAIDRAGIVGEDGET
HHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
HQGLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHDSSPCAFRYPRGSFALKEGVFEP
CCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHCCCCC
SGFVLGRSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDPNLSA
CCCEECHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHH
IIAPYQKLYVFSDNYKLGGVASAILEFLSEQNILKPVKSFEIMDEFIMHGNTALVEKSLG
HHCCCEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
LDTESLTDAILKDLGQER
CCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MILQNKTFDLNPNDIAGLELVCQTLRERILEVVSANGGHLSSSLGAVELIVGMHALFDCQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
KNPFIFDTSHQAYAHKLLTGRFESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIG
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEH
VGVAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDRKYPMIMILNDNEMSISTPIG
HHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHH
ALSKALSQLMKGPFYQSFRSKVKKILSTLPESVNYLASRFEESFKLITPGVFFEELGINY
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCE
IGPINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGL
ECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCHHHCCCCCCCCCCCC
SKKSKSTILSPTEAYSNTLLELAKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHH
QHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSLPIKLAIDRAGIVGEDGET
HHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
HQGLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHDSSPCAFRYPRGSFALKEGVFEP
CCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHCCCCC
SGFVLGRSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDPNLSA
CCCEECHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHH
IIAPYQKLYVFSDNYKLGGVASAILEFLSEQNILKPVKSFEIMDEFIMHGNTALVEKSLG
HHCCCEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
LDTESLTDAILKDLGQER
CCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA