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The map label for this gene is obgE [H]

Identifier: 108562730

GI number: 108562730

Start: 318284

End: 319366

Strand: Direct

Name: obgE [H]

Synonym: HPAG1_0305

Alternate gene names: 108562730

Gene position: 318284-319366 (Clockwise)

Preceding gene: 108562729

Following gene: 108562731

Centisome position: 19.94

GC content: 44.41

Gene sequence:

>1083_bases
GTGTTTGTAGATAGCGTGGAAATCATCATCGCTTCGGGTAAGGGGGGGCCTGGAATGGTGAGTTTTAGGCGAGAAAAGTT
TGTCATCAAAGGAGGCCCTGATGGGGGCGATGGGGGCGATGGGGGCGATGTGTATTTTGAAGTGGATAACAATACCGACA
CTTTAGCGAGTTTTAGAGGCACTAAACACCATAAGGCTAAAAACGGAGCTCCAGGAGGCACACGAAATTGCGCGGGCAAA
AAGGGCGAAGACAAAATTATTGTCGTGCCGCCAGGAACGCAAGTTTTTGTAGGTGACAAGTTGTGGCTTGATTTGATCAC
GCCTAAAGAAAGGGTGTTAGCCTTAAAAGGAGGCAAGGGAGGGTTGGGGAATGCGCATTTTAAAAGCGCGACTAAACAAC
AACCCACTTACGCGCAAAAAGGCTTGGAGGGGGTTGAAAAATGCGTGCGTTTGGAATTAAAACTCATCGCTGACATAGGG
TTAGTGGGCTTCCCTAATGCGGGTAAATCCACGCTCATTTCCACCATCTCTAACGCTAAGCCCAAAATCGCTAATTATGA
ATTCACGACTCTAGTGCCTAATTTAGGGGTTGTGAGCGTAGATGAAAAAAGCGAATTTCTAATGGCTGATATTCCTGGCA
TTATTGAAGGGGCTAGTCAGGGAAAAGGCTTAGGGATTAGCTTTTTAAAGCATATTGAACGCACCAAAGTTCTAGCCTTT
GTTTTAGACGCTTCTAGGCTGGATTTGGGTATTAAAGAGCAATACCAACGCTTGAGGTTGGAGCTGGAAAAATTTTCACC
CGCTTTGGCCAATAAGCCTTTTGGGGTGTTGCTCAATAAATGCGATGTTGTAGAAAACATTGATAAGATGGCTAAGGATT
TTTGCGCCTTTTTAAACTTAGAAGCGCAAAAATTAGAGGCGTTTGGTTTAGAGCCGTATTTAGGGTTTTTGCACCCCCAT
TTAACTAGCGATTTTGAAAATAACCCTAATGAAAAATCAGCGCTCTTTGTCTTACCCCTTTCAGCGGTTAGCGCTCTTAA
TACGCATGCGCTTAAATTTGTGTTGTTGGAAGCGTTACCATAA

Upstream 100 bases:

>100_bases
CGCTCCCAAGCACCCTTATACGCAGAAATTACTCAATGCGGTGCCGCATTTGGAAAAATCCATGCAAAGATTTGCCAAAT
AAAAGAAAGGGTATTAAGCT

Downstream 100 bases:

>100_bases
AACGCTATTTTTAGATCAATCCATTAAAATAAAGGCGTGGAATGAAAAGATTTGTTTTGTTTTTATCGTTCATGTTTGTT
TGCGTTTGCGTTCAAGCTTA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRGTKHHKAKNGAPGGTRNCAGK
KGEDKIIVVPPGTQVFVGDKLWLDLITPKERVLALKGGKGGLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIG
LVGFPNAGKSTLISTISNAKPKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASQGKGLGISFLKHIERTKVLAF
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDKMAKDFCAFLNLEAQKLEAFGLEPYLGFLHPH
LTSDFENNPNEKSALFVLPLSAVSALNTHALKFVLLEALP

Sequences:

>Translated_360_residues
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRGTKHHKAKNGAPGGTRNCAGK
KGEDKIIVVPPGTQVFVGDKLWLDLITPKERVLALKGGKGGLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIG
LVGFPNAGKSTLISTISNAKPKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASQGKGLGISFLKHIERTKVLAF
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDKMAKDFCAFLNLEAQKLEAFGLEPYLGFLHPH
LTSDFENNPNEKSALFVLPLSAVSALNTHALKFVLLEALP
>Mature_360_residues
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRGTKHHKAKNGAPGGTRNCAGK
KGEDKIIVVPPGTQVFVGDKLWLDLITPKERVLALKGGKGGLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIG
LVGFPNAGKSTLISTISNAKPKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASQGKGLGISFLKHIERTKVLAF
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDKMAKDFCAFLNLEAQKLEAFGLEPYLGFLHPH
LTSDFENNPNEKSALFVLPLSAVSALNTHALKFVLLEALP

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=284, Percent_Identity=41.1971830985916, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI111955139, Length=354, Percent_Identity=36.1581920903955, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI111955063, Length=210, Percent_Identity=37.6190476190476, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI4557537, Length=120, Percent_Identity=34.1666666666667, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4758796, Length=126, Percent_Identity=38.8888888888889, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789574, Length=295, Percent_Identity=48.135593220339, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1787454, Length=99, Percent_Identity=37.3737373737374, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=322, Percent_Identity=40.3726708074534, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17552324, Length=329, Percent_Identity=31.9148936170213, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71981008, Length=117, Percent_Identity=40.1709401709402, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=37.2881355932203, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=180, Percent_Identity=42.2222222222222, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321612, Length=124, Percent_Identity=39.5161290322581, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319281, Length=125, Percent_Identity=35.2, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20129375, Length=290, Percent_Identity=41.7241379310345, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24585318, Length=291, Percent_Identity=35.3951890034364, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21356473, Length=90, Percent_Identity=41.1111111111111, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17981711, Length=126, Percent_Identity=37.3015873015873, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 38747; Mature: 38747

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRG
CCCCCEEEEEEECCCCCCCEEEECEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHCC
TKHHKAKNGAPGGTRNCAGKKGEDKIIVVPPGTQVFVGDKLWLDLITPKERVLALKGGKG
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCEEEEEEECCCCEEEEEECCCC
GLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIGLVGFPNAGKSTLISTISNAK
CCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCC
PKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASQGKGLGISFLKHIERTKVLAF
CCCCCEEEEEECCCCCEEEECCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHE
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDKMAKDFCAFLNL
EECHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAQKLEAFGLEPYLGFLHPHLTSDFENNPNEKSALFVLPLSAVSALNTHALKFVLLEALP
CHHHHHHCCCCHHHHHHCHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRG
CCCCCEEEEEEECCCCCCCEEEECEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHCC
TKHHKAKNGAPGGTRNCAGKKGEDKIIVVPPGTQVFVGDKLWLDLITPKERVLALKGGKG
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCEEEEEEECCCCEEEEEECCCC
GLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIGLVGFPNAGKSTLISTISNAK
CCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCC
PKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASQGKGLGISFLKHIERTKVLAF
CCCCCEEEEEECCCCCEEEECCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHE
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDKMAKDFCAFLNL
EECHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAQKLEAFGLEPYLGFLHPHLTSDFENNPNEKSALFVLPLSAVSALNTHALKFVLLEALP
CHHHHHHCCCCHHHHHHCHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA