Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 103487122

GI number: 103487122

Start: 1719101

End: 1720351

Strand: Direct

Name: fadA [H]

Synonym: Sala_1637

Alternate gene names: 103487122

Gene position: 1719101-1720351 (Clockwise)

Preceding gene: 103487121

Following gene: 103487123

Centisome position: 51.39

GC content: 66.99

Gene sequence:

>1251_bases
ATGGCCGAAGCCTATATCATCGACGCCGTCCGCACCCCGCGCGGGATCGGCAAGCCCGGCAAGGGCGCGCTGTCGCATCT
CCACCCGCAACATCTCGCCGCAACGGTGCTGAAGGCGATCAGGGATCGCAATAATCTCGACACCAGGACCGTCGACGACA
TCATCTGGTCGACCTCGACCCAGCGCGGCAAACAGGGCGGCGACCTCGGCCGCATGGCAGCGCTGTCGGCGGGTTATGAC
ATCAAGGCATCGGGAACGACGCTCGACCGCTTCTGCGGCGGCGGCATCACCTCGGTCAATCTCGCCGCGGCGACGGTGAT
GAGCGGCATGGAGGATTGCGTCGTCGCGGGCGGCACCGAGATGATGAGCTACACCGCCCAGCTCGCGGCCGAAGAAGCGA
ATGCCGGGATCAAACCGCTCGGCATGGGTGCGGGCCACGCGGCGCTCGACGAGCTTCACCCGCAGTCGCATCAGGGCGTG
TGCGGCGACGCCATCGCCGCAATCGAGGGAATCGACCGTGCCGCCGTCGATGCGCTCGCGCTCGTCAGCCAGCGGCGCGC
CGACCGTGCGATCAAGGAGGGTCGCTTCGCCAAATCGCTGGTGCCCGTGCTCAACCCCGACGGCAGCATCGCACTCGACC
ATGAGGAGTTTCCGCGCCCCGAAACCACCGCCGAAGGTCTCGCCGCGCTCAAGCCGAGCTTCGACGCGATCGCCGATTTC
GACTTGGGCGGCGGCGTGACCTTCCGAAAGCAGATTCAGCGGCGCTATCCGGGGCTGGAGTTTCGCGGCGTCCACCATGC
CGGAAACTCGTCGGGGGTCGTCGACGGCGCTGCGGCGCTGCTCGTCACCTCGAAGGCCTATGCCGACAAACACGGCCTGA
AACCCCGCGCGCGCATCGTCGCCTACGCCAATATCGGCGACGATCCGACCTTGATGCTCAACGCCCCGGTCCCCGCGGCG
AAGAAGGTGCTCGATAAGGCGGGGCTCACCAGGGACGACATCGACGTCTGGGAAATCAACGAGGCTTTCGCCGTCGTTGC
GGAGAAGTTCATCCGCGACCTCGACCTGCCCCGCGACAAGGTCAACATCAACGGCGGCGCGATGGCGCTCGGCCACCCGA
TCGGCGCCACCGGATCGATCCTGATCGGCACCGCGCTCGACGAGCTGGAACGCTCGGGCGGTCGTTACGGCCTCGTCACC
ATGTGCGCCGCAGGCGGCATGGCGCCAGCGATCATCATCGAGCGGATCTGA

Upstream 100 bases:

>100_bases
CACGATTGCCGAAAAGATCCTCGGACTTCCGCAGGATTACCGCCCCGACAAGGGCGTCCCGTTCAACCAGATTCCCGCCT
GATCACAAGGATATCAGACC

Downstream 100 bases:

>100_bases
CCGGCTTTCCTGCGGGAGAATAGGAAATGGCTTTCAAGACGCGGATTACGGAGATGCTGGGGATTGCGCATCCGATCGTC
CAGGGGGGGATGCAGAGCGT

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAEAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLKAIRDRNNLDTRTVDDIIWSTSTQRGKQGGDLGRMAALSAGYD
IKASGTTLDRFCGGGITSVNLAAATVMSGMEDCVVAGGTEMMSYTAQLAAEEANAGIKPLGMGAGHAALDELHPQSHQGV
CGDAIAAIEGIDRAAVDALALVSQRRADRAIKEGRFAKSLVPVLNPDGSIALDHEEFPRPETTAEGLAALKPSFDAIADF
DLGGGVTFRKQIQRRYPGLEFRGVHHAGNSSGVVDGAAALLVTSKAYADKHGLKPRARIVAYANIGDDPTLMLNAPVPAA
KKVLDKAGLTRDDIDVWEINEAFAVVAEKFIRDLDLPRDKVNINGGAMALGHPIGATGSILIGTALDELERSGGRYGLVT
MCAAGGMAPAIIIERI

Sequences:

>Translated_416_residues
MAEAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLKAIRDRNNLDTRTVDDIIWSTSTQRGKQGGDLGRMAALSAGYD
IKASGTTLDRFCGGGITSVNLAAATVMSGMEDCVVAGGTEMMSYTAQLAAEEANAGIKPLGMGAGHAALDELHPQSHQGV
CGDAIAAIEGIDRAAVDALALVSQRRADRAIKEGRFAKSLVPVLNPDGSIALDHEEFPRPETTAEGLAALKPSFDAIADF
DLGGGVTFRKQIQRRYPGLEFRGVHHAGNSSGVVDGAAALLVTSKAYADKHGLKPRARIVAYANIGDDPTLMLNAPVPAA
KKVLDKAGLTRDDIDVWEINEAFAVVAEKFIRDLDLPRDKVNINGGAMALGHPIGATGSILIGTALDELERSGGRYGLVT
MCAAGGMAPAIIIERI
>Mature_415_residues
AEAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLKAIRDRNNLDTRTVDDIIWSTSTQRGKQGGDLGRMAALSAGYDI
KASGTTLDRFCGGGITSVNLAAATVMSGMEDCVVAGGTEMMSYTAQLAAEEANAGIKPLGMGAGHAALDELHPQSHQGVC
GDAIAAIEGIDRAAVDALALVSQRRADRAIKEGRFAKSLVPVLNPDGSIALDHEEFPRPETTAEGLAALKPSFDAIADFD
LGGGVTFRKQIQRRYPGLEFRGVHHAGNSSGVVDGAAALLVTSKAYADKHGLKPRARIVAYANIGDDPTLMLNAPVPAAK
KVLDKAGLTRDDIDVWEINEAFAVVAEKFIRDLDLPRDKVNINGGAMALGHPIGATGSILIGTALDELERSGGRYGLVTM
CAAGGMAPAIIIERI

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=414, Percent_Identity=35.024154589372, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI4501853, Length=421, Percent_Identity=34.2042755344418, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI167614485, Length=417, Percent_Identity=33.0935251798561, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4557237, Length=427, Percent_Identity=31.3817330210773, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI4504327, Length=446, Percent_Identity=30.2690582959641, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=52.8089887640449, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1787663, Length=429, Percent_Identity=40.0932400932401, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI48994986, Length=424, Percent_Identity=34.4339622641509, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1788554, Length=423, Percent_Identity=37.8250591016548, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI87082165, Length=420, Percent_Identity=35.2380952380952, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1788683, Length=421, Percent_Identity=25.8907363420428, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI133906874, Length=421, Percent_Identity=32.541567695962, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=418, Percent_Identity=29.4258373205742, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17535921, Length=419, Percent_Identity=27.4463007159904, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17551802, Length=452, Percent_Identity=28.9823008849558, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17535917, Length=164, Percent_Identity=35.3658536585366, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322031, Length=409, Percent_Identity=31.7848410757946, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=424, Percent_Identity=30.188679245283, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24655093, Length=425, Percent_Identity=35.5294117647059, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17648125, Length=426, Percent_Identity=32.8638497652582, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24640423, Length=422, Percent_Identity=30.8056872037915, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI17137578, Length=447, Percent_Identity=28.6353467561521, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 43508; Mature: 43377

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLKAIRDRNNLDTRTVDDIIWSTST
CCCEEEEECHHCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
QRGKQGGDLGRMAALSAGYDIKASGTTLDRFCGGGITSVNLAAATVMSGMEDCVVAGGTE
CCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCHH
MMSYTAQLAAEEANAGIKPLGMGAGHAALDELHPQSHQGVCGDAIAAIEGIDRAAVDALA
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
LVSQRRADRAIKEGRFAKSLVPVLNPDGSIALDHEEFPRPETTAEGLAALKPSFDAIADF
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEECHHHCCCCCCHHHHHHHHCCCCHHHCCC
DLGGGVTFRKQIQRRYPGLEFRGVHHAGNSSGVVDGAAALLVTSKAYADKHGLKPRARIV
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHEEHHHHHHHCCCCCCCEEE
AYANIGDDPTLMLNAPVPAAKKVLDKAGLTRDDIDVWEINEAFAVVAEKFIRDLDLPRDK
EEEECCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCE
VNINGGAMALGHPIGATGSILIGTALDELERSGGRYGLVTMCAAGGMAPAIIIERI
EECCCCEEEECCCCCCCCCEEEHHHHHHHHHCCCCEEHHHHHHCCCCCHHHEEECC
>Mature Secondary Structure 
AEAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLKAIRDRNNLDTRTVDDIIWSTST
CCEEEEECHHCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
QRGKQGGDLGRMAALSAGYDIKASGTTLDRFCGGGITSVNLAAATVMSGMEDCVVAGGTE
CCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCHH
MMSYTAQLAAEEANAGIKPLGMGAGHAALDELHPQSHQGVCGDAIAAIEGIDRAAVDALA
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
LVSQRRADRAIKEGRFAKSLVPVLNPDGSIALDHEEFPRPETTAEGLAALKPSFDAIADF
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEECHHHCCCCCCHHHHHHHHCCCCHHHCCC
DLGGGVTFRKQIQRRYPGLEFRGVHHAGNSSGVVDGAAALLVTSKAYADKHGLKPRARIV
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHEEHHHHHHHCCCCCCCEEE
AYANIGDDPTLMLNAPVPAAKKVLDKAGLTRDDIDVWEINEAFAVVAEKFIRDLDLPRDK
EEEECCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCE
VNINGGAMALGHPIGATGSILIGTALDELERSGGRYGLVTMCAAGGMAPAIIIERI
EECCCCEEEECCCCCCCCCEEEHHHHHHHHHCCCCEEHHHHHHCCCCCHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]